-
1
-
-
78649457568
-
Monitoring and surveillance of chronic non-communicable diseases: Progress and capacity in high-burden countries
-
Alwan A, Maclean DR, Riley LM, d'Espaignet ET, Mathers CD, Stevens GA, and Bettcher D (2010) Monitoring and surveillance of chronic non-communicable diseases: progress and capacity in high-burden countries. Lancet 376:1861-1868.
-
(2010)
Lancet
, vol.376
, pp. 1861-1868
-
-
Alwan, A.1
Maclean, D.R.2
Riley, L.M.3
D'Espaignet, E.T.4
Mathers, C.D.5
Stevens, G.A.6
Bettcher, D.7
-
2
-
-
0037327033
-
Cholesteryl ester transfer protein: A novel target for raising HDL and inhibiting atherosclerosis
-
Barter PJ, Brewer HB, Jr, Chapman MJ, Hennekens CH, Rader DJ, and Tall AR (2003) Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol 23:160-167.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 160-167
-
-
Barter, P.J.1
Brewer, H.B.2
Chapman, M.J.3
Hennekens, C.H.4
Rader, D.J.5
Tall, A.R.6
-
3
-
-
36348975228
-
Effects of torcetrapib in patients at high risk for coronary events
-
Barter PJ, Caulfield M, Eriksson M, Grundy SM, Kastelein JJ, Komajda M, Lopez-Sendon J, Mosca L, Tardif JC, Waters DD, et al.; ILLUMINATE Investigators (2007) Effects of torcetrapib in patients at high risk for coronary events. N Engl J Med 357:2109-2122.
-
(2007)
N Engl J Med
, vol.357
, pp. 2109-2122
-
-
ILLUMINATE Investigators1
Barter, P.J.2
Caulfield, M.3
Eriksson, M.4
Grundy, S.M.5
Kastelein, J.J.6
Komajda, M.7
Lopez-Sendon, J.8
Mosca, L.9
Tardif, J.C.10
Waters, D.D.11
-
4
-
-
84860226019
-
Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: Implications in diabetes mellitus-associated obesity and vascular dysfunction
-
Briones AM, Nguyen Dinh Cat A, Callera GE, Yogi A, Burger D, He Y, Corrêa JW, Gagnon AM, Gomez-Sanchez CE, Gomez-Sanchez EP, et al. (2012) Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction. Hypertension 59:1069-1078.
-
(2012)
Hypertension
, vol.59
, pp. 1069-1078
-
-
Briones, A.M.1
Cat, N.D.A.2
Callera, G.E.3
Yogi, A.4
Burger, D.5
He, Y.6
Corrêa, J.W.7
Gagnon, A.M.8
Gomez-Sanchez, C.E.9
Gomez-Sanchez, E.P.10
-
5
-
-
79955593549
-
Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR
-
Briones AM, Tabet F, Callera GE, Montezano AC, Yogi A, He Y, Quinn MT, Salaices M, and Touyz RM (2011) Differential regulation of Nox1, Nox2 and Nox4 in vascular smooth muscle cells from WKY and SHR. J Am Soc Hypertens 5:137-153.
-
(2011)
J Am Soc Hypertens
, vol.5
, pp. 137-153
-
-
Briones, A.M.1
Tabet, F.2
Callera, G.E.3
Montezano, A.C.4
Yogi, A.5
He, Y.6
Quinn, M.T.7
Salaices, M.8
Touyz, R.M.9
-
6
-
-
78049445175
-
Drug off-target effects predicted using structural analysis in the context of a metabolic network model
-
Chang RL, Xie L, Xie L, Bourne PE, and Palsson BO (2010) Drug off-target effects predicted using structural analysis in the context of a metabolic network model. PLOS Comput Biol 6:e1000938.
-
(2010)
PLOS Comput Biol
, vol.6
, pp. e1000938
-
-
Chang, R.L.1
Xie, L.2
Xie, L.3
Bourne, P.E.4
Palsson, B.O.5
-
7
-
-
54349100968
-
Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor
-
in humans
-
Dalvie D, Chen W, Zhang C, Vaz AD, Smolarek TA, Cox LM, Lin J, and Obach RS (2008) Pharmacokinetics, metabolism, and excretion of torcetrapib, a cholesteryl ester transfer protein inhibitor, in humans. Drug Metab Dispos 36:2185-2198.
-
(2008)
Drug Metab Dispos
, vol.36
, pp. 2185-2198
-
-
Dalvie, D.1
Chen, W.2
Zhang, C.3
Vaz, A.D.4
Smolarek, T.A.5
Cox, L.M.6
Lin, J.7
Obach, R.S.8
-
8
-
-
48149106322
-
Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
-
Forrest MJ, Bloomfield D, Briscoe RJ, Brown PN, Cumiskey AM, Ehrhart J, Hershey JC, Keller WJ, Ma X, McPherson HE, et al. (2008) Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone. Br J Pharmacol 154:1465-1473.
-
(2008)
Br J Pharmacol
, vol.154
, pp. 1465-1473
-
-
Forrest, M.J.1
Bloomfield, D.2
Briscoe, R.J.3
Brown, P.N.4
Cumiskey, A.M.5
Ehrhart, J.6
Hershey, J.C.7
Keller, W.J.8
Ma, X.9
McPherson, H.E.10
-
9
-
-
74949136043
-
Aldosterone, sodium, and hypertension: Lessons from torcetrapib?
-
Funder JW (2010) Aldosterone, sodium, and hypertension: lessons from torcetrapib? Hypertension 55:221-223.
-
(2010)
Hypertension
, vol.55
, pp. 221-223
-
-
Funder, J.W.1
-
10
-
-
0017384270
-
High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study
-
Gordon T, Castelli WP, Hjortland MC, Kannel WB, and Dawber TR (1977) High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am J Med 62:707-714.
-
(1977)
Am J Med
, vol.62
, pp. 707-714
-
-
Gordon, T.1
Castelli, W.P.2
Hjortland, M.C.3
Kannel, W.B.4
Dawber, T.R.5
-
11
-
-
84890436361
-
Evaluation of lipids, drug concentration, and safety parameters following cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib in patients with or at high risk for coronary heart disease
-
Gotto AM, Jr, Cannon CP, Li XS, Vaidya S, Kher U, Brinton EA, Davidson M, Moon JE, Shah S, Dansky HM, et al.; DEFINE Investigators (2014) Evaluation of lipids, drug concentration, and safety parameters following cessation of treatment with the cholesteryl ester transfer protein inhibitor anacetrapib in patients with or at high risk for coronary heart disease. Am J Cardiol 113:76-83.
-
(2014)
Am J Cardiol
, vol.113
, pp. 76-83
-
-
DEFINE Investigators1
Gotto, A.M.2
Cannon, C.P.3
Li, X.S.4
Vaidya, S.5
Kher, U.6
Brinton, E.A.7
Davidson, M.8
Moon, J.E.9
Shah, S.10
Dansky, H.M.11
-
13
-
-
66449084532
-
Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition
-
Hu X, Dietz JD, Xia C, Knight DR, Loging WT, Smith AH, Yuan H, Perry DA, and Keiser J (2009) Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology 150:2211-2219.
-
(2009)
Endocrinology
, vol.150
, pp. 2211-2219
-
-
Hu, X.1
Dietz, J.D.2
Xia, C.3
Knight, D.R.4
Loging, W.T.5
Smith, A.H.6
Yuan, H.7
Perry, D.A.8
Keiser, J.9
-
14
-
-
0025104275
-
Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation
-
Inazu A, Brown ML, Hesler CB, Agellon LB, Koizumi J, Takata K, Maruhama Y, Mabuchi H, and Tall AR (1990) Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. N Engl J Med 323:1234-1238.
-
(1990)
N Engl J Med
, vol.323
, pp. 1234-1238
-
-
Inazu, A.1
Brown, M.L.2
Hesler, C.B.3
Agellon, L.B.4
Koizumi, J.5
Takata, K.6
Maruhama, Y.7
Mabuchi, H.8
Tall, A.R.9
-
15
-
-
84857273957
-
On- and off-target pharmacology of torcetrapib: Current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors
-
Johns DG, Duffy J, Fisher T, Hubbard BK, and Forrest MJ (2012) On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors. Drugs 72:491-507.
-
(2012)
Drugs
, vol.72
, pp. 491-507
-
-
Johns, D.G.1
Duffy, J.2
Fisher, T.3
Hubbard, B.K.4
Forrest, M.J.5
-
16
-
-
44449145644
-
Spotlight on HDL-raising therapies: Insights from the torcetrapib trials
-
Kontush A, Guérin M, and Chapman MJ (2008) Spotlight on HDL-raising therapies: insights from the torcetrapib trials. Nat Clin Pract Cardiovasc Med 5:329-336.
-
(2008)
Nat Clin Pract Cardiovasc Med
, vol.5
, pp. 329-336
-
-
Kontush, A.1
Guérin, M.2
Chapman, M.J.3
-
17
-
-
0035710746
-
Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method
-
Livak KJ and Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C (T)) Method. Methods 25:402-408.
-
(2001)
Methods
, vol.25
, pp. 402-408
-
-
Livak, K.J.1
Schmittgen, T.D.2
-
18
-
-
84892907535
-
Highdensity lipoprotein: Vascular protective effects, dysfunction, and potential as therapeutic target
-
Lüscher TF, Landmesser U, von Eckardstein A, and Fogelman AM (2014) Highdensity lipoprotein: vascular protective effects, dysfunction, and potential as therapeutic target. Circ Res 114:171-182.
-
(2014)
Circ Res
, vol.114
, pp. 171-182
-
-
Lüscher, T.F.1
Landmesser, U.2
Von Eckardstein, A.3
Fogelman, A.M.4
-
19
-
-
0016433018
-
Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease
-
Miller GJ and Miller NE (1975) Plasma-high-density-lipoprotein concentration and development of ischaemic heart-disease. Lancet 1:16-19.
-
(1975)
Lancet
, vol.1
, pp. 16-19
-
-
Miller, G.J.1
Miller, N.E.2
-
20
-
-
84860554783
-
NADPH oxidase-derived H (2) O (2) contributes to angiotensin II-induced aldosterone synthesisin human and rat adrenal cortical cells
-
Rajamohan SB, Raghuraman G, Prabhakar NR, and Kumar GK (2012) NADPH oxidase-derived H (2) O (2) contributes to angiotensin II-induced aldosterone synthesisin human and rat adrenal cortical cells. Antioxid Redox Signal 17:445-459.
-
(2012)
Antioxid Redox Signal
, vol.17
, pp. 445-459
-
-
Rajamohan, S.B.1
Raghuraman, G.2
Prabhakar, N.R.3
Kumar, G.K.4
-
21
-
-
84906055628
-
Anacetrapib: A potential new therapy for dyslipidemia
-
Robinson LB and Frishman WH (2014) Anacetrapib: a potential new therapy for dyslipidemia. Cardiol Rev 22:253-261.
-
(2014)
Cardiol Rev
, vol.22
, pp. 253-261
-
-
Robinson, L.B.1
Frishman, W.H.2
-
22
-
-
0022638992
-
Atherosclerosis and lipoprotein metabolism: Role of reverse cholesterol transport
-
Roheim PS (1986) Atherosclerosis and lipoprotein metabolism: role of reverse cholesterol transport. Am J Cardiol 57:3C-10C.
-
(1986)
Am J Cardiol
, vol.57
, pp. 3C-10C
-
-
Roheim, P.S.1
-
23
-
-
84870045994
-
Effects of dalcetrapib in patients with a recent acute coronary syndrome
-
Schwartz GG, Olsson AG, Abt M, Ballantyne CM, Barter PJ, Brumm J, Chaitman BR, Holme IM, Kallend D, Leiter LA, et al.; dal-OUTCOMES Investigators (2012) Effects of dalcetrapib in patients with a recent acute coronary syndrome. N Engl J Med 367:2089-2099.
-
(2012)
N Engl J Med
, vol.367
, pp. 2089-2099
-
-
dal-OUTCOMES Investigators1
Schwartz, G.G.2
Olsson, A.G.3
Abt, M.4
Ballantyne, C.M.5
Barter, P.J.6
Brumm, J.7
Chaitman, B.R.8
Holme, I.M.9
Kallend, D.10
Leiter, L.A.11
-
24
-
-
67649359941
-
Short term regulation of aldosterone secretion after stimulation and suppression experiments in mice
-
Spyroglou A, Manolopoulou J, Wagner S, Bidlingmaier M, Reincke M, and Beuschlein F (2009) Short term regulation of aldosterone secretion after stimulation and suppression experiments in mice. J Mol Endocrinol 42:407-413.
-
(2009)
J Mol Endocrinol
, vol.42
, pp. 407-413
-
-
Spyroglou, A.1
Manolopoulou, J.2
Wagner, S.3
Bidlingmaier, M.4
Reincke, M.5
Beuschlein, F.6
-
25
-
-
0022692378
-
Plasma lipid transfer proteins
-
Tall AR (1986) Plasma lipid transfer proteins. J Lipid Res 27:361-367.
-
(1986)
J Lipid Res
, vol.27
, pp. 361-367
-
-
Tall, A.R.1
-
26
-
-
84864845456
-
Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
-
Voight BF, Peloso GM, Orho-Melander M, Frikke-Schmidt R, Barbalic M, Jensen MK, Hindy G, Hólm H, Ding EL, Johnson T, et al. (2012) Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study. Lancet 380:572-580.
-
(2012)
Lancet
, vol.380
, pp. 572-580
-
-
Voight, B.F.1
Peloso, G.M.2
Orho-Melander, M.3
Frikke-Schmidt, R.4
Barbalic, M.5
Jensen, M.K.6
Hindy, G.7
Hólm, H.8
Ding, E.L.9
Johnson, T.10
-
27
-
-
67049100457
-
Drug discovery using chemical systems biology: Identification of the protein-ligand binding network to explain the side effects of CETP inhibitors
-
Xie L, Li J, Xie L, and Bourne PE (2009) Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors. PLOS Comput Biol 5:e1000387.
-
(2009)
PLOS Comput Biol
, vol.5
, pp. e1000387
-
-
Xie, L.1
Li, J.2
Xie, L.3
Bourne, P.E.4
-
28
-
-
79251643937
-
JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription
-
Zhang K, Guo W, Yang Y, and Wu J (2011) JAK2/STAT3 pathway is involved in the early stage of adipogenesis through regulating C/EBPβ transcription. J Cell Biochem 112:488-497.
-
(2011)
J Cell Biochem
, vol.112
, pp. 488-497
-
-
Zhang, K.1
Guo, W.2
Yang, Y.3
Wu, J.4
|