Priming HIV-1 broadly neutralizing antibody precursors in human Ig loci transgenic mice

Science

Volumn 353, Issue 6307, 2016, Pages 1557-1560

  Sok, Devin ^a   Briney, Bryan ^a   Jardine, Joseph G ^a   Kulp, Daniel W ^a   Menis, Sergey ^a   Pauthner, Matthias ^a   Wood, Andrew ^b   Lee, E Chiang ^b   Le, Khoa M ^a   Jones, Meaghan ^a   Ramos, Alejandra ^a   Kalyuzhniy, Oleksandr ^a   Adachi, Yumiko ^a   Kubitz, Michael ^a   MacPherson, Skye ^a   Bradley, Allan ^b,c   Friedrich, Glenn A ^b   Schief, William R ^a,d   Burton, Dennis R ^a,d  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b Kymab Ltd   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ANTIGEN; BROADLY NEUTRALIZING ANTIBODY; EOD GT8 60MER ANTIGEN; EPITOPE; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; VRC01 NEUTRALIZING ANTIBODY; BLOCKING ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; MONOCLONAL ANTIBODY; NANOPARTICLE; VRC01 MONOCLONAL ANTIBODY;

ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNE SYSTEM; MEMORY; NANOPARTICLE; PHYSIOLOGY; RODENT; VACCINE;

ANIMAL EXPERIMENT; ANTIBODY RESPONSE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; BINDING SITE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; FEASIBILITY STUDY; FREQUENCY ANALYSIS; GENE LOCUS; GERM LINE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; IC50; IMMUNE RESPONSE; IMMUNIZATION; MEMORY CELL; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; ANIMAL; GENETICS; GERM CELL; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; PROTEIN DOMAIN; TRANSGENIC MOUSE;

HUMAN IMMUNODEFICIENCY VIRUS 1; MUS; MUS MUSCULUS;

AIDS VACCINES; ANIMALS; ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; GENES, IMMUNOGLOBULIN HEAVY CHAIN; GENETIC LOCI; GERM CELLS; HIV ANTIBODIES; HIV-1; HUMANS; IMMUNIZATION; IMMUNOLOGIC MEMORY; MICE; MICE, TRANSGENIC; NANOPARTICLES; PRECURSOR CELLS, B-LYMPHOID; PROTEIN DOMAINS;

EID: 84988698738     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aah3945     Document Type: Article

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