Sequential activation of NFAT and c-Myc transcription factors mediates the TGF-β switch from a suppressor to a promoter of cancer cell proliferation

Journal of Biological Chemistry

Volumn 285, Issue 35, 2010, Pages 27241-27250

  Singh, Garima ^a   Singh, Shiv K ^a   König, Alexander ^a   Reutlinger, Kristina ^a   Nye, Monica D ^c   Adhikary, Tillman ^a   Eilers, Martin ^b   Gress, Thomas M ^a   Fernandez Zapico, Martin E ^c   Ellenrieder, Volker ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; CANCER CELLS; CELL CYCLE; CELL-CYCLE ARREST; CELL-CYCLE PROGRESSION; CYCLINS; DUAL ROLE; GROWTH INHIBITOR; GROWTH PROMOTERS; GROWTH SUPPRESSIONS; MOLECULAR MECHANISM; REGULATORY PATHWAY; SEQUENTIAL ACTIVATION; TRANSCRIPTIONAL ACTIVATIONS; TRANSFORMING GROWTH FACTORS; UP-REGULATION;

ENZYME INHIBITION; GROWTH KINETICS; LAWS AND LEGISLATION; TRANSCRIPTION; TRANSCRIPTION FACTORS;

CELL PROLIFERATION;

CALCINEURIN; CYCLIN D; MYC PROTEIN; SMAD PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL GROWTH; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; GENE ACTIVATION; GENE INDUCTION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TUMOR GROWTH; UPREGULATION;

ANIMALS; CALCINEURIN; CELL CYCLE; CELL LINE, TUMOR; HUMANS; MICE; NEOPLASMS; NFATC TRANSCRIPTION FACTORS; PROTO-ONCOGENE PROTEINS C-MYC; SMAD PROTEINS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; TRANSFORMING GROWTH FACTOR BETA;

EID: 77956258205     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.100438     Document Type: Article

References (42)

1. Massagué, J. (2008) Cell 134, 215-230
2. Chen, C. R., Kang, Y., Siegel, P. M., and Massagué, J. (2002) Cell 110, 19-32
3. Hannon, G. J., and Beach, D. (1994) Nature 371, 257-261
4. Staller, P., Peukert, K., Kiermaier, A., Seoane, J., Lukas, J., Karsunky, H., Möröy, T., Bartek, J., Massagué, J., Hänel, F., and Eilers, M. (2001) Nat. Cell Biol. 3, 392-399
5. Seoane, J., Pouponnot, C., Staller, P., Schader, M., Eilers, M., and Massagué, J. (2001) Nat. Cell Biol. 3, 400-408
6. Orian, A., and Eisenman, R. N. (2001) Sci STKE 26, 88
7. Massagué, J., Blain, S. W., and Lo, R. S. (2000) Cell 103, 295-309
8. Gordon, K. J., and Blobe, G. C. (2008) Biochim. Biophys. Acta 1782, 197-228
9. Heldin, C. H., Landström, M., and Moustakas, A. (2009) Curr. Opin. Cell Biol. 21, 166-176
10. Shi, Y., and Massagué, J. (2003) Cell 113, 685-700
11. Levy, L., and Hill, C. S. (2005) Mol. Cell. Biol. 25, 8108-8125
12. Seoane, J. (2006) Carcinogenesis 27, 2148-2156
13. Kretzschmar, M., Doody, J., Timokhina, I., and Massagué, J. (1999) Genes Dev. 13, 804-816
14. Calonge, M. J., and Massagué, J. (1999) J. Biol. Chem. 274, 33637-33643
15. Roberts, A. B., and Wakefield, L. M. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 8621-8623
16. Moore, P. S., Sipos, B., Orlandini, S., Sorio, C., Real, F. X., Lemoine, N. R., Gress, T., Bassi, C., Klöppel, G., Kalthoff, H., Ungefroren, H., Löhr, M., and Scarpa, A. (2001) Virchows Arch. 439, 798-802
17. Buchholz, M., Schatz, A., Wagner, M., Michl, P., Linhart, T., Adler, G., Gress, T. M., and Ellenrieder, V. (2006) EMBO J. 25, 3714-3724
18. Pardali, K., Kurisaki, A., Morén, A., ten Dijke, P., Kardassis, D., and Moustakas, A. (2000) J. Biol. Chem. 275, 29244-29256
19. Frederick, J. P., Liberati, N. T., Waddell, D. S., Shi, Y., and Wang, X. F. (2004) Mol. Cell. Biol. 24, 2546-2559
20. Chen, C. R., Kang, Y., and Massagué, J. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 992-999
21. Im, S. H., and Rao, A. (2004) Mol. Cells 18, 1-9
22. Macian, F. (2005) Nat. Rev. Immunol. 5, 472-484
23. Yoeli-Lerner, M., Chin, Y. R., Hansen, C. K., and Toker, A. (2009) Mol. Cancer Res. 7, 425-432
24. Medyouf, H., and Ghysdael, J. (2008) Cell Cycle 7, 297-303
25. Robbs, B. K., Cruz, A. L., Werneck, M. B., Mognol, G. P., and Viola, J. P. (2008) Mol. Cell. Biol. 28, 7168-7181
26. Ten Dijke, P., Goumans, M. J., Itoh, F., and Itoh, S. (2002) J. Cell. Physiol. 191, 1-16
27. Bierie, B., and Moses, H. L. (2006) Nat. Rev. Cancer 6, 506-520
28. Hahn, S. A., Schutte, M., Hoque, A. T., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., and Kern, S. E. (1996) Science 271, 350-353
29. Woodford-Richens, K. L., Rowan, A. J., Gorman, P., Halford, S., Bicknell, D. C., Wasan, H. S., Roylance, R. R., Bodmer, W. F., and Tomlinson, I. P. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 9719-9723
30. Elliott, R. L., and Blobe, G. C. (2005) J. Clin. Oncol. 23, 2078-2093
31. de Caestecker, M. P., Piek, E., and Roberts, A. B. (2000) J. Natl. Cancer Inst. 92, 1388-1402
32. Engel, M. E., McDonnell, M. A., Law, B. K., and Moses, H. L. (1999) J. Biol. Chem. 274, 37413-37420
33. Javelaud, D., and Mauviel, A. (2005) Oncogene 24, 5742-5750
34. Derynck, R., and Zhang, Y. E. (2003) Nature 425, 577-584
35. Ellenrieder, V. (2008) Anticancer Res. 28, 1531-1539
36. Jonson, T., Albrechtsson, E., Axelson, J., Heidenblad, M., Gorunova, L., Johansson, B., and Höglund, M. (2001) Int. J. Oncol. 19, 71-81
37. Yan, Z., Kim, G. Y., Deng, X., and Friedman, E. (2002) J. Biol. Chem. 277, 9870-9879
38. Deleted in proof
39. Serfling, E., Berberich-Siebelt, F., and Avots, A. (2007) Sci STKE 398, 42
40. Rao, A., Luo, C., and Hogan, P. G. (1997) Annu. Rev. Immunol. 15, 707-747
41. Buchholz, M., and Ellenrieder, V. (2007) Cell Cycle 6, 16-19
42. Jauliac, S., López-Rodriguez, C., Shaw, L. M., Brown, L. F., Rao, A., and Toker, A. (2002) Nat. Cell Biol. 4, 540-544