메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Discovery of an antibody for pan-ebolavirus therapy

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA BETA INTERFERON RECEPTOR; EPITOPE; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY;

EID: 84958078190     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep20514     Document Type: Article
Times cited : (80)

References (48)
  • 1
    • 79952363727 scopus 로고    scopus 로고
    • Ebola haemorrhagic fever
    • Feldmann, H., Geisbert, T. W. Ebola haemorrhagic fever. Lancet 377, 849-862 (2011).
    • (2011) Lancet , vol.377 , pp. 849-862
    • Feldmann, H.1    Geisbert, T.W.2
  • 2
    • 84906811644 scopus 로고    scopus 로고
    • Ebola and Marburg virus diseases in Africa: Increased risk of outbreaks in previously unaffected areas
    • Changula, K., Kajihara, M., Mweene, A. S., Takada, A. Ebola and Marburg virus diseases in Africa: increased risk of outbreaks in previously unaffected areas? Microbiol. Immunol. 58, 483-491 (2014).
    • (2014) Microbiol Immunol , vol.58 , pp. 483-491
    • Changula, K.1    Kajihara, M.2    Mweene, A.S.3    Takada, A.4
  • 3
    • 84899932651 scopus 로고    scopus 로고
    • Virus nomenclature below the species level: A standardized nomenclature for filovirus strains and variants rescued from cDNA
    • Kuhn, J. H. et al. Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA. Arch. Virol. 159, 1229-1237 (2014).
    • (2014) Arch. Virol , vol.159 , pp. 1229-1237
    • Kuhn, J.H.1
  • 4
    • 84907867765 scopus 로고    scopus 로고
    • Emergence of zaire ebola virus disease in Guinea
    • Baize S. et al. Emergence of Zaire Ebola virus disease in Guinea. N. Engl. J. Med. 371, 1418-1425 (2014).
    • (2014) N. Engl. J. Med , vol.371 , pp. 1418-1425
    • Baize, S.1
  • 5
    • 0036893140 scopus 로고    scopus 로고
    • Covalent modifications of the Ebola virus glycoprotein
    • Jeffers, S. A., Sanders, D. A., Sanchez, A. Covalent modifications of the Ebola virus glycoprotein. J. Virol. 76, 12463-12472 (2002).
    • (2002) J. Virol , vol.76 , pp. 12463-12472
    • Jeffers, S.A.1    Sanders, D.A.2    Sanchez, A.3
  • 6
    • 0032510732 scopus 로고    scopus 로고
    • Processing of the Ebola virus glycoprotein by the proprotein convertase furin
    • Volchkov, V. E., Feldmann, H., Volchkova, V. A., Klenk, H. D. Processing of the Ebola virus glycoprotein by the proprotein convertase furin. Proc. Natl. Acad. Sci. USA 95, 5762-5767 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 5762-5767
    • Volchkov, V.E.1    Feldmann, H.2    Volchkova, V.A.3    Klenk, H.D.4
  • 7
    • 0029976177 scopus 로고    scopus 로고
    • The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing
    • Sanchez, A., Trappier, S. G., Mahy, B. W., Peters, C. J., Nichol, S. T. The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proc. Natl. Acad. Sci. USA 93, 3602-3607 (1996).
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3602-3607
    • Sanchez, A.1    Trappier, S.G.2    Mahy, B.W.3    Peters, C.J.4    Nichol, S.T.5
  • 8
    • 0032214714 scopus 로고    scopus 로고
    • Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain
    • Weissenhorn, W., Carfí, A., Lee, K.-H., Skehel, J. J., Wiley, D. C. Crystal structure of the Ebola virus membrane fusion subunit, GP2, from the envelope glycoprotein ectodomain. Mol. Cell. 2, 605-616 (1998).
    • (1998) Mol. Cell. , vol.2 , pp. 605-616
    • Weissenhorn, W.1    Carfí, A.2    Lee, K.-H.3    Skehel, J.J.4    Wiley, D.C.5
  • 9
    • 33645788357 scopus 로고    scopus 로고
    • Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein
    • Schornberg, K. et al. Role of endosomal cathepsins in entry mediated by the Ebola virus glycoprotein. J. Virol. 80, 4174-4178 (2006).
    • (2006) J. Virol , vol.80 , pp. 4174-4178
    • Schornberg, K.1
  • 10
    • 73949151882 scopus 로고    scopus 로고
    • Ebolavirus glycoprotein structure and mechanism of entry
    • Lee, J. E., Saphire, E. O. Ebolavirus glycoprotein structure and mechanism of entry. Future Virol. 4, 621-635 (2009).
    • (2009) Future Virol , vol.4 , pp. 621-635
    • Lee, J.E.1    Saphire, E.O.2
  • 11
    • 84859897771 scopus 로고    scopus 로고
    • A new player in the puzzle of filovirus entry
    • White, J. M., Schornberg, K. L. A new player in the puzzle of filovirus entry. Nat. Rev. Microbiol. 10, 317-322 (2012).
    • (2012) Nat. Rev. Microbiol , vol.10 , pp. 317-322
    • White, J.M.1    Schornberg, K.L.2
  • 12
    • 84907263545 scopus 로고    scopus 로고
    • Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp
    • Qiu, X. et al. Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp. Nature 514, 47-53 (2014).
    • (2014) Nature , vol.514 , pp. 47-53
    • Qiu, X.1
  • 13
    • 84859462127 scopus 로고    scopus 로고
    • Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease
    • Dye, J. M. et al. Postexposure antibody prophylaxis protects nonhuman primates from filovirus disease. Proc. Natl. Acad. Sci. USA 109, 5034-5039 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 5034-5039
    • Dye, J.M.1
  • 14
    • 84860456246 scopus 로고    scopus 로고
    • Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever
    • Marzi, A. et al. Protective efficacy of neutralizing monoclonal antibodies in a nonhuman primate model of Ebola hemorrhagic fever. PLoS ONE 7, e36192 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e36192
    • Marzi, A.1
  • 15
    • 84883864987 scopus 로고    scopus 로고
    • Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail
    • Pettitt, J. et al. Therapeutic intervention of Ebola virus infection in rhesus macaques with the MB-003 monoclonal antibody cocktail. Sci. Transl. Med. 5, 199-113 (2013).
    • (2013) Sci. Transl. Med , vol.5 , pp. 199-113
    • Pettitt, J.1
  • 16
    • 84868149422 scopus 로고    scopus 로고
    • Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques
    • Olinger, G. G. et al. Delayed treatment of Ebola virus infection with plant-derived monoclonal antibodies provides protection in rhesus macaques. Proc. Natl. Acad. Sci. USA 109, 18030-18035 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 18030-18035
    • Olinger, G.G.1
  • 17
    • 84912064043 scopus 로고    scopus 로고
    • US signs contract with ZMapp maker to accelerate development of the Ebola drug
    • McCarthy, M. US signs contract with ZMapp maker to accelerate development of the Ebola drug. BMJ 349, (2014).
    • (2014) BMJ , pp. 349
    • McCarthy, M.1
  • 18
    • 84912539210 scopus 로고    scopus 로고
    • Clinical care of two patients with Ebola virus disease in the United States
    • Lyon, G. M. et al. Clinical care of two patients with Ebola virus disease in the United States. N. Engl. J. Med. 371, 2402-2409 (2014).
    • (2014) N. Engl. J. Med , vol.371 , pp. 2402-2409
    • Lyon, G.M.1
  • 19
    • 84920982449 scopus 로고    scopus 로고
    • Potential and emerging treatment options for Ebola virus disease
    • Bishop, B. M. Potential and emerging treatment options for Ebola virus disease. Ann. Pharmacother. 49, 196-206 (2015).
    • (2015) Ann. Pharmacother , vol.49 , pp. 196-206
    • Bishop, B.M.1
  • 20
    • 84918791874 scopus 로고    scopus 로고
    • Ebola virus outbreak 2014: Clinical review for emergency physicians
    • Meyers, L., Frawley, T., Goss, S., Kang, C. Ebola virus outbreak 2014: clinical review for emergency physicians. Ann. Emerg. Med. 65, 101-108 (2015).
    • (2015) Ann. Emerg. Med , vol.65 , pp. 101-108
    • Meyers, L.1    Frawley, T.2    Goss, S.3    Kang, C.4
  • 21
    • 78449264916 scopus 로고    scopus 로고
    • Enzyme-Linked immunosorbent assay for detection of filovirus species-specific antibodies
    • Nakayama, E. et al. Enzyme-linked immunosorbent assay for detection of filovirus species-specific antibodies. Clin. Vaccine Immunol. 17, 1723-1728 (2010).
    • (2010) Clin. Vaccine Immunol , vol.17 , pp. 1723-1728
    • Nakayama, E.1
  • 22
    • 33845584363 scopus 로고    scopus 로고
    • Protective efficacy of neutralizing antibodies against Ebola virus infection
    • Takada, A., Ebihara, H., Jones, S., Feldmann, H., Kawaoka, Y. Protective efficacy of neutralizing antibodies against Ebola virus infection. Vaccine 25, 993-999 (2007).
    • (2007) Vaccine , vol.25 , pp. 993-999
    • Takada, A.1    Ebihara, H.2    Jones, S.3    Feldmann, H.4    Kawaoka, Y.5
  • 23
    • 0037229321 scopus 로고    scopus 로고
    • Identification of protective epitopes on Ebola virus glycoprotein at the single amino acid level by using recombinant vesicular stomatitis viruses
    • Takada, A. et al. Identification of protective epitopes on Ebola virus glycoprotein at the single amino acid level by using recombinant vesicular stomatitis viruses. J. Virol. 77, 1069-1074 (2003).
    • (2003) J. Virol , vol.77 , pp. 1069-1074
    • Takada, A.1
  • 24
    • 69249132055 scopus 로고    scopus 로고
    • Neutralizing ebolavirus: Structural insights into the envelope glycoprotein and antibodies targeted against it
    • Lee, J. E., Saphire, E. O. Neutralizing ebolavirus: structural insights into the envelope glycoprotein and antibodies targeted against it. Curr. Opin. Struct. Biol. 19, 408-417 (2009).
    • (2009) Curr. Opin. Struct. Biol , vol.19 , pp. 408-417
    • Lee, J.E.1    Saphire, E.O.2
  • 25
    • 78149355646 scopus 로고    scopus 로고
    • Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner
    • Nanbo, A. et al. Ebolavirus is internalized into host cells via macropinocytosis in a viral glycoprotein-dependent manner. PLoS Pathog. 6, e1001121 (2010).
    • (2010) PLoS Pathog , vol.6 , pp. e1001121
    • Nanbo, A.1
  • 26
    • 84929593783 scopus 로고    scopus 로고
    • The interaction between TIM-1 and NPC1 is important for the cellular entry of Ebola virus
    • Kuroda, M. et al. The interaction between TIM-1 and NPC1 is important for the cellular entry of Ebola virus. J. Virol. 89, 6481-6493 (2015).
    • (2015) J. Virol , vol.89 , pp. 6481-6493
    • Kuroda, M.1
  • 27
    • 84875237748 scopus 로고    scopus 로고
    • Monoclonal antibodies for prophylactic and therapeutic use against viral infections
    • Both, L. et al. Monoclonal antibodies for prophylactic and therapeutic use against viral infections. Vaccine 31, 1553-1559 (2013).
    • (2013) Vaccine , vol.31 , pp. 1553-1559
    • Both, L.1
  • 28
    • 0033062193 scopus 로고    scopus 로고
    • Muyembe-Tamfum, Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. International Scientific and Technical Committee
    • Mupapa, K. Colebunders, J. J., et al. Muyembe-Tamfum, Treatment of Ebola hemorrhagic fever with blood transfusions from convalescent patients. International Scientific and Technical Committee. J. Infect. Dis. 179 Suppl 1, S18-23 (1999).
    • (1999) J. Infect. Dis , vol.179 , pp. S18-23
    • Mupapa, K.1    Colebunders, J.J.2
  • 29
    • 84958069638 scopus 로고    scopus 로고
    • WHO Ebola R&D-Monday 20 July 2015 News on vaccines therapies diagnostics
    • WHO Ebola R&D-Monday, 20 July 2015, News on vaccines, therapies, diagnostics (http://www.who.int/medicines/ebolatreatment/WHO-Ebola-RandD-Newsletter-July.pdf?ua= 1) (2015).
    • (2015)
  • 30
    • 84862525229 scopus 로고    scopus 로고
    • Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies
    • Qiu, X. et al. Successful treatment of ebola virus-infected cynomolgus macaques with monoclonal antibodies. Sci. Transl. Med. 4, 138-181 (2012).
    • (2012) Sci. Transl. Med , vol.4 , pp. 138-181
    • Qiu, X.1
  • 31
    • 84889562469 scopus 로고    scopus 로고
    • Kobinger Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb
    • Qiu, X. et al. Kobinger, Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb. Sci. Rep. 3, 3365 (2013).
    • (2013) Sci. Rep , vol.3 , pp. 3365
    • Qiu, X.1
  • 32
    • 84943242445 scopus 로고    scopus 로고
    • Development and characterization of broadly cross-reactive monoclonal antibodies against all known Ebolavirus species
    • Hernandez, H. et al. Development and characterization of broadly cross-reactive monoclonal antibodies against all known Ebolavirus species. J. Infect. Dis. 212 Suppl 2, S410-413 (2015).
    • (2015) J. Infect. Dis , vol.212 , pp. S410-413
    • Hernandez, H.1
  • 33
    • 33846490649 scopus 로고    scopus 로고
    • Neutralizing antibody fails to impact the Course of Ebola vrus infection in monkeys
    • Oswald, W. B. et al. Neutralizing antibody fails to impact the Course of Ebola vrus infection in monkeys. PLoS Pathog. 3, e9 (2007).
    • (2007) PLoS Pathog , vol.3 , pp. e9
    • Oswald, W.B.1
  • 34
    • 84922806645 scopus 로고    scopus 로고
    • Molecular characterization of the monoclonal antibodies composing ZMAb: A protective cocktail against Ebola virus
    • Audet, J. et al. Molecular characterization of the monoclonal antibodies composing ZMAb: a protective cocktail against Ebola virus. Sci. Rep. 4, 6881 (2014).
    • (2014) Sci. Rep , vol.4 , pp. 6881
    • Audet, J.1
  • 35
    • 84945217199 scopus 로고    scopus 로고
    • Mechanism of binding to Ebola virus glycoprotein by the ZMapp ZMAb and MB-003 cocktail antibodies
    • Davidson, E. et al. Mechanism of binding to Ebola virus glycoprotein by the ZMapp, ZMAb, and MB-003 cocktail antibodies. J. Virol. 89, 10982-10992 (2015).
    • (2015) J. Virol , vol.89 , pp. 10982-10992
    • Davidson, E.1
  • 36
    • 84943244784 scopus 로고    scopus 로고
    • Characterization of a novel neutralizing monoclonal antibody against Ebola virus GP
    • Reynard, O., Volchkov, V. E. Characterization of a novel neutralizing monoclonal antibody against Ebola virus GP. J. Infect. Dis. 212 Suppl 2, S372-378 (2015).
    • (2015) J. Infect. Dis , vol.212 , pp. S372-378
    • Reynard, O.1    Volchkov, V.E.2
  • 37
    • 0034051595 scopus 로고    scopus 로고
    • Epitopes involved in antibody-mediated protection from Ebola virus
    • Wilson, J. A. et al. Epitopes involved in antibody-mediated protection from Ebola virus. Science 287, 1664-1666 (2000).
    • (2000) Science , vol.287 , pp. 1664-1666
    • Wilson, J.A.1
  • 38
    • 47049107589 scopus 로고    scopus 로고
    • Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
    • Lee, J. E. et al. Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor. Nature 454, 177-182 (2008).
    • (2008) Nature , vol.454 , pp. 177-182
    • Lee, J.E.1
  • 39
    • 82955233820 scopus 로고    scopus 로고
    • A shared structural solution for neutralizing ebolaviruses
    • Dias, J. M. et al. A shared structural solution for neutralizing ebolaviruses. Nat. Struct. Mol. Biol. 18, 1424-1427 (2011).
    • (2011) Nat. Struct. Mol. Biol , vol.18 , pp. 1424-1427
    • Dias, J.M.1
  • 40
    • 84914127561 scopus 로고    scopus 로고
    • Structures of protective antibodies reveal sites of vulnerability on Ebola virus
    • Murin, C. D. et al. Structures of protective antibodies reveal sites of vulnerability on Ebola virus. Proc. Natl. Acad. Sci. USA 111, 17182-17187 (2014).
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 17182-17187
    • Murin, C.D.1
  • 41
    • 84908204878 scopus 로고    scopus 로고
    • Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge
    • Chen, G. et al. Synthetic antibodies with a human framework that protect mice from lethal Sudan ebolavirus challenge. ACS Chem. Biol. 9, 2263-2273 (2014).
    • (2014) ACS Chem. Biol , vol.9 , pp. 2263-2273
    • Chen, G.1
  • 42
    • 84876818205 scopus 로고    scopus 로고
    • Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus
    • Pal, P. et al. Development of a highly protective combination monoclonal antibody therapy against Chikungunya virus. PLoS Pathog. 9, e1003312 (2013).
    • (2013) PLoS Pathog , vol.9 , pp. e1003312
    • Pal, P.1
  • 43
    • 33746424849 scopus 로고    scopus 로고
    • Human monoclonal antibody combination against SARS coronavirus: Synergy and coverage of escape mutants
    • Ter Meulen, J. et al. Human monoclonal antibody combination against SARS coronavirus: synergy and coverage of escape mutants. PLoS Med. 3, e237 (2006).
    • (2006) PLoS Med , vol.3 , pp. e237
    • Ter Meulen, J.1
  • 44
    • 21644487726 scopus 로고    scopus 로고
    • Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants
    • Bakker, A. B. et al. Novel human monoclonal antibody combination effectively neutralizing natural rabies virus variants and individual in vitro escape mutants. J. Virol. 79, 9062-9068 (2005).
    • (2005) J. Virol , vol.79 , pp. 9062-9068
    • Bakker, A.B.1
  • 45
    • 0031688699 scopus 로고    scopus 로고
    • A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever
    • Bray, M., Davis, K., Geisbert, T., Schmaljohn, C., Huggins, J. A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever. J. Infect. Dis. 178, 651-661 (1998).
    • (1998) J. Infect. Dis , vol.178 , pp. 651-661
    • Bray, M.1    Davis, K.2    Geisbert, T.3    Schmaljohn, C.4    Huggins, J.5
  • 46
    • 0031449064 scopus 로고    scopus 로고
    • A system for functional analysis of Ebola virus glycoprotein
    • Takada, A. et al. A system for functional analysis of Ebola virus glycoprotein. Proc. Natl. Acad. Sci. USA 94, 14764-14769 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 14764-14769
    • Takada, A.1
  • 47
    • 34249107414 scopus 로고    scopus 로고
    • Production and characterization of monoclonal antibodies against different epitopes of Ebola virus antigens
    • Shahhosseini, S. et al. Production and characterization of monoclonal antibodies against different epitopes of Ebola virus antigens. J. Virol. Methods 143, 29-37 (2007).
    • (2007) J. Virol. Methods , vol.143 , pp. 29-37
    • Shahhosseini, S.1
  • 48
    • 0026610767 scopus 로고
    • Assessment of protein models with three-dimensional profiles
    • Luthy, R., Bowie, J. U., Eisenberg, D. Assessment of protein models with three-dimensional profiles. Nature 356, 83-85 (1992).
    • (1992) Nature , vol.356 , pp. 83-85
    • Luthy, R.1    Bowie, J.U.2    Eisenberg, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.