Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages

International Immunopharmacology

Volumn 20, Issue 2, 2014, Pages 298-306

  Shi, Qinghai ^a   Cao, Jinjun ^a   Fang, Li ^b   Zhao, Hongyan ^a   Liu, Zhengxiang ^a   Ran, Jihua ^a   Zheng, Xinchuan ^c   Li, Xiaoling ^a   Zhou, Yu ^a   Ge, Di ^a   Zhang, Hongming ^a   Wang, Li ^a   Ran, Ying ^a   Fu, Jianfeng ^a  

^a Urumqi General Hospital of Lanzhou Military Region   (China)

^b Department of China Satellite Maritime Tracking and Control   (China)

^c THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Activator protein (AP) 1; Geniposide; Inflammation; Mitogen activated protein (MAP) kinases; Nuclear factor (NF) kB

Indexed keywords

CYCLOOXYGENASE 2; CYTOKINE; GENIPOSIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTIINFLAMMATORY AGENT; AUTACOID; IMIDAZOLE DERIVATIVE; IRIDOID; NITRILE; PYRIDINE DERIVATIVE; SULFONE;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CYTOKINE PRODUCTION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; DRUG EFFECTS; GARDENIA; GENETICS; IMMUNOLOGY; INBRED MOUSE STRAIN; MALE; METABOLISM; PERITONEUM MACROPHAGE; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BUTADIENES; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GARDENIA; IMIDAZOLES; INFLAMMATION MEDIATORS; INTERLEUKIN-6; IRIDOIDS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED STRAINS; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; NITRILES; PYRIDINES; SIGNAL TRANSDUCTION; SULFONES; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84899027714     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2014.04.004     Document Type: Article

References (30)

1. C. Nathan Points of control in inflammation Nature 420 2002 846 852
2. R. Medzhitov Origin and physiological roles of inflammation Nature 454 2008 428 435
3. T. Glaros, M. Larsen, and L. Li Macrophages and fibroblasts during inflammation, tissue damage and organ injury Front Biosci 14 2009 3988 3993
4. S. Yona, and S. Jung Monocytes: subsets, origins, fates and functions Curr Opin Hematol 17 2009 53 59
5. D.L. Laskin, and K.J. Pendino Macrophages and inflammatory mediators in tissue injury Annu Rev Pharmacol Toxicol 35 1995 655 677
6. C. Alexander, and E.T. Rietschel Bacterial lipopolysaccharides and innate immunity J Endotoxin Res 7 2001 167 202
7. J. Chun, R.J. Choi, S. Khan, D.S. Lee, Y.C. Kim, and Y.J. Nam et al. Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating NF-kappaB, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells Int Immunopharmacol 14 2012 375 383
8. J.A. Russell Management of sepsis N Engl J Med 355 2006 1699 1713
9. Q. Jiang, S. Akashi, K. Miyake, and H.R. Petty Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-kappa B J Immunol 165 2000 3541 3544
10. G.J. Feng, H.S. Goodridge, M.M. Harnett, X.Q. Wei, A.V. Nikolaev, and A.P. Higson et al. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase J Immunol 163 1999 6403 6412
11. A. Hoffmann, and D. Baltimore Circuitry of nuclear factor kappaB signaling Immunol Rev 210 2006 171 186
12. W. He, T. Qu, Q. Yu, Z. Wang, H. Lv, and J. Zhang et al. LPS induces IL-8 expression through TLR4, MyD88, NF-kappaB and MAPK pathways in human dental pulp stem cells Int Endod J 46 2012 128 136
13. J.L. Yeh, J.H. Hsu, Y.S. Hong, J.R. Wu, J.C. Liang, and B.N. Wu et al. Eugenolol and glyceryl-isoeugenol suppress LPS-induced iNOS expression by down-regulating NF-kappaB AND AP-1 through inhibition of MAPKS and AKT/IkappaBalpha signaling pathways in macrophages Int J Immunopathol Pharmacol 24 2011 345 356
14. Y. Lu, S.J. Suh, C.H. Kwak, K.M. Kwon, C.S. Seo, and Y. Li et al. Saucerneol F, a new lignan, inhibits iNOS expression via MAPKs, NF-kappaB and AP-1 inactivation in LPS-induced RAW264.7 cells Int Immunopharmacol 12 2011 175 181
15. Y. Xiaofeng, C. Qinren, H. Jingping, C. Xiao, W. Miaomiao, and F. Xiangru et al. Geniposide, an iridoid glucoside derived from Gardenia jasminoides, protects against lipopolysaccharide-induced acute lung injury in mice Planta Med 78 2012 557 564
16. Y. Fu, B. Liu, J. Liu, Z. Liu, D. Liang, and F. Li et al. Geniposide, from Gardenia jasminoides Ellis, inhibits the inflammatory response in the primary mouse macrophages and mouse models Int Immunopharmacol 14 2012 792 798
17. H.T. Liu, J.L. He, W.M. Li, Z. Yang, Y.X. Wang, and J. Yin et al. Geniposide inhibits interleukin-6 and interleukin-8 production in lipopolysaccharide-induced human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways Inflamm Res 59 2010 451 461
18. J. Wang, J. Hou, P. Zhang, D. Li, C. Zhang, and J. Liu Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway Neurochem Res 37 2012 2235 2248
19. H.J. Koo, K.H. Lim, H.J. Jung, and E.H. Park Anti-inflammatory evaluation of gardenia extract, geniposide and genipin J Ethnopharmacol 103 2006 496 500
20. X. Zheng, D. Yang, X. Liu, N. Wang, B. Li, and H. Cao et al. Identification of a new anti-LPS agent, geniposide, from Gardenia jasminoides Ellis, and its ability of direct binding and neutralization of lipopolysaccharide in vitro and in vivo Int Immunopharmacol 10 2010 1209 1219
21. C.Y. Kim, and J. Kim Preparative isolation and purification of geniposide from gardenia fruits by centrifugal partition chromatography Phytochem Anal 18 2007 115 117
22. J. Balsinde, B. Fernandez, and E. Diez Regulation of arachidonic acid release in mouse peritoneal macrophages. The role of extracellular calcium and protein kinase C J Immunol 144 1990 4298 4304
23. C. Nathan Nitric oxide as a secretory product of mammalian cells FASEB J 6 1992 3051 3064
24. S. Moncada Nitric oxide: discovery and impact on clinical medicine J R Soc Med 92 1999 164 169
25. M.E. Turini, and R.N. DuBois Cyclooxygenase-2: a therapeutic target Annu Rev Med 53 2002 35 57
26. B. Rocca, and G.A. FitzGerald Cyclooxygenases and prostaglandins: shaping up the immune response Int Immunopharmacol 2 2002 603 630
27. V.P. Singh, C.S. Patil, N.K. Jain, and S.K. Kulkarni Aggravation of inflammatory bowel disease by cyclooxygenase-2 inhibitors in rats Pharmacology 72 2004 77 84
28. N. Moriyama, M. Taniguchi, K. Miyano, M. Miyoshi, and T. Watanabe ANP inhibits LPS-induced stimulation of rat microglial cells by suppressing NF-kappaB and AP-1 activations Biochem Biophys Res Commun 350 2006 322 328
29. S.F. Chang, B.H. Chou, L.M. Yang, F.L. Hsu, W.K. Lin, and Y. Ho et al. Microbial transformation of isosteviol oxime and the inhibitory effects on NF-kappaB and AP-1 activation in LPS-stimulated macrophages Bioorg Med Chem 17 2009 6348 6353
30. Y.W. Su, W.F. Chiou, S.H. Chao, M.H. Lee, C.C. Chen, and Y.C. Tsai Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-kappaB and AP-1 signaling pathways Int Immunopharmacol 11 2011 1166 1172