Therapeutic intervention of ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail

Science Translational Medicine

Volumn 5, Issue 199, 2013, Pages

  Pettitt, James ^a   Zeitlin, Larry ^b   Kim, Do H ^b   Working, Cara ^c   Johnson, Joshua C ^a   Bohorov, Ognian ^b   Bratcher, Barry ^c   Hiatt, Ernie ^c   Hume, Steven D ^c   Johnson, Ashley K ^c   Morton, Josh ^c   Pauly, Michael H ^b   Whaley, Kevin J ^b   Ingram, Michael F ^a   Zovanyi, Ashley ^a   Heinrich, Megan ^a   Piper, Ashley ^a   Zelko, Justine ^a   Olinger, Gene G ^a  

^a UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^b Mapp Biopharmaceutical Inc   (United States)

^c Kentucky BioProcessing   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MB 003; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EBOLA HEMORRHAGIC FEVER; EBOLA VIRUS; FEMALE; FEVER; FOOD AND DRUG ADMINISTRATION; MALE; MORBIDITY; MORTALITY; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SURVIVAL; SYMPTOM; UNITED STATES;

ANIMALS; ANTIBODIES, MONOCLONAL, HUMANIZED; ANTIBODIES, VIRAL; DISEASE MODELS, ANIMAL; EBOLA VACCINES; EBOLAVIRUS; FEMALE; HEMORRHAGIC FEVER, EBOLA; HUMANS; MACACA MULATTA; MALE; PLANTIBODIES; POST-EXPOSURE PROPHYLAXIS; TRANSLATIONAL MEDICAL RESEARCH; VIREMIA;

EID: 84883864987     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3006608     Document Type: Article

References (19)

1. H. Feldmann, S. Jones, H. D. Klenk, H. J. Schnittler, Ebola virus: From discovery to vaccine. Nat. Rev. Immunol. 3, 677-685 (2003).
2. H. Feldmann, T. W. Geisbert, Ebola haemorrhagic fever. Lancet 377, 849-862 (2011).
3. H. M. Weingartl, C. Embury-Hyatt, C. Nfon, A. Leung, G. Smith, G. Kobinger, Transmission of Ebola virus from pigs to non-human primates. Sci. Rep. 2, 811 (2012).
4. A. MacNeil, P. E. Rollin, Ebola and Marburg hemorrhagic fevers: Neglected tropical diseases? PLoS Negl. Trop. Dis. 6, e1546 (2012).
5. D. Bente, J. Gren, J. E. Strong, H. Feldmann, Disease modeling for Ebola and Marburg viruses. Dis. Model. Mech. 2, 12-17 (2009).
6. T. W. Geisbert, A. C. Lee, M. Robbins, J. B. Geisbert, A. N. Honko, V. Sood, J. C. Johnson, S. de Jong, I. Tavakoli, A. Judge, L. E. Hensley, I. Maclachlan, Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: A proof-of-concept study. Lancet 375, 1896-1905 (2010).
7. K. L. Warfield, D. L. Swenson, G. G. Olinger, D. K. Nichols, W. D. Pratt, R. Blouch, D. A. Stein, M. J. Aman, P. L. Iversen, S. Bavari, Gene-specific countermeasures against Ebola virus based on antisense phosphorodiamidate morpholino oligomers. PLoS Pathog. 2, e1 (2006).
8. T. K. Warren, K. L. Warfield, J. Wells, D. L. Swenson, K. S. Donner, S. A. Van Tongeren, N. L. Garza, L. Dong, D. V. Mourich, S. Crumley, D. K. Nichols, P. L. Iversen, S. Bavari, Advanced antisense therapies for postexposure protection against lethal filovirus infections. Nat. Med. 16, 991-994 (2010).
9. J. M. Dye, A. S. Herbert, A. I. Kuehne, J. F. Barth, M. A. Muhammad, S. E. Zak, R. A. Ortiz, L. I. Prugar, W. D. Pratt, Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease. Proc. Natl. Acad. Sci. U.S.A. 109, 5034-5039 (2012).
10. X. Qiu, J. Audet, G. Wong, S. Pillet, A. Bello, T. Cabral, J. E. Strong, F. Plummer, C. R. Corbett, J. B. Alimonti, G. P. Kobinger, Successful treatment of Ebola virus-infected cynomolgus macaques with monoclonal antibodies. Sci. Transl. Med. 4, 138ra81 (2012).
11. G. G. Olinger Jr., J. Pettitt, D. Kim, C. Working, O. Bohorov, B. Bratcher, E. Hiatt, S. D. Hume, A. K. Johnson, J. Morton, M. Pauly, K. J. Whaley, C. M. Lear, J. E. Biggins, C. Scully, L. Hensley, L. Zeitlin, Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques. Proc. Natl. Acad. Sci. U.S.A. 109, 18030-18035 (2012).
12. J. A. Wilson, M. Hevey, R. Bakken, S. Guest, M. Bray, A. L. Schmaljohn, M. K. Hart, Epitopes involved in antibody-mediated protection from Ebola virus. Science 287, 1664-1666 (2000).
13. L. Zeitlin, J. Pettitt, C. Scully, N. Bohorova, D. Kim, M. Pauly, A. Hiatt, L. Ngo, H. Steinkellner, K. J. Whaley, G. G. Olinger, Enhanced potency of a fucose-freemonoclonal antibody being developed as an Ebola virus immunoprotectant. Proc. Natl. Acad. Sci. U.S.A. 108, 20690-20694 (2011).
14. + T cell responses in lethal Ebola virus infection. J. Immunol. 180, 4058-4066 (2008).
15. K. L. Warfield, G. G. Olinger, Protective role of cytotoxic T lymphocytes in filovirus hemorrhagic fever. J. Biomed. Biotechnol. 2011, 984241 (2011).
16. K. Haddley, Taliglucerase alfa for the treatment of Gaucher's disease. Drugs Today 48, 525-532 (2012).
17. K. J. Whaley, A. Hiatt, L. Zeitlin, Emerging antibody products and Nicotiana manufacturing. Hum. Vaccin. 7, 349-356 (2011).
18. A. Giritch, S. Marillonnet, C. Engler, G. van Eldik, J. Botterman, V. Klimyuk, Y. Gleba, Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors. Proc. Natl. Acad. Sci. U.S.A. 103, 14701-14706 (2006).
19. J. Pettitt, L. Zeitlin, D. H. Kim, C. Working, J. C. Johnson, O. Bohorov, B. Bratcher, E. Hiatt, S. D. Hume, A. K. Johnson, J. Morton, M. H. Pauly, K. J. Whaley, M. F. Ingram, A. Zovanyi, M. Heinrich, A. Piper, J. Zelko, G. G. Olinger, Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail. Sci. Transl. Med. 5, 199ra113 (2013).