Carbon monoxide releasing molecule-3 improves myocardial function in mice with sepsis by inhibiting NLRP3 inflammasome activation in cardiac fibroblasts

Basic Research in Cardiology

Volumn 112, Issue 2, 2017, Pages

  Zhang, Wenbo ^a,b   Tao, Aibin ^a,b   Lan, Ting ^b   Cepinskas, Gediminas ^b   Kao, Raymond ^b,c   Martin, Claudio M ^b,c   Rui, Tao ^a,b,c  

^a AFFILIATED PEOPLE S HOSPITAL OF JIANGSU UNIVERSITY   (China)

^b LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^c WESTERN UNIVERSITY   (Canada)

Author keywords

Carbon monoxide; Cardiac fibroblast cardiomyocyte interaction; Myocardial dysfunction; NLRP3 inflammasome; Sepsis

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARBON MONOXIDE RELEASING MOLECULE 3; CELL PROTEIN; CRYOPYRIN; HIGH MOBILITY GROUP B1 PROTEIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG; CARBON MONOXIDE; NLRP3 PROTEIN, MOUSE; ORGANOMETALLIC COMPOUND; TRICARBONYLCHLORO(GLYCINATO)RUTHENIUM(II);

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; HEART FIBROBLAST; HEART FUNCTION; MALE; MOLECULAR DYNAMICS; MOUSE; MYOCARDIAL DISEASE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEPSIS; ANIMAL; APOPTOSIS; C57BL MOUSE; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ENZYME LINKED IMMUNOSORBENT ASSAY; FIBROBLAST; FLUORESCENT ANTIBODY TECHNIQUE; HEART; IMMUNOPRECIPITATION; METABOLISM; PATHOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CARBON MONOXIDE; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; HEART; IMMUNOPRECIPITATION; INFLAMMASOMES; MICE; MICE, INBRED C57BL; MYOCARDIUM; MYOCYTES, CARDIAC; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; ORGANOMETALLIC COMPOUNDS; SEPSIS;

EID: 85011903583     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-017-0603-8     Document Type: Article

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