The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals

International Immunology

Volumn 16, Issue 8, 2004, Pages 1173-1179

  Kamezaki, Kenjirou ^a,b   Shimoda, Kazuya ^a,b   Numata, Akihiko ^a,b   Matsuda, Tadashi ^c   Nakayama, Kei Ichi ^d,e   Harada, Mine ^a,b  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d KYUSHU UNIVERSITY   (Japan)

^e JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

1L; IFN; Jak

Indexed keywords

BETA INTERFERON; ENDOTOXIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; JANUS KINASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; STAT1 PROTEIN; STAT4 PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENZYME ACTIVATION; ENZYME DEFICIENCY; HOST RESISTANCE; IMMUNOSTIMULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN FUNCTION; SEPTIC SHOCK; SIGNAL TRANSDUCTION;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; PROTEIN-TYROSINE KINASES; SHOCK, SEPTIC; STAT1 TRANSCRIPTION FACTOR; STAT2 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TYK2 KINASE;

EID: 4344640416     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/dxh118     Document Type: Article

References (25)

1. Akira, S. 2003. Mammalian Toll-like receptors. Curr. Opin. Immunol. 15:238.
2. Karaghiosoff, M., Steinborn, R., Kovarik, P., Kriegshauser, G., Baccarini, M., Donabauer, B., Reichart, U., Kolbe, T., Bogdan, C., Leanderson, T., Levy, D., Decker, T. and Muller, M. 2003. Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock. Nat Immunol. 4:471.
3. Car, B. D., Eng, V. M., Schnyder, B., Ozmen, L., Huang, S., Gallay, P., Heumann, D., Aguet, M. and Ryffel, B. 1994. Interferon gamma receptor deficient mice are resistant to endotoxic shock. J. Exp. Med. 179:1437.
4. Ihle, J. N., Nosaka, T., Thierfelder, W., Quelle, F. W. and Shimoda, K. 1997. Jaks and Stats in cytokine signaling. Stem Cells 15 (Suppl. 1): 105; discussion 112.
5. Ihle, J. N. 1995. Cytokine receptor signalling. Nature 377:591.
6. Velazquez, L., Fellous, M., Stark, G. R. and Pellegrini, S. 1992. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 70:313.
7. Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S. et al. 2000. Tyk2 plays a restricted role in IFN alpha signaling, although it is required for IL-12-mediated T cell function. Immunity 13:561.
8. Karaghiosoff, M., Neubauer, H., Lassnig, C., Kovarik, P., Schindler, H., Pircher, H., McCoy, B., Bogdan, C., Decker, T., Brem, G., Pfeffer, K. and Muller, M. 2000. Partial impairment of cytokine responses in Tyk2-deficient mice. Immunity 13:549.
9. Shimoda, K., Tsutsui, H., Aoki, K., Kato, K., Matsuda, T., Numata, A., Takase, K., Yamamoto, T., Nukina, H., Hoshino, T. et al. 2002. Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice. Blood 99:2094.
10. Matsumoto, S., Tsuji-Takayama, K., Aizawa, Y., Koide, K., Takeuchi, M., Ohta, T. and Kurimoto, M. 1997. Interleukin-18 activates NF-kappaB in murine T helper type 1 cells. Biochem. Biophys. Res. Commun. 234:454.
11. Meraz, M. A., White, J. M., Sheehan, K. C., Bach, E. A., Rodig, S. J., Dighe, A. S., Kaplan, D. H., Riley, J. K., Greenlund, A. C., Campbell, D. et al. 1996. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84:431.
12. Thierfelder, W. E., van Deursen, J. M., Yamamoto, K., Tripp, R. A., Sarawar, S. R., Carson, R. T., Sangster, M. Y., Vignali, D. A., Doherty, P. C., Grosveld, G. C. and Ihle, J. N. 1996. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382:171.
13. Shimoda, K., Feng, J., Murakami, H., Nagata, S., Watling, D., Rogers, N. C., Stark, G. R., Kerr, I. M. and Ihle, J. N. 1997. Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor. Blood 90:597.
14. Decker, T., Stockinger, S., Karaghiosoff, M., Muller, M. and Kovarik, P. 2002. IFNs and STATs in innate immunity to microorganisms. J Clin Invest 109:1271.
15. Sato, M., Suemori, H., Hata, N., Asagiri, M., Ogasawara, K., Nakao, K., Nakaya, T., Katsuki, M., Noguchi, S., Tanaka, N. and Taniguchi, T. 2000. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity 13:539.
16. Poltorak, A., He, X., Smirnova, I., Liu, M. Y., Van Huffel, C., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C. et al. 1998. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282:2085.
17. Hoshino, K., Takeuchi, O., Kawai, T., Sanjo, H., Ogawa, T., Takeda, Y., Takeda, K. and Akira, S. 1999. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162:3749.
18. Kawai, T., Adachi, O., Ogawa, T., Takeda, K. and Akira, S. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 11:115.
19. Suzuki, N., Suzuki, S., Duncan, G. S., Millar, D. G., Wada, T., Mirtsos, C., Takada, H., Wakeham, A., Itie, A., Li, S. et al. 2002. Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4. Nature 416:750.
20. Hochholzer, P., Lipford, G. B., Wagner, H., Pfeffer, K. and Heeg, K. 2000. Role of interleukin-18 (IL-18) during lethal shock: decreased lipopolysaccharide sensitivity but normal superantigen reaction in IL-18-deficient mice. Infect. Immun. 68:3502.
21. Ramana, C. V., Gil, M. P., Han, Y., Ransohoff, R. M., Schreiber, R. D. and Stark, G. R. 2001. Stat1-independent regulation of gene expression in response to IFN-gamma. Proc. Natl Acad. Sci. USA 98:6674.
22. Gil, M. P., Bohn, E., O'Guin, A. K., Ramana, C. V., Levine, B., Stark, G. R., Virgin, H. W. and Schreiber, R. D. 2001. Biologic consequences of Stat1-independent IFN signaling. Proc. Natl Acad. Sci. USA 98:6680.
23. Nguyen, K. B., Watford, W. T., Salomon, R., Hofmann, S. R., Pien, G. C., Morinobu, A., Gadina, M., O'Shea, J. J. and Biron, C. A. 2002. Critical role for STAT4 activation by type 1 interferons in the interferon-gamma response to viral infection. Science 297:2063.
24. Shimoda, K., Kamesaki, K., Numata, A., Aoki, K., Matsuda, T., Oritani, K., Tamiya, S., Kato, K., Takase, K., Imamura, R. et al. 2002. Cutting edge: tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-alpha-induced suppression of B lymphocyte formation. J. Immunol. 169:4707.
25. Gongora, R., Stephan, R. P., Schreiber, R. D. and Cooper, M. D. 2000. Stat-1 is not essential for inhibition of B lymphopoiesis by type I IFNs. J. Immunol. 165:2362.