메뉴 건너뛰기




Volumn 19, Issue 4, 2009, Pages 408-417

Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTEGRIN; CD209 ANTIGEN; EBOLA VACCINE; EPITOPE; FOLATE RECEPTOR; HIGH MOBILITY GROUP PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VIRUS ANTIBODY; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

EID: 69249132055     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sbi.2009.05.004     Document Type: Review
Times cited : (60)

References (56)
  • 2
    • 0029648688 scopus 로고
    • Isolation and partial characterisation of a new strain of Ebola virus
    • Le Guenno B., Formentry P., Wyers M., Gounon P., Walker F., and Boesch C. Isolation and partial characterisation of a new strain of Ebola virus. Lancet 345 (1995) 1271-1274
    • (1995) Lancet , vol.345 , pp. 1271-1274
    • Le Guenno, B.1    Formentry, P.2    Wyers, M.3    Gounon, P.4    Walker, F.5    Boesch, C.6
  • 3
    • 0031878483 scopus 로고    scopus 로고
    • Biochemical analysis of the secreted and virion glycoproteins of Ebola virus
    • Sanchez A., Yang Z.Y., Xu L., Nabel G.J., Crews T., and Peters C.J. Biochemical analysis of the secreted and virion glycoproteins of Ebola virus. J Virol 72 (1998) 6442-6447
    • (1998) J Virol , vol.72 , pp. 6442-6447
    • Sanchez, A.1    Yang, Z.Y.2    Xu, L.3    Nabel, G.J.4    Crews, T.5    Peters, C.J.6
  • 4
    • 0029976177 scopus 로고    scopus 로고
    • The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing
    • Sanchez A., Trappier S.G., Mahy B.W., Peters C.J., and Nichol S.T. The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proc Natl Acad Sci USA 93 (1996) 3602-3607
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3602-3607
    • Sanchez, A.1    Trappier, S.G.2    Mahy, B.W.3    Peters, C.J.4    Nichol, S.T.5
  • 5
    • 0032611382 scopus 로고    scopus 로고
    • The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis
    • Feldmann H., Volchkov V.E., Volchkova V.A., and Klenk H.D. The glycoproteins of Marburg and Ebola virus and their potential roles in pathogenesis. Arch Virol Suppl 15 (1999) 159-169
    • (1999) Arch Virol Suppl , vol.15 , pp. 159-169
    • Feldmann, H.1    Volchkov, V.E.2    Volchkova, V.A.3    Klenk, H.D.4
  • 7
    • 0002858305 scopus 로고    scopus 로고
    • Filoviridae: Marburg and Ebola viruses
    • Knipe D.M., and Howley P.M. (Eds), Lippincott, Williams, and Wilkins
    • Sanchez A., Khan A.S., Zaki S.R., Nabel G.J., Ksiazek T.G., and Peters C.J. Filoviridae: Marburg and Ebola viruses. In: Knipe D.M., and Howley P.M. (Eds). Fields Virology (2001), Lippincott, Williams, and Wilkins 1279-1304
    • (2001) Fields Virology , pp. 1279-1304
    • Sanchez, A.1    Khan, A.S.2    Zaki, S.R.3    Nabel, G.J.4    Ksiazek, T.G.5    Peters, C.J.6
  • 9
    • 4544228226 scopus 로고    scopus 로고
    • Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels
    • Sanchez A., Lukwiya M., Bausch D., Mahanty S., Sanchez A.J., Wagoner K.D., and Rollin P.E. Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels. J Virol 78 (2004) 10370-10377
    • (2004) J Virol , vol.78 , pp. 10370-10377
    • Sanchez, A.1    Lukwiya, M.2    Bausch, D.3    Mahanty, S.4    Sanchez, A.J.5    Wagoner, K.D.6    Rollin, P.E.7
  • 10
    • 0032999978 scopus 로고    scopus 로고
    • Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995
    • Ksiazek T.G., Rollin P.E., Williams A.J., Bressler D.S., Martin M.L., Swanepoel R., Burt F.J., Leman P.A., Khan A.S., Rowe A.K., et al. Clinical virology of Ebola hemorrhagic fever (EHF): virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo, 1995. J Infect Dis 179 Suppl 1 (1999) S177-S187
    • (1999) J Infect Dis , vol.179 , Issue.SUPPL. 1
    • Ksiazek, T.G.1    Rollin, P.E.2    Williams, A.J.3    Bressler, D.S.4    Martin, M.L.5    Swanepoel, R.6    Burt, F.J.7    Leman, P.A.8    Khan, A.S.9    Rowe, A.K.10
  • 15
    • 0033058392 scopus 로고    scopus 로고
    • Recombinant human monoclonal antibodies to Ebola virus
    • This paper describes the first set of human antibodies against ebolavirus infection, identified in outbreak survivors.
    • Maruyama T., Parren P.W., Sanchez A., Rensink I., Rodriguez L.L., Khan A.S., Peters C.J., and Burton D.R. Recombinant human monoclonal antibodies to Ebola virus. J Infect Dis 179 Suppl. 1 (1999) S235-S239. This paper describes the first set of human antibodies against ebolavirus infection, identified in outbreak survivors.
    • (1999) J Infect Dis , vol.179 , Issue.SUPPL. 1
    • Maruyama, T.1    Parren, P.W.2    Sanchez, A.3    Rensink, I.4    Rodriguez, L.L.5    Khan, A.S.6    Peters, C.J.7    Burton, D.R.8
  • 16
    • 0032993241 scopus 로고    scopus 로고
    • Preparation and use of hyperimmune serum for prophylaxis and therapy of Ebola virus infections
    • Kudoyarova-Zubavichene N.M., Sergeyev N.N., Chepurnov A.A., and Netesov S.V. Preparation and use of hyperimmune serum for prophylaxis and therapy of Ebola virus infections. J Infect Dis 179 Suppl. 1 (1999) S218-S223
    • (1999) J Infect Dis , vol.179 , Issue.SUPPL. 1
    • Kudoyarova-Zubavichene, N.M.1    Sergeyev, N.N.2    Chepurnov, A.A.3    Netesov, S.V.4
  • 18
    • 33845584363 scopus 로고    scopus 로고
    • Protective efficacy of neutralizing antibodies against Ebola virus infection
    • Takada A., Ebihara H., Jones S., Feldmann H., and Kawaoka Y. Protective efficacy of neutralizing antibodies against Ebola virus infection. Vaccine 25 (2007) 993-999
    • (2007) Vaccine , vol.25 , pp. 993-999
    • Takada, A.1    Ebihara, H.2    Jones, S.3    Feldmann, H.4    Kawaoka, Y.5
  • 21
    • 0033035994 scopus 로고    scopus 로고
    • Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: determinants of survival
    • Sadek R.F., Khan A.S., Stevens G., Peters C.J., and Ksiazek T.G. Ebola hemorrhagic fever, Democratic Republic of the Congo, 1995: determinants of survival. J Infect Dis 179 Suppl. 1 (1999) S24-S27
    • (1999) J Infect Dis , vol.179 , Issue.SUPPL. 1
    • Sadek, R.F.1    Khan, A.S.2    Stevens, G.3    Peters, C.J.4    Ksiazek, T.G.5
  • 22
    • 47049107589 scopus 로고    scopus 로고
    • Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
    • This paper describes the first structure of the prefusion, trimeric ebolavirus glycoprotein in complex with a neutralizing antibody identified from a human survivor of the 1995 Kikwit, Zaire outbreak and provides a model for ebolavirus entry and future therapeutic development.
    • Lee J.E., Fusco M.H., Hessell A.J., Oswald W.B., Burton D.R., and Saphire E.O. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature 454 (2008) 177-183. This paper describes the first structure of the prefusion, trimeric ebolavirus glycoprotein in complex with a neutralizing antibody identified from a human survivor of the 1995 Kikwit, Zaire outbreak and provides a model for ebolavirus entry and future therapeutic development.
    • (2008) Nature , vol.454 , pp. 177-183
    • Lee, J.E.1    Fusco, M.H.2    Hessell, A.J.3    Oswald, W.B.4    Burton, D.R.5    Saphire, E.O.6
  • 23
    • 0032214714 scopus 로고    scopus 로고
    • Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain
    • Weissenhorn W., Carfi A., Lee K.H., Skehel J.J., and Wiley D.C. Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain. Mol Cell 2 (1998) 605-616
    • (1998) Mol Cell , vol.2 , pp. 605-616
    • Weissenhorn, W.1    Carfi, A.2    Lee, K.H.3    Skehel, J.J.4    Wiley, D.C.5
  • 25
    • 64749109053 scopus 로고    scopus 로고
    • An efficient platform for screening expression and crystallization of glycoproteins produced in human cells
    • Lee J.E., Fusco M.H., and Saphire E.O. An efficient platform for screening expression and crystallization of glycoproteins produced in human cells. Nat Protocols 4 (2009) 592-604
    • (2009) Nat Protocols , vol.4 , pp. 592-604
    • Lee, J.E.1    Fusco, M.H.2    Saphire, E.O.3
  • 26
    • 0019890491 scopus 로고
    • Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution
    • Wilson I.A., Skehel J.J., and Wiley D.C. Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 Å resolution. Nature 289 (1981) 366-373
    • (1981) Nature , vol.289 , pp. 366-373
    • Wilson, I.A.1    Skehel, J.J.2    Wiley, D.C.3
  • 27
    • 30144436116 scopus 로고    scopus 로고
    • Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation
    • Yin H.S., Wen X., Paterson R.G., Lamb R.A., and Jardetzky T.S. Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation. Nature 439 (2006) 38-44
    • (2006) Nature , vol.439 , pp. 38-44
    • Yin, H.S.1    Wen, X.2    Paterson, R.G.3    Lamb, R.A.4    Jardetzky, T.S.5
  • 28
    • 0029014434 scopus 로고
    • The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution
    • Rey F.A., Heinz F.X., Mandl C., Kunz C., and Harrison S.C. The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution. Nature 375 (1995) 291-298
    • (1995) Nature , vol.375 , pp. 291-298
    • Rey, F.A.1    Heinz, F.X.2    Mandl, C.3    Kunz, C.4    Harrison, S.C.5
  • 29
    • 33846959065 scopus 로고    scopus 로고
    • Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G
    • Roche S., Rey F.A., Gaudin Y., and Bressanelli S. Structure of the prefusion form of the vesicular stomatitis virus glycoprotein G. Science 315 (2007) 843-848
    • (2007) Science , vol.315 , pp. 843-848
    • Roche, S.1    Rey, F.A.2    Gaudin, Y.3    Bressanelli, S.4
  • 31
    • 46449100666 scopus 로고    scopus 로고
    • Viral membrane fusion
    • Harrison S.C. Viral membrane fusion. Nat Struct Mol Biol 15 (2008) 690-698
    • (2008) Nat Struct Mol Biol , vol.15 , pp. 690-698
    • Harrison, S.C.1
  • 32
    • 34548824835 scopus 로고    scopus 로고
    • Structural basis of viral invasion: lessons from paramyxovirus F
    • Lamb R.A., and Jardetzky T.S. Structural basis of viral invasion: lessons from paramyxovirus F. Curr Opin Struct Biol 17 (2007) 427-436
    • (2007) Curr Opin Struct Biol , vol.17 , pp. 427-436
    • Lamb, R.A.1    Jardetzky, T.S.2
  • 33
    • 45849108331 scopus 로고    scopus 로고
    • Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme
    • A thorough and informative review on the three classes of viral membrane fusion proteins and their mechanisms of viral entry.
    • White J.M., Delos S.E., Brecher M., and Schornberg K. Structures and mechanisms of viral membrane fusion proteins: multiple variations on a common theme. Crit Rev Biochem Mol Biol 43 (2008) 189-219. A thorough and informative review on the three classes of viral membrane fusion proteins and their mechanisms of viral entry.
    • (2008) Crit Rev Biochem Mol Biol , vol.43 , pp. 189-219
    • White, J.M.1    Delos, S.E.2    Brecher, M.3    Schornberg, K.4
  • 34
    • 0036278649 scopus 로고    scopus 로고
    • C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans
    • Alvarez C.P., Lasala F., Carrillo J., Muniz O., Corbi A.L., and Delgado R. C-type lectins DC-SIGN and L-SIGN mediate cellular entry by Ebola virus in cis and in trans. J Virol 76 (2002) 6841-6844
    • (2002) J Virol , vol.76 , pp. 6841-6844
    • Alvarez, C.P.1    Lasala, F.2    Carrillo, J.3    Muniz, O.4    Corbi, A.L.5    Delgado, R.6
  • 38
    • 0034610176 scopus 로고    scopus 로고
    • Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry
    • Takada A., Watanabe S., Ito H., Okazaki K., Kida H., and Kawaoka Y. Downregulation of beta1 integrins by Ebola virus glycoprotein: implication for virus entry. Virology 278 (2000) 20-26
    • (2000) Virology , vol.278 , pp. 20-26
    • Takada, A.1    Watanabe, S.2    Ito, H.3    Okazaki, K.4    Kida, H.5    Kawaoka, Y.6
  • 39
    • 34447278575 scopus 로고    scopus 로고
    • Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events
    • Brindley M.A., Hughes L., Ruiz A., McCray Jr. P.B., Sanchez A., Sanders D.A., and Maury W. Ebola virus glycoprotein 1: identification of residues important for binding and postbinding events. J Virol 81 (2007) 7702-7709
    • (2007) J Virol , vol.81 , pp. 7702-7709
    • Brindley, M.A.1    Hughes, L.2    Ruiz, A.3    McCray Jr., P.B.4    Sanchez, A.5    Sanders, D.A.6    Maury, W.7
  • 40
    • 16244391124 scopus 로고    scopus 로고
    • Comprehensive analysis of Ebola virus GP1 in viral entry
    • Manicassamy B., Wang J., Jiang H., and Rong L. Comprehensive analysis of Ebola virus GP1 in viral entry. J Virol 79 (2005) 4793-4805
    • (2005) J Virol , vol.79 , pp. 4793-4805
    • Manicassamy, B.1    Wang, J.2    Jiang, H.3    Rong, L.4
  • 41
    • 33749133853 scopus 로고    scopus 로고
    • Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry
    • Mpanju O.M., Towner J.S., Dover J.E., Nichol S.T., and Wilson C.A. Identification of two amino acid residues on Ebola virus glycoprotein 1 critical for cell entry. Virus Res 121 (2006) 205-214
    • (2006) Virus Res , vol.121 , pp. 205-214
    • Mpanju, O.M.1    Towner, J.S.2    Dover, J.E.3    Nichol, S.T.4    Wilson, C.A.5
  • 43
    • 63149192804 scopus 로고    scopus 로고
    • The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding
    • Dube D., Brecher M.B., Delos S.E., Rose S.C., Park E.W., Schornberg K.L., Kuhn J.H., and White J.M. The primed ebolavirus glycoprotein (19-kilodalton GP1,2): sequence and residues critical for host cell binding. J Virol 83 (2009) 2883-2891
    • (2009) J Virol , vol.83 , pp. 2883-2891
    • Dube, D.1    Brecher, M.B.2    Delos, S.E.3    Rose, S.C.4    Park, E.W.5    Schornberg, K.L.6    Kuhn, J.H.7    White, J.M.8
  • 44
    • 19144365133 scopus 로고    scopus 로고
    • Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
    • This paper describes the original identification of the essential role for cathepsin B and L in ebolavirus GP-mediated entry.
    • Chandran K., Sullivan N.J., Felbor U., Whelan S.P., and Cunningham J.M. Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection. Science 308 (2005) 1643-1645. This paper describes the original identification of the essential role for cathepsin B and L in ebolavirus GP-mediated entry.
    • (2005) Science , vol.308 , pp. 1643-1645
    • Chandran, K.1    Sullivan, N.J.2    Felbor, U.3    Whelan, S.P.4    Cunningham, J.M.5
  • 45
    • 37049006295 scopus 로고    scopus 로고
    • Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity
    • Kaletsky R.L., Simmons G., and Bates P. Proteolysis of the Ebola virus glycoproteins enhances virus binding and infectivity. J Virol 81 (2007) 13378-13384
    • (2007) J Virol , vol.81 , pp. 13378-13384
    • Kaletsky, R.L.1    Simmons, G.2    Bates, P.3
  • 46
    • 33645788357 scopus 로고    scopus 로고
    • Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein
    • Schornberg K., Matsuyama S., Kabsch K., Delos S., Bouton A., and White J. Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein. J Virol 80 (2006) 4174-4178
    • (2006) J Virol , vol.80 , pp. 4174-4178
    • Schornberg, K.1    Matsuyama, S.2    Kabsch, K.3    Delos, S.4    Bouton, A.5    White, J.6
  • 49
    • 0037229321 scopus 로고    scopus 로고
    • Identification of protective epitopes on ebola virus glycoprotein at the single amino acid level by using recombinant vesicular stomatitis viruses
    • ••]) characterizes a series of murine antibodies and identifies its protective epitope on the ebolavirus glycoprotein.
    • ••]) characterizes a series of murine antibodies and identifies its protective epitope on the ebolavirus glycoprotein.
    • (2003) J Virol , vol.77 , pp. 1069-1074
    • Takada, A.1    Feldmann, H.2    Stroeher, U.3    Bray, M.4    Watanabe, S.5    Ito, H.6    McGregor, M.7    Kawaoka, Y.8
  • 50
    • 0034051595 scopus 로고    scopus 로고
    • Epitopes involved in antibody-mediated protection from Ebola virus
    • This study identifies a series of protective murine antibodies, directed towards five unique epitopes on the ebolavirus GP that protect mice against lethal EBOV challenge up to two days post-exposure.
    • Wilson J.A., Hevey M., Bakken R., Guest S., Bray M., Schmaljohn A.L., and Hart M.K. Epitopes involved in antibody-mediated protection from Ebola virus. Science 287 (2000) 1664-1666. This study identifies a series of protective murine antibodies, directed towards five unique epitopes on the ebolavirus GP that protect mice against lethal EBOV challenge up to two days post-exposure.
    • (2000) Science , vol.287 , pp. 1664-1666
    • Wilson, J.A.1    Hevey, M.2    Bakken, R.3    Guest, S.4    Bray, M.5    Schmaljohn, A.L.6    Hart, M.K.7
  • 51
    • 0036100307 scopus 로고    scopus 로고
    • Pre- and post-exposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody
    • Parren P.W.H.I., Geisbert T.W., Maruyama T., Jahrling P.B., and Burton D.R. Pre- and post-exposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody. J Virol 76 (2002) 6408-6412
    • (2002) J Virol , vol.76 , pp. 6408-6412
    • Parren, P.W.H.I.1    Geisbert, T.W.2    Maruyama, T.3    Jahrling, P.B.4    Burton, D.R.5
  • 55
    • 34249107414 scopus 로고    scopus 로고
    • Production and characterization of monoclonal antibodies against different epitopes of Ebola virus antigens
    • Shahhosseini S., Das D., Qiu X., Feldmann H., Jones S.M., and Suresh M.R. Production and characterization of monoclonal antibodies against different epitopes of Ebola virus antigens. J Virol Methods 143 (2007) 29-37
    • (2007) J Virol Methods , vol.143 , pp. 29-37
    • Shahhosseini, S.1    Das, D.2    Qiu, X.3    Feldmann, H.4    Jones, S.M.5    Suresh, M.R.6
  • 56
    • 36348950301 scopus 로고    scopus 로고
    • Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda × light chain
    • Lee J.E., Kuehne A., Abelson D.M., Fusco M.L., Hart M.K., and Saphire E.O. Complex of a protective antibody with its Ebola virus GP peptide epitope: unusual features of a V lambda × light chain. J Mol Biol 375 (2008) 202-216
    • (2008) J Mol Biol , vol.375 , pp. 202-216
    • Lee, J.E.1    Kuehne, A.2    Abelson, D.M.3    Fusco, M.L.4    Hart, M.K.5    Saphire, E.O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.