메뉴 건너뛰기




Volumn 11, Issue 8, 2011, Pages 1095-1102

Arctigenin inhibits lipopolysaccharide-induced iNOS expression in RAW264.7 cells through suppressing JAK-STAT signal pathway

Author keywords

Anti inflammation; Arctigenin; iNOS; JAK STAT

Indexed keywords

ARCTIGENIN; CYCLOOXYGENASE 2; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; JANUS KINASE 2; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; STAT1 PROTEIN; STAT3 PROTEIN;

EID: 84860390738     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.03.005     Document Type: Article
Times cited : (107)

References (41)
  • 3
    • 0035104119 scopus 로고    scopus 로고
    • LPS induction of gene expression in human monocytes
    • DOI 10.1016/S0898-6568(00)00149-2, PII S0898656800001492
    • Guha M, Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 2001;13:85-94. (Pubitemid 32222977)
    • (2001) Cellular Signalling , vol.13 , Issue.2 , pp. 85-94
    • Guha, M.1    Mackman, N.2
  • 4
    • 0038352039 scopus 로고    scopus 로고
    • 2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia
    • DOI 10.1074/jbc.M210819200
    • Park Eun Jung, Soo Young Park, Eun-hye Joe. 15d-PGJ2 and rosiglitazone suppress janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia. J Biol Chem 2003;17:14747-52. (Pubitemid 36799798)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.17 , pp. 14747-14752
    • Park, E.J.1    Park, S.Y.2    Joe, E.-H.3    Jou, I.4
  • 6
    • 33847351136 scopus 로고    scopus 로고
    • The JAK-STAT signaling pathway: Input and output integration
    • Murray PJ. The JAK-STAT signaling pathway: input and output integration. J Immunol 2007;178:2623-9. (Pubitemid 46333135)
    • (2007) Journal of Immunology , vol.178 , Issue.5 , pp. 2623-2629
    • Murray, P.J.1
  • 8
    • 0035862950 scopus 로고    scopus 로고
    • Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression
    • DOI 10.1093/emboj/20.1.91
    • Kovarik P, Mangold M, Ramsauer K, Heidari H, Steinborn R, Zotter A, et al. Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression. EMBO J 2001;20:91-100. (Pubitemid 32099105)
    • (2001) EMBO Journal , vol.20 , Issue.1-2 , pp. 91-100
    • Kovarik, P.1    Mangold, M.2    Ramsauer, K.3    Heidari, H.4    Steinborn, R.5    Zotter, A.6    Levy, D.E.7    Muller, M.8    Decker, T.9
  • 10
    • 0029117304 scopus 로고
    • Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation
    • Wen Z, Zhong Z, Darnell Jr. Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 1995;82:241-50.
    • (1995) Cell , vol.82 , pp. 241-250
    • Wen, Z.1    Zhong, Z.2    Darnell, Jr.3
  • 12
    • 0035074976 scopus 로고    scopus 로고
    • Anti-inflammatory activity of cubebin, a lignan from the leaves of Zanthoxyllum naranjillo Griseb
    • DOI 10.1016/S0378-8741(01)00171-4, PII S0378874101001714
    • Bastos JK, Carvalho JC, De Souza GH, Pedrazzi AH, Sarti SJ. Anti-inflammatory activity of cubebin, a lignan from the leaves of Zanthoxyllum naranjillo Griseb. J Ethnopharmacol 2001;75:279-82. (Pubitemid 32297745)
    • (2001) Journal of Ethnopharmacology , vol.75 , Issue.2-3 , pp. 279-282
    • Bastos, J.K.1    Carvalho, J.C.T.2    De Souza, G.H.B.3    Pedrazzi, A.H.P.4    Sarti, S.J.5
  • 13
    • 0034730949 scopus 로고    scopus 로고
    • Antitumor-promoting activity of lignans from the aerial part of Saussurea medusa
    • Midori T, Takao K, Katsuko K, Harukuni T, Hoyoku N. Antitumor-promoting activity of lignans from the aerial part of Saussurea medusa. Cancer Lett 2000;158:53-9.
    • (2000) Cancer Lett , vol.158 , pp. 53-59
    • Midori, T.1    Takao, K.2    Katsuko, K.3    Harukuni, T.4    Hoyoku, N.5
  • 15
    • 0034938119 scopus 로고    scopus 로고
    • Neuroprotective dibenzylbutyrolactonelignans of Torreya nucifera
    • Jang YP, Kim SR, Kim YC. Neuroprotective dibenzylbutyrolactonelignans of Torreya nucifera. Planta Med 2001;67:470-2.
    • (2001) Planta Med , vol.67 , pp. 470-472
    • Jang, Y.P.1    Kim, S.R.2    Kim, Y.C.3
  • 18
    • 0035185314 scopus 로고    scopus 로고
    • Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-κBα phosphorylation and of p65 nuclear translocation in macrophages
    • DOI 10.1016/S1567-5769(01)00153-9, PII S1567576901001539
    • Cho MK, Park JW, Jang YP, Kim YC, Kim SG. Potent inhibition of lipopolysaccharideinducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kBa phosphorylation and of p65 nuclear translocation in macrophages. Int Immunopharmacol 2002;2:105-16. (Pubitemid 33086808)
    • (2002) International Immunopharmacology , vol.2 , Issue.1 , pp. 105-116
    • Cho, M.K.1    Park, J.W.2    Jang, Y.P.3    Kim, Y.C.4    Kim, S.G.5
  • 19
    • 63649103383 scopus 로고    scopus 로고
    • In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway
    • Feng Zhao, LuWang, Ke Liu. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L., through inhibition on iNOS pathway. J Ethnopharmacol 2009;122:457-62.
    • (2009) J Ethnopharmacol , vol.122 , pp. 457-462
    • Zhao, F.1    Ke Liu, L.2
  • 20
    • 34047122615 scopus 로고    scopus 로고
    • STAT1 and STAT3 phosphorylation by porins are independent of JAKs but are dependent on MAPK pathway and plays a role in U937 cells production of interleukin-6
    • DOI 10.1016/j.cyto.2006.12.003, PII S1043466606003450
    • Galdiero M, Vitiello M, D'Isanto M, Raieta K, Galdiero E. STAT1 and STAT3 phosphorylation by porins are independent of JAKs but are dependent on MAPK pathway and plays a role in U937 cells production of interleukin-6. Cytokine 2006;36:218-28. (Pubitemid 46529473)
    • (2006) Cytokine , vol.36 , Issue.5-6 , pp. 218-228
    • Galdiero, M.1    Vitiello, M.2    D'Isanto, M.3    Raieta, K.4    Galdiero, E.5
  • 21
    • 3142728480 scopus 로고    scopus 로고
    • Oxidized phospholipids increase interleukin 8 (IL-8) synthesis by activation of the c-src/signal transducers and activators of transcription (STAT)3 pathway
    • DOI 10.1074/jbc.M312198200
    • Yeh M, Gharavi NM, Choi J, Hsieh X, Reed E, Mouillesseaux KP, et al. Oxidized phospholipids increase interleukin 8(IL-8) synthesis by activation of the c-src/ signal transducers and activators of transcription (STAT)3 pathway. J Biol Chem 2004;279:30175-81. (Pubitemid 38937941)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.29 , pp. 30175-30181
    • Yeh, M.1    Gharavi, N.M.2    Choi, J.3    Hsieh, X.4    Reed, E.5    Mouillesseaux, K.P.6    Cole, A.L.7    Reddy, S.T.8    Berliner, J.A.9
  • 22
    • 33748919803 scopus 로고    scopus 로고
    • Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals
    • DOI 10.1038/sj.onc.1209576, PII 1209576
    • Wu YF, Fan YM, Xue B, Luo L, Shen JY, Yin ZM. Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2-ASK1 signals. Oncogene 2006;25: 5787-800. (Pubitemid 44435255)
    • (2006) Oncogene , vol.25 , Issue.42 , pp. 5787-5800
    • Wu, Y.1    Fan, Y.2    Xue, B.3    Luo, L.4    Shen, J.5    Zhang, S.6    Jiang, Y.7    Yin, Z.8
  • 23
    • 43549084328 scopus 로고    scopus 로고
    • Dipyrithione inhibits lipopolysaccharideinduced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic shock in mice
    • Liu Ziwen, Fan Yumei, Luo Lan, Yin Zhimin. Dipyrithione inhibits lipopolysaccharideinduced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic shock in mice. FEBS Lett 2008;582:1643-50.
    • (2008) FEBS Lett , vol.582 , pp. 1643-1650
    • Ziwen, L.1    Yumei, F.2    Lan, L.3    Zhimin, Y.4
  • 24
    • 51349142546 scopus 로고    scopus 로고
    • Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia
    • Kim HongSook, Cho IkHyun, Kim JaEun. Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia. Free Radic Biol Med 2008;45:950-63.
    • (2008) Free Radic Biol Med , vol.45 , pp. 950-963
    • Hongsook, K.1    Ikhyun, C.2    JaEun, K.3
  • 25
    • 0035067108 scopus 로고    scopus 로고
    • Requirement for STAT1 in LPS-induced gene expression in macrophages
    • Ohmori Y, Hamilton TA. Requirement for STAT1 in LPS-induced gene expression in macrophages. J Leukoc Biol 2001;69:598-604. (Pubitemid 32294845)
    • (2001) Journal of Leukocyte Biology , vol.69 , Issue.4 , pp. 598-604
    • Ohmori, Y.1    Hamilton, T.A.2
  • 26
    • 33645959483 scopus 로고    scopus 로고
    • STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice
    • Cho ML, Kang JW, Moon YM, Nam HJ, Jhun JY, Heo SB, et al. STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice. J Immunol 2006;176:5652-61.
    • (2006) J Immunol , vol.176 , pp. 5652-5661
    • Cho, M.L.1    Kang, J.W.2    Moon, Y.M.3    Nam, H.J.4    Jhun, J.Y.5    Heo, S.B.6
  • 28
    • 33644843382 scopus 로고    scopus 로고
    • Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin (IL)-1β and IL-6 production
    • Lee C, Lim HK, Sakong J, Lee YS, Kim JR, Baek SH. Janus kinase-signal transducer and activator of transcription mediates phosphatidic acid-induced interleukin IL-1βand IL-6 production. Mol Pharmacol 2006;69:1041-7. (Pubitemid 43363880)
    • (2006) Molecular Pharmacology , vol.69 , Issue.3 , pp. 1041-1047
    • Lee, C.1    Lim, H.-K.2    Sakong, J.3    Lee, Y.-S.4    Kim, J.-R.5    Baek, S.-H.6
  • 29
    • 34548134831 scopus 로고    scopus 로고
    • Signaling molecules involved in production and regulation of IL-1β by murine peritoneal macrophages in vitro on treatment with Concanavalin A
    • DOI 10.1016/j.intimp.2007.07.004, PII S1567576907001981
    • Sodhi A, Kesherwani V. Signaling molecules involved in production and regulation of IL-1beta bymurine peritoneal macrophages in vitro on treatment with concanavalin A. Int Immunopharmacol 2007;7:1403-13. (Pubitemid 47302889)
    • (2007) International Immunopharmacology , vol.7 , Issue.11 , pp. 1403-1413
    • Sodhi, A.1    Kesherwani, V.2
  • 31
    • 16244370418 scopus 로고    scopus 로고
    • Coexposure of lead and lipopolysaccharideinduced liver injury in rats: Involvement of nitric oxide-initiated oxidative stress and TNF-alpha
    • Liu MY, Cheng YJ, Chen CK, Yang BC. Coexposure of lead and lipopolysaccharideinduced liver injury in rats: involvement of nitric oxide-initiated oxidative stress and TNF-alpha. Shock 2005;23:360-4.
    • (2005) Shock , vol.23 , pp. 360-364
    • Liu, M.Y.1    Cheng, Y.J.2    Chen, C.K.3    Yang, B.C.4
  • 33
    • 0034082217 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling pathways
    • DOI 10.1146/annurev.immunol.18.1.143
    • Yasukawa H, Sasaki A, Yoshimura A. Negative regulation of cytokine signaling pathways. Annu Rev Immunol 2000;18:143-64. (Pubitemid 30365377)
    • (2000) Annual Review of Immunology , vol.18 , pp. 143-164
    • Yasukawa, H.1    Sasaki, A.2    Yoshimura, A.3
  • 37
    • 0035313701 scopus 로고    scopus 로고
    • The Stat family in cytokine signaling
    • hle JN The Stat family in cytokine signaling. Curr Opin Cell Biol 2001 13 211-7.
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 211-217
    • Hle, J.N.1
  • 38
    • 64149112132 scopus 로고    scopus 로고
    • STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria
    • Samavati Lobelia, Rastogi Ruchi, Wenjin Du, Hüttemannc Maik, Fitea Alemu, Franchid Luigi. STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria. Mol Immunol 2009;46:1867-77.
    • (2009) Mol Immunol , vol.46 , pp. 1867-1877
    • Lobelia, S.1    Ruchi, R.2    Du, W.3    Maik, H.4    Alemu, F.5    Luigi, F.6
  • 39
    • 0036797750 scopus 로고    scopus 로고
    • Signal transducers and activators of transcription 3 (STAT3) inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor κB
    • DOI 10.1042/BJ20020588
    • Yu Z, Zhang W, Kone BC. Signal transducers and activators of STAT3 inhibits transcription of the inducible nitric oxide synthase gene by interacting with nuclear factor kappaB. Biochem J 2002;367:97-105. (Pubitemid 35176895)
    • (2002) Biochemical Journal , vol.367 , Issue.1 , pp. 97-105
    • Yu, Z.1    Zhang, W.2    Kone, B.C.3
  • 40
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFκB
    • DOI 10.1101/gad.1553707
    • Yang J, Liao X, Agarwal MK, Barnes L, Auron PE, Stark GR. Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev 2007;21:1396-408. (Pubitemid 46871042)
    • (2007) Genes and Development , vol.21 , Issue.11 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 41
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
    • Lee H, Herrmann A, JH Deng, Kujawski M, Niu G, Li Z, et al Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 2009 15 283-93.
    • (2009) Cancer Cell , vol.15 , pp. 283-293
    • Lee, H.1    Herrmann, A.2    Deng, J.H.3    Kujawski, M.4    Niu, G.5    Li, Z.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.