Xanthotoxin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis

Osteoporosis International

Volumn 27, Issue 7, 2016, Pages 2335-2344

  Dou, C ^a   Chen, Y ^a   Ding, N ^a   Li, N ^a   Jiang, H ^a   Zhao, C ^a   Kang, F ^a   Cao, Z ^a   Quan, H ^a   Luo, F ^a   Xu, J ^a   Dong, S ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Bone loss; Calcium oscillation; Osteoclasts; ROS; Xanthotoxin

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; CALCIUM ION; DICHLORODIHYDROFLUORESCEIN DIACETATE; FOCAL ADHESION KINASE 2; METHOXSALEN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; CALCIUM; TNFSF11 PROTEIN, MOUSE;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BONE ATROPHY; BONE MARROW DERIVED MACROPHAGE; BONE MICROARCHITECTURE; BONE SLICE; BONE STRENGTH; CALCIUM SIGNALING; CELL COUNT; CELL DIFFERENTIATION; CELL SURFACE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFECT; DRUG MEGADOSE; FEMALE; FOCAL ADHESION; IN VIVO STUDY; LOW DRUG DOSE; MOUSE; MOUSE MODEL; NONHUMAN; OSTEOCLAST; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OSTEOLYSIS; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRABECULAR BONE; WESTERN BLOTTING; ANIMAL; BONE DEVELOPMENT; C57BL MOUSE; DRUG EFFECTS; MACROPHAGE; METABOLISM;

ANIMALS; BONE RESORPTION; CALCIUM; CELL DIFFERENTIATION; FEMALE; MACROPHAGES; METHOXSALEN; MICE; MICE, INBRED C57BL; OSTEOCLASTS; OSTEOGENESIS; OVARIECTOMY; RANK LIGAND; REACTIVE OXYGEN SPECIES;

EID: 84955312400     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-016-3496-8     Document Type: Article

References (37)

1. Cummings SR, Melton LJ (2002) Epidemiology and outcomes of osteoporotic fractures. Lancet 359(9319):1761–1767. doi:10.1016/S0140-6736(02)08657-9
2. Reginster JY, Burlet N (2006) Osteoporosis: a still increasing prevalence. Bone 38(2 Suppl 1):S4–S9. doi:10.1016/j.bone.2005.11.024
3. Melton LJ 3rd, Chrischilles EA, Cooper C, Lane AW, Riggs BL (1992) Perspective. How many women have osteoporosis? J Bone Miner Res 7(9):1005–1010. doi:10.1002/jbmr.5650070902
4. Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93(2):165–176
5. Garrett IR, Boyce BF, Oreffo RO, Bonewald L, Poser J, Mundy GR (1990) Oxygen-derived free radicals stimulate osteoclastic bone resorption in rodent bone in vitro and in vivo. J Clin Invest 85(3):632–639. doi:10.1172/JCI114485
6. Ha H, Kwak HB, Lee SW, Jin HM, Kim HM, Kim HH, Lee ZH (2004) Reactive oxygen species mediate RANK signaling in osteoclasts. Exp Cell Res 301(2):119–127. doi:10.1016/j.yexcr.2004.07.035
7. Lee NK, Choi YG, Baik JY, Han SY, Jeong DW, Bae YS, Kim N, Lee SY (2005) A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 106(3):852–859. doi:10.1182/blood-2004-09-3662
8. Bhatt NY, Kelley TW, Khramtsov VV, Wang Y, Lam GK, Clanton TL, Marsh CB (2002) Macrophage-colony-stimulating factor-induced activation of extracellular-regulated kinase involves phosphatidylinositol 3-kinase and reactive oxygen species in human monocytes. J Immunol 169(11):6427–6434
9. Lean JM, Davies JT, Fuller K, Jagger CJ, Kirstein B, Partington GA, Urry ZL, Chambers TJ (2003) A crucial role for thiol antioxidants in estrogen-deficiency bone loss. J Clin Invest 112(6):915–923. doi:10.1172/JCI18859
10. Manolagas SC (2010) From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis. Endocr Rev 31(3):266–300. doi:10.1210/er.2009-0024
11. Sato K, Suematsu A, Nakashima T, Takemoto-Kimura S, Aoki K, Morishita Y, Asahara H, Ohya K, Yamaguchi A, Takai T, Kodama T, Chatila TA, Bito H, Takayanagi H (2006) Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med 12(12):1410–1416. doi:10.1038/nm1515
12. Ishii KA, Fumoto T, Iwai K, Takeshita S, Ito M, Shimohata N, Aburatani H, Taketani S, Lelliott CJ, Vidal-Puig A, Ikeda K (2009) Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation. Nat Med 15(3):259–266. doi:10.1038/nm.1910
13. Hwang SY, Putney JW Jr (2011) Calcium signaling in osteoclasts. Biochim Biophys Acta 1813(5):979–983. doi:10.1016/j.bbamcr.2010.11.002
14. Li P, Liu C, Hu M, Long M, Zhang D, Huo B (2014) Fluid flow-induced calcium response in osteoclasts: signaling pathways. Ann Biomed Eng 42(6):1250–1260. doi:10.1007/s10439-014-0984-x
15. Purohit M, Pande D, Datta A, Srivastava PS (1995) Enhanced xanthotoxin content in regenerating cultures of Ammi majus and micropropagation. Planta Med 61(5):481–482. doi:10.1055/s-2006-958144
16. Ehsani AH, Ghaninejad H, Kiani A, Daneshpazhooh M, Hosseini SH, Noormohammadpoor P (2011) Comparison of topical 8-methoxypsoralen and narrowband ultraviolet B with narrowband ultraviolet B alone in treatment-resistant sites in plaque-type psoriasis: a placebo-controlled study. Photodermatol Photoimmunol Photomed 27(6):294–296. doi:10.1111/j.1600-0781.2011.00615.x
17. McNeely W, Goa KL (1998) 5-Methoxypsoralen. A review of its effects in psoriasis and vitiligo. Drugs 56(4):667–690
18. Lim HW, Edelson RL (1995) Photopheresis for the treatment of cutaneous T-cell lymphoma. Hematol Oncol Clin North Am 9(5):1117–1126
19. Malawista SE, Trock D, Edelson RL (1991) Photopheresis for rheumatoid arthritis. Ann N Y Acad Sci 636:217–226
20. Sumiyoshi M, Sakanaka M, Taniguchi M, Baba K, Kimura Y (2014) Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits of Angelica and Cnidium species under ultraviolet A irradiation. J Nat Med 68(1):83–94. doi:10.1007/s11418-013-0774-z
21. Bartosova J, Kuzelova K, Pluskalova M, Marinov I, Halada P, Gasova Z (2006) UVA-activated 8-methoxypsoralen (PUVA) causes G2/M cell cycle arrest in Karpas 299 T-lymphoma cells. J Photochem Photobiol B 85(1):39–48. doi:10.1016/j.jphotobiol.2006.04.002
22. Ng TB, Liu F, Wang ZT (2000) Antioxidative activity of natural products from plants. Life Sci 66(8):709–723
23. Potapenko A, Moshnin MV, Abyev GA, Gerashchenko PG, Belikov NG (1982) Effect of antioxidants on photoaddition of 8-methoxypsoralen to thymine, double-helix DNA and photosensitized inactivation of Escherichia coli. Biofizika 27(6):995–999
24. Zhang XQ, Zheng M, Mou KH, Feng J (2009) Effects of 8-methoxypsoralen on intracellular [Ca(2+)]i and cytoskeleton actin organization in human melanocytes in vitro. Zhejiang Da Xue Xue Bao Yi Xue Ban 38(4):348–351
25. Dou C, Zhang C, Kang F, Yang X, Jiang H, Bai Y, Xiang J, Xu J, Dong S (2014) MiR-7b directly targets DC-STAMP causing suppression of NFATc1 and c-Fos signaling during osteoclast fusion and differentiation. Biochim Biophys Acta 1839(11):1084–1096. doi:10.1016/j.bbagrm.2014.08.002
26. Dou C, Li J, Kang F, Cao Z, Yang X, Jiang H, Yang B, Xiang J, Xu J, Dong S (2014) Dual Effect of Cyanidin on RANKL-Induced differentiation and fusion of osteoclasts. Journal of cellular physiology. doi:10.1002/jcp.24916
27. Dolmetsch RE, Lewis RS (1994) Signaling between intracellular Ca2+ stores and depletion-activated Ca2+ channels generates [Ca2+]i oscillations in T lymphocytes. J Gen Physiol 103(3):365–388
28. Li S, Miller CH, Giannopoulou E, Hu X, Ivashkiv LB, Zhao B (2014) RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis. J Clin Invest 124(11):5057–5073. doi:10.1172/JCI71882
29. Banfi G, Iorio EL, Corsi MM (2008) Oxidative stress, free radicals and bone remodeling. Clin Chem Lab Med 46(11):1550–1555. doi:10.1515/CCLM.2008.302
30. Lander HM (1997) An essential role for free radicals and derived species in signal transduction. FASEB J 11(2):118–124
31. Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M (2014) FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun 5:3773. doi:10.1038/ncomms4773
32. Kajiya H (2012) Calcium signaling in osteoclast differentiation and bone resorption. Adv Exp Med Biol 740:917–932. doi:10.1007/978-94-007-2888-2_41
33. Rachner TD, Khosla S, Hofbauer LC (2011) Osteoporosis: now and the future. Lancet 377(9773):1276–1287. doi:10.1016/S0140-6736(10)62349-5
34. Goettsch C, Babelova A, Trummer O, Erben RG, Rauner M, Rammelt S, Weissmann N, Weinberger V, Benkhoff S, Kampschulte M, Obermayer-Pietsch B, Hofbauer LC, Brandes RP, Schroder K (2013) NADPH oxidase 4 limits bone mass by promoting osteoclastogenesis. J Clin Invest 123(11):4731–4738. doi:10.1172/JCI67603
35. Jiang BQ, Zhong PH, Cheng XB, Yang XL, Yang J, Cao YF (2007) Investigation of health and nutrition status of middle-aged and old residents in the urban district of Chongqing. Asia Pac J Clin Nutr 16(Suppl 1):17–21
36. Wang Y, Tao Y, Hyman ME, Li J, Chen Y (2009) Osteoporosis in China. Osteoporos Int 20(10):1651–1662. doi:10.1007/s00198-009-0925-y
37. Moon HJ, Ko WK, Han SW, Kim DS, Hwang YS, Park HK, Kwon IK (2012) Antioxidants, like coenzyme Q10, selenite, and curcumin, inhibited osteoclast differentiation by suppressing reactive oxygen species generation. Biochem Biophys Res Commun 418(2):247–253. doi:10.1016/j.bbrc.2012.01.005