Vaccine-elicited primate antibodies use a distinct approach to the HIV-1 primary receptor binding site informing vaccine redesign

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 7, 2014, Pages

  Tran, Karen ^a   Poulsen, Christian ^a   Guenaga, Javier ^a   De Val Alda, Natalia ^b   Wilson, Richard ^a   Sundling, Christopher ^c   Li, Yuxing ^a,d   Stanfield, Robyn L ^b   Wilson, Ian A ^a,b,e   Ward, Andrew B ^a,b,e   Hedestam, Gunilla B Karlsson ^c   Wyatt, Richard T ^a,d  

^a INTERNATIONAL AIDS VACCINE INITIATIVE   (United States)

^b Integrative Structural and Computational Biology   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

^d Immunology and Microbial Science   (United States)

^e SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Mode of recognition; Neutralizing antibodies; NHP

Indexed keywords

ALANINE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; EPITOPE; GLYCOPROTEIN GP 120; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS ENVELOPE PROTEIN; VIRUS RECEPTOR; FLUCICLOVINE F 18;

AMINO ACID SUBSTITUTION; ANTIGEN ANTIBODY REACTION; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; DRUG DESIGN; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; TARGET CELL; VACCINE PRODUCTION; VIRUS CELL INTERACTION; VIRUS NEUTRALIZATION; X RAY CRYSTALLOGRAPHY; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; HYDROGEN BOND; HYDROPHOBICITY; INTERFEROMETRY;

MODE OF RECOGNITION; NEUTRALIZING ANTIBODIES; NHP;

AIDS VACCINES; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; BINDING SITES; CRYSTALLIZATION; DRUG DESIGN; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; MACACA MULATTA; MICROSCOPY, INTERFERENCE; MODELS, MOLECULAR; NEUTRALIZATION TESTS; PROTEIN CONFORMATION;

EID: 84894355475     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1319512111     Document Type: Article

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