-
1
-
-
0021225388
-
Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence
-
Ahmed, R., Salmi, A., Butler, L.D., Chiller, J.M., Oldstone, M.B., Selection of genetic variants of lymphocytic choriomeningitis virus in spleens of persistently infected mice. Role in suppression of cytotoxic T lymphocyte response and viral persistence. J. Exp. Med. 160 (1984), 521–540.
-
(1984)
J. Exp. Med.
, vol.160
, pp. 521-540
-
-
Ahmed, R.1
Salmi, A.2
Butler, L.D.3
Chiller, J.M.4
Oldstone, M.B.5
-
2
-
-
84878423346
-
Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response
-
Babcock, J.T., Nguyen, H.B., He, Y., Hendricks, J.W., Wek, R.C., Quilliam, L.A., Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response. J. Biol. Chem. 288 (2013), 15687–15698.
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 15687-15698
-
-
Babcock, J.T.1
Nguyen, H.B.2
He, Y.3
Hendricks, J.W.4
Wek, R.C.5
Quilliam, L.A.6
-
3
-
-
85003791429
-
The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells
-
Battello, N., Zimmer, A.D., Goebel, C., Dong, X., Behrmann, I., Haan, C., Hiller, K., Wegner, A., The role of HIF-1 in oncostatin M-dependent metabolic reprogramming of hepatic cells. Cancer Metab., 4, 2016, 3.
-
(2016)
Cancer Metab.
, vol.4
, pp. 3
-
-
Battello, N.1
Zimmer, A.D.2
Goebel, C.3
Dong, X.4
Behrmann, I.5
Haan, C.6
Hiller, K.7
Wegner, A.8
-
4
-
-
84892931838
-
Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells
-
Brenner, D., Brüstle, A., Lin, G.H., Lang, P.A., Duncan, G.S., Knobbe-Thomsen, C.B., St Paul, M., Reardon, C., Tusche, M.W., Snow, B., et al. Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells. Proc. Natl. Acad. Sci. USA 111 (2014), 1060–1065.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 1060-1065
-
-
Brenner, D.1
Brüstle, A.2
Lin, G.H.3
Lang, P.A.4
Duncan, G.S.5
Knobbe-Thomsen, C.B.6
St Paul, M.7
Reardon, C.8
Tusche, M.W.9
Snow, B.10
-
5
-
-
84875419278
-
T cell receptor signalling networks: branched, diversified and bounded
-
Brownlie, R.J., Zamoyska, R., T cell receptor signalling networks: branched, diversified and bounded. Nat. Rev. Immunol. 13 (2013), 257–269.
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 257-269
-
-
Brownlie, R.J.1
Zamoyska, R.2
-
6
-
-
34548128307
-
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
-
Brüstle, A., Heink, S., Huber, M., Rosenplänter, C., Stadelmann, C., Yu, P., Arpaia, E., Mak, T.W., Kamradt, T., Lohoff, M., The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat. Immunol. 8 (2007), 958–966.
-
(2007)
Nat. Immunol.
, vol.8
, pp. 958-966
-
-
Brüstle, A.1
Heink, S.2
Huber, M.3
Rosenplänter, C.4
Stadelmann, C.5
Yu, P.6
Arpaia, E.7
Mak, T.W.8
Kamradt, T.9
Lohoff, M.10
-
7
-
-
84870521827
-
The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells
-
Brüstle, A., Brenner, D., Knobbe, C.B., Lang, P.A., Virtanen, C., Hershenfield, B.M., Reardon, C., Lacher, S.M., Ruland, J., Ohashi, P.S., Mak, T.W., The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells. J. Clin. Invest. 122 (2012), 4698–4709.
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 4698-4709
-
-
Brüstle, A.1
Brenner, D.2
Knobbe, C.B.3
Lang, P.A.4
Virtanen, C.5
Hershenfield, B.M.6
Reardon, C.7
Lacher, S.M.8
Ruland, J.9
Ohashi, P.S.10
Mak, T.W.11
-
8
-
-
33747616250
-
Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway
-
Buchholz, M., Schatz, A., Wagner, M., Michl, P., Linhart, T., Adler, G., Gress, T.M., Ellenrieder, V., Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J. 25 (2006), 3714–3724.
-
(2006)
EMBO J.
, vol.25
, pp. 3714-3724
-
-
Buchholz, M.1
Schatz, A.2
Wagner, M.3
Michl, P.4
Linhart, T.5
Adler, G.6
Gress, T.M.7
Ellenrieder, V.8
-
9
-
-
79251517382
-
Regulation of cancer cell metabolism
-
Cairns, R.A., Harris, I.S., Mak, T.W., Regulation of cancer cell metabolism. Nat. Rev. Cancer 11 (2011), 85–95.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 85-95
-
-
Cairns, R.A.1
Harris, I.S.2
Mak, T.W.3
-
10
-
-
77955475969
-
Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
-
Carr, E.L., Kelman, A., Wu, G.S., Gopaul, R., Senkevitch, E., Aghvanyan, A., Turay, A.M., Frauwirth, K.A., Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J. Immunol. 185 (2010), 1037–1044.
-
(2010)
J. Immunol.
, vol.185
, pp. 1037-1044
-
-
Carr, E.L.1
Kelman, A.2
Wu, G.S.3
Gopaul, R.4
Senkevitch, E.5
Aghvanyan, A.6
Turay, A.M.7
Frauwirth, K.A.8
-
11
-
-
84878831880
-
Posttranscriptional control of T cell effector function by aerobic glycolysis
-
Chang, C.H., Curtis, J.D., Maggi, L.B. Jr., Faubert, B., Villarino, A.V., O'Sullivan, D., Huang, S.C., van der Windt, G.J., Blagih, J., Qiu, J., et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell 153 (2013), 1239–1251.
-
(2013)
Cell
, vol.153
, pp. 1239-1251
-
-
Chang, C.H.1
Curtis, J.D.2
Maggi, L.B.3
Faubert, B.4
Villarino, A.V.5
O'Sullivan, D.6
Huang, S.C.7
van der Windt, G.J.8
Blagih, J.9
Qiu, J.10
-
12
-
-
26644449682
-
Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels
-
Chen, Y., Shertzer, H.G., Schneider, S.N., Nebert, D.W., Dalton, T.P., Glutamate cysteine ligase catalysis: dependence on ATP and modifier subunit for regulation of tissue glutathione levels. J. Biol. Chem. 280 (2005), 33766–33774.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 33766-33774
-
-
Chen, Y.1
Shertzer, H.G.2
Schneider, S.N.3
Nebert, D.W.4
Dalton, T.P.5
-
13
-
-
34248641168
-
Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure
-
Chen, Y., Yang, Y., Miller, M.L., Shen, D., Shertzer, H.G., Stringer, K.F., Wang, B., Schneider, S.N., Nebert, D.W., Dalton, T.P., Hepatocyte-specific Gclc deletion leads to rapid onset of steatosis with mitochondrial injury and liver failure. Hepatology 45 (2007), 1118–1128.
-
(2007)
Hepatology
, vol.45
, pp. 1118-1128
-
-
Chen, Y.1
Yang, Y.2
Miller, M.L.3
Shen, D.4
Shertzer, H.G.5
Stringer, K.F.6
Wang, B.7
Schneider, S.N.8
Nebert, D.W.9
Dalton, T.P.10
-
14
-
-
75149150660
-
HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer
-
David, C.J., Chen, M., Assanah, M., Canoll, P., Manley, J.L., HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer. Nature 463 (2010), 364–368.
-
(2010)
Nature
, vol.463
, pp. 364-368
-
-
David, C.J.1
Chen, M.2
Assanah, M.3
Canoll, P.4
Manley, J.L.5
-
15
-
-
0037033433
-
Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression
-
Devadas, S., Zaritskaya, L., Rhee, S.G., Oberley, L., Williams, M.S., Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J. Exp. Med. 195 (2002), 59–70.
-
(2002)
J. Exp. Med.
, vol.195
, pp. 59-70
-
-
Devadas, S.1
Zaritskaya, L.2
Rhee, S.G.3
Oberley, L.4
Williams, M.S.5
-
16
-
-
0035320527
-
Defining the specific physiological requirements for c-Myc in T cell development
-
Douglas, N.C., Jacobs, H., Bothwell, A.L., Hayday, A.C., Defining the specific physiological requirements for c-Myc in T cell development. Nat. Immunol. 2 (2001), 307–315.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 307-315
-
-
Douglas, N.C.1
Jacobs, H.2
Bothwell, A.L.3
Hayday, A.C.4
-
17
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Düvel, K., Yecies, J.L., Menon, S., Raman, P., Lipovsky, A.I., Souza, A.L., Triantafellow, E., Ma, Q., Gorski, R., Cleaver, S., et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol. Cell 39 (2010), 171–183.
-
(2010)
Mol. Cell
, vol.39
, pp. 171-183
-
-
Düvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
-
18
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
Frauwirth, K.A., Riley, J.L., Harris, M.H., Parry, R.V., Rathmell, J.C., Plas, D.R., Elstrom, R.L., June, C.H., Thompson, C.B., The CD28 signaling pathway regulates glucose metabolism. Immunity 16 (2002), 769–777.
-
(2002)
Immunity
, vol.16
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
Elstrom, R.L.7
June, C.H.8
Thompson, C.B.9
-
19
-
-
84859140799
-
Metabolic pathways in T cell fate and function
-
Gerriets, V.A., Rathmell, J.C., Metabolic pathways in T cell fate and function. Trends Immunol. 33 (2012), 168–173.
-
(2012)
Trends Immunol.
, vol.33
, pp. 168-173
-
-
Gerriets, V.A.1
Rathmell, J.C.2
-
20
-
-
84889575198
-
Modulation of oxidative stress as an anticancer strategy
-
Gorrini, C., Harris, I.S., Mak, T.W., Modulation of oxidative stress as an anticancer strategy. Nat. Rev. Drug Discov. 12 (2013), 931–947.
-
(2013)
Nat. Rev. Drug Discov.
, vol.12
, pp. 931-947
-
-
Gorrini, C.1
Harris, I.S.2
Mak, T.W.3
-
21
-
-
17844379481
-
HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death
-
Gülow, K., Kaminski, M., Darvas, K., Süss, D., Li-Weber, M., Krammer, P.H., HIV-1 trans-activator of transcription substitutes for oxidative signaling in activation-induced T cell death. J. Immunol. 174 (2005), 5249–5260.
-
(2005)
J. Immunol.
, vol.174
, pp. 5249-5260
-
-
Gülow, K.1
Kaminski, M.2
Darvas, K.3
Süss, D.4
Li-Weber, M.5
Krammer, P.H.6
-
22
-
-
25444524850
-
Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity
-
Hahn-Windgassen, A., Nogueira, V., Chen, C.C., Skeen, J.E., Sonenberg, N., Hay, N., Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity. J. Biol. Chem. 280 (2005), 32081–32089.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 32081-32089
-
-
Hahn-Windgassen, A.1
Nogueira, V.2
Chen, C.C.3
Skeen, J.E.4
Sonenberg, N.5
Hay, N.6
-
23
-
-
84858782079
-
AMPK: a nutrient and energy sensor that maintains energy homeostasis
-
Hardie, D.G., Ross, F.A., Hawley, S.A., AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat. Rev. Mol. Cell Biol. 13 (2012), 251–262.
-
(2012)
Nat. Rev. Mol. Cell Biol.
, vol.13
, pp. 251-262
-
-
Hardie, D.G.1
Ross, F.A.2
Hawley, S.A.3
-
24
-
-
84922783167
-
Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression
-
Harris, I.S., Treloar, A.E., Inoue, S., Sasaki, M., Gorrini, C., Lee, K.C., Yung, K.Y., Brenner, D., Knobbe-Thomsen, C.B., Cox, M.A., et al. Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. Cancer Cell 27 (2015), 211–222.
-
(2015)
Cancer Cell
, vol.27
, pp. 211-222
-
-
Harris, I.S.1
Treloar, A.E.2
Inoue, S.3
Sasaki, M.4
Gorrini, C.5
Lee, K.C.6
Yung, K.Y.7
Brenner, D.8
Knobbe-Thomsen, C.B.9
Cox, M.A.10
-
25
-
-
0027770941
-
Exogenous glutamine requirement is confined to late events of T cell activation
-
Hörig, H., Spagnoli, G.C., Filgueira, L., Babst, R., Gallati, H., Harder, F., Juretic, A., Heberer, M., Exogenous glutamine requirement is confined to late events of T cell activation. J. Cell. Biochem. 53 (1993), 343–351.
-
(1993)
J. Cell. Biochem.
, vol.53
, pp. 343-351
-
-
Hörig, H.1
Spagnoli, G.C.2
Filgueira, L.3
Babst, R.4
Gallati, H.5
Harder, F.6
Juretic, A.7
Heberer, M.8
-
26
-
-
0031755688
-
Studies on the mechanism of resistance to rapamycin in human cancer cells
-
Hosoi, H., Dilling, M.B., Liu, L.N., Danks, M.K., Shikata, T., Sekulic, A., Abraham, R.T., Lawrence, J.C. Jr., Houghton, P.J., Studies on the mechanism of resistance to rapamycin in human cancer cells. Mol. Pharmacol. 54 (1998), 815–824.
-
(1998)
Mol. Pharmacol.
, vol.54
, pp. 815-824
-
-
Hosoi, H.1
Dilling, M.B.2
Liu, L.N.3
Danks, M.K.4
Shikata, T.5
Sekulic, A.6
Abraham, R.T.7
Lawrence, J.C.8
Houghton, P.J.9
-
27
-
-
70350091586
-
Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions
-
Hwang, N.R., Yim, S.H., Kim, Y.M., Jeong, J., Song, E.J., Lee, Y., Lee, J.H., Choi, S., Lee, K.J., Oxidative modifications of glyceraldehyde-3-phosphate dehydrogenase play a key role in its multiple cellular functions. Biochem. J. 423 (2009), 253–264.
-
(2009)
Biochem. J.
, vol.423
, pp. 253-264
-
-
Hwang, N.R.1
Yim, S.H.2
Kim, Y.M.3
Jeong, J.4
Song, E.J.5
Lee, Y.6
Lee, J.H.7
Choi, S.8
Lee, K.J.9
-
28
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki, K., Li, Y., Zhu, T., Wu, J., Guan, K.L., TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4 (2002), 648–657.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
29
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126 (2006), 955–968.
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
-
30
-
-
4444221709
-
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
-
Jackson, S.H., Devadas, S., Kwon, J., Pinto, L.A., Williams, M.S., T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat. Immunol. 5 (2004), 818–827.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 818-827
-
-
Jackson, S.H.1
Devadas, S.2
Kwon, J.3
Pinto, L.A.4
Williams, M.S.5
-
31
-
-
14844327760
-
Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
-
Kamata, H., Honda, S., Maeda, S., Chang, L., Hirata, H., Karin, M., Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120 (2005), 649–661.
-
(2005)
Cell
, vol.120
, pp. 649-661
-
-
Kamata, H.1
Honda, S.2
Maeda, S.3
Chang, L.4
Hirata, H.5
Karin, M.6
-
32
-
-
77249176619
-
NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells
-
1189–99.e1, 2
-
Köenig, A., Linhart, T., Schlengemann, K., Reutlinger, K., Wegele, J., Adler, G., Singh, G., Hofmann, L., Kunsch, S., Büch, T., et al. NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells. Gastroenterology, 138, 2010 1189–99.e1, 2.
-
(2010)
Gastroenterology
, vol.138
-
-
Köenig, A.1
Linhart, T.2
Schlengemann, K.3
Reutlinger, K.4
Wegele, J.5
Adler, G.6
Singh, G.7
Hofmann, L.8
Kunsch, S.9
Büch, T.10
-
33
-
-
13244283212
-
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
-
Langrish, C.L., Chen, Y., Blumenschein, W.M., Mattson, J., Basham, B., Sedgwick, J.D., McClanahan, T., Kastelein, R.A., Cua, D.J., IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201 (2005), 233–240.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 233-240
-
-
Langrish, C.L.1
Chen, Y.2
Blumenschein, W.M.3
Mattson, J.4
Basham, B.5
Sedgwick, J.D.6
McClanahan, T.7
Kastelein, R.A.8
Cua, D.J.9
-
34
-
-
84859778293
-
mTOR signaling in growth control and disease
-
Laplante, M., Sabatini, D.M., mTOR signaling in growth control and disease. Cell 149 (2012), 274–293.
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
35
-
-
84928238774
-
T cell lipid peroxidation induces ferroptosis and prevents immunity to infection
-
Matsushita, M., Freigang, S., Schneider, C., Conrad, M., Bornkamm, G.W., Kopf, M., T cell lipid peroxidation induces ferroptosis and prevents immunity to infection. J. Exp. Med. 212 (2015), 555–568.
-
(2015)
J. Exp. Med.
, vol.212
, pp. 555-568
-
-
Matsushita, M.1
Freigang, S.2
Schneider, C.3
Conrad, M.4
Bornkamm, G.W.5
Kopf, M.6
-
36
-
-
33750909999
-
Reactive oxygen species-induced activation of the MAP kinase signaling pathways
-
McCubrey, J.A., Lahair, M.M., Franklin, R.A., Reactive oxygen species-induced activation of the MAP kinase signaling pathways. Antioxid. Redox Signal. 8 (2006), 1775–1789.
-
(2006)
Antioxid. Redox Signal.
, vol.8
, pp. 1775-1789
-
-
McCubrey, J.A.1
Lahair, M.M.2
Franklin, R.A.3
-
37
-
-
0020537304
-
Selective modification of glutathione metabolism
-
Meister, A., Selective modification of glutathione metabolism. Science 220 (1983), 472–477.
-
(1983)
Science
, vol.220
, pp. 472-477
-
-
Meister, A.1
-
38
-
-
84900440370
-
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
-
Nakaya, M., Xiao, Y., Zhou, X., Chang, J.H., Chang, M., Cheng, X., Blonska, M., Lin, X., Sun, S.C., Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity 40 (2014), 692–705.
-
(2014)
Immunity
, vol.40
, pp. 692-705
-
-
Nakaya, M.1
Xiao, Y.2
Zhou, X.3
Chang, J.H.4
Chang, M.5
Cheng, X.6
Blonska, M.7
Lin, X.8
Sun, S.C.9
-
39
-
-
0037155226
-
Redox control of calcineurin by targeting the binuclear Fe(2+)-Zn(2+) center at the enzyme active site
-
Namgaladze, D., Hofer, H.W., Ullrich, V., Redox control of calcineurin by targeting the binuclear Fe(2+)-Zn(2+) center at the enzyme active site. J. Biol. Chem. 277 (2002), 5962–5969.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 5962-5969
-
-
Namgaladze, D.1
Hofer, H.W.2
Ullrich, V.3
-
40
-
-
0022196860
-
Glutamine metabolism in lymphocytes: Its biochemical, physiological and clinical importance
-
Newsholme, E.A., Crabtree, B., Ardawi, M.S., Glutamine metabolism in lymphocytes: Its biochemical, physiological and clinical importance. Q. J. Exp. Physiol. 70 (1985), 473–489.
-
(1985)
Q. J. Exp. Physiol.
, vol.70
, pp. 473-489
-
-
Newsholme, E.A.1
Crabtree, B.2
Ardawi, M.S.3
-
41
-
-
59049087460
-
Bidirectional transport of amino acids regulates mTOR and autophagy
-
Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136 (2009), 521–534.
-
(2009)
Cell
, vol.136
, pp. 521-534
-
-
Nicklin, P.1
Bergman, P.2
Zhang, B.3
Triantafellow, E.4
Wang, H.5
Nyfeler, B.6
Yang, H.7
Hild, M.8
Kung, C.9
Wilson, C.10
-
42
-
-
84876758617
-
Metabolic pathways in immune cell activation and quiescence
-
Pearce, E.L., Pearce, E.J., Metabolic pathways in immune cell activation and quiescence. Immunity 38 (2013), 633–643.
-
(2013)
Immunity
, vol.38
, pp. 633-643
-
-
Pearce, E.L.1
Pearce, E.J.2
-
43
-
-
84903277871
-
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
-
Pollizzi, K.N., Powell, J.D., Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat. Rev. Immunol. 14 (2014), 435–446.
-
(2014)
Nat. Rev. Immunol.
, vol.14
, pp. 435-446
-
-
Pollizzi, K.N.1
Powell, J.D.2
-
44
-
-
0033779701
-
Calcineurin: form and function
-
Rusnak, F., Mertz, P., Calcineurin: form and function. Physiol. Rev. 80 (2000), 1483–1521.
-
(2000)
Physiol. Rev.
, vol.80
, pp. 1483-1521
-
-
Rusnak, F.1
Mertz, P.2
-
45
-
-
65949122722
-
Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway
-
Schmidt, E.V., Ravitz, M.J., Chen, L., Lynch, M., Growth controls connect: interactions between c-myc and the tuberous sclerosis complex-mTOR pathway. Cell Cycle 8 (2009), 1344–1351.
-
(2009)
Cell Cycle
, vol.8
, pp. 1344-1351
-
-
Schmidt, E.V.1
Ravitz, M.J.2
Chen, L.3
Lynch, M.4
-
46
-
-
84868007565
-
Physiological roles of mitochondrial reactive oxygen species
-
Sena, L.A., Chandel, N.S., Physiological roles of mitochondrial reactive oxygen species. Mol. Cell 48 (2012), 158–167.
-
(2012)
Mol. Cell
, vol.48
, pp. 158-167
-
-
Sena, L.A.1
Chandel, N.S.2
-
47
-
-
84874242919
-
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
-
Sena, L.A., Li, S., Jairaman, A., Prakriya, M., Ezponda, T., Hildeman, D.A., Wang, C.R., Schumacker, P.T., Licht, J.D., Perlman, H., et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 38 (2013), 225–236.
-
(2013)
Immunity
, vol.38
, pp. 225-236
-
-
Sena, L.A.1
Li, S.2
Jairaman, A.3
Prakriya, M.4
Ezponda, T.5
Hildeman, D.A.6
Wang, C.R.7
Schumacker, P.T.8
Licht, J.D.9
Perlman, H.10
-
48
-
-
84876514626
-
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
-
Sinclair, L.V., Rolf, J., Emslie, E., Shi, Y.B., Taylor, P.M., Cantrell, D.A., Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat. Immunol. 14 (2013), 500–508.
-
(2013)
Nat. Immunol.
, vol.14
, pp. 500-508
-
-
Sinclair, L.V.1
Rolf, J.2
Emslie, E.3
Shi, Y.B.4
Taylor, P.M.5
Cantrell, D.A.6
-
49
-
-
77956258205
-
Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation
-
Singh, G., Singh, S.K., König, A., Reutlinger, K., Nye, M.D., Adhikary, T., Eilers, M., Gress, T.M., Fernandez-Zapico, M.E., Ellenrieder, V., Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-beta switch from a suppressor to a promoter of cancer cell proliferation. J. Biol. Chem. 285 (2010), 27241–27250.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 27241-27250
-
-
Singh, G.1
Singh, S.K.2
König, A.3
Reutlinger, K.4
Nye, M.D.5
Adhikary, T.6
Eilers, M.7
Gress, T.M.8
Fernandez-Zapico, M.E.9
Ellenrieder, V.10
-
50
-
-
84964527036
-
Metabolic maintenance of cell asymmetry following division in activated T lymphocytes
-
Verbist, K.C., Guy, C.S., Milasta, S., Liedmann, S., Kamiński, M.M., Wang, R., Green, D.R., Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature 532 (2016), 389–393.
-
(2016)
Nature
, vol.532
, pp. 389-393
-
-
Verbist, K.C.1
Guy, C.S.2
Milasta, S.3
Liedmann, S.4
Kamiński, M.M.5
Wang, R.6
Green, D.R.7
-
51
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang, R., Dillon, C.P., Shi, L.Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L.L., Fitzgerald, P., Chi, H., Munger, J., Green, D.R., The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 35 (2011), 871–882.
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
Dillon, C.P.2
Shi, L.Z.3
Milasta, S.4
Carter, R.5
Finkelstein, D.6
McCormick, L.L.7
Fitzgerald, P.8
Chi, H.9
Munger, J.10
Green, D.R.11
-
52
-
-
0032514376
-
Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway
-
West, M.J., Stoneley, M., Willis, A.E., Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway. Oncogene 17 (1998), 769–780.
-
(1998)
Oncogene
, vol.17
, pp. 769-780
-
-
West, M.J.1
Stoneley, M.2
Willis, A.E.3
-
53
-
-
5844299536
-
Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development
-
Wolfer, A., Bakker, T., Wilson, A., Nicolas, M., Ioannidis, V., Littman, D.R., Lee, P.P., Wilson, C.B., Held, W., MacDonald, H.R., Radtke, F., Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development. Nat. Immunol. 2 (2001), 235–241.
-
(2001)
Nat. Immunol.
, vol.2
, pp. 235-241
-
-
Wolfer, A.1
Bakker, T.2
Wilson, A.3
Nicolas, M.4
Ioannidis, V.5
Littman, D.R.6
Lee, P.P.7
Wilson, C.B.8
Held, W.9
MacDonald, H.R.10
Radtke, F.11
-
54
-
-
0030745596
-
Glutamine requirement of proliferating T lymphocytes
-
Yaqoob, P., Calder, P.C., Glutamine requirement of proliferating T lymphocytes. Nutrition 13 (1997), 646–651.
-
(1997)
Nutrition
, vol.13
, pp. 646-651
-
-
Yaqoob, P.1
Calder, P.C.2
-
55
-
-
33745812415
-
Electron transport complex I is required for CD8+ T cell function
-
Yi, J.S., Holbrook, B.C., Michalek, R.D., Laniewski, N.G., Grayson, J.M., Electron transport complex I is required for CD8+ T cell function. J. Immunol. 177 (2006), 852–862.
-
(2006)
J. Immunol.
, vol.177
, pp. 852-862
-
-
Yi, J.S.1
Holbrook, B.C.2
Michalek, R.D.3
Laniewski, N.G.4
Grayson, J.M.5
|