Mammalian Target of Rapamycin Complex 1 (mTORC1) enhances bortezomib-induced death in Tuberous Sclerosis Complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response

Journal of Biological Chemistry

Volumn 288, Issue 22, 2013, Pages 15687-15698

  Babcock, Justin T ^a   Nguyen, Hoa B ^a   He, Yujun ^a   Hendricks, Jeremiah W ^a   Wek, Ronald C ^a   Quilliam, Lawrence A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; ENDOPLASMIC RETICULUM STRESS; MAMMALIAN TARGET; PROTEASOME INHIBITORS; RAPAMYCIN TREATMENT; SIGNALING PATHWAYS; TUBEROUS SCLEROSIS; UNFOLDED PROTEIN RESPONSE;

ANTIBIOTICS; CELL MEMBRANES; PATIENT TREATMENT; RAT CONTROL; TRANSCRIPTION FACTORS; TUBES (COMPONENTS);

CELL DEATH;

ACTIVATING TRANSCRIPTION FACTOR 4; BORTEZOMIB; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MYC PROTEIN; RAPAMYCIN; TUBERIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RAT; REGULATORY MECHANISM; UNFOLDED PROTEIN RESPONSE;

APOPTOSIS; ATF4; BORTEZOMIB; MTOR; MYC; RAPAMYCIN; TUBEROUS SCLEROSIS (TSC); UNFOLDED PROTEIN RESPONSE;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BORONIC ACIDS; CELL LINE, TUMOR; GENE EXPRESSION REGULATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; PROTEIN BIOSYNTHESIS; PROTEINS; PROTO-ONCOGENE PROTEINS C-MYC; PYRAZINES; RATS; SIGNAL TRANSDUCTION; SIROLIMUS; TRANSCRIPTION FACTOR CHOP; TUMOR SUPPRESSOR PROTEINS; UNFOLDED PROTEIN RESPONSE;

EUKARYOTA; MAMMALIA; RATTUS;

EID: 84878423346     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.431056     Document Type: Article

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