Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes

BMC Neuroscience

Volumn 16, Issue 1, 2015, Pages

  Rannikko, Emmy H ^a,c   Weber, Stephanie S ^a   Kahle, Philipp J ^a,b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Astrocytes; Cyclooxygenase; Cytokines; Endocytosis; MAP kinases; Neuroinflammation; NF B; Nitric oxide synthase; Synuclein; Toll like receptor TLR4

Indexed keywords

ALPHA SYNUCLEIN; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE SYNTHASE; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; RECOMBINANT PROTEIN; RELA PROTEIN, MOUSE; SNCA PROTEIN, HUMAN; TLR4 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CELL NUCLEUS; CONTROLLED STUDY; GENE EXPRESSION; GENOTYPE; HUMAN; IMMUNOBLOTTING; INTERNALIZATION; MICROGLIA; MOUSE; NERVE CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; ACTIVE TRANSPORT; ANIMAL; BRAIN; CELL CULTURE; ESCHERICHIA COLI; EXTRACELLULAR SPACE; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; TRANSGENIC MOUSE;

ACTIVE TRANSPORT, CELL NUCLEUS; ALPHA-SYNUCLEIN; ANIMALS; ASTROCYTES; BRAIN; CELLS, CULTURED; CYCLOOXYGENASE 2; ESCHERICHIA COLI; EXTRACELLULAR SPACE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE, KNOCKOUT; MICE, TRANSGENIC; NITRIC OXIDE SYNTHASE TYPE II; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RECOMBINANT PROTEINS; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA;

EID: 84941022770     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/s12868-015-0192-0     Document Type: Article

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