Xanthotoxin suppresses LPS-induced expression of iNOS, COX-2, TNF-α, and IL-6 via AP-1, NF-κB, and JAK-STAT inactivation in RAW 264.7 macrophages

International Immunopharmacology

Volumn 49, Issue , 2017, Pages 21-29

  Lee, Seung Bin ^a   Lee, Woo Seok ^a   Shin, Ji Sun ^a   Jang, Dae Sik ^a   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Activator protein 1; Janus kinase signal transducers and activators of transcription; Nuclear factor B; Xanthotoxin

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; JANUS KINASE 1; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MESSENGER RNA; METHOXSALEN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROSTAGLANDIN E2; PROTEIN C FOS; PROTEIN C JUN; SERINE; STAT1 PROTEIN; STAT3 PROTEIN; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; TYROSINE; JANUS KINASE; NITRIC OXIDE; NOS2 PROTEIN, MOUSE; PTGS2 PROTEIN, MOUSE; STAT PROTEIN;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA BINDING; DOWN REGULATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; GENETIC TRANSCRIPTION; MACROPHAGE; MEDIATOR; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAW 264.7 CELL LINE; SIGNAL TRANSDUCTION; ANIMAL; GENETICS; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOUSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CYCLOOXYGENASE 2; INFLAMMATION; INTERLEUKIN-6; JANUS KINASES; LIPOPOLYSACCHARIDES; MACROPHAGES; METHOXSALEN; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RAW 264.7 CELLS; SIGNAL TRANSDUCTION; STAT TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 85019630426     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2017.05.021     Document Type: Article

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