PEGylated carboxyhemoglobin bovine (SANGUINATE): Results of a phase I clinical trial

Artificial Organs

Volumn 38, Issue 8, 2014, Pages 702-707

  Misra, Hemant ^a   Lickliter, Jason ^b   Kazo, Friedericke ^a   Abuchowski, Abraham ^a  

^a Prolong Pharmaceuticals   (United States)

^b Nucleus Network Ltd   (Australia)

Author keywords

Clinical trial; Safety; SANGUINATE

Indexed keywords

ARTIFICIAL ORGANS; CARBON MONOXIDE; CONTROLLED DRUG DELIVERY; MEDICAL APPLICATIONS; OXYGEN; TARGETED DRUG DELIVERY;

BLOOD RHEOLOGY; CEREBRAL ISCHEMIA; CLINICAL TRIAL; DUAL ACTION; ISCHAEMIA; PEGYLATED; PHASE I; REACTIVE OXYGEN SPECIES; SANGUINATE; TRANSFER AGENTS;

MAMMALS;

BIOLOGICAL PRODUCT; CARBON MONOXIDE; HAPTOGLOBIN; HEMOGLOBIN; MACROGOL; PLACEBO; SANGUINATE; SODIUM CHLORIDE; UNCLASSIFIED DRUG; CARBOXYHEMOGLOBIN; MACROGOL DERIVATIVE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; DIZZINESS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; DRUG URINE LEVEL; HUMAN; HYPERTENSION; IN VIVO STUDY; LETHARGY; LIMIT OF DETECTION; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; PHARMACOKINETICS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; URINALYSIS; ADOLESCENT; ANIMAL; ANOXIA; BRAIN ISCHEMIA; CLINICAL TRIAL; DISEASE MODEL; MIDDLE AGED; MYOCARDIAL ISCHEMIA; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; YOUNG ADULT;

ANIMALIA; BOVINAE;

ADOLESCENT; ADULT; ANIMALS; ANOXIA; BRAIN ISCHEMIA; CARBOXYHEMOGLOBIN; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MIDDLE AGED; MYOCARDIAL ISCHEMIA; POLYETHYLENE GLYCOLS; SINGLE-BLIND METHOD; YOUNG ADULT;

EID: 84906790540     PISSN: 0160564X     EISSN: 15251594     Source Type: Journal    
DOI: 10.1111/aor.12341     Document Type: Article

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