Constituents of PG201 (Layla®), a multi-component phytopharmaceutical, with inhibitory activity on LPS-induced nitric oxide and prostaglandin E2 productions in macrophages

Archives of Pharmacal Research

Volumn 39, Issue 2, 2016, Pages 231-239

  Kim, Hyun Ji ^a   Kim, Hye Mi ^a   Ryu, Byeol ^a   Lee, Woo Seok ^a   Shin, Ji Sun ^a   Lee, Kyung Tae ^a   Jang, Dae Sik ^a  

^a Kyung Hee University   (South Korea)

Author keywords

Constituents; Layla ; Nitric oxide; PG201; Phytopharmaceutical; Prostaglandin E2

Indexed keywords

ANTIINFLAMMATORY AGENT; CHIKUSETSU SAPONIN; CHIKUSETSUSAPONIN IVA METHYL ESTER; CNIDILIDE; COUMARIN; DECURSIN; DECURSINOL; DECURSINOL ANGELATE; DEMETHYLSUBEROSIN; ETHYL CAFFEATE; FARNESOL; LINOLEIC ACID; LIPOPOLYSACCHARIDE; METHOXSALEN; NITRIC OXIDE; NITRITE; PG 201; PLANT MEDICINAL PRODUCT; PROSTAGLANDIN E2; PROSTAGLANDIN INHIBITOR; PSORALEN; SYRINGARESINOL; UNCLASSIFIED DRUG; HERBAL EXTRACT PG201; PLANT EXTRACT;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL LINE RAW 264.7; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; FRACTIONATION; IC50; IN VITRO STUDY; MOUSE; NONHUMAN; PROSTAGLANDIN SYNTHESIS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; INFLAMMATION; MACROPHAGE; MEDICINAL PLANT; METABOLISM; PHYTOTHERAPY; RAW 264.7 CELL LINE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MOLECULAR STRUCTURE; NITRIC OXIDE; PHYTOTHERAPY; PLANT EXTRACTS; PLANTS, MEDICINAL; RAW 264.7 CELLS;

EID: 84958123755     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-015-0654-z     Document Type: Article

References (36)

1. Boeck, F., M. Blazejak, M.R. Anneser, and L. Hintermann. 2012. Cyclization of ortho-hydroxycinnamates to coumarins under mild conditions: a nucleophilic organocatalysis approach. Beilstein Journal of Organic Chemistry 8: 1630-1636.
2. Chiang, Y.M., C.P. Lo, Y.P. Chen, S.Y. Wang, N.S. Yang, Y.H. Kuo, and L.F. Shyur. 2005. Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin. British Journal of Pharmacology 146: 352-363.
3. Choi, J., S.H. Kim, and S. Kim. 2012. Suppressive effects of PG201, an antiarthritic botanical formulation, on lipopolysaccharide-induced inflammatory mediators in Raw264.7 cells. Experimental Biology and Medicine 237: 499-508.
4. Choi, J., J. Lee, S.H. Kim, J. Kim, and S. Kim. 2013. PG201 downregulates the production of nitrite by upregulating heme oxygenase-1 expression through the control of phosphatidylinositol 3-kinase and NF-E2-related factor 2. Nitric Oxide 33: 42-55.
5. Choi, S.H., and H.J. Kim. 2000. Volatile flavor components of Angelica gigas Nakai by the storage conditions. Korean Journal of Food Science and Technology 32: 513-518.
6. Fernandez-Martinez, J., M.D. Rio, and A.D. Haro. 1993. Survey of Safflower (Carthamus tinctorius L.) germplasm for variants in fatty acid composition and other seed characters. Euphytica 69: 115-122.
7. Guo, H., H.P. Mao, G.X. Pan, H. Zhang, G.W. Fan, W.W. Li, K. Zhou, Y. Zhu, N. Yanagihara, and X.M. Gao. 2013. Antagonism of Cortex Periplocae extract-induced catecholamines secretion by Panax notoginseng saponins in cultured bovine adrenal medullary cells by drug combinations. Journal of Ethnopharmacology 147: 447-455.
8. Huang, W.C., Z. Li, X.J. Li, L.M. Gong, X.Q. Liu, O.K. Kwon, H.X. Ye, and H.K. Lee. 2014. Chemical composition, anti-inflammatory activity and cytotoxic activity of the liposoluble constituents from different parts of Acanthopanax evodiaefolius by the herbal blitzkrieg extracter. Environmental Toxicology and Pharmacology 38: 406-411.
9. Jia, S.P., Z.Y. Yu, Z.F. Hao, and J.X. Li. 2006. Isolation and identification of triterpenoids from roots of Achyranthes bidetata in Henan. Zhongguo Zhong Yao Za Zhi 31: 1244-2147.
10. Kim, D.H., K.T. Lee, E.A. Bae, M.J. Han, and H.J. Park. 1999. Metabolism of liriodendrin and syringin by human intestinal bacteria and their relation to in vitro cytotoxicity. Archives of Pharmacal Research 22: 30-34.
11. Kim, S.J., Y.W. Chin, K.D. Yoon, M.Y. Ryu, M.H. Yang, J.H. Lee, and J.W. Kim. 2008. Chemical constituents of Saposhnikovia divaricata. Korean Journal of Pharmacognosy 39: 357-364.
12. Lee, D.Y., K.H. Seo, R.H. Jeong, S.M. Lee, G.S. Kim, H.J. Noh, S.Y. Kim, G.W. Kim, J.Y. Kim, and N.I. Baek. 2013. Anti-inflammaory lignans from the fruits of Acanthopanax sessiliflorus. Molecules 18: 41-49.
13. Lee, J.H., H.B. Bang, S.Y. Han, and J.G. Jun. 2007. An efficient synthesis of (+)-decursinol from umbelliferone. Tetrahedron Letters 48: 2889-2892.
14. Lee, S.H., D.S. Shin, J.S. Kim, K.B. Oh, and S.S. Kang. 2003. Antibacterial coumarins from Angelica gigas roots. Archives of Pharmacal Research 26: 449-452.
15. Li, J., Z.M. Bi, Y.J. Xiao, and P. Li. 2007. Studies on triterpenoid saponins from Achyranthese bidentata B.I. Chinese Pharmaceutical Journal 42: 178-180.
16. Li, Y., S.F. Wang, Y.L. Zhao, K.C. Liu, X.M. Wang, Y.P. Yang, and X.L. Li. 2009. Chemical constituents from Clematis delavayi var. spinescens. Molecules 14: 4433-4439.
17. Li, W.X., Y.P. Tang, Y.Y. Chen, and J.A. Duan. 2012. Advances in the chemical analysis and biological activities of Chuanxiong. Molecules 17: 10614-10651.
18. Liao, J.C., J.S. Deng, C.S. Chiu, W.C. Hou, S.S. Huang, P.H. Shie, and G.J. Huang. 2012. Anti-inflammatory activities of Cinnamomum cassia constituents in vitro and in vivo. Evidence-Based Complementary and Alternative Medicine 2012: 1-12.
19. Lim, T.K. 2012. Cydonia oblonga. Edible medicinal and non-medicinal plants: fruits, vol. 4, 371-380. Netherlands: Springer.
20. Liu, R., A. Li, A. Sun, and L. Kong. 2004. Preparative isolation and purification of psoralen and isopsoralen from Psoralea corylifolia by high-speed counter-current chromatography. Journal of Chromatography A 1057: 225-228.
21. Ma, Y.F., J.Y. Jung, Y.J. Jung, J.H. Choi, W.S. Jeong, Y.S. Song, J.S. Kang, K. Bi, and M.J. Kim. 2009. Anti-inflammatory activites of coumarins isolated from Angelica gigas Nakai on LPS-stimulated RAW 264.7 cells. Journal of Food and Science Nutrition 14: 179-187.
22. Mills, S., and K. Bone. 2000. Principles and practice of phytotherapy. New York: Churchill Livingston.
23. Park, H.Y., S.B. Kwon, N.K. Heo, W.J. Chun, M.J. Kim, and Y.S. Kwon. 2011. Constituents of the stem of Angelica gigas with rat lens aldose reductase inhibitory activity. Journal of the Korean Society for Applied Biological Chemistry 54: 194-199.
24. Park, K.C., E.J. Park, E.R. Kim, Y. Kim, S.H. Chung, B.W. Cho, S. Kim, and M. Jin. 2005. Therapeutic effects of PG201, an ethanol extract from herbs, through cartilage protection on collagenase-induced arthritis in rabbits. Biochemical and Biophysical Research Communications 331: 1469-1477.
25. Peng, W., T. Han, Y. Wang, W.B. Xin, C.J. Zheng, and L.P. Qin. 2011. Chemical constituents of the aerial part of Atractylodes macricephala. Chemistry of Natural Compounds 46: 959-960.
26. Piao, X.L., J.H. Park, J. Cui, D.H. Kim, and H.H. Yoo. 2007. Development of gas chromatographic/mass spectrometry-pattern recognition method for the quality control of Korean Angelica. Journal of Pharmaceutical and Biomedical Analysis 44: 1163-1167.
27. Ryu, S., J.S. Shin, Y.W. Cho, H.K. Kim, S.H. Paik, J.H. Lee, Y.H. Chi, J.H. Kim, and K.T. Lee. 2013. Fimasartan, anti-hypertension drug, suppressed inducible nitric oxide synthase expressions via nuclear factor-kappa B and activator protein-1 inactivation. Biological and Pharmaceutical Bulletin 36: 467-474.
28. Shin, S.S., M. Jin, H.J. Jung, B. Kim, H. Jeon, and J.J. Choi. 2003. Suppressive effects of PG201, an ethanol extract from herbs, on collagen-induced arthritis in mice. Rheumatology 42: 665-672.
29. Spelman, K., J.J. Burns, D. Nichols, N. Winters, S. Ottersberg, and M. Tenborg. 2006a. Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Alternative Medicine Review 11: 128-150.
30. Spelman, K., J.A. Duke, and M.J. Bogenschutz-Godwin. 2006b. The synergy principle in plants, pathogens, insects, herbivores and humans. In Natural products from plants, vol. 2e, ed. P.B. Kaufman, 475-501. Boca Raton: CRC Press.
31. Trumble, J.T., and J.G. Millar. 1996. Biological activity of marmesin and demethylsuberosin against a generalist herbivore, Spodoptera exigua (Lepidoptera: Noctuidae). Journal of Agriculture and Food Chemistry 44: 2859-2864.
32. Tsukamoto, T., Y. Ishikawa, and M. Miyazawa. 2005. Larvicidal and adulticidal activity of alkylphthalide derivatives from rhizome of Cnidium officinale against Drosophila melanogaster. Journal of Agriculture and Food Chemistry 53: 5549-5553.
33. Wada, T., K. Kobata, Y. Hayashi, and H. Shibata. 1995. Two chemotypes of Boletinus cavipes. Bioscience Biotechnology and Biochemistry 59: 1036-1039.
34. Walker, A.F. 2006. Herbal medicine: the science of the art. Proceedings of the Nutrition Society 65: 145-152.
35. Yin, M., X.Y. Wang, M. Wang, Y. Chen, Y.F. Dong, Y.Y. Zhao, and X. Feng. 2012. A new triterpenoid saponin and other saponins from Salicornia europaea. Chemistry of Natural Compounds 48: 258-261.
36. ®)) and celecoxib in the treatment of symptomatic knee osteoarthritis: a double-blinded, randomized, multi-center, active drug comparative, parallel-group, non-inferiority, phase III study. Rheumatology International 34: 1369-1378.