Use of carbon monoxide as a therapeutic agent: Promises and challenges

Intensive Care Medicine

Volumn 34, Issue 4, 2008, Pages 649-658

  Foresti, Roberta ^a   Bani Hani, Mohamed G ^a   Motterlini, Roberto ^a  

^a NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BORANOCARBONATE; CARBON DIOXIDE; CARBON MONOXIDE; CARBON MONOXIDE RELEASING MOLECULE; CARBONIC ACID DERIVATIVE; CYCLIC GMP; HEME OXYGENASE; HEME OXYGENASE 1; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; PROTOPORPHYRIN COBALT; STEROID; TUMOR NECROSIS FACTOR ALPHA;

ALLERGIC ASTHMA; ANTIHYPERTENSIVE ACTIVITY; ASTHMA; BILIRUBIN BLOOD LEVEL; BIOLOGICAL ACTIVITY; CARBON MONOXIDE BLOOD LEVEL; CARBON MONOXIDE INTOXICATION; CARDIOVASCULAR DISEASE; CATABOLISM; CELL PROTECTION; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; DISEASE MARKER; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ENDOTOXEMIA; EXPERIMENTAL MODEL; HAY FEVER; HEART INFARCTION; HEART PROTECTION; HEPATITIS; HUMAN; HYPOTENSION; INFLAMMATION; INTENSIVE CARE; ISCHEMIA; KIDNEY BLOOD FLOW; LUNG DISEASE; LUNG DYSPLASIA; LUNG INJURY; LUNG TOXICITY; MAMMAL; NEWBORN SEPSIS; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PNEUMONIA; QUANTITATIVE ANALYSIS; RENAL PROTECTION; REPERFUSION INJURY; RESPIRATORY DISTRESS SYNDROME; REVIEW; SEPSIS; SIGNAL TRANSDUCTION; STEROID THERAPY; TISSUE OXYGENATION; TREATMENT RESPONSE; ULCERATIVE COLITIS; VASODILATATION;

ADMINISTRATION, INHALATION; ANTIMETABOLITES; BIOLOGICAL MARKERS; BORANES; CARBON MONOXIDE; CARBONATES; DRUG CARRIERS; HUMANS; ORGANOMETALLIC COMPOUNDS; SIGNAL TRANSDUCTION; VASODILATOR AGENTS;

EID: 43349092136     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-008-1011-1     Document Type: Review

References (95)

1. Piantadosi CA (2002) Biological chemistry of carbon monoxide. Antioxid Redox Signal 4:259-270
2. Gorman D, Drewry A, Huang YL, Sames C (2003) The clinical toxicology of carbon monoxide. Toxicology 187:25-38
3. Maines MD (1997) The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 37:517-554
4. Kim HP, Ryter SW, Choi AM (2006) CO as a Cellular Signaling Molecule. Annu Rev Pharmacol Toxicol 46:411-449
5. Sato K, Balla J, Otterbein L, Smith RN, Brouard S, Lin Y, Csizmadia E, Sevigny J, Robson SC, Vercellotti G, Choi AM, Bach FH, Soares MP (2001) Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplants. J Immunol 166:4185-4194
6. Rosenthal LD (2006) Carbon monoxide poisoning. Immediate diagnosis and treatment are crucial to avoid complications. Am J Nurs 106:40-46
7. Ryter SW, Alam J, Choi AM (2006) Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 86:583-650
8. Otterbein LE, Bach FH, Alam J, Soares M, Tao Lu H, Wysk M, Davis RJ, Flavell RA, Choi AM (2000) Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nature Med 6:422-428
9. Zuckerbraun BS, Chin BY, Wegiel B, Billiar TR, Czsimadia E, Rao J, Shimoda L, Ifedigbo E, Kanno S, Otterbein LE (2006) Carbon monoxide reverses established pulmonary hypertension. J Exp Med 203:2109-2119
10. Otterbein LE, Mantell LL, Choi AMK (1999) Carbon monoxide provides protection against hyperoxic lung injury. Am J Physiol 276:L688-L694
11. Ndisang JF, Tabien HE, Wang R (2004) Carbon monoxide and hypertension. J Hypertens 22:1057-1074
12. Motterlini R, Gonzales A, Foresti R, Clark JE, Green CJ, Winslow RM (1998) Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo. Circ Res 83:568-577
13. Motterlini R, Mann BE, Foresti R (2005) Therapeutic applications of carbon monoxide-releasing molecules (CO-RMs). Expert Opin Investig Drugs 14:1305-1318
14. Boczkowski J, Poderoso JJ, Motterlini R (2006) CO-metal interaction: vital signaling from a lethal gas. Trends Biochem Sci 31:614-621
15. Alberto R, Motterlini R (2007) Chemistry and biological activities of CO-releasing molecules (CORMs) and transition metal complexes. Dalton Trans 17:1651-1660
16. Meyer J, Prien T, Van Aken H, Bone HG, Waurick R, Theilmeier G, Booke M (1998) Arterio-venous carboxyhemoglobin difference suggests carbon monoxide production by human lungs. Biochem Biophys Res Commun 244:230-232
17. Scharte M, von Ostrowski TA, Daudel F, Freise H, Van Aken H, Bone HG (2006) Endogenous carbon monoxide production correlates weakly with severity of acute illness. Eur J Anaesthesiol 23:117-122
18. Zegdi R, Perrin D, Burdin M, Boiteau R, Tenaillon A (2002) Increased endogenous carbon monoxide production in severe sepsis. Intensive Care Med 28:793-796
19. Morimatsu H, Takahashi T, Maeshima K, Inoue K, Kawakami T, Shimizu H, Takeuchi M, Yokoyama M, Katayama H, Morita K (2006) Increased heme catabolism in critically ill patients: correlation among exhaled carbon monoxide, arterial carboxyhemoglobin and serum bilirubin IX{alpha} concentrations. Am J Physiol Lung Cell Mol Physiol 290:L114-L119
20. Hunter K, Mascia M, Eudaric P, Simpkins C (1994) Evidence that carbon monoxide is a mediator of critical illness. Cell Mol Biol (Noisy-le-grand) 40:507-510
21. Shi Y, Pan F, Li H, Pan J, Qin S, Jiang D, Shen C (2000) Plasma carbon monoxide levels in term newborn infants with sepsis. Biol Neonate 78:230-232
22. van Bel F, Latour V, Vreman HJ, Wong RJ, Stevenson DK, Steendijk P, Egberts J, Krediet TG (2005) Is carbon monoxide-mediated cyclic guanosine monophosphate production responsible for low blood pressure in neonatal respiratory distress syndrome? J Appl Physiol 98:1044-1049
23. Sylvester KP, Patey RA, Rafferty GF, Rees D, Thein SL, Greenough A (2005) Exhaled carbon monoxide levels in children with sickle cell disease. Eur J Pediatr 164:162-165
24. Zayasu K, Sekizawa K, Okinaga S, Yamaya M, Ohrui T, Sasaki H (1997) Increased carbon monoxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med 156:1140-1143
25. Andersson JA, Uddman R, Cardell LO (2002) Increased carbon monoxide levels in the nasal airways of subjects with a history of seasonal allergic rhinitis and in patients with upper respiratory tract infection. Clin Exp Allergy 32:224-227
26. Takagi T, Naito Y, Tsuboi H, Isozaki Y, Katada K, Suzuki T, Terao K, Handa O, Kokura S, Ichikawa H, Yoshida N, Okuyama Y, Yagi N, Ueda H, Yoshikawa T (2006) Increased intestinal luminal carbon monoxide gas in patients with ulcerative colitis. Aliment Pharmacol Ther 24 Suppl 4:233-238
27. May C, Patel S, Peacock J, Milner A, Rafferty GF, Greenough A (2007) End-tidal carbon monoxide levels in prematurely born infants developing bronchopulmonary dysplasia. Pediatr Res 61:474-478
28. Terheggen-Lagro SW, Bink MW, Vreman HJ, van der Ent CK (2003) End-tidal carbon monoxide corrected for lung volume is elevated in patients with cystic fibrosis. Am J Respir Crit Care Med 168:1227-1231
29. Tran TT, Martin P, Ly H, Balfe D, Mosenifar Z (2007) Carboxyhemoglobin and its correlation to disease severity in cirrhotics. J Clin Gastroenterol 41:211-215
30. Melley DD, Finney SJ, Elia A, Lagan AL, Quinlan GJ, Evans TW (2007) Arterial carboxyhemoglobin level and outcome in critically ill patients. Crit Care Med 35:1882-1887
31. Fujita T, Toda K, Karimova A, Yan SF, Naka Y, Yet SF, Pinsky DJ (2001) Paradoxical rescue from ischemic lung injury by inhaled carbon monoxide driven by derepression of fibrinolysis. Nat Med 7:598-604
32. Mumby S, Upton RL, Chen Y, Stanford SJ, Quinlan GJ, Nicholson AG, Gutteridge JM, Lamb NJ, Evans TW (2004) Lung heme oxygenase-1 is elevated in acute respiratory distress syndrome. Crit Care Med 32:1130-1135
33. Liu HL, Zhao JY, Chen L (2004) Changes of carbon monoxide, nitric oxide levels and heme oxygenase system in acute respiratory distress syndrome induced by oleic acid. Zhonghua Yu Fang Yi Xue Za Zhi 38:240-243
34. Zegdi R, Fabre O, Lila N, Fornes P, Cambillau M, Shen M, Herve P, Carpentier A, Fabiani JN (2003) Exhaled carbon monoxide and inducible heme oxygenase expression in a rat model of postperfusion acute lung injury. J Thorac Cardiovasc Surg 126:1867-1874
35. Lee PJ, Alam J, Wiegand GW, Choi AMK (1996) Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia. Proc Natl Acad Sci USA 93:10393-10398
36. Tulis DA, Durante W, Peyton KJ, Evans AJ, Schafer AI (2001) Heme oxygenase-1 attenuates vascular remodeling following balloon injury in rat carotid arteries. Atherosclerosis 155:113-122
37. Zhang X, Shan P, Otterbein LE, Alam J, Flavell RA, Davis RJ, Choi AM, Lee PJ (2003) Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3. J Biol Chem 278:1248-1258
38. Foresti R, Green CJ, Motterlini R (2004) Generation of bile pigments by heme oxygenase: a refined cellular stratagem in response to stressful insults. Biochem Soc Symp 71:177-192
39. Chapman JT, Otterbein LE, Elias JA, Choi AM (2001) Carbon monoxide attenuates aeroallergen-induced inflammation in mice. Am J Physiol Lung Cell Mol Physiol 281:L209-L216
40. Song R, Kubo M, Morse D, Zhou Z, Zhang X, Dauber JH, Fabisiak J, Alber SM, Watkins SC, Zuckerbraun BS, Otterbein LE, Ning W, Oury TD, Lee PJ, McCurry KR, Choi AM (2003) Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects. Am J Pathol 163:231-242
41. Otterbein LE, Otterbein SL, Ifedigbo E, Liu F, Morse DE, Fearns C, Ulevitch RJ, Knickelbein R, Flavell RA, Choi AM (2003) MKK3 Mitogen-activated protein kinase pathway mediates carbon monoxide-induced protection against oxidant-induced lung injury. Am J Pathol 163:2555-2563
42. Mishra S, Fujita T, Lama VN, Nam D, Liao H, Okada M, Minamoto K, Yoshikawa Y, Harada H, Pinsky DJ (2006) Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes. Proc Natl Acad Sci USA 103:5191-5196
43. Dolinay T, Szilasi M, Liu M, Choi AM (2004) Inhaled carbon monoxide confers antiinflammatory effects against ventilator-induced lung injury. Am J Respir Crit Care Med 170:613-620
44. Clayton CE, Carraway MS, Suliman HB, Thalmann ED, Thalmann KN, Schmechel DE, Piantadosi CA (2001) Inhaled carbon monoxide and hyperoxic lung injury in rats. Am J Physiol Lung Cell Mol Physiol 281:L949-L957
45. Mazzola S, Forni M, Albertini M, Bacci ML, Zannoni A, Gentilini F, Lavitrano M, Bach FH, Otterbein LE, Clement MG (2005) Carbon monoxide pretreatment prevents respiratory derangement and ameliorates hyperacute endotoxic shock in pigs. FASEB J 19:2045-2047
46. Kohmoto J, Nakao A, Kaizu T, Tsung A, Ikeda A, Tomiyama K, Billiar TR, Choi AM, Murase N, McCurry KR (2006) Low-dose carbon monoxide inhalation prevents ischemia/reperfusion injury of transplanted rat lung grafts. Surgery 140:179-185
47. Willis D, Moore AR, Frederick R, Willoughby DA (1996) Heme oxygenase: a novel target for the modulation of inflammatory response. Nature Med 2:87-90
48. Otterbein LE (2002) Carbon monoxide: innovative anti-inflammatory properties of an age-old gas molecule. Antioxid Redox Signal 4:309-319
49. Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S (1999) Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 103:129-135
50. Tsui TY, Obed A, Siu YT, Yet SF, Prantl L, Schlitt HJ, Fan ST (2007) Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism. Shock 27:165-171
51. Mayr FB, Spiel A, Leitner J, Marsik C, Germann P, Ullrich R, Wagner O, Jilma B (2005) Effects of carbon monoxide inhalation during experimental endotoxemia in humans. Am J Respir Crit Care Med 171:354-360
52. Sarady JK, Zuckerbraun BS, Bilban M, Wagner O, Usheva A, Liu F, Ifedigbo E, Zamora R, Choi AM, Otterbein LE (2004) Carbon monoxide protection against endotoxic shock involves reciprocal effects on iNOS in the lung and liver. FASEB J 18:854-856
53. Sorhaug S, Steinshamn S, Nilsen OG, Waldum HL (2006) Chronic inhalation of carbon monoxide: effects on the respiratory and cardiovascular system at doses corresponding to tobacco smoking. Toxicology 228:280-290
54. Neto JS, Nakao A, Kimizuka K, Romanosky AJ, Stolz DB, Uchiyama T, Nalesnik MA, Otterbein LE, Murase N (2004) Protection of transplant-induced renal ischemia/reperfusion injury with carbon monoxide. Am J Physiol Renal Physiol 287:F979-F989
55. Nakao A, Choi AM, Murase N (2006) Protective effect of carbon monoxide in transplantation. J Cell Mol Med 10:650-671
56. Suliman HB, Carraway MS, Tatro LG, Piantadosi CA (2006) A new activating role for CO in cardiac mitochondrial biogenesis. J Cell Sci 120:299-308
57. Lavitrano M, Smolenski RT, Musumeci A, Maccherini M, Slominska E, Di Florio E, Bracco A, Mancini A, Stassi G, Patti M, Giovannoni R, Froio A, Simeone F, Forni M, Bacci ML, D'Alise G, Cozzi E, Otterbein LE, Yacoub MH, Bach FH, Calise F (2004) Carbon monoxide improves cardiac energetics and safeguards the heart during reperfusion after cardiopulmonary bypass in pigs. FASEB J 18:1093-1095
58. Luckraz H, Tsui SS, Parameshwar J, Wallwork J, Large SR (2001) Improved outcome with organs from carbon monoxide poisoned donors for intrathoracic transplantation. Ann Thorac Surg 72:709-713
59. Sandouka A, Fuller BJ, Mann BE, Green CJ, Foresti R, Motterlini R (2006) Treatment with carbon monoxide-releasing molecules (CO-RMs) during cold storage improves renal function at reperfusion. Kidney Int 69:239-247
60. Wang R, Wang ZZ, Wu LY (1997) Carbon monoxide-induced vasorelaxation and the underlying mechanisms. Br J Pharmacol 121:927-934
61. Johnson FK, Johnson RA (2003) Carbon monoxide promotes endothelium-dependent constriction of isolated gracilis muscle arterioles. Am J Physiol Regul Integr Comp Physiol 285:R536-R541
62. Foresti R, Hammad J, Clark JE, Johnson RA, Mann BE, Friebe A, Green CJ, Motterlini R (2004) Vasoactive properties of CORM-3, a novel water-soluble carbon monoxide-releasing molecule. Br J Pharmacol 142:453-460
63. Hangai-Hoger N, Tsai AG, Cabrales P, Suematsu M, Intaglietta M (2007) Microvascular and systemic effects following top load administration of saturated carbon monoxide-saline solution. Crit Care Med 35:1123-1132
64. Herrmann WA (1990) 100 Years of metal carbonyls. A serendipitous chemical discovery of major scientific and industrial impact. J Organomet Chem 383:21-44
65. Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ (2002) Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res 90:E17-E24
66. Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, Foresti R, Motterlini R (2003) Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res 93:e2-e8
67. Motterlini R, Sawle P, Bains S, Hammad J, Alberto R, Foresti R, Green CJ (2005) CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule. FASEB J 19:284-286
68. Guo Y, Stein AB, Wu WJ, Tan W, Zhu X, Li QH, Dawn B, Motterlini R, Bolli R (2004) Administration of a CO-releasing molecule at the time of reperfusion reduces infarct size in vivo. Am J Physiol Heart Circ Physiol 286:H1649-H1653
69. Musameh MD, Fuller BJ, Mann BE, Green CJ, Motterlini R (2006) Positive inotropic effects of carbon monoxide-releasing molecules (CO-RMs) in the isolated perfused rat heart. Br J Pharmacol 149:1104-1112
70. Sawle P, Foresti R, Mann BE, Johnson TR, Green CJ, Motterlini R (2005) Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages. Br J Pharmacol 145:800-810
71. Bani-Hani MG, Greenstein D, Mann BE, Green CJ, Motterlini R (2006) Modulation of thrombin-induced neuroinflammation in BV-2 microglia by a carbon monoxide-releasing molecule (CORM-3). J Pharmacol Exp Ther 318:1315-1322
72. Urquhart P, Rosignoli G, Cooper D, Motterlini R, Perretti M (2007) Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow. J Pharmacol Exp Ther 321:656-662
73. Freitas A, Alves-Filho JC, Secco DD, Neto AF, Ferreira SH, Barja-Fidalgo C, Cunha FQ (2006) Heme oxygenase/carbon monoxide-biliverdin pathway down regulates neutrophil rolling, adhesion and migration in acute inflammation. Br J Pharmacol 149:345-354
74. Megias J, Busserolles J, Alcaraz MJ (2007) The carbon monoxide-releasing molecule CORM-2 inhibits the inflammatory response induced by cytokines in Caco-2 cells. Br J Pharmacol 150:977-986
75. Vannacci A, Giannini L, Fabrizi F, Uliva C, Mastroianni R, Masini E, Motterlini R, Mannaioni PF (2007) Effects of the carbon monoxide releasing molecule CORM-3 in a coincubation model of rat mast cells with human neutrophils. Inflamm Res 56:S13-S14
76. Chlopicki S, Olszanecki R, Marcinkiewicz E, Lomnicka M, Motterlini R (2006) Carbon monoxide released by CORM-3 inhibits human platelets by a mechanism independent of soluble guanylate cyclase. Cardiovasc Res 71:393-401
77. Fiumana E, Parfenova H, Jagger JH, Leffler CW (2003) Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs. Am J Physiol Heart Circ Physiol 284:H1073-H1079
78. Parfenova H, Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW (2005) Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: contributions of HO-1 and HO-2 to cytoprotection. Am J Physiol Cell Physiol 290:C1399-C1410
79. Li MH, Cha YN, Surh YJ (2006) Carbon monoxide protects PC12 cells from peroxynitrite-induced apoptotic death by preventing the depolarization of mitochondrial transmembrane potential. Biochem Biophys Res Commun 342:990
80. Sun BW, Chen ZY, Chen X, Liu C (2007) Attenuation of leukocytes sequestration by carbon monoxide-releasing molecules: liberated carbon monoxide in the liver of thermally injured mice. J Burn Care Res 28:173-181
81. Allanson M, Reeve VE (2007) Carbon monoxide signalling reduces photocarcinogenesis in the hairless mouse. Cancer Immunol Immunother 56:1807-1815
82. Tayem Y, Johnson TR, Mann BE, Green CJ, Motterlini R (2006) Protection against cisplatin-induced nephrotoxicity by a carbon monoxide-releasing molecule. Am J Physiol Renal Physiol 290:F789-F794
83. Taille C, El-Benna J, Lanone S, Boczkowski J, Motterlini R (2005) Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle. J Biol Chem 280:25350-25360
84. Bolognesi M, Sacerdoti D, Piva A, Di Pascoli M, Zampieri F, Quarta S, Motterlini R, Angeli P, Merkel C, Gatta A (2007) Carbon monoxide-mediated activation of large-conductance calcium-activated potassium channels contributes to mesenteric vasodilatation in cirrhotic rats. J Pharmacol Exp Ther 321:187-194
85. Srisook K, Han SS, Choi HS, Li MH, Ueda H, Kim C, Cha YN (2006) CO from enhanced HO activity or from CORM-2 inhibits both O2- and NO production and downregulates HO-1 expression in LPS-stimulated macrophages. Biochem Pharmacol 71:307-318
86. Sandouka A, Balogun E, Foresti R, Mann BE, Johnson TR, Tayem Y, Green CJ, Fuller B, Motterlini R (2005) Carbon monoxide-releasing molecules (CO-RMs) modulate respiration in isolated mitochondria. Cell Mol Biol 51:425-432
87. Jozkowicz A, Huk I, Nigisch A, Weigel G, Dietrich W, Motterlini R, Dulak J (2003) Heme oxygenase-1 and angiogenic activity of endothelial cells: stimulation by carbon monoxide, inhibition by tin protoporphyrin IX. Antioxid Redox Signal 5:155-162
88. Ryter SW, Otterbein LE (2004) Carbon monoxide in biology and medicine. BioEssays 26:270-280
89. Vera T, Henegar JR, Drummond HA, Rimoldi JM, Stec DE (2005) Protective effect of carbon monoxide-releasing compounds in ischemia-induced acute renal failure. J Am Soc Nephrol 16:950-958
90. Ryan MJ, Jernigan NL, Drummond HA, McLemore GR Jr, Rimoldi JM, Poreddy SR, Gadepalli RS, Stec DE (2006) Renal vascular responses to CORM-A1 in the mouse. Pharmacol Res 54:24-29
91. Sawle P, Hammad J, Fairlamb IJ, Moulton B, O'Brien CT, Lynam JM, Duhme-Klair AK, Foresti R, Motterlini R (2006) Bioactive properties of iron-containing carbon monoxide-releasing molecules (CO-RMs). J Pharmacol Exp Ther 318:403-410
92. Arregui B, Lopez B, Salom MG, Valero F, Navarro C, Fenoy FJ (2004) Acute renal hemodynamic effects of dimanganese decacarbonyl and cobalt protoporphyrin. Kidney Int 65:564-574
93. Botros FT, Navar LG (2006) Interaction between endogenously-produced carbon monoxide and nitric oxide in regulation of renal afferent arterioles. Am J Physiol Heart Circ Physiol 291:H2772-H2778
94. Deshane J, Chen S, Caballero S, Grochot-Przeczek A, Was H, Li CS, Lach R, Hock TD, Chen B, Hill-Kapturczak N, Siegal GP, Dulak J, Jozkowicz A, Grant MB, Agarwal A (2007) Stromal cell-derived factor 1 promotes angiogenesis via a heme oxygenase 1-dependent mechanism. J Exp Med 204:605-618
95. Stein AB, Guo Y, Tan W, Wu WJ, Zhu X, Li Q, Luo C, Dawn B, Johnson TR, Motterlini R, Bolli R (2005) Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction. J Mol Cell Cardiol 38:127-134