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Volumn 26, Issue 5, 2017, Pages 603-617

Investigational therapies for hypercholesterolemia

Author keywords

) PCSK9: low density lipoprotein; Apolipoprotein A1; Apolipoprotein Clll; cholesteryl ester transfer protein (CETP); diabetes; dyslipidaemia; LDL receptor: microsomal triglyceride transfer protein (MTP); lipoprotein (a); low density lipoprotein LDL; Niemann Pick C1 like1 (NPC1 L1); Triglyceride

Indexed keywords

ABC TRANSPORTER A1; ALIROCUMAB; ANGIOPOIETIN; ANGIOPOIETIN 8; APOLIPOPROTEIN A5; CHOLESTEROL; COMPLEMENTARY RNA; DIACYLGLYCEROL ACYLTRANSFERASE 1; EVOLOCUMAB; HUMAN MONOCLONAL ANTIBODY; LIPOPROTEIN; LOMITAPIDE; LOW DENSITY LIPOPROTEIN RECEPTOR; MICRORNA; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; PIOGLITAZONE; PROPROTEIN CONVERTASE 9; UNCLASSIFIED DRUG; HYPOCHOLESTEROLEMIC AGENT; NEW DRUG; TRIACYLGLYCEROL;

EID: 85018636307     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1080/13543784.2017.1315407     Document Type: Review
Times cited : (4)

References (137)
  • 1
    • 84937216336 scopus 로고    scopus 로고
    • Association of cardiometabolic multimorbidity with mortality
    • Di Angelantonio E, Kaptoge S, Wormser D, et al.; Emerging Risk Factors Collaboration. Association of cardiometabolic multimorbidity with mortality. JAMA. 2015;314:52–60.
    • (2015) JAMA , vol.314 , pp. 52-60
    • Di Angelantonio, E.1    Kaptoge, S.2    Wormser, D.3
  • 2
    • 85018644407 scopus 로고    scopus 로고
    • American diabetes guidelines
    • American diabetes guidelines. Diabetes Care. 2016;(supl 1):S13–22.
    • (2016) Diabetes Care , Issue.supl 1 , pp. S13-S22
  • 3
    • 70350121639 scopus 로고    scopus 로고
    • Investigators. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes: an analysis from the Collaborative Atorvastatin Diabetes Study (CARDS)
    • Colhoun HM, Betteridge DJ, Durrington PN, et al. Investigators. Effects of atorvastatin on kidney outcomes and cardiovascular disease in patients with diabetes:an analysis from the Collaborative Atorvastatin Diabetes Study (CARDS). Am J Kidney Dis. 2009;54:810–819.
    • (2009) Am J Kidney Dis , vol.54 , pp. 810-819
    • Colhoun, H.M.1    Betteridge, D.J.2    Durrington, P.N.3
  • 4
    • 84897970506 scopus 로고    scopus 로고
    • 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American college of cardiology/American heart association task force on practice guidelines
    • Stone NJ, Robinson JG, Lichtenstein AH., 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults:a report of the American college of cardiology/American heart association task force on practice guidelines. Circulation. 2014;129:S1–45.
    • (2014) Circulation , vol.129 , pp. S1-S45
    • Stone, N.J.1    Robinson, J.G.2    Lichtenstein, A.H.3
  • 5
    • 84904497282 scopus 로고    scopus 로고
    • Lipid modification and cardiovascular risk assessment for the primary and secondary prevention of cardiovascular disease: summary of updated NICE guidance
    • Rabar S, Harker M, O’Flynn N, et al., Guideline Development Group. Lipid modification and cardiovascular risk assessment for the primary and secondary prevention of cardiovascular disease:summary of updated NICE guidance. Bmj. 2014;349:g4356.
    • (2014) Bmj , vol.349 , pp. g4356
    • Rabar, S.1    Harker, M.2    O’Flynn, N.3
  • 6
    • 4544275379 scopus 로고    scopus 로고
    • Coordinating committee of the national cholesterol education program. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines
    • Review
    • Grundy SM, Cleeman JI, Merz CN, et al. Coordinating committee of the national cholesterol education program. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III Guidelines. J Am Coll Cardiol. 2004;44:720–732. Review.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 720-732
    • Grundy, S.M.1    Cleeman, J.I.2    Merz, C.N.3
  • 7
    • 0035897696 scopus 로고    scopus 로고
    • Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III)
    • Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive summary of the third report of the national cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (adult treatment panel III). Jama. 2001;285:2486–2497.
    • (2001) Jama , vol.285 , pp. 2486-2497
  • 8
    • 84927521244 scopus 로고    scopus 로고
    • Lipid target achievement among patients with very high and high cardiovascular risk in a lipid clinic
    • Barkas F, Liberopoulos EN, Kostapanos MS, et al. Lipid target achievement among patients with very high and high cardiovascular risk in a lipid clinic. Angiology. 2015;66:346–353.
    • (2015) Angiology , vol.66 , pp. 346-353
    • Barkas, F.1    Liberopoulos, E.N.2    Kostapanos, M.S.3
  • 9
    • 84929872143 scopus 로고    scopus 로고
    • Attainment of multifactorial treatment targets among the elderly in a lipid clinic
    • Barkas F, Liberopoulos E, Klouras E, et al. Attainment of multifactorial treatment targets among the elderly in a lipid clinic. J Geriatr Cardiol. 2015;12:239–245.• A study to show that expert lipid clinics are less effective than we might expect.
    • (2015) J Geriatr Cardiol , vol.12 , pp. 239-245
    • Barkas, F.1    Liberopoulos, E.2    Klouras, E.3
  • 10
    • 84862119222 scopus 로고    scopus 로고
    • European guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts)
    • Perk J, De Backer G, Gohlke H, et al. European guidelines on cardiovascular disease prevention in clinical practice (version 2012). The fifth joint task force of the European society of cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur Heart J. 2012;33:1635–1701.
    • (2012) Eur Heart J , vol.33 , pp. 1635-1701
    • Perk, J.1    De Backer, G.2    Gohlke, H.3
  • 11
    • 84988672681 scopus 로고    scopus 로고
    • 2016 European Guidelines on cardiovascular disease prevention in clinical practice: the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
    • Piepoli MF, Hoes AW, Agewall S, et al.; Task Force Members. 2016 European Guidelines on cardiovascular disease prevention in clinical practice:the Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts) Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Atherosclerosis. 2016;252:207–274.
    • (2016) Atherosclerosis , vol.252 , pp. 207-274
    • Piepoli, M.F.1    Hoes, A.W.2    Agewall, S.3
  • 12
    • 84947313617 scopus 로고    scopus 로고
    • Metabolic dyslipidemia and risk of coronary heart disease in 28,318 adults with diabetes mellitus and low-density lipoprotein cholesterol <100 mg/dl
    • Rana JS, Liu JY, Moffet HH, et al. Metabolic dyslipidemia and risk of coronary heart disease in 28,318 adults with diabetes mellitus and low-density lipoprotein cholesterol <100 mg/dl. Am J Cardiol. 2015;116:1700–1704.
    • (2015) Am J Cardiol , vol.116 , pp. 1700-1704
    • Rana, J.S.1    Liu, J.Y.2    Moffet, H.H.3
  • 13
    • 20444371945 scopus 로고    scopus 로고
    • The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1)
    • Jun
    • Garcia-Calvo M, Lisnock J, Bull HG, et al. The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8132–8137.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.23 , pp. 8132-8137
    • Garcia-Calvo, M.1    Lisnock, J.2    Bull, H.G.3
  • 14
    • 77954509575 scopus 로고    scopus 로고
    • Atherosclerosis, diabetes and lipoproteins
    • Tomkin GH., Atherosclerosis, diabetes and lipoproteins. Expert Rev Cardiovasc Ther. 2010;8:1015–1029.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , pp. 1015-1029
    • Tomkin, G.H.1
  • 15
    • 84940753794 scopus 로고    scopus 로고
    • Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states
    • Lino M, Farr S, Baker C, et al. Intestinal scavenger receptor class B type I as a novel regulator of chylomicron production in healthy and diet-induced obese states. Am J Physiol Gastrointest Liver Physiol. 2015;309:G350–9.• A new player in chylomicron regulation. May become a target for treatment.
    • (2015) Am J Physiol Gastrointest Liver Physiol , vol.309 , pp. G350-G359
    • Lino, M.1    Farr, S.2    Baker, C.3
  • 16
    • 84954569743 scopus 로고    scopus 로고
    • Upate on the molecular biology of dyslipidemias
    • Ramasamy I. Upate on the molecular biology of dyslipidemias. Clin Chim Acta. 2016;454:143–185.•• A wonderful review and very well referenced.
    • (2016) Clin Chim Acta , vol.454 , pp. 143-185
    • Ramasamy, I.1
  • 17
    • 84958903756 scopus 로고    scopus 로고
    • Icosabutate for the treatment of very high triglycerides: A placebo-controlled, randomized, double- blind, 12-week clinical trial
    • Bays HE, Hallén J, Vige R, et al. Icosabutate for the treatment of very high triglycerides:A placebo-controlled, randomized, double- blind, 12-week clinical trial. J Clin Lipidol. 2016;10:181–191.
    • (2016) J Clin Lipidol , vol.10 , pp. 181-191
    • Bays, H.E.1    Hallén, J.2    Vige, R.3
  • 18
    • 57649233035 scopus 로고    scopus 로고
    • Acylation of acylglycerols by acyl coenzyme A: diacylglycerolacyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption
    • Cheng D, Iqbal J, Devenny J, et al. Acylation of acylglycerols by acyl coenzyme A:diacylglycerolacyltransferase 1 (DGAT1). Functional importance of DGAT1 in the intestinal fat absorption. J Biol Chem. 2008;283:29802–29811.
    • (2008) J Biol Chem , vol.283 , pp. 29802-29811
    • Cheng, D.1    Iqbal, J.2    Devenny, J.3
  • 19
    • 84924958950 scopus 로고    scopus 로고
    • Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome
    • Meyers CD, Tremblay K, Amer A, et al. Effect of the DGAT1 inhibitor pradigastat on triglyceride and apoB48 levels in patients with familial chylomicronemia syndrome. Lipids Health Dis. 2015;14:8.
    • (2015) Lipids Health Dis , vol.14 , pp. 8
    • Meyers, C.D.1    Tremblay, K.2    Amer, A.3
  • 20
    • 84964543730 scopus 로고    scopus 로고
    • The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking
    • Zhang R. The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking. Open Biol. 2016;6:150272.
    • (2016) Open Biol , vol.6 , pp. 150272
    • Zhang, R.1
  • 21
    • 84937132242 scopus 로고    scopus 로고
    • ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys
    • Gusarova V, Alexa CA, Wang Y, et al. ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys. J Lipid Res. 2015;56:1308–1317.
    • (2015) J Lipid Res , vol.56 , pp. 1308-1317
    • Gusarova, V.1    Alexa, C.A.2    Wang, Y.3
  • 23
    • 84859163688 scopus 로고    scopus 로고
    • Apolipoprotein A-V dependent modulation of plasma triacylglycerol: a puzzlement
    • Sharma V, Ryan RO, Forte TM. Apolipoprotein A-V dependent modulation of plasma triacylglycerol:a puzzlement. Biochim Biophys Acta. 2012;1821:795–799.
    • (2012) Biochim Biophys Acta , vol.1821 , pp. 795-799
    • Sharma, V.1    Ryan, R.O.2    Forte, T.M.3
  • 24
    • 84875222908 scopus 로고    scopus 로고
    • Influence of apolipoprotein A-V on the metabolic fate of triacylglycerol
    • Sharma V, Forte TM, Ryan RO. Influence of apolipoprotein A-V on the metabolic fate of triacylglycerol. Curr Opin Lipidol. 2013;24:153–159.
    • (2013) Curr Opin Lipidol , vol.24 , pp. 153-159
    • Sharma, V.1    Forte, T.M.2    Ryan, R.O.3
  • 25
    • 84975463212 scopus 로고    scopus 로고
    • Apolipoprotein A-V gene therapy for disease prevention /treatment: a critical analysis
    • Forte TM, Sharma V, Ryan RO. Apolipoprotein A-V gene therapy for disease prevention /treatment:a critical analysis. J Biomed Res. 2015;30:88–93.• An excellent review of a fascinating relatively new player in triglyceride metabolism.
    • (2015) J Biomed Res , vol.30 , pp. 88-93
    • Forte, T.M.1    Sharma, V.2    Ryan, R.O.3
  • 26
    • 84871945617 scopus 로고    scopus 로고
    • Phase 3 HoFH Lomitapide Study investigators. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia: a single-arm, open- label, phase 3 study
    • Cuchel M, Meagher EA, Du Toit TH, et al. Phase 3 HoFH Lomitapide Study investigators. Efficacy and safety of a microsomal triglyceride transfer protein inhibitor in patients with homozygous familial hypercholesterolaemia:a single-arm, open- label, phase 3 study. Lancet. 2013;381:40–46.
    • (2013) Lancet , vol.381 , pp. 40-46
    • Cuchel, M.1    Meagher, E.A.2    Du Toit, T.H.3
  • 27
    • 84952700857 scopus 로고    scopus 로고
    • LOWER investigators. LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia: rationale and design
    • Blom DJ, Fayad ZA, Kastelein JJ, et al. LOWER investigators. LOWER, a registry of lomitapide-treated patients with homozygous familial hypercholesterolemia:rationale and design. J Clin Lipidol. 2016;10:273–282.
    • (2016) J Clin Lipidol , vol.10 , pp. 273-282
    • Blom, D.J.1    Fayad, Z.A.2    Kastelein, J.J.3
  • 28
    • 26844580001 scopus 로고    scopus 로고
    • JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs
    • Aggarwal D, West KL, Zern TL, et al. JTT-130, a microsomal triglyceride transfer protein (MTP) inhibitor lowers plasma triglycerides and LDL cholesterol concentrations without increasing hepatic triglycerides in guinea pigs. BMC Cardiovasc Disord. 2005;5:30.
    • (2005) BMC Cardiovasc Disord , vol.5 , pp. 30
    • Aggarwal, D.1    West, K.L.2    Zern, T.L.3
  • 29
    • 78751531122 scopus 로고    scopus 로고
    • Pharmacological characterization of diethyl-2- (3-dimethylcarbamoyl-4-[(4ʹ-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT- 130), an intestine-specific inhibitor of microsomal triglyceride transfer protein
    • Mera Y, Odani N, Kawai T, et al. Pharmacological characterization of diethyl-2- (3-dimethylcarbamoyl-4-[(4ʹ-trifluoromethylbiphenyl-2-carbonyl)amino]phenyl}acetyloxymethyl)-2-phenylmalonate (JTT- 130), an intestine-specific inhibitor of microsomal triglyceride transfer protein. J Pharmacol Exp Ther. 2011;336:321–327.
    • (2011) J Pharmacol Exp Ther , vol.336 , pp. 321-327
    • Mera, Y.1    Odani, N.2    Kawai, T.3
  • 30
    • 84880288761 scopus 로고    scopus 로고
    • MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion
    • Soh J, Iqbal J, Queiroz J, et al. MicroRNA-30c reduces hyperlipidemia and atherosclerosis in mice by decreasing lipid synthesis and lipoprotein secretion. Nat Med. 2013;19:892–900.
    • (2013) Nat Med , vol.19 , pp. 892-900
    • Soh, J.1    Iqbal, J.2    Queiroz, J.3
  • 31
    • 84959064263 scopus 로고    scopus 로고
    • MicroRNA regulation of atherosclerosis
    • Feinberg MW, Moore KJ. MicroRNA regulation of atherosclerosis. Circ Res. 2016;118:703–720.•• MicroRNAs are here to stay. An excellent review of their potential importance.
    • (2016) Circ Res , vol.118 , pp. 703-720
    • Feinberg, M.W.1    Moore, K.J.2
  • 32
    • 84956696730 scopus 로고    scopus 로고
    • microRNAs in lipoprotein metabolism and cardiometabolic disorders
    • Rotllan N, Price N, Pati P, et al. microRNAs in lipoprotein metabolism and cardiometabolic disorders. Atherosclerosis. 2016;246:352–360.
    • (2016) Atherosclerosis , vol.246 , pp. 352-360
    • Rotllan, N.1    Price, N.2    Pati, P.3
  • 33
    • 84953425720 scopus 로고    scopus 로고
    • Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and associated with better outcomes in IMPROVE-IT
    • Bohula EA, Giugliano RP, Cannon CP, et al. Achievement of dual low-density lipoprotein cholesterol and high-sensitivity C-reactive protein targets more frequent with the addition of ezetimibe to simvastatin and associated with better outcomes in IMPROVE-IT. Circulation. 2015;132:1224–1233.
    • (2015) Circulation , vol.132 , pp. 1224-1233
    • Bohula, E.A.1    Giugliano, R.P.2    Cannon, C.P.3
  • 34
    • 84959370789 scopus 로고    scopus 로고
    • Reduction in total cardiovascular events with ezetimibe/simvastatin post-acute coronary syndrome: the IMPROVE-IT trial
    • Murphy SA, Cannon CP, Blazing MA, et al. Reduction in total cardiovascular events with ezetimibe/simvastatin post-acute coronary syndrome:the IMPROVE-IT trial. J Am Coll Cardiol. 2016;67:353–361.
    • (2016) J Am Coll Cardiol , vol.67 , pp. 353-361
    • Murphy, S.A.1    Cannon, C.P.2    Blazing, M.A.3
  • 35
    • 85008315576 scopus 로고    scopus 로고
    • Combination therapy of rosuvastatin and ezetimibe in patients with high cardiovascular risk
    • Yang YJ, Lee SH, Kim BS, et al. Combination therapy of rosuvastatin and ezetimibe in patients with high cardiovascular risk. Clin Ther. 2017;39:107–117.
    • (2017) Clin Ther , vol.39 , pp. 107-117
    • Yang, Y.J.1    Lee, S.H.2    Kim, B.S.3
  • 36
    • 77951490605 scopus 로고    scopus 로고
    • Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low- density lipoprotein phenotype
    • Zheng C, Khoo C, Furtado J, et al. Apolipoprotein C-III and the metabolic basis for hypertriglyceridemia and the dense low- density lipoprotein phenotype. Circulation. 2010;121:1722–1734.
    • (2010) Circulation , vol.121 , pp. 1722-1734
    • Zheng, C.1    Khoo, C.2    Furtado, J.3
  • 37
    • 0021798836 scopus 로고
    • Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver
    • Windler E, Havel RJ. Inhibitory effects of C apolipoproteins from rats and humans on the uptake of triglyceride-rich lipoproteins and their remnants by the perfused rat liver. J Lipid Res. 1985;26:556–565.
    • (1985) J Lipid Res , vol.26 , pp. 556-565
    • Windler, E.1    Havel, R.J.2
  • 38
    • 80855152977 scopus 로고    scopus 로고
    • Low-density lipoproteins containing apolipoprotein C-III and the risk of coronary heart disease
    • Mendivil CO, Rimm EB, Furtado J, et al. Low-density lipoproteins containing apolipoprotein C-III and the risk of coronary heart disease. Circulation. 2011;124:2065–2072.
    • (2011) Circulation , vol.124 , pp. 2065-2072
    • Mendivil, C.O.1    Rimm, E.B.2    Furtado, J.3
  • 39
    • 84938070383 scopus 로고    scopus 로고
    • The risk of cardiovascular events with increased apolipoprotein CIII: A systematic review and meta-analysis
    • Wyler Von Ballmoos MC, Haring B, Sacks FM. The risk of cardiovascular events with increased apolipoprotein CIII:A systematic review and meta-analysis. J Clin Lipidol. 2015;9:498–510.•• The authors believe apo C111 is a most exciting new player in atherosclerosis.
    • (2015) J Clin Lipidol , vol.9 , pp. 498-510
    • Wyler Von Ballmoos, M.C.1    Haring, B.2    Sacks, F.M.3
  • 40
    • 84938401608 scopus 로고    scopus 로고
    • Antisense inhibition of apolipoprotein C-III in patients with hypertriglyceridemia
    • Gaudet D, Alexander VJ, Baker BF, et al. Antisense inhibition of apolipoprotein C-III in patients with hypertriglyceridemia. N Engl J Med. 2015;373:438–447.
    • (2015) N Engl J Med , vol.373 , pp. 438-447
    • Gaudet, D.1    Alexander, V.J.2    Baker, B.F.3
  • 41
    • 84963836241 scopus 로고    scopus 로고
    • Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy: phase 2 randomized trial results
    • Yang X, Lee SR, Choi YS, et al. Reduction in lipoprotein-associated apoC-III levels following volanesorsen therapy:phase 2 randomized trial results. J Lipid Res. 2016;57:706–713.
    • (2016) J Lipid Res , vol.57 , pp. 706-713
    • Yang, X.1    Lee, S.R.2    Choi, Y.S.3
  • 42
    • 84980396029 scopus 로고    scopus 로고
    • Antisense-mediated lowering of plasma apolipoprotein C-III by volanesorsen improves dyslipidemia and insulin sensitivity in type 2
    • Digenio A, Dunbar RL, Alexander VJ, et al. Antisense-mediated lowering of plasma apolipoprotein C-III by volanesorsen improves dyslipidemia and insulin sensitivity in type 2. Diabetes Care. 2016;39:1408–1415.
    • (2016) Diabetes Care , vol.39 , pp. 1408-1415
    • Digenio, A.1    Dunbar, R.L.2    Alexander, V.J.3
  • 45
    • 15444357807 scopus 로고    scopus 로고
    • A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor
    • Bisgaier CL, Essenburg AD, Barnett BC, et al. A novel compound that elevates high density lipoprotein and activates the peroxisome proliferator activated receptor. J Lipid Res. 1998;39:17–30.
    • (1998) J Lipid Res , vol.39 , pp. 17-30
    • Bisgaier, C.L.1    Essenburg, A.D.2    Barnett, B.C.3
  • 46
    • 33644812717 scopus 로고    scopus 로고
    • Model-based development of gemcabene, a new lipid-altering agent
    • Mandema JW, Hermann D, Wang W, et al. Model-based development of gemcabene, a new lipid-altering agent. Aaps J. 2005;7:E513–22.
    • (2005) Aaps J , vol.7 , pp. E513-E522
    • Mandema, J.W.1    Hermann, D.2    Wang, W.3
  • 47
    • 84994106781 scopus 로고    scopus 로고
    • Efficacy and safety of gemcabene as add- on to stable statin therapy in hypercholesterolemic patients
    • Stein E, Bays H, Koren M, et al. Efficacy and safety of gemcabene as add- on to stable statin therapy in hypercholesterolemic patients. J Clin Lipidol. 2016;10:1212–1222.
    • (2016) J Clin Lipidol , vol.10 , pp. 1212-1222
    • Stein, E.1    Bays, H.2    Koren, M.3
  • 48
    • 84924415690 scopus 로고    scopus 로고
    • Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia: 2- year interim results of an open-label extension
    • Santos RD, Duell PB, East C, et al. Long-term efficacy and safety of mipomersen in patients with familial hypercholesterolaemia:2- year interim results of an open-label extension. Eur Heart J. 2015;36:566–575.
    • (2015) Eur Heart J , vol.36 , pp. 566-575
    • Santos, R.D.1    Duell, P.B.2    East, C.3
  • 49
    • 84928823457 scopus 로고    scopus 로고
    • Mipomersen preferentially reduces small low-density lipoprotein particle number in patients with hypercholesterolemia
    • Santos RD, Raal FJ, Donovan JM, et al. Mipomersen preferentially reduces small low-density lipoprotein particle number in patients with hypercholesterolemia. J Clin Lipidol. 2015;9:201–209.
    • (2015) J Clin Lipidol , vol.9 , pp. 201-209
    • Santos, R.D.1    Raal, F.J.2    Donovan, J.M.3
  • 50
    • 84928824286 scopus 로고    scopus 로고
    • Efficacy and safety of mipomersen in treatment of dyslipidemia: a meta-analysis of randomized controlled trials
    • Panta R, Dahal K, Kunwar S. Efficacy and safety of mipomersen in treatment of dyslipidemia:a meta-analysis of randomized controlled trials. J Clin Lipidol. 2015;9:217–225.
    • (2015) J Clin Lipidol , vol.9 , pp. 217-225
    • Panta, R.1    Dahal, K.2    Kunwar, S.3
  • 51
    • 84978529098 scopus 로고    scopus 로고
    • Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia
    • Duell PB, Santos RD, Kirwan BA, et al. Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia. J Clin Lipidol. 2016;10:1011–1021.
    • (2016) J Clin Lipidol , vol.10 , pp. 1011-1021
    • Duell, P.B.1    Santos, R.D.2    Kirwan, B.A.3
  • 52
    • 84963959871 scopus 로고    scopus 로고
    • Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia
    • Raal FJ, Braamskamp MJ, Selvey SL, et al. Pediatric experience with mipomersen as adjunctive therapy for homozygous familial hypercholesterolemia. J Clin Lipidol. 2016;10:860–869.
    • (2016) J Clin Lipidol , vol.10 , pp. 860-869
    • Raal, F.J.1    Braamskamp, M.J.2    Selvey, S.L.3
  • 53
    • 84925638146 scopus 로고    scopus 로고
    • Apolipoprotein B-100- targeted negatively charged nanoliposomes for the treatment of dyslipidemia
    • Sahebkar A, Badiee A, Hatamipour M, et al. Apolipoprotein B-100- targeted negatively charged nanoliposomes for the treatment of dyslipidemia. Colloids Surf B Biointerfaces. 2015;129:71–78.
    • (2015) Colloids Surf B Biointerfaces , vol.129 , pp. 71-78
    • Sahebkar, A.1    Badiee, A.2    Hatamipour, M.3
  • 54
    • 84881259052 scopus 로고    scopus 로고
    • Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression
    • Parker RA, Garcia R, Ryan CS, et al. Bile acid and sterol metabolism with combined HMG-CoA reductase and PCSK9 suppression. J Lipid Res. 2013;54:2400–2409.
    • (2013) J Lipid Res , vol.54 , pp. 2400-2409
    • Parker, R.A.1    Garcia, R.2    Ryan, C.S.3
  • 55
    • 84921262461 scopus 로고    scopus 로고
    • On the function and homeostasis of PCSK9: reciprocal interaction with LDLR and additional lipid effects
    • Tavori H, Rashid S, Fazio S. On the function and homeostasis of PCSK9:reciprocal interaction with LDLR and additional lipid effects. Atherosclerosis. 2015;238:264–270.
    • (2015) Atherosclerosis , vol.238 , pp. 264-270
    • Tavori, H.1    Rashid, S.2    Fazio, S.3
  • 56
    • 85002734003 scopus 로고    scopus 로고
    • Effect of evolocumab on cholesterol synthesis and absorption
    • Peach M, Xu R, Fitzpatrick D, et al. Effect of evolocumab on cholesterol synthesis and absorption. J Lipid Res. 2016;57(12):2217–2224.
    • (2016) J Lipid Res , vol.57 , Issue.12 , pp. 2217-2224
    • Peach, M.1    Xu, R.2    Fitzpatrick, D.3
  • 57
    • 84975155684 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin type 9 and high-density lipoprotein metabolism: experimental animal models and clinical evidence
    • Ferri N, Corsini A, Macchi C, et al. Proprotein convertase subtilisin kexin type 9 and high-density lipoprotein metabolism:experimental animal models and clinical evidence. Transl Res. 2016;173:19–29.
    • (2016) Transl Res , vol.173 , pp. 19-29
    • Ferri, N.1    Corsini, A.2    Macchi, C.3
  • 58
    • 84979752705 scopus 로고    scopus 로고
    • PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement
    • Ferri N, Marchianò S, Tibolla G, et al. PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement. Atherosclerosis. 2016;253:214–224.
    • (2016) Atherosclerosis , vol.253 , pp. 214-224
    • Ferri, N.1    Marchianò, S.2    Tibolla, G.3
  • 59
    • 84947976529 scopus 로고    scopus 로고
    • Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients: the ODYSSEY OPTIONS II randomized trial
    • Farnier M, Jones P, Severance R, et al. Efficacy and safety of adding alirocumab to rosuvastatin versus adding ezetimibe or doubling the rosuvastatin dose in high cardiovascular-risk patients:the ODYSSEY OPTIONS II randomized trial. Atherosclerosis. 2016;244:138–146.
    • (2016) Atherosclerosis , vol.244 , pp. 138-146
    • Farnier, M.1    Jones, P.2    Severance, R.3
  • 60
    • 84921483643 scopus 로고    scopus 로고
    • RUTHERFORD-2 Investigators. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial
    • Raal FJ, Stein EA, Dufour R, et al. RUTHERFORD-2 Investigators. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2):a randomised, double-blind, placebo-controlled trial. Lancet. 2015;385:331–340.
    • (2015) Lancet , vol.385 , pp. 331-340
    • Raal, F.J.1    Stein, E.A.2    Dufour, R.3
  • 61
    • 84947965019 scopus 로고    scopus 로고
    • ODYSSEY ALTERNATIVE Investigators Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin re-challenge arm: the ODYSSEY ALTERNATIVE randomized trial
    • Moriarty PM, Thompson PD, Cannon CP, et al. ODYSSEY ALTERNATIVE Investigators Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin re-challenge arm:the ODYSSEY ALTERNATIVE randomized trial. J Clin Lipidol. 2015;9:758–769.
    • (2015) J Clin Lipidol , vol.9 , pp. 758-769
    • Moriarty, P.M.1    Thompson, P.D.2    Cannon, C.P.3
  • 62
    • 84957644236 scopus 로고    scopus 로고
    • Effect of alirocumab on specific lipoprotein non-high-density lipoprotein cholesterol and subfractions as measured by the vertical auto profile method: analysis of 3 randomized trials versus placebo
    • Toth PP, Hamon SC, Jones SR, et al. Effect of alirocumab on specific lipoprotein non-high-density lipoprotein cholesterol and subfractions as measured by the vertical auto profile method:analysis of 3 randomized trials versus placebo. Lipids Health Dis. 2016;13(15):28.
    • (2016) Lipids Health Dis , vol.13 , Issue.15 , pp. 28
    • Toth, P.P.1    Hamon, S.C.2    Jones, S.R.3
  • 63
    • 84992221814 scopus 로고    scopus 로고
    • Safety of alirocumab (A PCSK9 Monoclonal Antibody) from 14 randomized trials
    • ;15(118):1805–1811
    • Jones PH, Bays HE, Chaudhari U, et al. Safety of alirocumab (A PCSK9 Monoclonal Antibody) from 14 randomized trials. Am J Cardiol. 2016;15(118):1805–1811.
    • (2016) Am J Cardiol
    • Jones, P.H.1    Bays, H.E.2    Chaudhari, U.3
  • 64
    • 84987890774 scopus 로고    scopus 로고
    • No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies
    • Colhoun HM, Ginsberg HN, Robinson JG, et al. No effect of PCSK9 inhibitor alirocumab on the incidence of diabetes in a pooled analysis from 10 ODYSSEY Phase 3 studies. Eur Heart J. 2016;14(37):2981–2989.
    • (2016) Eur Heart J
    • Colhoun, H.M.1    Ginsberg, H.N.2    Robinson, J.G.3
  • 65
    • 84926206074 scopus 로고    scopus 로고
    • Open-label study of long-term evaluation against LDL Cholesterol (OSLER) Investigators.Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
    • Sabatine MS, Giugliano RP, Wiviott SD, et al. Open-label study of long-term evaluation against LDL Cholesterol (OSLER) Investigators.Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med. 2015;372:1500–1509.• An example of the efficacy of PCSK9 inhibitors in reducing LDL cholesterol and getting patients to target.
    • (2015) N Engl J Med , vol.372 , pp. 1500-1509
    • Sabatine, M.S.1    Giugliano, R.P.2    Wiviott, S.D.3
  • 66
    • 85007568915 scopus 로고    scopus 로고
    • Effect of evolocumab on progression of coronary disease in statin-treated patients: the GLAGOV randomized clinical trial
    • Nicholls SJ, Puri R, Anderson T, et al. Effect of evolocumab on progression of coronary disease in statin-treated patients:the GLAGOV randomized clinical trial. Jama. 2016;316:2373–2384.
    • (2016) Jama , vol.316 , pp. 2373-2384
    • Nicholls, S.J.1    Puri, R.2    Anderson, T.3
  • 67
    • 84957928187 scopus 로고    scopus 로고
    • Lipid-lowering efficacy of the PCSK9 inhibitor evolocumab (AMG 145) in patients with type 2 diabetes: a meta-analysis of individual patient data
    • Sattar N, Preiss D, Robinson JG, et al. Lipid-lowering efficacy of the PCSK9 inhibitor evolocumab (AMG 145) in patients with type 2 diabetes:a meta-analysis of individual patient data. Lancet Diabetes Endocrinol. 2016;4:403–410.
    • (2016) Lancet Diabetes Endocrinol , vol.4 , pp. 403-410
    • Sattar, N.1    Preiss, D.2    Robinson, J.G.3
  • 68
    • 84994051920 scopus 로고    scopus 로고
    • Effect of alirocumab on lipoprotein(a) Over ≥1.5 Years (from the Phase 3 ODYSSEY Program)
    • Gaudet D, Watts GF, Robinson JG, et al. Effect of alirocumab on lipoprotein(a) Over ≥1.5 Years (from the Phase 3 ODYSSEY Program). Am J Cardiol. 2017;119:40–46.
    • (2017) Am J Cardiol , vol.119 , pp. 40-46
    • Gaudet, D.1    Watts, G.F.2    Robinson, J.G.3
  • 69
    • 84979942215 scopus 로고    scopus 로고
    • Therapeutic efficacy of PCSK9 monoclonal antibodies in statin-nonresponsive patients with hypercholesterolemia and dyslipidemia: A systematic review and meta-analysis
    • Jul
    • Peng W, Qiang F, Peng W, et al. Therapeutic efficacy of PCSK9 monoclonal antibodies in statin-nonresponsive patients with hypercholesterolemia and dyslipidemia:A systematic review and meta-analysis. Int J Cardiol. 2016 Jul 30;222:119–129.
    • (2016) Int J Cardiol , vol.222 , pp. 119-129
    • Peng, W.1    Qiang, F.2    Peng, W.3
  • 70
    • 84979680841 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors to treat hypercholesterolemia: effect on stroke risk
    • Milionis H, Barkas F, Ntaios G, et al. Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors to treat hypercholesterolemia:effect on stroke risk. Eur J Intern Med. 2016;34:54–57.
    • (2016) Eur J Intern Med
    • Milionis, H.1    Barkas, F.2    Ntaios, G.3
  • 71
    • 84990219696 scopus 로고    scopus 로고
    • Systematic review of published phase 3 data on anti-PCSK9 monoclonal antibodies in patients with hypercholesterolaemia
    • Aug
    • Gouni-Berthold I, Descamps OS, Fraass U, et al. Systematic review of published phase 3 data on anti-PCSK9 monoclonal antibodies in patients with hypercholesterolaemia. Br J Clin Pharmacol. 2016 Aug 1. DOI:10.1111/bcp.13066.
    • (2016) Br J Clin Pharmacol
    • Gouni-Berthold, I.1    Descamps, O.S.2    Fraass, U.3
  • 72
    • 84961589437 scopus 로고    scopus 로고
    • PCSK9 in relation to coronary plaque inflammation: results of the ATHEROREMO-IVUS study
    • Cheng JM, Oemrawsingh RM, Garcia-Garcia HM, et al. PCSK9 in relation to coronary plaque inflammation:results of the ATHEROREMO-IVUS study. Atherosclerosis. 2016;248:117–122.
    • (2016) Atherosclerosis , vol.248 , pp. 117-122
    • Cheng, J.M.1    Oemrawsingh, R.M.2    Garcia-Garcia, H.M.3
  • 73
    • 84962159581 scopus 로고    scopus 로고
    • The impact of pro-protein convertase subtilisin-kexin type 9 serine protease inhibitors on lipid levels and outcomes in patients with primary hypercholesterolaemia: a network meta-analysis
    • Lipinski MJ, Benedetto U, Escarcega RO. The impact of pro-protein convertase subtilisin-kexin type 9 serine protease inhibitors on lipid levels and outcomes in patients with primary hypercholesterolaemia:a network meta-analysis. Eur Heart J. 2016;37(7):536–545.
    • (2016) Eur Heart J , vol.37 , Issue.7 , pp. 536-545
    • Lipinski, M.J.1    Benedetto, U.2    Escarcega, R.O.3
  • 74
    • 84927578440 scopus 로고    scopus 로고
    • Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia
    • Ballantyne CM, Neutel J, Cropp A, et al. Results of bococizumab, a monoclonal antibody against proprotein convertase subtilisin/kexin type 9, from a randomized, placebo-controlled, dose-ranging study in statin-treated subjects with hypercholesterolemia. Am J Cardiol. 2015;115:1212–1221.
    • (2015) Am J Cardiol , vol.115 , pp. 1212-1221
    • Ballantyne, C.M.1    Neutel, J.2    Cropp, A.3
  • 75
    • 84966587946 scopus 로고    scopus 로고
    • Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9): a randomized, placebo-controlled Phase 2 study
    • Kastelein JJ, Nissen SE, Coxson PG, et al. Safety and efficacy of LY3015014, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9):a randomized, placebo-controlled Phase 2 study. Eur Heart J. 2016;37:1360–1369.
    • (2016) Eur Heart J , vol.37 , pp. 1360-1369
    • Kastelein, J.J.1    Nissen, S.E.2    Coxson, P.G.3
  • 76
    • 85015675094 scopus 로고    scopus 로고
    • New class of drugs: therapeutic RNAi inhibition of PCSK9 as a specific IDL-C lowering therapy
    • Strat AL, Ghiciuc CM, Lupuşoru CE, et al. New class of drugs:therapeutic RNAi inhibition of PCSK9 as a specific IDL-C lowering therapy. Rev Med Chir Soc Med Nat Iasi. 2016;120:228–232.
    • (2016) Rev Med Chir Soc Med Nat Iasi , vol.120 , pp. 228-232
    • Strat, A.L.1    Ghiciuc, C.M.2    Lupuşoru, C.E.3
  • 77
    • 85008485863 scopus 로고    scopus 로고
    • A highly durable rnai therapeutic inhibitor of PCSK9
    • Fitzgerald K, White S, Borodovsky A, et al. A highly durable rnai therapeutic inhibitor of PCSK9. N Engl J Med. 2017;376:41–51.
    • (2017) N Engl J Med , vol.376 , pp. 41-51
    • Fitzgerald, K.1    White, S.2    Borodovsky, A.3
  • 78
    • 84999053643 scopus 로고    scopus 로고
    • Variation in PCSK9 and HMGCR and risk of cardiovascular disease and diabetes
    • Ference BA, Robinson JG, Brook RD, et al. Variation in PCSK9 and HMGCR and risk of cardiovascular disease and diabetes. N Engl J Med. 2016;375:2144–2153.
    • (2016) N Engl J Med , vol.375 , pp. 2144-2153
    • Ference, B.A.1    Robinson, J.G.2    Brook, R.D.3
  • 79
    • 85007330927 scopus 로고    scopus 로고
    • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
    • Schmidt AF, Swerdlow DI, Holmes MV, et al. PCSK9 genetic variants and risk of type 2 diabetes:a mendelian randomisation study. Lancet Diabetes Endocrinol. 2017;2:97–105.
    • (2017) Lancet Diabetes Endocrinol , vol.2 , pp. 97-105
    • Schmidt, A.F.1    Swerdlow, D.I.2    Holmes, M.V.3
  • 80
    • 84960903460 scopus 로고    scopus 로고
    • Eligibility for PCSK9 treatment in 734 Hypercholesterolemic patients referred to a regional cholesterol treatment centre with LDL cholesterol ≥70 mg/dl despite maximal tolerated cholesterol lowering therapy
    • Glueck CJ, Shah P, Goldenberg N, et al. Eligibility for PCSK9 treatment in 734 Hypercholesterolemic patients referred to a regional cholesterol treatment centre with LDL cholesterol ≥70 mg/dl despite maximal tolerated cholesterol lowering therapy. Lipids Health Dis. 2016;12(15):55.• An anlysis of the cost implications if PCSK9 turns out to be very effective in cardiovascular event reduction.
    • (2016) Lipids Health Dis. , vol.12 , Issue.15 , pp. 55
    • Glueck, C.J.1    Shah, P.2    Goldenberg, N.3
  • 81
    • 84987653542 scopus 로고    scopus 로고
    • Cost-effectiveness of PCSK9 inhibitor therapy in patients with heterozygous familial hypercholesterolemia or atherosclerotic cardiovascular disease
    • Aug
    • Kazi DS, Moran AE, Coxson PG, et al. Cost-effectiveness of PCSK9 inhibitor therapy in patients with heterozygous familial hypercholesterolemia or atherosclerotic cardiovascular disease. Jama. 2016 Aug 16;316(7):743–753. DOI:10.1001/jama.2016.11004.
    • (2016) Jama , vol.316 , Issue.7 , pp. 743-753
    • Kazi, D.S.1    Moran, A.E.2    Coxson, P.G.3
  • 82
    • 84983392056 scopus 로고    scopus 로고
    • 2Pharmacoeconomics of PCSK9 inhibitors in 103 hypercholesterolemic patients referred for diagnosis and treatment to a cholesterol treatment center
    • 2Pharmacoeconomics of PCSK9 inhibitors in 103 hypercholesterolemic patients referred for diagnosis and treatment to a cholesterol treatment center. Lipids Health Dis. 2016;15:132.
    • (2016) Lipids Health Dis , vol.15 , pp. 132
    • Shah, P.1    Glueck, C.J.2    Jetty, V.3
  • 83
    • 84945339933 scopus 로고    scopus 로고
    • MicroRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator
    • Jiang H, Zhang J, Du Y, et al. MicroRNA-185 modulates low density lipoprotein receptor expression as a key posttranscriptional regulator. Atherosclerosis. 2015;243:523–532.
    • (2015) Atherosclerosis , vol.243 , pp. 523-532
    • Jiang, H.1    Zhang, J.2    Du, Y.3
  • 84
    • 84940094557 scopus 로고    scopus 로고
    • MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis
    • Alvarez ML, Khosroheidari M, Eddy E, et al. MicroRNA-27a decreases the level and efficiency of the LDL receptor and contributes to the dysregulation of cholesterol homeostasis. Atherosclerosis. 2015;242:595–604.
    • (2015) Atherosclerosis , vol.242 , pp. 595-604
    • Alvarez, M.L.1    Khosroheidari, M.2    Eddy, E.3
  • 85
    • 84881255684 scopus 로고    scopus 로고
    • ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK
    • Filippov S, Pinkosky SL, Lister RJ, et al. ETC-1002 regulates immune response, leukocyte homing, and adipose tissue inflammation via LKB1-dependent activation of macrophage AMPK. J Lipid Res. 2013;54:2095–2108.
    • (2013) J Lipid Res , vol.54 , pp. 2095-2108
    • Filippov, S.1    Pinkosky, S.L.2    Lister, R.J.3
  • 86
    • 84871226706 scopus 로고    scopus 로고
    • AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism
    • Pinkosky SL, Filippov S, Srivastava RA, et al. AMP-activated protein kinase and ATP-citrate lyase are two distinct molecular targets for ETC-1002, a novel small molecule regulator of lipid and carbohydrate metabolism. J Lipid Res. 2013;54:134–151.
    • (2013) J Lipid Res , vol.54 , pp. 134-151
    • Pinkosky, S.L.1    Filippov, S.2    Srivastava, R.A.3
  • 87
    • 84894573802 scopus 로고    scopus 로고
    • Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein- cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus
    • Gutierrez MJ, Rosenberg NL, Macdougall DE. Efficacy and safety of ETC-1002, a novel investigational low-density lipoprotein- cholesterol-lowering therapy for the treatment of patients with hypercholesterolemia and type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2014;34:676–683.
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 676-683
    • Gutierrez, M.J.1    Rosenberg, N.L.2    Macdougall, D.E.3
  • 88
    • 84964627298 scopus 로고    scopus 로고
    • Effect of ETC- 1002 on serum low-density lipoprotein cholesterol in hypercholesterolemic patients receiving statin therapy
    • Ballantyne CM, McKenney JM, MacDougall DE. Effect of ETC- 1002 on serum low-density lipoprotein cholesterol in hypercholesterolemic patients receiving statin therapy. Am J Cardiol. 2016;69149:30430–30431.
    • (2016) Am J Cardiol , vol.69149 , pp. 30430-30431
    • Ballantyne, C.M.1    McKenney, J.M.2    MacDougall, D.E.3
  • 89
    • 84893877716 scopus 로고    scopus 로고
    • Lipoprotein(a): there’s life in the old dog yet
    • Kronenberg F. Lipoprotein(a):there’s life in the old dog yet. Circulation. 2014;129(11):619–621.•• Why Lp(a) has resurfaced as an important, interesting lipoprotein.
    • (2014) Circulation , vol.129 , Issue.11 , pp. 619-621
    • Kronenberg, F.1
  • 90
    • 84961112691 scopus 로고    scopus 로고
    • Human genetics and the causal role of lipoprotein (a) for various diseases
    • Kronenberg F. Human genetics and the causal role of lipoprotein (a) for various diseases. Cardiovasc Drugs Ther. 2016;30:87–100.
    • (2016) Cardiovasc Drugs Ther , vol.30 , pp. 87-100
    • Kronenberg, F.1
  • 91
    • 73549097512 scopus 로고    scopus 로고
    • PROCARDIS ConsortiumGenetic variants associated with Lp(a) lipoprotein level and coronary disease
    • Clarke R, Peden JF, Hopewell JC, et al. PROCARDIS ConsortiumGenetic variants associated with Lp(a) lipoprotein level and coronary disease. N Engl J Med. 2009;361:2518–2528.
    • (2009) N Engl J Med , vol.361 , pp. 2518-2528
    • Clarke, R.1    Peden, J.F.2    Hopewell, J.C.3
  • 92
    • 67651210632 scopus 로고    scopus 로고
    • Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality
    • Erqou S, Kaptoge S, Perry PL, et al.; Emerging Risk Factors Collaboration. Lipoprotein(a) concentration and the risk of coronary heart disease, stroke, and nonvascular mortality. Jama. 2009;302:412–423.
    • (2009) Jama , vol.302 , pp. 412-423
    • Erqou, S.1    Kaptoge, S.2    Perry, P.L.3
  • 93
    • 67049167090 scopus 로고    scopus 로고
    • Genetically elevated lipoprotein(a) and increased risk of myocardial infarction
    • Kamstrup PR, Tybjaerg-Hansen A, Steffensen R, et al. Genetically elevated lipoprotein(a) and increased risk of myocardial infarction. Jama. 2009;301:2331–2339.
    • (2009) Jama , vol.301 , pp. 2331-2339
    • Kamstrup, P.R.1    Tybjaerg-Hansen, A.2    Steffensen, R.3
  • 94
    • 84873513160 scopus 로고    scopus 로고
    • Genetic associations with valvular calcification and aortic stenosis
    • Thanassoulis G, Campbell CY, Owens DS, et al. Genetic associations with valvular calcification and aortic stenosis. N Engl J Med. 2013;368:503–512.
    • (2013) N Engl J Med , vol.368 , pp. 503-512
    • Thanassoulis, G.1    Campbell, C.Y.2    Owens, D.S.3
  • 95
    • 84964699793 scopus 로고    scopus 로고
    • PCSK9 association with lipoprotein(a)
    • Apr, pii: CIRCRESAHA. 116. 308811
    • Tavori H, Christian DC, Minnier J, et al. PCSK9 association with lipoprotein(a). Circ Res. 2016 Apr 27. pii:CIRCRESAHA. 116. 308811.
    • (2016) Circ Res
    • Tavori, H.1    Christian, D.C.2    Minnier, J.3
  • 96
    • 77955237337 scopus 로고    scopus 로고
    • Lipoprotein(a) and risk of type 2 diabetes
    • Mora S, Kamstrup PR, Rifai N, et al. Lipoprotein(a) and risk of type 2 diabetes. Clin Chem. 2010;56:1252–1260.
    • (2010) Clin Chem , vol.56 , pp. 1252-1260
    • Mora, S.1    Kamstrup, P.R.2    Rifai, N.3
  • 97
    • 84927558530 scopus 로고    scopus 로고
    • Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population
    • Ding L, Song A, Dai M, et al. Serum lipoprotein (a) concentrations are inversely associated with T2D, prediabetes, and insulin resistance in a middle-aged and elderly Chinese population. J Lipid Res. 2015;56:920–926.
    • (2015) J Lipid Res , vol.56 , pp. 920-926
    • Ding, L.1    Song, A.2    Dai, M.3
  • 98
    • 84994045135 scopus 로고    scopus 로고
    • Lipoprotein (a) as a cause of cardiovascular disease: insights from epidemiology, genetics, and biology
    • Nordestgaard BG, Langsted A. Lipoprotein (a) as a cause of cardiovascular disease:insights from epidemiology, genetics, and biology. J Lipid Res. 2016;57:1953–1975.
    • (2016) J Lipid Res , vol.57 , pp. 1953-1975
    • Nordestgaard, B.G.1    Langsted, A.2
  • 99
    • 84921866616 scopus 로고    scopus 로고
    • Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia: results of 4 phase III trials
    • Santos RD, Raal FJ, Catapano A, et al. Mipomersen, an antisense oligonucleotide to apolipoprotein B-100, reduces lipoprotein(a) in various populations with hypercholesterolemia:results of 4 phase III trials. Arterioscler Thromb Vasc Biol. 2015;35:689–699.
    • (2015) Arterioscler Thromb Vasc Biol , vol.35 , pp. 689-699
    • Santos, R.D.1    Raal, F.J.2    Catapano, A.3
  • 100
    • 84994607113 scopus 로고    scopus 로고
    • Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials
    • Viney NJ, Van Capelleveen JC, Geary RS. Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a):two randomised, double-blind, placebo-controlled, dose-ranging trials. Lancet. 2016;388:2239–2253.
    • (2016) Lancet
    • Viney, N.J.1    Van Capelleveen, J.C.2    Geary, R.S.3
  • 101
    • 84890904215 scopus 로고    scopus 로고
    • Pro(a) LiFe Study Group*. Lipoprotein apheresis in patients with maximally tolerated lipid-lowering therapy, lipoprotein(a)-hyperlipoproteinemia, and progressive cardiovascular disease: prospective observational multicenter study
    • Leebmann J, Roeseler E, Julius U, et al. Pro(a) LiFe Study Group*. Lipoprotein apheresis in patients with maximally tolerated lipid-lowering therapy, lipoprotein(a)-hyperlipoproteinemia, and progressive cardiovascular disease:prospective observational multicenter study. Circulation. 2013;128:2567–2576.
    • (2013) Circulation , vol.128 , pp. 2567-2576
    • Leebmann, J.1    Roeseler, E.2    Julius, U.3
  • 102
    • 78649888517 scopus 로고    scopus 로고
    • Lipoprotein(a) as a cardiovascular risk factor: current status. European Atherosclerosis Society Consensus Panel
    • Nordestgaard BG, Chapman MJ, Ray K, et al. Lipoprotein(a) as a cardiovascular risk factor:current status. European Atherosclerosis Society Consensus Panel. Eur Heart J. 2010;31:2844–2853.
    • (2010) Eur Heart J , vol.31 , pp. 2844-2853
    • Nordestgaard, B.G.1    Chapman, M.J.2    Ray, K.3
  • 104
    • 0025193688 scopus 로고
    • Apolipoprotein AIMilano. Disulfide-linked dimers increase high density lipoprotein stability and hinder particle interconversion in carrier plasma
    • Franceschini G, Calabresi L, Tosi C, et al. Apolipoprotein AIMilano. Disulfide-linked dimers increase high density lipoprotein stability and hinder particle interconversion in carrier plasma. J Biol Chem. 1990;265:12224–12231.
    • (1990) J Biol Chem , vol.265 , pp. 12224-12231
    • Franceschini, G.1    Calabresi, L.2    Tosi, C.3
  • 105
    • 0242577955 scopus 로고    scopus 로고
    • Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial
    • Nissen SE, Tsunoda T, Tuzcu EM, et al. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes:a randomized controlled trial. Jama. 2003;290:2292–2300.
    • (2003) Jama , vol.290 , pp. 2292-2300
    • Nissen, S.E.1    Tsunoda, T.2    Tuzcu, E.M.3
  • 106
    • 84907539382 scopus 로고    scopus 로고
    • In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I
    • Zhao Y, Black AS, Bonnet DJ, et al. In vivo efficacy of HDL-like nanolipid particles containing multivalent peptide mimetics of apolipoprotein A-I. J Lipid Res. 2014;55:2053–2063.
    • (2014) J Lipid Res , vol.55 , pp. 2053-2063
    • Zhao, Y.1    Black, A.S.2    Bonnet, D.J.3
  • 107
    • 84930941165 scopus 로고    scopus 로고
    • Newly developed polipoprotein A-I mimetic peptide promotes macrophage reverse cholesterol transport in vivo
    • Shimizu T, Tanigawa H, Miura S, et al. Newly developed polipoprotein A-I mimetic peptide promotes macrophage reverse cholesterol transport in vivo. Int J Cardiol. 2015;192:82–88.
    • (2015) Int J Cardiol , vol.192 , pp. 82-88
    • Shimizu, T.1    Tanigawa, H.2    Miura, S.3
  • 108
    • 84962388437 scopus 로고    scopus 로고
    • High-density lipoprotein mimetics: a therapeutic tool for atherosclerotic diseases
    • Ikenaga M, Higaki Y, Saku K, et al. High-density lipoprotein mimetics:a therapeutic tool for atherosclerotic diseases. J Atheroscler Thromb. 2016;23:385–394.•• An excellent review which explains clearly the potential for this class of lipoprotein mimetics.
    • (2016) J Atheroscler Thromb , vol.23 , pp. 385-394
    • Ikenaga, M.1    Higaki, Y.2    Saku, K.3
  • 109
    • 84925299931 scopus 로고    scopus 로고
    • Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA
    • Kootte RS, Smits LP, Van Der Valk FM, et al. Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA. J Lipid Res. 2015;56:703–712.
    • (2015) J Lipid Res , vol.56 , pp. 703-712
    • Kootte, R.S.1    Smits, L.P.2    Van Der Valk, F.M.3
  • 110
    • 84960435630 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibition with anacetrapib decreases fractional clearance rates of high-density lipoprotein apolipoprotein A-I and plasma cholesteryl ester transfer protein
    • Reyes-Soffer G, Millar JS, Ngai C, et al. Cholesteryl ester transfer protein inhibition with anacetrapib decreases fractional clearance rates of high-density lipoprotein apolipoprotein A-I and plasma cholesteryl ester transfer protein. Arterioscler Thromb Vasc Biol. 2016;36:994–1002.
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 994-1002
    • Reyes-Soffer, G.1    Millar, J.S.2    Ngai, C.3
  • 111
    • 84930402044 scopus 로고    scopus 로고
    • Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects
    • Millar JS, Reyes-Soffer G, Jumes P, et al. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest. 2015;125:2510–2522.
    • (2015) J Clin Invest , vol.125 , pp. 2510-2522
    • Millar, J.S.1    Reyes-Soffer, G.2    Jumes, P.3
  • 112
    • 36348975228 scopus 로고    scopus 로고
    • ILLUMINATE Investigators. Effects of torcetrapib in patients at high risk for coronary events
    • Barter PJ, Caulfield M, Eriksson M. ILLUMINATE Investigators. Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med. 2007;357:2109–2122.
    • (2007) N Engl J Med , vol.357 , pp. 2109-2122
    • Barter, P.J.1    Caulfield, M.2    Eriksson, M.3
  • 113
    • 84923346612 scopus 로고    scopus 로고
    • Cholesteryl ester- transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes
    • Rios FJ, Neves KB, Nguyen Dinh Cat A, et al. Cholesteryl ester- transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes. J Pharmacol Exp Ther. 2015;353:27–34.
    • (2015) J Pharmacol Exp Ther , vol.353 , pp. 27-34
    • Rios, F.J.1    Neves, K.B.2    Nguyen Dinh Cat, A.3
  • 115
    • 84918807616 scopus 로고    scopus 로고
    • Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults
    • Suico JG, Wang MD, Friedrich S, et al. Effects of the cholesteryl ester transfer protein inhibitor evacetrapib on lipoproteins, apolipoproteins and 24-h ambulatory blood pressure in healthy adults. J Pharm Pharmacol. 2014;66:1576–1585.
    • (2014) J Pharm Pharmacol , vol.66 , pp. 1576-1585
    • Suico, J.G.1    Wang, M.D.2    Friedrich, S.3
  • 116
    • 84946763626 scopus 로고    scopus 로고
    • Cholesterol efflux capacity and pre-beta-1 HDL concentrations are increased in dyslipidemic patients treated with evacetrapib
    • Nicholls SJ, Ruotolo G, Brewer HB, et al. Cholesterol efflux capacity and pre-beta-1 HDL concentrations are increased in dyslipidemic patients treated with evacetrapib. J Am Coll Cardiol. 2015;66(17):2201–2210.
    • (2015) J Am Coll Cardiol , vol.66 , Issue.17 , pp. 2201-2210
    • Nicholls, S.J.1    Ruotolo, G.2    Brewer, H.B.3
  • 117
    • 81855206655 scopus 로고    scopus 로고
    • Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure
    • Cao G, Beyer TP, Zhang Y, et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J Lipid Res. 2012;52:2169–2176.
    • (2012) J Lipid Res , vol.52 , pp. 2169-2176
    • Cao, G.1    Beyer, T.P.2    Zhang, Y.3
  • 118
    • 84957429728 scopus 로고    scopus 로고
    • Anacetrapib for the treatment of dyslipidaemia: the last bastion of the cholesteryl ester transfer protein inhibitors?
    • Page MM, Hooper AJ, Burnett JR. Anacetrapib for the treatment of dyslipidaemia:the last bastion of the cholesteryl ester transfer protein inhibitors? Expert Opin Pharmacother. 2016;17:275–281.
    • (2016) Expert Opin Pharmacother , vol.17 , pp. 275-281
    • Page, M.M.1    Hooper, A.J.2    Burnett, J.R.3
  • 119
    • 84930088585 scopus 로고    scopus 로고
    • Anacetrapib as lipid- modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study
    • Kastelein JJ, Besseling J, Shah S, et al. Anacetrapib as lipid- modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE):a randomised, double-blind, placebo-controlled, phase 3 study. Lancet. 2015;385:2153–2161.
    • (2015) Lancet , vol.385 , pp. 2153-2161
    • Kastelein, J.J.1    Besseling, J.2    Shah, S.3
  • 120
    • 84930088585 scopus 로고    scopus 로고
    • Anacetrapib as lipid- modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE): a randomised, double-blind, placebo-controlled, phase 3 study
    • Hovingh GK, Al-Saady N, Koeijvoets M, et al. Anacetrapib as lipid- modifying therapy in patients with heterozygous familial hypercholesterolaemia (REALIZE):a randomised, double-blind, placebo-controlled, phase 3 study. Lancet. 2015;385:2153–2161.
    • (2015) Lancet , vol.385 , pp. 2153-2161
    • Hovingh, G.K.1    Al-Saady, N.2    Koeijvoets, M.3
  • 121
    • 84964587106 scopus 로고    scopus 로고
    • Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib in Japanese patients with heterozygous familial hypercholesterolemia
    • Arai H, Teramoto T, Daida H. Efficacy and safety of the cholesteryl ester transfer protein inhibitor anacetrapib in Japanese patients with heterozygous familial hypercholesterolemia. Atherosclerosis. 2016;249:215–223.
    • (2016) Atherosclerosis , vol.249 , pp. 215-223
    • Arai, H.1    Teramoto, T.2    Daida, H.3
  • 122
    • 85018660127 scopus 로고    scopus 로고
    • The Reveal Trial randomised evaluation of the effects of anacetripib through lipid modification Clinical Trials. Gov Identifiere NCT 01252953.
    • Gov Identifiere NCT 01252953
  • 123
    • 84938748425 scopus 로고    scopus 로고
    • Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial
    • Hovingh GK, Kastelein JJ, Van Deventer SJ, et al. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP):a randomised, double-blind, placebo-controlled phase 2 trial. Lancet. 2015;386:452–460.
    • (2015) Lancet , vol.386 , pp. 452-460
    • Hovingh, G.K.1    Kastelein, J.J.2    Van Deventer, S.J.3
  • 124
    • 85008414304 scopus 로고    scopus 로고
    • Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses
    • e3
    • Van Capelleveen JC, Kastelein JJ, Zwinderman AH, et al. Effects of the cholesteryl ester transfer protein inhibitor, TA-8995, on cholesterol efflux capacity and high-density lipoprotein particle subclasses. J Clin Lipidol. 2016;10:1137–1144.e3.
    • (2016) J Clin Lipidol , vol.10 , pp. 1137-1144
    • Van Capelleveen, J.C.1    Kastelein, J.J.2    Zwinderman, A.H.3
  • 125
    • 84964313174 scopus 로고    scopus 로고
    • Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease: a meta-analysis using a Mendelian randomization approach
    • Wu Z, Lou Y, Qiu X, et al. Association of cholesteryl ester transfer protein (CETP) gene polymorphism, high density lipoprotein cholesterol and risk of coronary artery disease:a meta-analysis using a Mendelian randomization approach. BMC Med Genet. 2014;23(15):118.
    • (2014) BMC Med Genet , vol.23 , Issue.15 , pp. 118
    • Wu, Z.1    Lou, Y.2    Qiu, X.3
  • 126
    • 84919343998 scopus 로고    scopus 로고
    • HDL cholesterol efflux capacity and incident cardiovascular events
    • Rohatgi A, Khera A, Berry JD, et al. HDL cholesterol efflux capacity and incident cardiovascular events. N Engl J Med. 2014;371:2383.
    • (2014) N Engl J Med , vol.371 , pp. 2383
    • Rohatgi, A.1    Khera, A.2    Berry, J.D.3
  • 127
    • 84991728562 scopus 로고    scopus 로고
    • Fragment-based discovery of novel pentacyclic triterpenoid derivatives as cholesteryl ester transfer protein inhibitors
    • Sep
    • Chang Y, Zhou S, Li E. Fragment-based discovery of novel pentacyclic triterpenoid derivatives as cholesteryl ester transfer protein inhibitors. Eur J Med Chem. 2016 Sep 30;126:143–153.
    • (2016) Eur J Med Chem , vol.126 , pp. 143-153
    • Chang, Y.1    Zhou, S.2    Li, E.3
  • 128
    • 84959569935 scopus 로고    scopus 로고
    • Cholesteryl ester transfer protein inhibition is not yet dead–pro
    • Barter PJ, Rye KA. Cholesteryl ester transfer protein inhibition is not yet dead–pro. Arterioscler Thromb Vasc Biol. 2016;36:439–441.
    • (2016) Arterioscler Thromb Vasc Biol , vol.36 , pp. 439-441
    • Barter, P.J.1    Rye, K.A.2
  • 129
    • 84957837612 scopus 로고    scopus 로고
    • Corrigendum to “RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I/HDL and represses pathways that contribute to cardiovascular disease
    • Gilham D, Wasiak S, Tsujikawa LM, et al. Corrigendum to “RVX-208, a BET-inhibitor for treating atherosclerotic cardiovascular disease, raises ApoA-I/HDL and represses pathways that contribute to cardiovascular disease”. Atherosclerosis. 2016;247:48–57.
    • (2016) Atherosclerosis , vol.247 , pp. 48-57
    • Gilham, D.1    Wasiak, S.2    Tsujikawa, L.M.3
  • 130
    • 84956621195 scopus 로고    scopus 로고
    • Effect of the BET protein inhibitor, RVX-208, on progression of coronary atherosclerosis: results of the Phase 2b, randomized, double-blind, multicenter, ASSURE trial
    • Nicholls SJ, Puri R, Wolski K, et al. Effect of the BET protein inhibitor, RVX-208, on progression of coronary atherosclerosis:results of the Phase 2b, randomized, double-blind, multicenter, ASSURE trial. Am J Cardiovasc Drugs. 2016;16:55–65.
    • (2016) Am J Cardiovasc Drugs , vol.16 , pp. 55-65
    • Nicholls, S.J.1    Puri, R.2    Wolski, K.3
  • 131
    • 84963828933 scopus 로고    scopus 로고
    • Effects of the BET- inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial
    • Siebel AL, Trinh SK, Formosa MF, et al. Effects of the BET- inhibitor, RVX-208 on the HDL lipidome and glucose metabolism in individuals with prediabetes:A randomized controlled trial. Metabolism. 2016;65:904–914.
    • (2016) Metabolism , vol.65 , pp. 904-914
    • Siebel, A.L.1    Trinh, S.K.2    Formosa, M.F.3
  • 132
    • 34547700634 scopus 로고    scopus 로고
    • Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo
    • Wang X, Collins HL, Ranalletta M, et al. Macrophage ABCA1 and ABCG1, but not SR-BI, promote macrophage reverse cholesterol transport in vivo. J Clin Invest. 2007;117:2216–2224.
    • (2007) J Clin Invest , vol.117 , pp. 2216-2224
    • Wang, X.1    Collins, H.L.2    Ranalletta, M.3
  • 133
    • 77953787211 scopus 로고    scopus 로고
    • MiR-33 contributes to the regulation of cholesterol homeostasis
    • Rayner KJ, Suárez Y, Dávalos A, et al. MiR-33 contributes to the regulation of cholesterol homeostasis. Science. 2010;328:1570–1573.
    • (2010) Science , vol.328 , pp. 1570-1573
    • Rayner, K.J.1    Suárez, Y.2    Dávalos, A.3
  • 134
    • 77955456415 scopus 로고    scopus 로고
    • miR-33 links SREBP-2 induction to repression of sterol transporters
    • Marquart TJ, Allen RM, Ory DS, et al. miR-33 links SREBP-2 induction to repression of sterol transporters. Proc Natl Acad Sci USA. 2010;107:12228–12232.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12228-12232
    • Marquart, T.J.1    Allen, R.M.2    Ory, D.S.3
  • 135
    • 79960015327 scopus 로고    scopus 로고
    • Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis
    • Rayner KJ, Sheedy FJ, Esau CC, et al. Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis. J Clin Invest. 2011;121:2921–2931.
    • (2011) J Clin Invest , vol.121 , pp. 2921-2931
    • Rayner, K.J.1    Sheedy, F.J.2    Esau, C.C.3
  • 136
    • 84881029988 scopus 로고    scopus 로고
    • Fernández-Hernando C Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr-/- mice–brief report
    • Rotllan N, Ramírez CM, Aryal B, et al. Fernández-Hernando C Therapeutic silencing of microRNA-33 inhibits the progression of atherosclerosis in Ldlr-/- mice–brief report. Arterioscler Thromb Vasc Biol. 2013;33:1973–1977.
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1973-1977
    • Rotllan, N.1    Ramírez, C.M.2    Aryal, B.3
  • 137
    • 84928430152 scopus 로고    scopus 로고
    • Efficacy, safety and tolerability of aleglitazar in patients with type 2 diabetes: pooled findings from three randomized phase III trials
    • Henry RR, Buse JB, Wu H, et al. Efficacy, safety and tolerability of aleglitazar in patients with type 2 diabetes:pooled findings from three randomized phase III trials. Diabetes Obes Metab. 2015;17:560–565.
    • (2015) Diabetes Obes Metab , vol.17 , pp. 560-565
    • Henry, R.R.1    Buse, J.B.2    Wu, H.3


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