Cell entry by a novel European filovirus requires host endosomal cysteine proteases and Niemann-Pick C1

Virology

Volumn 468, Issue , 2014, Pages 637-646

  Ng, Melinda ^a   Ndungo, Esther ^a   Jangra, Rohit K ^a   Cai, Yingyun ^b   Postnikova, Elena ^b   Radoshitzky, Sheli R ^c   Dye, John M ^c   Ramírez de Arellano, Eva ^d   Negredo, Ana ^d   Palacios, Gustavo ^c   Kuhn, Jens H ^b   Chandran, Kartik ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

Cuevavirus; Ebola; Endosomal cysteine proteases; Filoviridae; Filovirus; Lloviu virus; Niemann Pick C1; NPC1; Viral entry; Viral glycoprotein; Viral membrane fusion; Viral receptor

Indexed keywords

CATHEPSIN B; CYSTEINE PROTEINASE; FURIN; MEMBRANE PROTEIN; NIEMANN PICK C1 PROTEIN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS RECEPTOR; CARRIER PROTEIN; CELL SURFACE RECEPTOR; NPC1 PROTEIN, HUMAN; VIRUS ANTIBODY;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL PH; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; FILOVIRUS; HUMAN; HUMAN CELL; LLOVIU VIRUS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; VIRUS CELL INTERACTION; VIRUS ENTRY; VIRUS INFECTIVITY; ANIMAL; CELL LINE; CHLOROCEBUS AETHIOPS; ENDOSOME; ENZYMOLOGY; FIBROBLAST; FILOVIRIDAE; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; TRANSMISSION ELECTRON MICROSCOPY; VERO CELL LINE; VIROLOGY;

FILOVIRIDAE; MARBURGVIRUS;

ANIMALS; ANTIBODIES, VIRAL; CARRIER PROTEINS; CELL LINE; CERCOPITHECUS AETHIOPS; CYSTEINE PROTEASES; ENDOSOMES; FIBROBLASTS; FILOVIRIDAE; HUMANS; MEMBRANE GLYCOPROTEINS; MICROSCOPY, ELECTRON, TRANSMISSION; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE; RECEPTORS, VIRUS; VERO CELLS; VIRUS INTERNALIZATION;

EID: 84907978073     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2014.08.019     Document Type: Article

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