Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury

Nature Medicine

Volumn 22, Issue 11, 2016, Pages 1335-1341

  Choi, Yoon Kyung ^a   Maki, Takakuni ^a   Mandeville, Emiri T ^a   Koh, Seong Ho ^a,b   Hayakawa, Kazuhide ^a   Arai, Ken ^a   Kim, Young Myeong ^c   Whalen, Michael J ^a   Xing, Changhong ^a   Wang, Xiaoying ^a   Kim, Kyu Won ^d   Lo, Eng H ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Hanyang University College of Medicine   (South Korea)

^c Kangwon National University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON MONOXIDE; NEURON SPECIFIC NUCLEAR PROTEIN; NITRIC OXIDE SYNTHASE; BROXURIDINE; HIF1A PROTEIN, HUMAN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NERVE PROTEIN; NEUN PROTEIN, MOUSE; NEURONAL NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, HUMAN; NUCLEAR PROTEIN; ORGANOMETALLIC COMPOUND; REACTIVE OXYGEN METABOLITE; TRICARBONYLCHLORO(GLYCINATO)RUTHENIUM(II);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROTECTION; CONTROLLED STUDY; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PATHOPHYSIOLOGY; PERICYTE; PRIORITY JOURNAL; RAT; TRAUMATIC BRAIN INJURY; WORKING MEMORY; ANIMAL; ANIMAL BEHAVIOR; ANTAGONISTS AND INHIBITORS; BRAIN; C57BL MOUSE; CELL CULTURE; CELL PROLIFERATION; CYTOLOGY; DISEASE MODEL; DRUG EFFECTS; GENETICS; HUMAN; HUMAN EMBRYONIC STEM CELL; IMMUNOHISTOCHEMISTRY; MAZE TEST; METABOLISM; NERVE CELL; WESTERN BLOTTING;

ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; BRAIN; BRAIN INJURIES, TRAUMATIC; BROMODEOXYURIDINE; CARBON MONOXIDE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMAN EMBRYONIC STEM CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; IN VITRO TECHNIQUES; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; NEUROGENESIS; NEURONS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; NUCLEAR PROTEINS; ORGANOMETALLIC COMPOUNDS; PERICYTES; REACTIVE OXYGEN SPECIES;

EID: 84988701332     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.4188     Document Type: Article

References (18)

1. Motterlini, R. & Otterbein, L.E. The therapeutic potential of carbon monoxide. Nat. Rev. Drug Discov. 9, 728-743 (2010).
2. Verma, A., Hirsch, D.J., Glatt, C.E., Ronnett, G.V. & Snyder, S.H. Carbon monoxide: a putative neural messenger. Science 259, 381-384 (1993).
3. Loane, D.J. & Faden, A.I. Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies. Trends Pharmacol. Sci. 31, 596-604 (2010).
4. Xiong, Y., Mahmood, A. & Chopp, M. Animal models of traumatic brain injury. Nat. Rev. Neurosci. 14, 128-142 (2013).
5. Xiong, Y., Mahmood, A. & Chopp, M. Emerging treatments for traumatic brain injury. Expert Opin. Emerg. Drugs 14, 67-84 (2009).
6. Wang, G. et al. HDAC inhibition prevents white matter injury by modulating microglia-macrophage polarization through the GSK-3β-PTEN-Akt axis. Proc. Natl. Acad. Sci. USA 112, 2853-2858 (2015).
7. Hu, X. et al. Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles. Prog. Neurobiol. 119-120, 60-84 (2014).
8. Bell, R.D. et al. Pericytes control key neurovascular functions and neuronal phenotype in the adult brain and during brain aging. Neuron 68, 409-427 (2010).
9. Bell, R.D. et al. Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516 (2012).
10. Goldman, S.A. & Chen, Z. Perivascular instruction of cell genesis and fate in the adult brain. Nat. Neurosci. 14, 1382-1389 (2011).
11. Chen, J. et al. The localization of neuronal nitric oxide synthase may infuence its role in neuronal precursor proliferation and synaptic maintenance. Dev. Biol. 269, 165-182 (2004).
12. Yemisci, M. et al. Pericyte contraction induced by oxidative-nitrative stress impairs capillary refow despite successful opening of an occluded cerebral artery. Nat. Med. 15, 1031-1037 (2009).
13. Winkler, E.A., Bell, R.D. & Zlokovic, B.V. Central nervous system pericytes in health and disease. Nat. Neurosci. 14, 1398-1405 (2011).
14. Lo, E.H., Lok, J., Ning, M. & Whalen, M. (eds.) Vascular Mechanisms in CNS Trauma (Springer, New York, 2014).
15. Xing, C. & Lo, E.H. Help-me signaling: non-cell-autonomous mechanisms of neuroprotection and neurorecovery. Prog. Neurobiol. S0301-0082(15)30024-1 (2016).
16. Fujita, T. et al. Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by de-repression of fbrinolysis. Nat. Med. 7, 598-604 (2001).
17. Lo, E.H. Degeneration and repair in central nervous system disease. Nat. Med. 16, 1205-1209 (2010).
18. National Research Council. Guide for the Care and Use of Laboratory Animals 8th edn. (The National Academies Press, 2011).