메뉴 건너뛰기




Volumn 92, Issue 6, 2017, Pages 569-582

The role of carbon monoxide and heme oxygenase in the prevention of sickle cell disease vaso-occlusive crises

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; GASOTRANSMITTER; HEME; HEME OXYGENASE; HEMOGLOBIN;

EID: 85018949420     PISSN: 03618609     EISSN: 10968652     Source Type: Journal    
DOI: 10.1002/ajh.24750     Document Type: Review
Times cited : (34)

References (169)
  • 1
    • 78851468762 scopus 로고    scopus 로고
    • Reconstructing sickle cell disease: a data-based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence-based medicine
    • Hebbel RP. Reconstructing sickle cell disease: a data-based analysis of the “hyperhemolysis paradigm” for pulmonary hypertension from the perspective of evidence-based medicine. Am J Hematol. 2011;86:123–154.
    • (2011) Am J Hematol. , vol.86 , pp. 123-154
    • Hebbel, R.P.1
  • 2
    • 84876935063 scopus 로고    scopus 로고
    • Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine beta145
    • Cooper CE, Schaer DJ, Buehler PW, et al. Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine beta145. Antioxid Redox Signal. 2013;18:2264–2273.
    • (2013) Antioxid Redox Signal. , vol.18 , pp. 2264-2273
    • Cooper, C.E.1    Schaer, D.J.2    Buehler, P.W.3
  • 3
    • 4544246612 scopus 로고    scopus 로고
    • CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response
    • Moestrup SK, Moller HJ. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Annal Med. 2004;36:347–354.
    • (2004) Annal Med. , vol.36 , pp. 347-354
    • Moestrup, S.K.1    Moller, H.J.2
  • 5
    • 0014360531 scopus 로고
    • Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases
    • Muller-Eberhard U, Javid J, Liem HH, Hanstein A, Hanna M. Plasma concentrations of hemopexin, haptoglobin and heme in patients with various hemolytic diseases. Blood. 1968;32:811–815.
    • (1968) Blood. , vol.32 , pp. 811-815
    • Muller-Eberhard, U.1    Javid, J.2    Liem, H.H.3    Hanstein, A.4    Hanna, M.5
  • 6
    • 0036908599 scopus 로고    scopus 로고
    • Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease
    • Reiter CD, Wang X, Tanus-Santos JE, et al. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med. 2002;8:1383–1389.
    • (2002) Nat Med. , vol.8 , pp. 1383-1389
    • Reiter, C.D.1    Wang, X.2    Tanus-Santos, J.E.3
  • 7
    • 59249083671 scopus 로고    scopus 로고
    • Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders
    • Morris CR, Gladwin MT, Kato GJ. Nitric oxide and arginine dysregulation: a novel pathway to pulmonary hypertension in hemolytic disorders. Curr Mol Med. 2008;8:620–632.
    • (2008) Curr Mol Med. , vol.8 , pp. 620-632
    • Morris, C.R.1    Gladwin, M.T.2    Kato, G.J.3
  • 8
    • 84894567032 scopus 로고    scopus 로고
    • Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease
    • Belcher JD, Chen C, Nguyen J, et al. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood. 2014;123:377–390.
    • (2014) Blood. , vol.123 , pp. 377-390
    • Belcher, J.D.1    Chen, C.2    Nguyen, J.3
  • 9
    • 0014408353 scopus 로고
    • Exchange of heme among hemoglobins and between hemoglobin and albumin
    • Bunn HF, Jandl JH. Exchange of heme among hemoglobins and between hemoglobin and albumin. J Biol Chem. 1968;243:465–475.
    • (1968) J Biol Chem. , vol.243 , pp. 465-475
    • Bunn, H.F.1    Jandl, J.H.2
  • 10
    • 33846476692 scopus 로고    scopus 로고
    • Methemoglobin–it's not just blue: a concise review
    • Umbreit J. Methemoglobin–it's not just blue: a concise review. Am J Hematol. 2007;82:134–144.
    • (2007) Am J Hematol. , vol.82 , pp. 134-144
    • Umbreit, J.1
  • 11
    • 0015980699 scopus 로고
    • Transfer of heme from ferrihemoglobin and ferrihemoglobin isolated chains to hemopexin
    • Hrkal Z, Vodrazka Z, Kalousek I. Transfer of heme from ferrihemoglobin and ferrihemoglobin isolated chains to hemopexin. Eur J Biochem. 1974;43:73–78.
    • (1974) Eur J Biochem. , vol.43 , pp. 73-78
    • Hrkal, Z.1    Vodrazka, Z.2    Kalousek, I.3
  • 13
    • 0018634705 scopus 로고
    • Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein
    • Smith A, Morgan WT. Haem transport to the liver by haemopexin. Receptor-mediated uptake with recycling of the protein. Biochem J. 1979;182:47–54.
    • (1979) Biochem J. , vol.182 , pp. 47-54
    • Smith, A.1    Morgan, W.T.2
  • 14
    • 0027358877 scopus 로고
    • Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage
    • Balla J, Jacob HS, Balla G, Nath K, Eaton JW, Vercellotti GM. Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage. Proc Natl Acad Sci U S A. 1993;90:9285–9289.
    • (1993) Proc Natl Acad Sci U S A. , vol.90 , pp. 9285-9289
    • Balla, J.1    Jacob, H.S.2    Balla, G.3    Nath, K.4    Eaton, J.W.5    Vercellotti, G.M.6
  • 15
    • 0033153333 scopus 로고    scopus 로고
    • Low-density lipoprotein susceptibility to oxidation and cytotoxicity to endothelium in sickle cell anemia
    • Belcher JD, Marker PH, Geiger P, et al. Low-density lipoprotein susceptibility to oxidation and cytotoxicity to endothelium in sickle cell anemia. J Lab Clin Med. 1999;133:605–612.
    • (1999) J Lab Clin Med. , vol.133 , pp. 605-612
    • Belcher, J.D.1    Marker, P.H.2    Geiger, P.3
  • 16
    • 84931271446 scopus 로고    scopus 로고
    • Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease
    • Camus SM, De Moraes JA, Bonnin P, et al. Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease. Blood. 2015;125:3805–3814.
    • (2015) Blood. , vol.125 , pp. 3805-3814
    • Camus, S.M.1    De Moraes, J.A.2    Bonnin, P.3
  • 17
    • 79960843530 scopus 로고    scopus 로고
    • Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction
    • Hanson MS, Piknova B, Keszler A, et al. Methaemalbumin formation in sickle cell disease: effect on oxidative protein modification and HO-1 induction. Br J Haematol. 2011;154:502–511.
    • (2011) Br J Haematol. , vol.154 , pp. 502-511
    • Hanson, M.S.1    Piknova, B.2    Keszler, A.3
  • 18
    • 0026318447 scopus 로고
    • Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury
    • Balla G, Jacob HS, Eaton JW, Belcher JD, Vercellotti GM. Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury. Arterioscler Thromb. 1991;11:1700–1711.
    • (1991) Arterioscler Thromb. , vol.11 , pp. 1700-1711
    • Balla, G.1    Jacob, H.S.2    Eaton, J.W.3    Belcher, J.D.4    Vercellotti, G.M.5
  • 19
    • 84907546730 scopus 로고    scopus 로고
    • Hemolysis-induced lethality involves inflammasome activation by heme
    • Dutra FF, Alves LS, Rodrigues D, et al. Hemolysis-induced lethality involves inflammasome activation by heme. Proc Natl Acad Sci USA. 2014;111:E4110–E4118.
    • (2014) Proc Natl Acad Sci USA. , vol.111 , pp. E4110-E4118
    • Dutra, F.F.1    Alves, L.S.2    Rodrigues, D.3
  • 20
    • 34547120742 scopus 로고    scopus 로고
    • Characterization of heme as activator of Toll-like receptor 4
    • Figueiredo RT, Fernandez PL, Mourao-Sa DS, et al. Characterization of heme as activator of Toll-like receptor 4. J Biol Chem. 2007;282:20221–20229.
    • (2007) J Biol Chem. , vol.282 , pp. 20221-20229
    • Figueiredo, R.T.1    Fernandez, P.L.2    Mourao-Sa, D.S.3
  • 21
    • 0036682472 scopus 로고    scopus 로고
    • Pro-oxidant and cytotoxic effects of circulating heme
    • Jeney V, Balla J, Yachie A, et al. Pro-oxidant and cytotoxic effects of circulating heme. Blood. 2002;100:879–887.
    • (2002) Blood. , vol.100 , pp. 879-887
    • Jeney, V.1    Balla, J.2    Yachie, A.3
  • 22
    • 34548226931 scopus 로고    scopus 로고
    • Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors
    • Porto BN, Alves LS, Fernandez PL, et al. Heme induces neutrophil migration and reactive oxygen species generation through signaling pathways characteristic of chemotactic receptors. J Biol Chem. 2007;282:24430–24436.
    • (2007) J Biol Chem. , vol.282 , pp. 24430-24436
    • Porto, B.N.1    Alves, L.S.2    Fernandez, P.L.3
  • 23
    • 85026580481 scopus 로고    scopus 로고
    • Nonhaemopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice
    • 2016 Apr 7
    • Ghosh S, Ihunnah CA, Hazra R, et al. Nonhaemopoietic Nrf2 dominantly impedes adult progression of sickle cell anemia in mice. JCI Insight. 2016;1: pii:epub 2016 Apr 7.
    • (2016) JCI Insight. , vol.1
    • Ghosh, S.1    Ihunnah, C.A.2    Hazra, R.3
  • 24
    • 64149108317 scopus 로고    scopus 로고
    • Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury
    • Hidalgo A, Chang J, Jang JE, Peired AJ, Chiang EY, Frenette PS. Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury. Nat Med. 2009;15:384–391.
    • (2009) Nat Med. , vol.15 , pp. 384-391
    • Hidalgo, A.1    Chang, J.2    Jang, J.E.3    Peired, A.J.4    Chiang, E.Y.5    Frenette, P.S.6
  • 25
    • 84897499880 scopus 로고    scopus 로고
    • Neutrophil AKT2 regulates heterotypic neutrophil-platelet interactions during vascular inflammation
    • Li J, Kim K, Hahm E, et al. Neutrophil AKT2 regulates heterotypic neutrophil-platelet interactions during vascular inflammation. J Clin Invest. 2014;124:1483–1496.
    • (2014) J Clin Invest. , vol.124 , pp. 1483-1496
    • Li, J.1    Kim, K.2    Hahm, E.3
  • 26
    • 84891121208 scopus 로고    scopus 로고
    • Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies
    • Manwani D, Frenette PS. Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Blood. 2013;122:3892–3898.
    • (2013) Blood. , vol.122 , pp. 3892-3898
    • Manwani, D.1    Frenette, P.S.2
  • 28
    • 84942524791 scopus 로고    scopus 로고
    • Neutrophil ageing is regulated by the microbiome
    • Zhang D, Chen G, Manwani D, et al. Neutrophil ageing is regulated by the microbiome. Nature. 2015;525:528–532.
    • (2015) Nature. , vol.525 , pp. 528-532
    • Zhang, D.1    Chen, G.2    Manwani, D.3
  • 30
    • 3242792093 scopus 로고    scopus 로고
    • The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy
    • Hebbel RP, Osarogiagbon R, Kaul D. The endothelial biology of sickle cell disease: inflammation and a chronic vasculopathy. Microcirculation. 2004;11:129–151.
    • (2004) Microcirculation. , vol.11 , pp. 129-151
    • Hebbel, R.P.1    Osarogiagbon, R.2    Kaul, D.3
  • 33
    • 84987827733 scopus 로고    scopus 로고
    • Survival in adults with sickle cell disease in a high-income setting
    • Gardner K, Douiri A, Drasar E, et al. Survival in adults with sickle cell disease in a high-income setting. Blood. 2016; 28(10):1436–1438.
    • (2016) Blood. , vol.28 , Issue.10 , pp. 1436-1438
    • Gardner, K.1    Douiri, A.2    Drasar, E.3
  • 34
    • 0021250668 scopus 로고
    • Influence of sickle hemoglobinopathies on growth and development
    • Platt OS, Rosenstock W, Espeland MA. Influence of sickle hemoglobinopathies on growth and development. N Engl J Med. 1984;311:7–12.
    • (1984) N Engl J Med. , vol.311 , pp. 7-12
    • Platt, O.S.1    Rosenstock, W.2    Espeland, M.A.3
  • 35
    • 85019314050 scopus 로고    scopus 로고
    • A moving target
    • Pleasants S. A moving target. Nature. 2014;515:S2
    • (2014) Nature. , vol.515 , pp. S2
    • Pleasants, S.1
  • 36
    • 85019308426 scopus 로고    scopus 로고
    • Bethesda, MD US Department of Health and Human Services, National Institutes of Health, National Heart, LungBlood Institute;, Available from
    • National Heart, Lung, and Blood Institute. Disease and conditions index. Sickle cell anemia: who is at risk? Bethesda, MD: US Department of Health and Human Services, National Institutes of Health, National Heart, Lung, and Blood Institute; 2016. Available from: https://www.nhlbi.nih.gov/health/health-topics/topics/sca/atrisk.
    • (2016) Disease and conditions index. Sickle cell anemia who is at risk?
  • 38
    • 84881220584 scopus 로고    scopus 로고
    • Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions
    • Piel FB, Hay SI, Gupta S, Weatherall DJ, Williams TN. Global burden of sickle cell anaemia in children under five, 2010-2050: modelling based on demographics, excess mortality, and interventions. PLoS Med. 2013;10(7):e1001484
    • (2013) PLoS Med. , vol.10 , Issue.7
    • Piel, F.B.1    Hay, S.I.2    Gupta, S.3    Weatherall, D.J.4    Williams, T.N.5
  • 39
    • 84959333693 scopus 로고    scopus 로고
    • Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease
    • Telen MJ. Beyond hydroxyurea: new and old drugs in the pipeline for sickle cell disease. Blood. 2016;127:810–819.
    • (2016) Blood. , vol.127 , pp. 810-819
    • Telen, M.J.1
  • 40
    • 77956323967 scopus 로고    scopus 로고
    • The therapeutic potential of carbon monoxide
    • Motterlini R, Otterbein LE. The therapeutic potential of carbon monoxide. Nat Rev Drug Discov. 2010;9(9):728–743.
    • (2010) Nat Rev Drug Discov. , vol.9 , Issue.9 , pp. 728-743
    • Motterlini, R.1    Otterbein, L.E.2
  • 41
    • 43349092136 scopus 로고    scopus 로고
    • Use of carbon monoxide as a therapeutic agent: promises and challenges
    • Foresti R, Bani-Hani MG, Motterlini R. Use of carbon monoxide as a therapeutic agent: promises and challenges. Intensive Care Med. 2008;34:649–658.
    • (2008) Intensive Care Med. , vol.34 , pp. 649-658
    • Foresti, R.1    Bani-Hani, M.G.2    Motterlini, R.3
  • 42
    • 0025523352 scopus 로고
    • Heme uptake by endothelium synergizes polymorphonuclear granulocyte-mediated damage
    • Balla G, Vercellotti G, Eaton JW, Jacob HS. Heme uptake by endothelium synergizes polymorphonuclear granulocyte-mediated damage. Trans Assoc Am Physicians. 1990;103:174–179.
    • (1990) Trans Assoc Am Physicians. , vol.103 , pp. 174-179
    • Balla, G.1    Vercellotti, G.2    Eaton, J.W.3    Jacob, H.S.4
  • 43
    • 0043268709 scopus 로고    scopus 로고
    • Heme oxygenase-1: unleashing the protective properties of heme
    • Otterbein LE, Soares MP, Yamashita K, Bach FH. Heme oxygenase-1: unleashing the protective properties of heme. Trends Immunol. 2003;24(8):449–455.
    • (2003) Trends Immunol. , vol.24 , Issue.8 , pp. 449-455
    • Otterbein, L.E.1    Soares, M.P.2    Yamashita, K.3    Bach, F.H.4
  • 44
    • 0035200007 scopus 로고    scopus 로고
    • Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection
    • Foresti R, Goatly H, Green CJ, Motterlini R. Role of heme oxygenase-1 in hypoxia-reoxygenation: requirement of substrate heme to promote cardioprotection. Am J Physiol Heart Circ Physiol. 2001;281(5):H1976–H1984.
    • (2001) Am J Physiol Heart Circ Physiol. , vol.281 , Issue.5 , pp. H1976-H1984
    • Foresti, R.1    Goatly, H.2    Green, C.J.3    Motterlini, R.4
  • 46
    • 0029392368 scopus 로고
    • Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am
    • Camhi SL, Alam J, Otterbein LE, Sylvester SL, Choi AMK. Induction of heme oxygenase-1 gene expression by lipopolysaccharide is mediated by AP-1 activation. Am J Respir Cell Mol Biol. 1995;13:387–398.
    • (1995) J Respir Cell Mol Biol. , vol.13 , pp. 387-398
    • Camhi, S.L.1    Alam, J.2    Otterbein, L.E.3    Sylvester, S.L.4    Choi, A.M.K.5
  • 47
    • 0030923630 scopus 로고    scopus 로고
    • The heme oxygenase system: A regulator of second messenger gases
    • Maines MD. The heme oxygenase system: A regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997;37:517–554.
    • (1997) Annu Rev Pharmacol Toxicol. , vol.37 , pp. 517-554
    • Maines, M.D.1
  • 48
    • 0026033907 scopus 로고
    • Induction of heme oxygenase: A general response to oxidant stress in cultured mammalian cells
    • Applegate LA, Luscher P, Tyrell RM. Induction of heme oxygenase: A general response to oxidant stress in cultured mammalian cells. Cancer Res. 1991;51:974–978.
    • (1991) Cancer Res. , vol.51 , pp. 974-978
    • Applegate, L.A.1    Luscher, P.2    Tyrell, R.M.3
  • 49
    • 0024497521 scopus 로고
    • Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite
    • Keyse SM, Tyrell RM. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. Proc Natl Acad Sci USA. 1989;86:99–103.
    • (1989) Proc Natl Acad Sci USA. , vol.86 , pp. 99-103
    • Keyse, S.M.1    Tyrell, R.M.2
  • 51
    • 84888260688 scopus 로고    scopus 로고
    • MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation and vaso-occlusion in transgenic sickle cell mice
    • Belcher JD, Young M, Chen C, et al. MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation and vaso-occlusion in transgenic sickle cell mice. Blood. 2013;122:2757–2764.
    • (2013) Blood. , vol.122 , pp. 2757-2764
    • Belcher, J.D.1    Young, M.2    Chen, C.3
  • 53
    • 0014748520 scopus 로고
    • The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin
    • Tenhunen R, Marver HS, Schmidt R. The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin. J Lab Clin Med. 1970;75:410–421.
    • (1970) J Lab Clin Med. , vol.75 , pp. 410-421
    • Tenhunen, R.1    Marver, H.S.2    Schmidt, R.3
  • 54
    • 0034071424 scopus 로고    scopus 로고
    • Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
    • Otterbein LE, Bach FH, Alam J, et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med. 2000;4: 422–428.
    • (2000) Nat Med. , vol.4 , pp. 422-428
    • Otterbein, L.E.1    Bach, F.H.2    Alam, J.3
  • 55
    • 37349006900 scopus 로고    scopus 로고
    • Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress
    • Kim KM, Pae HO, Zheng M, Park R, Kim YM, Chung HT. Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress. Circ Res. 2007;101(9):919–927.
    • (2007) Circ Res. , vol.101 , Issue.9 , pp. 919-927
    • Kim, K.M.1    Pae, H.O.2    Zheng, M.3    Park, R.4    Kim, Y.M.5    Chung, H.T.6
  • 56
    • 84937858789 scopus 로고    scopus 로고
    • CO Induces Nrf2-dependent heme oxygenase-1 transcription by cooperating with sp1 and c-jun in rat brain astrocytes
    • Chi PL, Lin CC, Chen YW, Hsiao LD, Yang CM. CO Induces Nrf2-dependent heme oxygenase-1 transcription by cooperating with sp1 and c-jun in rat brain astrocytes. Mol Neurobiol. 2015;52(1):277–292.
    • (2015) Mol Neurobiol. , vol.52 , Issue.1 , pp. 277-292
    • Chi, P.L.1    Lin, C.C.2    Chen, Y.W.3    Hsiao, L.D.4    Yang, C.M.5
  • 57
    • 84858658101 scopus 로고    scopus 로고
    • Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways
    • Shin DY, Chung J, Joe Y, et al. Pretreatment with CO-releasing molecules suppresses hepcidin expression during inflammation and endoplasmic reticulum stress through inhibition of the STAT3 and CREBH pathways. Blood. 2012;119(11):2523–2532.
    • (2012) Blood. , vol.119 , Issue.11 , pp. 2523-2532
    • Shin, D.Y.1    Chung, J.2    Joe, Y.3
  • 58
    • 67349252035 scopus 로고    scopus 로고
    • Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease
    • Morse D, Lin L, Choi AM, Ryter SW. Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease. Free Radic Biol Med. 2009;47(1):1–12.
    • (2009) Free Radic Biol Med. , vol.47 , Issue.1 , pp. 1-12
    • Morse, D.1    Lin, L.2    Choi, A.M.3    Ryter, S.W.4
  • 59
    • 80051928702 scopus 로고    scopus 로고
    • Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response
    • Chung J, Shin DY, Zheng M, et al. Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response. Mol Immunol. 2011;48(15-16):1793–1799.
    • (2011) Mol Immunol. , vol.48 , Issue.15-16 , pp. 1793-1799
    • Chung, J.1    Shin, D.Y.2    Zheng, M.3
  • 60
    • 23044459608 scopus 로고    scopus 로고
    • Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
    • Sawle P, Foresti R, Mann BE, Johnson TR, Green CJ, Motterlini R. Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br J Pharmacol. 2005;145(6):800–810.
    • (2005) Br J Pharmacol. , vol.145 , Issue.6 , pp. 800-810
    • Sawle, P.1    Foresti, R.2    Mann, B.E.3    Johnson, T.R.4    Green, C.J.5    Motterlini, R.6
  • 61
    • 15744378615 scopus 로고    scopus 로고
    • Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury
    • Zhang X, Shan P, Alam J, Fu XY, Lee PJ. Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. J Biol Chem. 2005;280(10):8714–8721.
    • (2005) J Biol Chem. , vol.280 , Issue.10 , pp. 8714-8721
    • Zhang, X.1    Shan, P.2    Alam, J.3    Fu, X.Y.4    Lee, P.J.5
  • 62
    • 0016417059 scopus 로고
    • The effect of carbon monoxide on humans
    • Stewart RD. The effect of carbon monoxide on humans. Annu Rev Pharmacol. 1975;15:409–423.
    • (1975) Annu Rev Pharmacol. , vol.15 , pp. 409-423
    • Stewart, R.D.1
  • 65
    • 84930942746 scopus 로고    scopus 로고
    • Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function
    • Levitt DG, Levitt MD. Carbon monoxide: a critical quantitative analysis and review of the extent and limitations of its second messenger function. Clin Pharmacol. 2015;7:37–56.
    • (2015) Clin Pharmacol. , vol.7 , pp. 37-56
    • Levitt, D.G.1    Levitt, M.D.2
  • 67
    • 0035869629 scopus 로고    scopus 로고
    • Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants
    • Sato K, Balla J, Otterbein L, et al. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol. 2001;166:4185–4194.
    • (2001) J Immunol. , vol.166 , pp. 4185-4194
    • Sato, K.1    Balla, J.2    Otterbein, L.3
  • 68
    • 0032901266 scopus 로고    scopus 로고
    • Carbon monoxide provides protection against hyperoxic lung injury
    • Otterbein LE, Mantell LL, Choi AM. Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol. 1999;276:L688–L694.
    • (1999) Am J Physiol. , vol.276 , pp. L688-L694
    • Otterbein, L.E.1    Mantell, L.L.2    Choi, A.M.3
  • 69
    • 70349730056 scopus 로고    scopus 로고
    • Low doses of carbon monoxide protect against experimental focal brain ischemia
    • Zeynalov E, Dore S. Low doses of carbon monoxide protect against experimental focal brain ischemia. Neurotox Res. 2009;15:133–137.
    • (2009) Neurotox Res. , vol.15 , pp. 133-137
    • Zeynalov, E.1    Dore, S.2
  • 70
    • 79957441392 scopus 로고    scopus 로고
    • Carbon monoxide enhances early liver regeneration in mice after hepatectomy
    • Kuramitsu K, Gallo D, Yoon M, et al. Carbon monoxide enhances early liver regeneration in mice after hepatectomy. Hepatology. 2011;53:2016–2026.
    • (2011) Hepatology. , vol.53 , pp. 2016-2026
    • Kuramitsu, K.1    Gallo, D.2    Yoon, M.3
  • 71
    • 84936817005 scopus 로고    scopus 로고
    • Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1
    • Schallner N, Pandit R, LeBlanc R, 3rd, et al. Microglia regulate blood clearance in subarachnoid hemorrhage by heme oxygenase-1. J Clin Invest. 2015;125:2609–2615.
    • (2015) J Clin Invest. , vol.125 , pp. 2609-2615
    • Schallner, N.1    Pandit, R.2    LeBlanc, R.3
  • 72
    • 0035039579 scopus 로고    scopus 로고
    • Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis
    • Fujita T, Toda K, Karimova A, et al. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med. 2001;7:598–604.
    • (2001) Nat Med. , vol.7 , pp. 598-604
    • Fujita, T.1    Toda, K.2    Karimova, A.3
  • 74
    • 0018101149 scopus 로고
    • Extent of polymerization in partially liganded sickle hemoglobin
    • Chung LL, Magdorff-Fairchild B. Extent of polymerization in partially liganded sickle hemoglobin. Arch Biochem Biophys. 1978;189(2):535–539.
    • (1978) Arch Biochem Biophys. , vol.189 , Issue.2 , pp. 535-539
    • Chung, L.L.1    Magdorff-Fairchild, B.2
  • 75
    • 0006979178 scopus 로고
    • The use of carbon monoxide to prevent sickle-cell formation
    • Sirs JA. The use of carbon monoxide to prevent sickle-cell formation. Lancet. 1963;1:971–972.
    • (1963) Lancet. , vol.1 , pp. 971-972
    • Sirs, J.A.1
  • 77
    • 77649297696 scopus 로고    scopus 로고
    • Hypoxia activates a Ca2+-permeable cation conductance channel sensitive to CO and to GsMTx-4 in human and mouse sickle erythrocytes
    • Vandorpe DH1, Xu C, Shmukler BE, et al. Hypoxia activates a Ca2+-permeable cation conductance channel sensitive to CO and to GsMTx-4 in human and mouse sickle erythrocytes. PLoS One. 2010;5(1):e8732
    • (2010) PLoS One. , vol.5 , Issue.1
    • Vandorpe, D.H.1    Xu, C.2    Shmukler, B.E.3
  • 78
    • 85009348471 scopus 로고    scopus 로고
    • Determination of extinction coefficients of human hemoglobin in various redox states
    • Epub 2017 Jan 6
    • Meng F, Alayash AI. Determination of extinction coefficients of human hemoglobin in various redox states. Anal Biochem. 2017;521:11–19. doi: 10.1016/j.ab.2017.01.002. Epub 2017 Jan 6.
    • (2017) Anal Biochem. , vol.521 , pp. 11-19
    • Meng, F.1    Alayash, A.I.2
  • 79
    • 84982873215 scopus 로고    scopus 로고
    • Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase-1
    • Kassa T, Jana S, Meng F, Alayash AI. Differential heme release from various hemoglobin redox states and the upregulation of cellular heme oxygenase-1. FEBS Open Bio. 2016;6(9):876–884.
    • (2016) FEBS Open Bio. , vol.6 , Issue.9 , pp. 876-884
    • Kassa, T.1    Jana, S.2    Meng, F.3    Alayash, A.I.4
  • 80
    • 33749322644 scopus 로고    scopus 로고
    • Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
    • Nakahira K, Kim HP, Geng XH, et al. Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts. J Exp Med. 2006;2;203(10):2377–2389.
    • (2006) J Exp Med. , vol.203 , Issue.10 , pp. 2377-2389
    • Nakahira, K.1    Kim, H.P.2    Geng, X.H.3
  • 81
    • 34247571886 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning
    • Chin BY, Jiang G, Wegiel B, et al. Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning. Proc Natl Acad Sci U S A. 2007;104(12):5109–5114.
    • (2007) Proc Natl Acad Sci U S A. , vol.104 , Issue.12 , pp. 5109-5114
    • Chin, B.Y.1    Jiang, G.2    Wegiel, B.3
  • 82
    • 33646579079 scopus 로고    scopus 로고
    • Carbon monoxide orchestrates a protective response through PPARgamma
    • Bilban M, Bach FH, Otterbein SL, et al. Carbon monoxide orchestrates a protective response through PPARgamma. Immunity. 2006;24(5):601–610.
    • (2006) Immunity. , vol.24 , Issue.5 , pp. 601-610
    • Bilban, M.1    Bach, F.H.2    Otterbein, S.L.3
  • 84
    • 80055033765 scopus 로고    scopus 로고
    • Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages
    • Haschemi A, Chin BY, Jeitler M, et al. Carbon monoxide induced PPARγ SUMOylation and UCP2 block inflammatory gene expression in macrophages. PLoS One. 2011;6(10):e26376
    • (2011) PLoS One. , vol.6 , Issue.10
    • Haschemi, A.1    Chin, B.Y.2    Jeitler, M.3
  • 85
    • 77954541322 scopus 로고    scopus 로고
    • Heme-oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease
    • Belcher JD, Vineyard JV, Bruzzone CM, et al. Heme-oxygenase-1 gene delivery by Sleeping Beauty inhibits vascular stasis in a murine model of sickle cell disease. J Mol Med. 2010;88:665–675.
    • (2010) J Mol Med. , vol.88 , pp. 665-675
    • Belcher, J.D.1    Vineyard, J.V.2    Bruzzone, C.M.3
  • 86
    • 0016739178 scopus 로고
    • The effect of carbon monoxide on red cell life span in sickle cell disease
    • Beutler E. The effect of carbon monoxide on red cell life span in sickle cell disease. Blood. 1975;46:253–259.
    • (1975) Blood. , vol.46 , pp. 253-259
    • Beutler, E.1
  • 87
    • 33847402262 scopus 로고    scopus 로고
    • The associations between air quality and the number of hospital admissions for acute pain and sickle-cell disease in an urban environment
    • Yallop D, Duncan ER, Norris E, et al. The associations between air quality and the number of hospital admissions for acute pain and sickle-cell disease in an urban environment. Br J Haematol. 2007;136(6):844–848.
    • (2007) Br J Haematol. , vol.136 , Issue.6 , pp. 844-848
    • Yallop, D.1    Duncan, E.R.2    Norris, E.3
  • 88
    • 84907856044 scopus 로고    scopus 로고
    • Neuroprotective, neurotherapeutic and neurometabolic effects of corbon monoxide
    • Mahan VL. Neuroprotective, neurotherapeutic and neurometabolic effects of corbon monoxide. Med Gas Res. 2012;2:32–36.
    • (2012) Med Gas Res. , vol.2 , pp. 32-36
    • Mahan, V.L.1
  • 90
    • 85007557280 scopus 로고    scopus 로고
    • A phase 1b open label, randomized, safety study of SANGUINATE in patients with sickle cell anemia
    • Misra H, Bainbridge J, Berryman J, et al. A phase 1b open label, randomized, safety study of SANGUINATE in patients with sickle cell anemia. Braz J Hematol Hemother. 2017;39: 20–27.
    • (2017) Braz J Hematol Hemother. , vol.39 , pp. 20-27
    • Misra, H.1    Bainbridge, J.2    Berryman, J.3
  • 91
    • 84906790540 scopus 로고    scopus 로고
    • PEGylated carboxyhemoglobin bovine (SANGUINATE): results of a phase I clinical trial
    • Misra H, Lickliter J, Kazo F, Abuchowski A. PEGylated carboxyhemoglobin bovine (SANGUINATE): results of a phase I clinical trial. Artif Organs. 2014;38(8):702–707. Doi: 10.1111/aor.12341
    • (2014) Artif Organs. , vol.38 , Issue.8 , pp. 702-707
    • Misra, H.1    Lickliter, J.2    Kazo, F.3    Abuchowski, A.4
  • 92
    • 38849158556 scopus 로고    scopus 로고
    • Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study
    • Bathoorn E, Slebos DJ, Postma DS, et al. Anti-inflammatory effects of inhaled carbon monoxide in patients with COPD: a pilot study. Eur Respir J. 2007;30:1131–1137.
    • (2007) Eur Respir J. , vol.30 , pp. 1131-1137
    • Bathoorn, E.1    Slebos, D.J.2    Postma, D.S.3
  • 93
    • 13544271775 scopus 로고    scopus 로고
    • Effects of carbon monoxide inhalation during experimental endotoxemia in humans
    • Epub 2004 Nov 19
    • Mayr FB, Spiel A, Leitner J, et al. Effects of carbon monoxide inhalation during experimental endotoxemia in humans. Am J Respir Crit Care Med. 2005;171(4):354–360. Epub 2004 Nov 19.
    • (2005) Am J Respir Crit Care Med. , vol.171 , Issue.4 , pp. 354-360
    • Mayr, F.B.1    Spiel, A.2    Leitner, J.3
  • 94
    • 67650067091 scopus 로고    scopus 로고
    • Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans
    • Rhodes MA, Carraway MS, Piantadosi CA, et al. Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans. Am J Physiol Heart Circ Physiol. 2009;297(1):H392–H399.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297 , Issue.1 , pp. H392-H399
    • Rhodes, M.A.1    Carraway, M.S.2    Piantadosi, C.A.3
  • 95
    • 84959368742 scopus 로고    scopus 로고
    • Central nervous system complications and management in sickle cell disease
    • DeBaun MR, Kirkham FJ. Central nervous system complications and management in sickle cell disease. Blood. 2016;127:829–838.
    • (2016) Blood. , vol.127 , pp. 829-838
    • DeBaun, M.R.1    Kirkham, F.J.2
  • 96
    • 0035942334 scopus 로고    scopus 로고
    • Poor school and cognitive functioning with silent cerebral infarcts and sickle cell disease
    • Schatz J, Brown RT, Pascual JM, Hsu L, Debaum MR. Poor school and cognitive functioning with silent cerebral infarcts and sickle cell disease. Neurology. 2001;56:1109–1111.
    • (2001) Neurology. , vol.56 , pp. 1109-1111
    • Schatz, J.1    Brown, R.T.2    Pascual, J.M.3    Hsu, L.4    Debaum, M.R.5
  • 97
    • 0023490534 scopus 로고
    • Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase
    • Brüne B, Ullrich V. Inhibition of platelet aggregation by carbon monoxide is mediated by activation of guanylate cyclase. Mol Pharmacol. 1987;32(4):497–504.
    • (1987) Mol Pharmacol. , vol.32 , Issue.4 , pp. 497-504
    • Brüne, B.1    Ullrich, V.2
  • 98
    • 0028228808 scopus 로고
    • Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states
    • Stone JR, Marletta MA. Soluble guanylate cyclase from bovine lung: activation with nitric oxide and carbon monoxide and spectral characterization of the ferrous and ferric states. Biochemistry. 1994; 33(18):5636–5640.
    • (1994) Biochemistry. , vol.33 , Issue.18 , pp. 5636-5640
    • Stone, J.R.1    Marletta, M.A.2
  • 100
    • 33644618423 scopus 로고    scopus 로고
    • Carbon monoxide protects PC12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential
    • Li MH, Cha YN, Surh YJ. Carbon monoxide protects PC12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential. Biochem Biophys Res Commun. 2006;342(3):984–990.
    • (2006) Biochem Biophys Res Commun. , vol.342 , Issue.3 , pp. 984-990
    • Li, M.H.1    Cha, Y.N.2    Surh, Y.J.3
  • 101
    • 33646185795 scopus 로고    scopus 로고
    • Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway
    • Kim HS, Loughran PA, Kim PK, Billiar TR, Zuckerbraun BS. Carbon monoxide protects hepatocytes from TNF-alpha/Actinomycin D by inhibition of the caspase-8-mediated apoptotic pathway. Biochem Biophys Res Commun. 2006;344(4):1172–1178.
    • (2006) Biochem Biophys Res Commun. , vol.344 , Issue.4 , pp. 1172-1178
    • Kim, H.S.1    Loughran, P.A.2    Kim, P.K.3    Billiar, T.R.4    Zuckerbraun, B.S.5
  • 102
    • 33847291917 scopus 로고    scopus 로고
    • Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation
    • Wang X, Wang Y, Kim HP, Nakahira K, Ryter SW, Choi AM. Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation. J Biol Chem. 2007;282(3):1718–1726.
    • (2007) J Biol Chem. , vol.282 , Issue.3 , pp. 1718-1726
    • Wang, X.1    Wang, Y.2    Kim, H.P.3    Nakahira, K.4    Ryter, S.W.5    Choi, A.M.6
  • 103
    • 53149154867 scopus 로고    scopus 로고
    • Preconditioning indiced by carbon monoxide provides neuronal protection against apoptosis
    • Vieira HL, Queiroga CS, Alves PM. Preconditioning indiced by carbon monoxide provides neuronal protection against apoptosis. J Neurochem. 2008;107:375–384.
    • (2008) J Neurochem. , vol.107 , pp. 375-384
    • Vieira, H.L.1    Queiroga, C.S.2    Alves, P.M.3
  • 104
    • 84923687073 scopus 로고    scopus 로고
    • Carbon monoxide and the CNS: challenges and achievements
    • Queiroga CSF, Vercelli A, Vieira HLA. Carbon monoxide and the CNS: challenges and achievements. Br J Pharmacol. 2015;172: 1533–1545.
    • (2015) Br J Pharmacol. , vol.172 , pp. 1533-1545
    • Queiroga, C.S.F.1    Vercelli, A.2    Vieira, H.L.A.3
  • 105
    • 84859514318 scopus 로고    scopus 로고
    • Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: role of Bcl-2
    • Almeida AS, Queiroga CS, Sousa MF, Alves PM, Vieira HL. Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: role of Bcl-2. J Biol Chem. 2012;287:10762–10770.
    • (2012) J Biol Chem. , vol.287 , pp. 10762-10770
    • Almeida, A.S.1    Queiroga, C.S.2    Sousa, M.F.3    Alves, P.M.4    Vieira, H.L.5
  • 106
    • 79955528559 scopus 로고    scopus 로고
    • Sickle hemoglobin confers tolerance to Plasmodium infection
    • Ferreira A, Marguti I, Bechmann I, et al. Sickle hemoglobin confers tolerance to Plasmodium infection. Cell. 2011;145: 398–409.
    • (2011) Cell. , vol.145 , pp. 398-409
    • Ferreira, A.1    Marguti, I.2    Bechmann, I.3
  • 107
    • 65449130775 scopus 로고    scopus 로고
    • The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1
    • Wang XM, Kim HP, Nakahira K, Ryter SW, Choi AM. The heme oxygenase-1/carbon monoxide pathway suppresses TLR4 signaling by regulating the interaction of TLR4 with caveolin-1. J Immunol. 2009;182(6):3809–3818.
    • (2009) J Immunol. , vol.182 , Issue.6 , pp. 3809-3818
    • Wang, X.M.1    Kim, H.P.2    Nakahira, K.3    Ryter, S.W.4    Choi, A.M.5
  • 108
    • 77956942676 scopus 로고    scopus 로고
    • Carbon monoxide suppresses membrane expression of TLR4 via myeloid differentiation factor-2 in betaTC3 cells
    • Rocuts F, Ma Y, Zhang X, et al. Carbon monoxide suppresses membrane expression of TLR4 via myeloid differentiation factor-2 in betaTC3 cells. J Immunol. 2010;185(4):2134–2139.
    • (2010) J Immunol. , vol.185 , Issue.4 , pp. 2134-2139
    • Rocuts, F.1    Ma, Y.2    Zhang, X.3
  • 109
    • 84922569947 scopus 로고    scopus 로고
    • Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility
    • Riquelme SA1, Bueno SM, Kalergis AM. Carbon monoxide down-modulates Toll-like receptor 4/MD2 expression on innate immune cells and reduces endotoxic shock susceptibility. Immunology. 2015;144(2):321–332.
    • (2015) Immunology. , vol.144 , Issue.2 , pp. 321-332
    • Riquelme, S.A.1    Bueno, S.M.2    Kalergis, A.M.3
  • 110
    • 84930848355 scopus 로고    scopus 로고
    • Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages
    • Jung SS, Moon JS, Xu JF, et al. Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages. Am J Physiol Lung Cell Mol Physiol. 2015;308(10):L1058–L1067.
    • (2015) Am J Physiol Lung Cell Mol Physiol. , vol.308 , Issue.10 , pp. L1058-L1067
    • Jung, S.S.1    Moon, J.S.2    Xu, J.F.3
  • 111
    • 84940476321 scopus 로고    scopus 로고
    • Exogenous carbon monoxide decreases sepsis-induced acute kidney injury and inhibits NLRP3 inflammasome activation in rats
    • Wang P, Huang J, Li Y, et al. Exogenous carbon monoxide decreases sepsis-induced acute kidney injury and inhibits NLRP3 inflammasome activation in rats. Int J Mol Sci. 2015;16(9):20595–20608.
    • (2015) Int J Mol Sci. , vol.16 , Issue.9 , pp. 20595-20608
    • Wang, P.1    Huang, J.2    Li, Y.3
  • 112
    • 84978173507 scopus 로고    scopus 로고
    • CORM-2 inhibits TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury
    • Jiang L, Fei D, Gong R, et al. CORM-2 inhibits TXNIP/NLRP3 inflammasome pathway in LPS-induced acute lung injury. Inflamm Res. 2016;65(11):905–915.
    • (2016) Inflamm Res. , vol.65 , Issue.11 , pp. 905-915
    • Jiang, L.1    Fei, D.2    Gong, R.3
  • 113
    • 85011903583 scopus 로고    scopus 로고
    • Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts
    • Zhang W, Tao A, Lan T, et al. Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts. Basic Res Cardiol. 2017;112(2):16. doi: 10.1007
    • (2017) Basic Res Cardiol. , vol.112 , Issue.2 , pp. 16
    • Zhang, W.1    Tao, A.2    Lan, T.3
  • 114
    • 76349103022 scopus 로고    scopus 로고
    • Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury
    • Wegiel B, Gallo DJ, Raman KG, et al. Nitric oxide-dependent bone marrow progenitor mobilization by carbon monoxide enhances endothelial repair after vascular injury. Circulation. 2010;2;121(4):537–548.
    • (2010) Circulation. , vol.121 , Issue.4 , pp. 537-548
    • Wegiel, B.1    Gallo, D.J.2    Raman, K.G.3
  • 115
    • 33748455321 scopus 로고    scopus 로고
    • Carbon monoxide reverses established pulmonary hypertension
    • Zuckerbraun BS, Chin BY, Wegiel B, et al. Carbon monoxide reverses established pulmonary hypertension. J Exp Med. 2006;203(9):2109–2119.
    • (2006) J Exp Med. , vol.203 , Issue.9 , pp. 2109-2119
    • Zuckerbraun, B.S.1    Chin, B.Y.2    Wegiel, B.3
  • 116
    • 70349630108 scopus 로고    scopus 로고
    • Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease
    • Beckman J, Belcher JD, Vineyard JV, et al. Inhaled carbon monoxide reduces leukocytosis in a murine model of sickle cell disease. Am J Physiol Heart Circ Physiol. 2009;297:H1243–H1253.
    • (2009) Am J Physiol Heart Circ Physiol. , vol.297 , pp. H1243-H1253
    • Beckman, J.1    Belcher, J.D.2    Vineyard, J.V.3
  • 117
    • 75149157571 scopus 로고    scopus 로고
    • Human sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity
    • Bains SK, Foresti R, Howard J, Atwal S, Green CJ, Motterlini R. Human sickle cell blood modulates endothelial heme oxygenase activity: effects on vascular adhesion and reactivity. Arterioscler Thromb Vasc Biol. 2010;30(2):305–312.
    • (2010) Arterioscler Thromb Vasc Biol. , vol.30 , Issue.2 , pp. 305-312
    • Bains, S.K.1    Foresti, R.2    Howard, J.3    Atwal, S.4    Green, C.J.5    Motterlini, R.6
  • 119
    • 0034120108 scopus 로고    scopus 로고
    • Multicenter prospective study of children with sickle cell disease: radiographic and psychometric correlation
    • Bernaudin F, Verlhac S, Freard F, et al. Multicenter prospective study of children with sickle cell disease: radiographic and psychometric correlation. J Child Neurol. 2000;15:333–343.
    • (2000) J Child Neurol. , vol.15 , pp. 333-343
    • Bernaudin, F.1    Verlhac, S.2    Freard, F.3
  • 120
    • 84965017488 scopus 로고    scopus 로고
    • Silent cerebral infarcts and cerebral aneurysms are prevalent in adults with sickle cell anemia
    • Kassim AA, Pruthi S, Day M, et al. Silent cerebral infarcts and cerebral aneurysms are prevalent in adults with sickle cell anemia. Blood. 2016;127:2038–2040.
    • (2016) Blood. , vol.127 , pp. 2038-2040
    • Kassim, A.A.1    Pruthi, S.2    Day, M.3
  • 121
    • 0031965089 scopus 로고    scopus 로고
    • Cerebrovascular accidents in sickle cell disease: rates and risk factors
    • Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood. 1998;91:288–294.
    • (1998) Blood. , vol.91 , pp. 288-294
    • Ohene-Frempong, K.1    Weiner, S.J.2    Sleeper, L.A.3
  • 122
    • 0032512036 scopus 로고    scopus 로고
    • Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial doppler ultrasonography
    • Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial doppler ultrasonography. N Engl J Med. 1998;339:5–11.
    • (1998) N Engl J Med. , vol.339 , pp. 5-11
    • Adams, R.J.1    McKie, V.C.2    Hsu, L.3
  • 123
    • 84860348352 scopus 로고    scopus 로고
    • Stroke with transfusion changing to hydroxyurea
    • Ware RE, Helms RW, et al. Stroke with transfusion changing to hydroxyurea (SWiTCH). Blood. 2012;118:3925–3932.
    • (2012) (SWiTCH). Blood. , vol.118 , pp. 3925-3932
    • Ware, R.E.1    Helms, R.W.2
  • 124
    • 80053302622 scopus 로고    scopus 로고
    • Autoimmune responses to the brain after stroke are associated with worse outcome
    • Becker KJ, Kalil AJ, Tanzi P, et al. Autoimmune responses to the brain after stroke are associated with worse outcome. Stroke. 2011;42:2763–2769.
    • (2011) Stroke. , vol.42 , pp. 2763-2769
    • Becker, K.J.1    Kalil, A.J.2    Tanzi, P.3
  • 126
    • 0032972686 scopus 로고    scopus 로고
    • Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice
    • Panahian N, Yoshiura M, Maines MD. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem. 1999;72:1187–1203.
    • (1999) J Neurochem. , vol.72 , pp. 1187-1203
    • Panahian, N.1    Yoshiura, M.2    Maines, M.D.3
  • 127
    • 80052420822 scopus 로고    scopus 로고
    • Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia
    • Wang B, Cao W, Biswal S, Dore S. Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia. Stroke. 2011;42:2605–2610.
    • (2011) Stroke. , vol.42 , pp. 2605-2610
    • Wang, B.1    Cao, W.2    Biswal, S.3    Dore, S.4
  • 128
    • 84868331120 scopus 로고    scopus 로고
    • Up-regulation of heme oxygenase-1 attenuates brain damage after cerebral ischemia via simultaneous inhibition of superoxide production and preservation of NO bioavailability
    • Chao XD, Ma YH, Luo P, et al. Up-regulation of heme oxygenase-1 attenuates brain damage after cerebral ischemia via simultaneous inhibition of superoxide production and preservation of NO bioavailability. Exp Neurol. 2013;239:163–169.
    • (2013) Exp Neurol. , vol.239 , pp. 163-169
    • Chao, X.D.1    Ma, Y.H.2    Luo, P.3
  • 129
    • 84870406409 scopus 로고    scopus 로고
    • Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia
    • Zhang J, Cao S, Kwansa H, Crafa D, Kibler KK, Koehler RC. Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia. J Appl Physiol. 2012;113:1709–1717.
    • (2012) J Appl Physiol. , vol.113 , pp. 1709-1717
    • Zhang, J.1    Cao, S.2    Kwansa, H.3    Crafa, D.4    Kibler, K.K.5    Koehler, R.C.6
  • 130
    • 33747232569 scopus 로고    scopus 로고
    • Heme oxygenase-1 protects brain from acute excitotoxicity
    • Ahmad AS, Zhuang H, Dore S. Heme oxygenase-1 protects brain from acute excitotoxicity. Neuroscience. 2006;141:1703–1708.
    • (2006) Neuroscience. , vol.141 , pp. 1703-1708
    • Ahmad, A.S.1    Zhuang, H.2    Dore, S.3
  • 131
    • 0029736955 scopus 로고    scopus 로고
    • Spatiotemporal relationship of apoptotic cell death to lymphomonocytic infiltration in photochemically induced focal ischemia of the rat cerebral cortex
    • Braun JS, Jander S, Schroeter M, Witte OW, Stoll G. Spatiotemporal relationship of apoptotic cell death to lymphomonocytic infiltration in photochemically induced focal ischemia of the rat cerebral cortex. Acta Neuropathol. 1996;92:255–263.
    • (1996) Acta Neuropathol. , vol.92 , pp. 255-263
    • Braun, J.S.1    Jander, S.2    Schroeter, M.3    Witte, O.W.4    Stoll, G.5
  • 132
    • 0028854369 scopus 로고
    • Lymphocytic infiltration and expression of intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex
    • Jander S, Kraemer M, Schroeter M, Witte OW, Stoll G. Lymphocytic infiltration and expression of intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex. J Cereb Blood Flow Metab. 1995;15:42–51.
    • (1995) J Cereb Blood Flow Metab. , vol.15 , pp. 42-51
    • Jander, S.1    Kraemer, M.2    Schroeter, M.3    Witte, O.W.4    Stoll, G.5
  • 133
    • 60549104213 scopus 로고    scopus 로고
    • Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE
    • van Zwam M, Huizinga R, Melief MJ, et al. Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE. J Mol Med. 2009;87:273–286.
    • (2009) J Mol Med. , vol.87 , pp. 273-286
    • van Zwam, M.1    Huizinga, R.2    Melief, M.J.3
  • 135
    • 0017345844 scopus 로고
    • Effect of encephalitogenic protein on migration in agarose of leukoytes from patients with multiple sclerosis. A longitudinal study of patients with relapsing multiple sclerosis or with cerebral infarction
    • Kallen B, Nilsson O, Thelin C. Effect of encephalitogenic protein on migration in agarose of leukoytes from patients with multiple sclerosis. A longitudinal study of patients with relapsing multiple sclerosis or with cerebral infarction. Acta Neurol Scand. 1977;55:47–56.
    • (1977) Acta Neurol Scand. , vol.55 , pp. 47-56
    • Kallen, B.1    Nilsson, O.2    Thelin, C.3
  • 136
    • 0016183214 scopus 로고
    • Cellular-immune response to myelin protein: absence in multiple sclerosis and presence in cerebrovascular accidents
    • Youngchaiyud U, Coates AS, Whittingham S, Mackay IR. Cellular-immune response to myelin protein: absence in multiple sclerosis and presence in cerebrovascular accidents. Aust N Z J Med. 1974;4:535–538.
    • (1974) Aust N Z J Med. , vol.4 , pp. 535-538
    • Youngchaiyud, U.1    Coates, A.S.2    Whittingham, S.3    Mackay, I.R.4
  • 139
    • 0141615744 scopus 로고    scopus 로고
    • Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke
    • Dambinova SA, Khounteev GA, Izykenova GA, Zavolokov IG, Ilyukhina AY, Skoromets AA. Blood test detecting autoantibodies to N-methyl-D-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke. Clin Chem. 2003;49:1752–1762.
    • (2003) Clin Chem. , vol.49 , pp. 1752-1762
    • Dambinova, S.A.1    Khounteev, G.A.2    Izykenova, G.A.3    Zavolokov, I.G.4    Ilyukhina, A.Y.5    Skoromets, A.A.6
  • 140
    • 84880825962 scopus 로고    scopus 로고
    • Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size
    • Kalev-Zylinska ML, Symes W, Little KC, et al. Stroke patients develop antibodies that react with components of N-methyl-D-aspartate receptor subunit 1 in proportion to lesion size. Stroke. 2013;44:2212–2219.
    • (2013) Stroke , vol.44 , pp. 2212-2219
    • Kalev-Zylinska, M.L.1    Symes, W.2    Little, K.C.3
  • 142
    • 44449167217 scopus 로고    scopus 로고
    • Induction of immunologic tolerance to myelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke
    • Gee JM, Kalil A, Thullbery M, Becker KJ. Induction of immunologic tolerance to myelin basic protein prevents central nervous system autoimmunity and improves outcome after stroke. Stroke. 2008;39:1575–1582.
    • (2008) Stroke. , vol.39 , pp. 1575-1582
    • Gee, J.M.1    Kalil, A.2    Thullbery, M.3    Becker, K.J.4
  • 143
    • 77958013973 scopus 로고    scopus 로고
    • Long term immunologic consequences of experimental stroke and mucosal tolerance
    • Gee JM, Zierath D, Hadwin J, et al. Long term immunologic consequences of experimental stroke and mucosal tolerance. Exp Transl Stroke Med. 2009;1:3.
    • (2009) Exp Transl Stroke Med. , vol.1 , pp. 3
    • Gee, J.M.1    Zierath, D.2    Hadwin, J.3
  • 144
    • 84884815486 scopus 로고    scopus 로고
    • The immunologic profile of adoptively transferred lymphocytes influences stroke outcome of recipients
    • Zierath D, Schulze J, Kunze A, et al. The immunologic profile of adoptively transferred lymphocytes influences stroke outcome of recipients. J Neuroimmunol. 2013;263:28–34.
    • (2013) J Neuroimmunol. , vol.263 , pp. 28-34
    • Zierath, D.1    Schulze, J.2    Kunze, A.3
  • 145
    • 68349160698 scopus 로고    scopus 로고
    • Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury
    • Shichita T, Sugiyama Y, Ooboshi H, et al. Pivotal role of cerebral interleukin-17-producing gammadeltaT cells in the delayed phase of ischemic brain injury. Nat Med. 2009;15:946–950.
    • (2009) Nat Med. , vol.15 , pp. 946-950
    • Shichita, T.1    Sugiyama, Y.2    Ooboshi, H.3
  • 146
    • 78549273305 scopus 로고    scopus 로고
    • Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model
    • Konoeda F, Shichita T, Yoshida H, et al. Therapeutic effect of IL-12/23 and their signaling pathway blockade on brain ischemia model. Biochem Biophys Res Commun. 2010;402:500–506.
    • (2010) Biochem Biophys Res Commun. , vol.402 , pp. 500-506
    • Konoeda, F.1    Shichita, T.2    Yoshida, H.3
  • 147
    • 84868602402 scopus 로고    scopus 로고
    • Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke
    • Gelderblom M, Weymar A, Bernreuther C, et al. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood. 2012;120:3793–3802.
    • (2012) Blood. , vol.120 , pp. 3793-3802
    • Gelderblom, M.1    Weymar, A.2    Bernreuther, C.3
  • 149
    • 84903640356 scopus 로고    scopus 로고
    • Imbalance between IL-17A-producing cells and regulatory T cells during ischemic stroke
    • Hu Y, Zheng Y, Wu Y, Ni B, Shi S. Imbalance between IL-17A-producing cells and regulatory T cells during ischemic stroke. Mediators Inflamm. 2014;2014:813045.
    • (2014) Mediators Inflamm. , vol.2014 , pp. 813045
    • Hu, Y.1    Zheng, Y.2    Wu, Y.3    Ni, B.4    Shi, S.5
  • 150
    • 0030924054 scopus 로고    scopus 로고
    • Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia
    • Becker KJ, McCarron RM, Ruetzler C, et al. Immunologic tolerance to myelin basic protein decreases stroke size after transient focal cerebral ischemia. Proc Natl Acad Sci USA. 1997;94:10873–10878.
    • (1997) Proc Natl Acad Sci USA. , vol.94 , pp. 10873-10878
    • Becker, K.J.1    McCarron, R.M.2    Ruetzler, C.3
  • 151
    • 33846819008 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation
    • Chora AA, Fontoura P, Cunha A, et al. Heme oxygenase-1 and carbon monoxide suppress autoimmune neuroinflammation. J Clin Invest. 2007;117:438–447.
    • (2007) J Clin Invest. , vol.117 , pp. 438-447
    • Chora, A.A.1    Fontoura, P.2    Cunha, A.3
  • 152
    • 84888072960 scopus 로고    scopus 로고
    • Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells
    • Tardif V, Riquelme SA, Remy S, et al. Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells. Eur J Immunol. 2013;43:2832–2844.
    • (2013) Eur J Immunol. , vol.43 , pp. 2832-2844
    • Tardif, V.1    Riquelme, S.A.2    Remy, S.3
  • 153
    • 33747609353 scopus 로고    scopus 로고
    • Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3
    • Bani-Hani MG, Greenstein D, Mann BE, Green CJ, Motterlini R. Modulation of thrombin-induced neuroinflammation in BV-2 microglia by carbon monoxide-releasing molecule 3. J Pharmacol Exp Ther. 2006;318:1315–1322.
    • (2006) J Pharmacol Exp Ther. , vol.318 , pp. 1315-1322
    • Bani-Hani, M.G.1    Greenstein, D.2    Mann, B.E.3    Green, C.J.4    Motterlini, R.5
  • 154
    • 84856145785 scopus 로고    scopus 로고
    • CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke
    • Yabluchansky A, Sawle P, Homer-Vanniasinkam S, Green CJ, Foresti R, Motterlini R. CORM-3, a carbon monoxide-releasing molecule, alters the inflammatory response and reduces brain damage in a rat model of hemorrhagic stroke. Crit Care Med. 2012;40: 544–552.
    • (2012) Crit Care Med , vol.40 , pp. 544-552
    • Yabluchansky, A.1    Sawle, P.2    Homer-Vanniasinkam, S.3    Green, C.J.4    Foresti, R.5    Motterlini, R.6
  • 155
    • 35349005733 scopus 로고    scopus 로고
    • Cerebroprotective effects of the CO-releasing releasing molecule CORM-A1 against seizure-induced neonatal vascular injury
    • Zimmermann A, Leffler CW, Tcheranova D, Fedinec AL, Parfenova H. Cerebroprotective effects of the CO-releasing releasing molecule CORM-A1 against seizure-induced neonatal vascular injury. Am J Physiol Heart Circ Physiol. 2007;293:H2501–H2507.
    • (2007) Am J Physiol Heart Circ Physiol. , vol.293 , pp. H2501-H2507
    • Zimmermann, A.1    Leffler, C.W.2    Tcheranova, D.3    Fedinec, A.L.4    Parfenova, H.5
  • 156
    • 84864656602 scopus 로고    scopus 로고
    • Inhaled carbon monoxide provides cerebral cytoprotection in pigs
    • Mahan VL, Zurakowski D, Otterbein LE, Pigula FA. Inhaled carbon monoxide provides cerebral cytoprotection in pigs. PLoS One. 2012;7(8):e41982.
    • (2012) PLoS One. , vol.7 , Issue.8
    • Mahan, V.L.1    Zurakowski, D.2    Otterbein, L.E.3    Pigula, F.A.4
  • 157
    • 84988701332 scopus 로고    scopus 로고
    • Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury
    • Choi YK, Maki T, Mandeville ET, et al. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016;22(11):1335–1441.
    • (2016) Nat Med. , vol.22 , Issue.11 , pp. 1335-1441
    • Choi, Y.K.1    Maki, T.2    Mandeville, E.T.3
  • 158
    • 0037622140 scopus 로고    scopus 로고
    • Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
    • Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res. 2002;90:E17–E24.
    • (2002) Circ Res. , vol.90 , pp. E17-E24
    • Motterlini, R.1    Clark, J.E.2    Foresti, R.3    Sarathchandra, P.4    Mann, B.E.5    Green, C.J.6
  • 159
    • 84964465052 scopus 로고    scopus 로고
    • Toward carbon-monoxide-based therapeutics: Critical drug delivery and developmentability issues
    • Ji X, Damera K, Zheng Y, Yu B, Otterbein LE, Wang B. Toward carbon-monoxide-based therapeutics: Critical drug delivery and developmentability issues. J Pharm Sci. 2016;105:406–416.
    • (2016) J Pharm Sci. , vol.105 , pp. 406-416
    • Ji, X.1    Damera, K.2    Zheng, Y.3    Yu, B.4    Otterbein, L.E.5    Wang, B.6
  • 161
    • 84944188222 scopus 로고    scopus 로고
    • Design of biomaterials for intracellular delivery of carbon monoxide
    • Inaba H, Fujita K, Ueno T. Design of biomaterials for intracellular delivery of carbon monoxide. Biomater Sci. 2015;3:1423–1438.
    • (2015) Biomater Sci. , vol.3 , pp. 1423-1438
    • Inaba, H.1    Fujita, K.2    Ueno, T.3
  • 162
    • 84915819052 scopus 로고    scopus 로고
    • Design and synthesuis of new hybrid molecules that activates the transcription factor Nrf2 and simultaneously release carbon monoxide
    • Wilson JL, Kobeissi S, Oudir S, et al. Design and synthesuis of new hybrid molecules that activates the transcription factor Nrf2 and simultaneously release carbon monoxide. Chem Eur J. 2014;20:14698–14704.
    • (2014) Chem Eur J. , vol.20 , pp. 14698-14704
    • Wilson, J.L.1    Kobeissi, S.2    Oudir, S.3
  • 163
    • 44249093233 scopus 로고    scopus 로고
    • Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis
    • Natanson C, Kem SJ, Lurie P, Banks SM, Wolfe SM. Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA. 2008;299:2304–2312.
    • (2008) JAMA. , vol.299 , pp. 2304-2312
    • Natanson, C.1    Kem, S.J.2    Lurie, P.3    Banks, S.M.4    Wolfe, S.M.5
  • 164
    • 85009754849 scopus 로고    scopus 로고
    • Hemoglobin-based blood substitutes and the treatment of sickle cell disease: more harm than help?
    • Alayash AI. Hemoglobin-based blood substitutes and the treatment of sickle cell disease: more harm than help? Biomolecules. 2017; 47(1): pii E2.
    • (2017) Biomolecules. , vol.47 , Issue.1
    • Alayash, A.I.1
  • 165
    • 85019307918 scopus 로고    scopus 로고
    • The pharmacokinetic evaluation of oral administered carbon monoxide instilled in a liquid formulation (CO-LF) to rats to determine carbon monoxide hemoglobin levels with potential efficacy in patients with Sickle Cell Disease (SCD)
    • [Abstract]
    • Gomperts E, Forman HJ, Liu H, Lee M. The pharmacokinetic evaluation of oral administered carbon monoxide instilled in a liquid formulation (CO-LF) to rats to determine carbon monoxide hemoglobin levels with potential efficacy in patients with Sickle Cell Disease (SCD). Am Soc Hematol. 2013. [Abstract]
    • (2013) Am Soc Hematol.
    • Gomperts, E.1    Forman, H.J.2    Liu, H.3    Lee, M.4
  • 166
    • 84973866222 scopus 로고    scopus 로고
    • Heme oxygenase-1 and carbon monoxide in the heart: The balancing act between danger signaling and pro-survival
    • Otterbein LE, Foresti R, Motterlini R. Heme oxygenase-1 and carbon monoxide in the heart: The balancing act between danger signaling and pro-survival. Circ Res. 2016;118(12):1940–1959.
    • (2016) Circ Res. , vol.118 , Issue.12 , pp. 1940-1959
    • Otterbein, L.E.1    Foresti, R.2    Motterlini, R.3
  • 167
    • 0014430658 scopus 로고
    • Carbon monoxide uptake in the gut
    • Coburn RF. Carbon monoxide uptake in the gut. Ann N Y Acad Sci. 1968;150:13–21.
    • (1968) Ann N Y Acad Sci , vol.150 , pp. 13-21
    • Coburn, R.F.1
  • 169
    • 85019336557 scopus 로고    scopus 로고
    • HBI-002, an oral carbon monoxide therapeutic, is a modulator of vaso-occlusion in transgenic sickle cell mice
    • [Abstract]
    • Belcher JD, Gomperts E, Levy H, Otterbein L, Vercellotti GM. HBI-002, an oral carbon monoxide therapeutic, is a modulator of vaso-occlusion in transgenic sickle cell mice. Found Sickle Cell Dis Res. 2017. [Abstract]
    • (2017) Found Sickle Cell Dis Res.
    • Belcher, J.D.1    Gomperts, E.2    Levy, H.3    Otterbein, L.4    Vercellotti, G.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.