Zedoarondiol isolated from the rhizoma of Curcuma heyneana is involved in the inhibition of iNOS, COX-2 and pro-inflammatory cytokines via the downregulation of NF-κB pathway in LPS-stimulated murine macrophages

International Immunopharmacology

Volumn 9, Issue 9, 2009, Pages 1049-1057

  Cho, Woong ^a   Nam, Joo Won ^b   Kang, Hyun Jun ^a   Windono, Tri ^c   Seo, Eun Kyoung ^b   Lee, Kyung Tae ^a  

^a Kyung Hee University   (South Korea)

^b Ewha Womans University   (South Korea)

^c UNIVERSITY OF SURABAYA   (Indonesia)

Author keywords

Cyclooxygenase 2; Inducible nitric oxide synthase; Lipopolysaccharide; Nuclear factor B; Zedoarondiol

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ZEDOARONDIOL;

ANIMAL CELL; ARTICLE; CELL NUCLEUS; CELL STIMULATION; CELL VIABILITY; CHEMICAL STRUCTURE; CURCUMA HEYNEANA; CYTOKINE PRODUCTION; DNA BINDING; DOWN REGULATION; DRUG ISOLATION; ENZYME INHIBITION; ENZYME REPRESSION; MEDICINAL PLANT; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; RHIZOME; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CURCUMA; CYCLOOXYGENASE 2; DOWN-REGULATION; INFLAMMATION MEDIATORS; LACTONES; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; RHIZOME; SESQUITERPENES; SIGNAL TRANSDUCTION;

EID: 67649584085     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.04.012     Document Type: Article

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