Glial involvement in diffuse Lewy body disease

Acta Neuropathologica

Volumn 105, Issue 2, 2003, Pages 163-169

  Terada, Seishi ^a   Ishizu, Hideki ^b   Yokota, Osamu ^a   Tsuchiya, Kuniaki ^c   Nakashima, Hanae ^a   Ishihara, Takeshi ^a   Fujita, Daisuke ^a   Uéda, Kenji ^d   Ikeda, Kenji ^d   Kuroda, Shigetoshi ^a  

^a OKAYAMA UNIVERSITY   (Japan)

^b Zikei Institute of Psychiatry   (Japan)

^c TOKYO METROPOLITAN MATSUZAWA HOSPITAL   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Coiled bodies; Diffuse Lewy body disease; Glia; Star like astrocyte; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; FORMIC ACID; MONOCLONAL ANTIBODY; NERVE PROTEIN; SNCA PROTEIN, HUMAN; SYNUCLEIN;

ADULT; AGED; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN STEM; CELL INCLUSION; CLINICAL ARTICLE; COILED BODY; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; FEMALE; GLIA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LEWY BODY; MALE; NERVE CELL; NEURITE; NEUROPIL THREAD; PATHOGENESIS; PRIORITY JOURNAL; TEMPORAL CORTEX; BRAIN; CONFOCAL MICROSCOPY; METABOLISM; MIDDLE AGED; PATHOLOGY; SCANNING ELECTRON MICROSCOPY; ULTRASTRUCTURE;

AGED; AGED, 80 AND OVER; ALPHA-SYNUCLEIN; ASTROCYTES; BRAIN; COILED BODIES; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; LEWY BODIES; LEWY BODY DISEASE; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, SCANNING; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROGLIA; NEURONS; NEUROPIL THREADS; SYNUCLEINS;

EID: 0037313281     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00401-002-0622-9     Document Type: Article

References (19)

1. Arai T, Uéda K, Ikeda K, Akiyama H, Haga C, Kondo H, Kuroki N, Niizato K, Iritani S, Tsuchiya K (1999) Argyrophilic glial inclusions in the midbrain of patients with Parkinson's disease and diffuse Lewy body disease are immunopositive for NACP/α-synuclein. Neurosci Lett 259:83-86
2. Arima K, Uéda K, Sunohara N, Arakawa K, Hirai S, Nakamura M, Tonozuka-Uehara H, Kawai M (1998) NACP/alpha-synuclein immunoreactivity in fibrillary components of neuronal and oligodendroglial cytoplasmic inclusions in the pontine nuclei in multiple system atrophy. Acta Neuropathol 96:439-444
3. Arima K, Uéda K, Sunohara N, Hirai S, Izumiyama Y, Tonozuka-Uehara H, Kawai M (1998) Immunoelectron-microscopic demonstration of NACP/alpha-synuclein-epitopes on the filamentous component of Lewy bodies in Parkinson's disease and in dementia with Lewy bodies. Brain Res 808:93-100
4. Arima K, Mizutani T, Alim MA, Tonozuka-Uehara H, Izumiyama Y, Hirai S, Uéda K (2000) NACP/alpha-synuclein and tau constitute two distinctive subsets of filaments in the same neuronal inclusions in brains from a family of parkinsonism and dementia with Lewy bodies: double-immunolabeling fluorescence and electron microscopic studies. Acta Neuropathol 100:115-121
5. Dickson DW, Liu W, Hardy J, Farrer M, Mehta N, Uitti R, Mark M, Zimmerman T, Golbe L, Sage J, Sima A, D'Amato C, Albin R, Gilman S, Yen SH (1999) Widespread alterations of alpha-synuclein in multiple system atrophy. Am J Pathol 155: 1241-1251
6. Hossain MS, Alim MA, Takeda K, Kaji H, Tomotaka S, Uéda K (2001) Limited proteolysis of NACP/alpha-synuclein. J Alzheimer's Dis 3:1-8
7. Kosaka K (1990) Diffuse Lewy body disease in Japan. J Neurol 237:197-204
8. Kuroda S, Hosokawa K, Iguchi K, Tateishi J (1978) An autopsy case of presenile dementia with numerous Lewy bodies in the cerebral cortex (in Japanese). Clin Neurol (Tokyo) 18: 346-350
9. Kuroda S, Otsuki S, Hayashi Y (1987) Diffuse Lewy body disease: an autopsy case. Acta Med Okayama 41:133-139
10. Kuyama K, Kuroda S, Otsuki S, Shinagawa S, Morioka E (1987) An autopsy case of "Lewy body disease" presenting dementia (in Japanese). Clin Neurol (Tokyo) 27:94-98
11. Matsusaka H, Ikeda K, Akiyama H, Arai T, Inoue M, Yagishita S (1998) Astrocytic pathology in progressive supranuclear palsy: significance for neuropathological diagnosis. Acta Neuropathol 96:248-252
12. McKeith IG, Galasko D, Kosaka K, Perry EK, Dickson DW, Hansen LA, Salmon DP, Lowe J, Mirra SS, Byrne EJ, Lennox G, Quinn NP, Edwardson JA, Ince PG, Bergeron C, Burns A, Miller BL, Lovestone S, Collerton D, Jansen ENH, Ballard C, de Vos RAI, Wilcock GK, Jellinger KA, Perry RH (1996) Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): report of the Consortium on DLB International Workshop. Neurology 47:1113-1124
13. Piao YS, Wakabayashi K, Hayashi S, Yoshimoto M, Takahashi H (2000) Aggregation of alpha-synuclein/NACP in the neuronal and glial cells in diffuse Lewy body disease: a survey of six patients. Clin Neuropathol 19:163-169
14. Shoji M, Harigaya Y, Sasaki A, Uéda K, Ishiguro K, Matsubara E, Watanabe M, Ikeda M, Kanai M, Tomidokoro Y, Shizuka M, Amari M, Kosaka K, Nakazato Y, Okamoto K, Hirai S (2000) Accumulation of NACP/alpha-synuclein in lewy body disease and multiple system atrophy. J Neurol Neurosurg Psychiatry 68:605-608
15. Takeda A, Hashimoto M, Mallory M, Sundsumo M, Hansen L, Masliah E (2000) C-terminal alpha-synuclein immunoreactivity in structures other than Lewy bodies in neurodegenerative disorders. Acta Neuropathol 99:296-304
16. Terada S, Ishizu H, Haraguchi T, Takehisa Y, Tanabe Y, Kawai K, Kuroda S (2000) Tau-negative astrocytic star-like inclusions and coiled bodies in dementia with Lewy bodies. Acta Neuropathol 100:464-468
17. Wakabayashi K, Engelender S, Yoshimoto M, Tsuji S, Ross CA, Takahashi H (2000) Synphilin-1 is present in Lewy bodies in Parkinson's disease. Ann Neurol 47:521-523
18. Wirths O, Weickert S, Majtenyi K, Havas L, Kahle PJ, Okochi M, Haass C, Multhaup G, Beyreuther K, Bayer TA (2000) Lewy body variant of Alzheimer's disease: alpha-synuclein in dystrophic neurites of Aβ plaques. Neuroreport 11:3737-3741
19. Yokota O, Terada S, Ishizu H, Tsuchiya K, Kitamura Y, Ikeda K, Uéda K, Kuroda S (2002) NACP/α-synuclein immunoreactivity in diffuse neurofibrillary tangles with calcification (DNTC). Acta Neuropathol 104:333-341