-
1
-
-
33746216577
-
The proprotein convertases and their implication in sterol and/or lipid metabolism
-
Seidah NG, Khatib AM, Prat A. The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol Chem 2006;387:871-7.
-
(2006)
Biol Chem
, vol.387
, pp. 871-877
-
-
Seidah, N.G.1
Khatib, A.M.2
Prat, A.3
-
2
-
-
84922680162
-
Proprotein convertase subtilisin/kexin type 9: From the discovery to the development of new therapies for cardiovascular diseases
-
Ferri N. Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases. Scientifica 2012;2012:927352.
-
(2012)
Scientifica
, vol.2012
, pp. 927352
-
-
Ferri, N.1
-
3
-
-
0038394566
-
Precursor convertases in the secretory pathway, cytosol and extracellular milieu
-
Seidah NG, Prat A. Precursor convertases in the secretory pathway, cytosol and extracellular milieu. Essays Biochem 2002;38:79-94.
-
(2002)
Essays Biochem
, vol.38
, pp. 79-94
-
-
Seidah, N.G.1
Prat, A.2
-
4
-
-
43049141452
-
The activation and physiological functions of the proprotein convertases
-
Seidah NG, Mayer G, Zaid A, et al. The activation and physiological functions of the proprotein convertases. Int J Biochem Cell Biol 2008;40:1111-25.
-
(2008)
Int J Biochem Cell Biol
, vol.40
, pp. 1111-1125
-
-
Seidah, N.G.1
Mayer, G.2
Zaid, A.3
-
6
-
-
84908635367
-
Proprotein convertase subtilisin/kexin type 9 (PCSK9): Lessons learned from patients with hypercholesterolemia
-
Awan Z, Baass A, Genest J. Proprotein convertase subtilisin/kexin type 9 (PCSK9): lessons learned from patients with hypercholesterolemia. Clin Chem 2014;60:1380-9.
-
(2014)
Clin Chem
, vol.60
, pp. 1380-1389
-
-
Awan, Z.1
Baass, A.2
Genest, J.3
-
7
-
-
34247899771
-
The proprotein convertases are potential targets in the treatment of dyslipidemia
-
Seidah NG, Prat A. The proprotein convertases are potential targets in the treatment of dyslipidemia. J Mol Med 2007;85: 685-96.
-
(2007)
J Mol Med
, vol.85
, pp. 685-696
-
-
Seidah, N.G.1
Prat, A.2
-
8
-
-
0037417807
-
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
-
Seidah NG, Benjannet S, Wickham L, et al. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci U S A 2003;100:928-33.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 928-933
-
-
Seidah, N.G.1
Benjannet, S.2
Wickham, L.3
-
9
-
-
10344253854
-
NARC-1/PCSK9 and its natural mutants: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
-
Benjannet S, Rhainds D, Essalmani R, et al. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem 2004;279:48865-75.
-
(2004)
J Biol Chem
, vol.279
, pp. 48865-48875
-
-
Benjannet, S.1
Rhainds, D.2
Essalmani, R.3
-
10
-
-
79953022875
-
In vivo evidence that furin from hepatocytes inactivates PCSK9
-
Essalmani R, Susan-Resiga D, Chamberland A, et al. In vivo evidence that furin from hepatocytes inactivates PCSK9. J Biol Chem 2011;286:4257-63.
-
(2011)
J Biol Chem
, vol.286
, pp. 4257-4263
-
-
Essalmani, R.1
Susan-Resiga, D.2
Chamberland, A.3
-
11
-
-
33750090075
-
The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and posttranslational modifications
-
Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and posttranslational modifications. J Biol Chem 2006;281:30561-72.
-
(2006)
J Biol Chem
, vol.281
, pp. 30561-30572
-
-
Benjannet, S.1
Rhainds, D.2
Hamelin, J.3
Nassoury, N.4
Seidah, N.G.5
-
12
-
-
84903977790
-
Isolation and characterization of the circulating truncated form of PCSK9
-
Han B, Eacho PI, Knierman MD, et al. Isolation and characterization of the circulating truncated form of PCSK9. J Lipid Res 2014;55:1505-14.
-
(2014)
J Lipid Res
, vol.55
, pp. 1505-1514
-
-
Han, B.1
Eacho, P.I.2
Knierman, M.D.3
-
13
-
-
84871587036
-
Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels
-
Lipari MT, Li W, Moran P, et al. Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels. J Biol Chem 2012;287:43482-91.
-
(2012)
J Biol Chem
, vol.287
, pp. 43482-43491
-
-
Lipari, M.T.1
Li, W.2
Moran, P.3
-
14
-
-
29944443017
-
Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia
-
Allard D, Amsellem S, Abifadel M, et al. Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia. Hum Mutat 2005;26:497.
-
(2005)
Hum Mutat
, vol.26
, pp. 497
-
-
Allard, D.1
Amsellem, S.2
Abifadel, M.3
-
15
-
-
44949241428
-
PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans
-
Dewpura T, Raymond A, Hamelin J, et al. PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. FEBS J 2008;275:3480-93.
-
(2008)
FEBS J
, vol.275
, pp. 3480-3493
-
-
Dewpura, T.1
Raymond, A.2
Hamelin, J.3
-
16
-
-
84890053040
-
PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum
-
Strom TB, Tveten K, Leren TP. PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum. Biochem J 2014;457:99-105.
-
(2014)
Biochem J
, vol.457
, pp. 99-105
-
-
Strom, T.B.1
Tveten, K.2
Leren, T.P.3
-
17
-
-
70350746156
-
Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: Evidence for an intracellular route
-
Poirier S, Mayer G, Poupon V, et al. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. J Biol Chem 2009;284:28856-64.
-
(2009)
J Biol Chem
, vol.284
, pp. 28856-28864
-
-
Poirier, S.1
Mayer, G.2
Poupon, V.3
-
18
-
-
84877675332
-
Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)
-
Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG. Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). PLoS One 2013;8:e64145.
-
(2013)
PLoS One
, vol.8
, pp. e64145
-
-
Canuel, M.1
Sun, X.2
Asselin, M.C.3
Paramithiotis, E.4
Prat, A.5
Seidah, N.G.6
-
19
-
-
84908363070
-
Effect of alirocumab, a monoclonal proprotein convertase subtilisin/kexin 9 antibody, on lipoprotein(a) concentrations (a pooled analysis of 150 mg every two weeks dosing from phase 2 trials
-
Gaudet D, Kereiakes DJ, McKenney JM, et al. Effect of alirocumab, a monoclonal proprotein convertase subtilisin/kexin 9 antibody, on lipoprotein(a) concentrations (a pooled analysis of 150 mg every two weeks dosing from phase 2 trials). Am J Cardiol 2014;114:711-5.
-
(2014)
Am J Cardiol
, vol.114
, pp. 711-715
-
-
Gaudet, D.1
Kereiakes, D.J.2
McKenney, J.M.3
-
20
-
-
84929493809
-
Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor
-
Romagnuolo R, Scipione CA, Boffa MB, Marcovina SM, Seidah NG, Koschinsky ML. Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor. J Biol Chem 2015;290:11649-62.
-
(2015)
J Biol Chem
, vol.290
, pp. 11649-11662
-
-
Romagnuolo, R.1
Scipione, C.A.2
Boffa, M.B.3
Marcovina, S.M.4
Seidah, N.G.5
Koschinsky, M.L.6
-
21
-
-
3943060193
-
Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
-
Dubuc G, Chamberland A, Wassef H, et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2004;24:1454-9.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 1454-1459
-
-
Dubuc, G.1
Chamberland, A.2
Wassef, H.3
-
22
-
-
84856077137
-
Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: The JUPITER trial
-
Awan Z, Seidah NG, MacFadyen JG, et al. Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. Clin Chem 2012;58: 183-9.
-
(2012)
Clin Chem
, vol.58
, pp. 183-189
-
-
Awan, Z.1
Seidah, N.G.2
MacFadyen, J.G.3
-
23
-
-
77956230636
-
Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients
-
Costet P, Hoffmann MM, Cariou B, Guyomarc'h Delasalle B, Konrad T,Winkler K. Plasma PCSK9 is increased by fenofibrate and atorvastatin in a non-additive fashion in diabetic patients. Atherosclerosis 2010;212:246-51.
-
(2010)
Atherosclerosis
, vol.212
, pp. 246-251
-
-
Costet, P.1
Hoffmann, M.M.2
Cariou, B.3
Guyomarc'h Delasalle, B.4
Konrad, T.5
Winkler, K.6
-
24
-
-
38949109659
-
Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
-
Careskey HE, Davis RA, Alborn WE, Troutt JS, Cao G, Konrad RJ. Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J Lipid Res 2008; 49:394-8.
-
(2008)
J Lipid Res
, vol.49
, pp. 394-398
-
-
Careskey, H.E.1
Davis, R.A.2
Alborn, W.E.3
Troutt, J.S.4
Cao, G.5
Konrad, R.J.6
-
25
-
-
84860735288
-
Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: A nested case-control study
-
Huijgen R, Boekholdt SM, Arsenault BJ, et al. Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: a nested case-control study. J Am Coll Cardiol 2012;59:1778-84.
-
(2012)
J Am Coll Cardiol
, vol.59
, pp. 1778-1784
-
-
Huijgen, R.1
Boekholdt, S.M.2
Arsenault, B.J.3
-
26
-
-
84875474072
-
Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels
-
Berthold HK, Seidah NG, Benjannet S, Gouni-Berthold I. Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels. PLoS One 2013; 8:e60095.
-
(2013)
PLoS One
, vol.8
, pp. e60095
-
-
Berthold, H.K.1
Seidah, N.G.2
Benjannet, S.3
Gouni-Berthold, I.4
-
27
-
-
17244377696
-
Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
-
Rashid S, Curtis DE, Garuti R, et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A 2005;102:5374-9.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 5374-5379
-
-
Rashid, S.1
Curtis, D.E.2
Garuti, R.3
-
28
-
-
84869025466
-
The PCSK9 decade
-
Lambert G, Sjouke B, Choque B, Kastelein JJ, Hovingh GK. The PCSK9 decade. J Lipid Res 2012;53:2515-24.
-
(2012)
J Lipid Res
, vol.53
, pp. 2515-2524
-
-
Lambert, G.1
Sjouke, B.2
Choque, B.3
Kastelein, J.J.4
Hovingh, G.K.5
-
29
-
-
73449109571
-
Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels
-
Davignon J, Dubuc G. Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels. Trans Am Clin Climatol Assoc 2009;120:163-73.
-
(2009)
Trans Am Clin Climatol Assoc
, vol.120
, pp. 163-173
-
-
Davignon, J.1
Dubuc, G.2
-
30
-
-
73149094934
-
A new method for measurement of total plasma PCSK9: Clinical applications
-
Dubuc G, Tremblay M, Pare G, et al. A new method for measurement of total plasma PCSK9: clinical applications. J Lipid Res 2010;51:140-9.
-
(2010)
J Lipid Res
, vol.51
, pp. 140-149
-
-
Dubuc, G.1
Tremblay, M.2
Pare, G.3
-
31
-
-
84930273014
-
Impact of ezetimibe alone or in addition to a statin on plasma PCSK9 concentrations in patients with type 2 diabetes and hypercholesterolemia: A pilot study
-
Miyoshi T, Nakamura K, Doi M, Ito H. Impact of ezetimibe alone or in addition to a statin on plasma PCSK9 concentrations in patients with type 2 diabetes and hypercholesterolemia: a pilot study. Am J Cardiovasc Drugs 2015;15:213-9.
-
(2015)
Am J Cardiovasc Drugs
, vol.15
, pp. 213-219
-
-
Miyoshi, T.1
Nakamura, K.2
Doi, M.3
Ito, H.4
-
32
-
-
79952049508
-
Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents
-
Konrad RJ, Troutt JS, Cao G. Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents. Lipids Health Dis 2011;10:38.
-
(2011)
Lipids Health Dis
, vol.10
, pp. 38
-
-
Konrad, R.J.1
Troutt, J.S.2
Cao, G.3
-
33
-
-
58149476450
-
Relation of clinical benefit of raising high-density lipoprotein cholesterol to serum levels of low-density lipoprotein cholesterol in patients with coronary heart disease (from the Bezafibrate Infarction Prevention Trial
-
Goldenberg I, Benderly M, Sidi R, et al. Relation of clinical benefit of raising high-density lipoprotein cholesterol to serum levels of low-density lipoprotein cholesterol in patients with coronary heart disease (from the Bezafibrate Infarction Prevention Trial). Am J Cardiol 2009;103:41-5.
-
(2009)
Am J Cardiol
, vol.103
, pp. 41-45
-
-
Goldenberg, I.1
Benderly, M.2
Sidi, R.3
-
34
-
-
84880807814
-
Future of cholesteryl ester transfer protein (CETP) inhibitors: A pharmacological perspective
-
Mohammadpour AH, Akhlaghi F. Future of cholesteryl ester transfer protein (CETP) inhibitors: a pharmacological perspective. Clin Pharmacokinet 2013;52:615-26.
-
(2013)
Clin Pharmacokinet
, vol.52
, pp. 615-626
-
-
Mohammadpour, A.H.1
Akhlaghi, F.2
-
35
-
-
84938748425
-
Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidemia (TULIP): A randomised, double-blind, placebo-controlled phase 2 trial
-
Hovingh GK, Kastelein JJ, van Deventer SJ, et al. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet 2015;386:452-60.
-
(2015)
Lancet
, vol.386
, pp. 452-460
-
-
Hovingh, G.K.1
Kastelein, J.J.2
Van Deventer, S.J.3
-
36
-
-
84930402044
-
Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects
-
Millar JS, Reyes-Soffer G, Jumes P, et al. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest 2015;125:2510-22.
-
(2015)
J Clin Invest
, vol.125
, pp. 2510-2522
-
-
Millar, J.S.1
Reyes-Soffer, G.2
Jumes, P.3
-
37
-
-
84948799852
-
Anacetrapib reduces (V)LDL-cholesterol by inhibition of CETP activity and reduction of plasma PCSK9
-
Van der Tuin SJ, Kuhnast S, Berbee JF, et al. Anacetrapib reduces (V)LDL-cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res 2015;56:2085-93.
-
(2015)
J Lipid Res
, vol.56
, pp. 2085-2093
-
-
Van Der Tuin, S.J.1
Kuhnast, S.2
Berbee, J.F.3
-
38
-
-
84920513669
-
CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism
-
Dong B, Singh AB, Fung C, Kan K, Liu J. CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism. Atherosclerosis 2014;235:449-62.
-
(2014)
Atherosclerosis
, vol.235
, pp. 449-462
-
-
Dong, B.1
Singh, A.B.2
Fung, C.3
Kan, K.4
Liu, J.5
-
39
-
-
84937558497
-
New CETP inhibitor K-312 reduces PCSK9 expression: A potential effect on LDL cholesterol metabolism
-
Miyosawa K,Watanabe Y, Murakami K, et al. New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism. Am J Physiol Endocrinol Metab 2015; 309:E177-90.
-
(2015)
Am J Physiol Endocrinol Metab
, vol.309
, pp. E177-E190
-
-
Miyosawa, K.1
Watanabe, Y.2
Murakami, K.3
-
40
-
-
84919439236
-
Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques
-
Roddy TP, McLaren DG, Chen Y, et al. Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques. Eur J Pharmacol 2014;740:410-6.
-
(2014)
Eur J Pharmacol
, vol.740
, pp. 410-416
-
-
Roddy, T.P.1
McLaren, D.G.2
Chen, Y.3
-
41
-
-
33646547336
-
Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c
-
Costet P, Cariou B, Lambert G, et al. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J Biol Chem 2006;281:6211-8.
-
(2006)
J Biol Chem
, vol.281
, pp. 6211-6218
-
-
Costet, P.1
Cariou, B.2
Lambert, G.3
-
42
-
-
70450267457
-
PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion
-
Langhi C, Le May C, Gmyr V, et al. PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion. Biochem Biophys Res Commun 2009;390:1288-93.
-
(2009)
Biochem Biophys Res Commun
, vol.390
, pp. 1288-1293
-
-
Langhi, C.1
Le May, C.2
Gmyr, V.3
-
43
-
-
84893982496
-
Nutraceutical approach to moderate cardiometabolic risk: Results of a randomized, double-blind and crossover study with Armolipid Plus
-
Ruscica M, Gomaraschi M, Mombelli G, et al. Nutraceutical approach to moderate cardiometabolic risk: results of a randomized, double-blind and crossover study with Armolipid Plus. J Clin Lipidol 2014;8:61-8.
-
(2014)
J Clin Lipidol
, vol.8
, pp. 61-68
-
-
Ruscica, M.1
Gomaraschi, M.2
Mombelli, G.3
-
44
-
-
56649086377
-
Berberine decreases PCSK9 expression in HepG2 cells
-
Cameron J, Ranheim T, Kulseth MA, Leren TP, Berge KE. Berberine decreases PCSK9 expression in HepG2 cells. Atherosclerosis 2008;201:266-73.
-
(2008)
Atherosclerosis
, vol.201
, pp. 266-273
-
-
Cameron, J.1
Ranheim, T.2
Kulseth, M.A.3
Leren, T.P.4
Berge, K.E.5
-
45
-
-
84922831823
-
Inhibition of PCSK9 transcription by berberine involves down-regulation of hepatic HNF1a protein expression through the ubiquitin-proteasome degradation pathway
-
Dong B, Li H, Singh AB, Cao A, Liu J. Inhibition of PCSK9 transcription by berberine involves down-regulation of hepatic HNF1a protein expression through the ubiquitin-proteasome degradation pathway. J Biol Chem 2015;290:4047-58.
-
(2015)
J Biol Chem
, vol.290
, pp. 4047-4058
-
-
Dong, B.1
Li, H.2
Singh, A.B.3
Cao, A.4
Liu, J.5
-
46
-
-
84899899100
-
Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats
-
Jia YJ, Xu RX, Sun J, Tang Y, Li JJ. Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats. J Transl Med 2014;12:103.
-
(2014)
J Transl Med
, vol.12
, pp. 103
-
-
Jia, Y.J.1
Xu, R.X.2
Sun, J.3
Tang, Y.4
Li, J.J.5
-
47
-
-
0037082099
-
Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
-
Goldstein JL, Rawson RB, Brown MS. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch Biochem Biophys 2002;397:139-48.
-
(2002)
Arch Biochem Biophys
, vol.397
, pp. 139-148
-
-
Goldstein, J.L.1
Rawson, R.B.2
Brown, M.S.3
-
48
-
-
27644578453
-
Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase
-
Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. J Biol Chem 2005; 280:36551-9.
-
(2005)
J Biol Chem
, vol.280
, pp. 36551-36559
-
-
Jin, W.1
Fuki, I.V.2
Seidah, N.G.3
Benjannet, S.4
Glick, J.M.5
Rader, D.J.6
-
49
-
-
0037314398
-
Endothelial lipase is a major determinant of HDL level
-
Ishida T, Choi S, Kundu RK, et al. Endothelial lipase is a major determinant of HDL level. J Clin Invest 2003;111:347-55.
-
(2003)
J Clin Invest
, vol.111
, pp. 347-355
-
-
Ishida, T.1
Choi, S.2
Kundu, R.K.3
-
50
-
-
0032901331
-
A novel endothelial-derived lipase thatmodulatesHDLmetabolism
-
Jaye M, Lynch KJ, Krawiec J, et al. A novel endothelial-derived lipase thatmodulatesHDLmetabolism.NatGenet 1999;21:424-8.
-
(1999)
NatGenet
, vol.21
, pp. 424-428
-
-
Jaye, M.1
Lynch, K.J.2
Krawiec, J.3
-
51
-
-
0344406740
-
Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
-
Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A 2003;100:2748-53.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 2748-2753
-
-
Ma, K.1
Cilingiroglu, M.2
Otvos, J.D.3
Ballantyne, C.M.4
Marian, A.J.5
Chan, L.6
-
52
-
-
0037354633
-
The lipoprotein lipase gene HindIII polymorphism is associated with lipid levels in early-onset type 2 diabetic patients
-
Ma YQ, Thomas GN, Ng MC, Critchley JA, Chan JC, Tomlinson B. The lipoprotein lipase gene HindIII polymorphism is associated with lipid levels in early-onset type 2 diabetic patients. Metabolism 2003;52:338-43.
-
(2003)
Metabolism
, vol.52
, pp. 338-343
-
-
Ma, Y.Q.1
Thomas, G.N.2
Ng, M.C.3
Critchley, J.A.4
Chan, J.C.5
Tomlinson, B.6
-
53
-
-
34547571901
-
Hepatic proprotein convertases modulate HDL metabolism
-
Jin W, Wang X, Millar JS, et al. Hepatic proprotein convertases modulate HDL metabolism. Cell Metab 2007;6:129-36.
-
(2007)
Cell Metab
, vol.6
, pp. 129-136
-
-
Jin, W.1
Wang, X.2
Millar, J.S.3
-
54
-
-
84884197551
-
Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes
-
Essalmani R, Susan-Resiga D, Chamberland A, et al. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J Biol Chem 2013;288:26410-8.
-
(2013)
J Biol Chem
, vol.288
, pp. 26410-26418
-
-
Essalmani, R.1
Susan-Resiga, D.2
Chamberland, A.3
-
55
-
-
84964199888
-
Intake levels of dietary polyunsaturated fatty acids modify the association between the genetic variation in PCSK5 and HDL cholesterol
-
Jang HB, Hwang JY, Park JE, et al. Intake levels of dietary polyunsaturated fatty acids modify the association between the genetic variation in PCSK5 and HDL cholesterol. J Med Genet 2014;51:782-8.
-
(2014)
J Med Genet
, vol.51
, pp. 782-788
-
-
Jang, H.B.1
Hwang, J.Y.2
Park, J.E.3
-
56
-
-
77949429060
-
Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels
-
Iatan I, Dastani Z, Do R, et al. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circ Cardiovasc Genet 2009;2: 467-75.
-
(2009)
Circ Cardiovasc Genet
, vol.2
, pp. 467-475
-
-
Iatan, I.1
Dastani, Z.2
Do, R.3
-
57
-
-
34147136507
-
Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
-
Graham MJ, Lemonidis KM, Whipple CP, et al. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J Lipid Res 2007; 48:763-7.
-
(2007)
J Lipid Res
, vol.48
, pp. 763-767
-
-
Graham, M.J.1
Lemonidis, K.M.2
Whipple, C.P.3
-
58
-
-
67649834056
-
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
-
Chan JC, Piper DE, Cao Q, et al. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A 2009; 106:9820-5.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 9820-9825
-
-
Chan, J.C.1
Piper, D.E.2
Cao, Q.3
-
59
-
-
84880901358
-
Decreased APOEcontaining HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9
-
Choi S, Aljakna A, Srivastava U, et al. Decreased APOEcontaining HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9. Lipids Health Dis 2013; 12:112.
-
(2013)
Lipids Health Dis
, vol.12
, pp. 112
-
-
Choi, S.1
Aljakna, A.2
Srivastava, U.3
-
60
-
-
0020013576
-
Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species
-
Ha YC, Barter PJ. Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species. Comp Biochem Physiol B 1982;71:265-9.
-
(1982)
Comp Biochem Physiol B
, vol.71
, pp. 265-269
-
-
Ha, Y.C.1
Barter, P.J.2
-
61
-
-
33745026603
-
The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
-
Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955;34:1345-53.
-
(1955)
J Clin Invest
, vol.34
, pp. 1345-1353
-
-
Havel, R.J.1
Eder, H.A.2
Bragdon, J.H.3
-
62
-
-
0037327033
-
Cholesteryl ester transfer protein: A novel target for raising HDL and inhibiting atherosclerosis
-
Barter PJ, Brewer HB Jr, Chapman MJ, Hennekens CH, Rader DJ, Tall AR. Cholesteryl ester transfer protein: a novel target for raising HDL and inhibiting atherosclerosis. Arterioscler Thromb Vasc Biol 2003;23:160-7.
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 160-167
-
-
Barter, P.J.1
Brewer, H.B.2
Chapman, M.J.3
Hennekens, C.H.4
Rader, D.J.5
Tall, A.R.6
-
63
-
-
77952525684
-
High-density lipoprotein quantity or quality for cardiovascular prevention?
-
Calabresi L, Gomaraschi M, Franceschini G. High-density lipoprotein quantity or quality for cardiovascular prevention? Curr Pharm Des 2010;16:1494-503.
-
(2010)
Curr Pharm des
, vol.16
, pp. 1494-1503
-
-
Calabresi, L.1
Gomaraschi, M.2
Franceschini, G.3
-
64
-
-
84976897420
-
Relation of plasma PCSK9 levels to lipoprotein subfractions in patients with stable coronary artery disease
-
Xu RX, Li S, Zhang Y, et al. Relation of plasma PCSK9 levels to lipoprotein subfractions in patients with stable coronary artery disease. Lipids Health Dis 2014;13:188.
-
(2014)
Lipids Health Dis
, vol.13
, pp. 188
-
-
Xu, R.X.1
Li, S.2
Zhang, Y.3
-
65
-
-
2942548997
-
The dallas heart study: A population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health
-
Victor RG, Haley RW,Willett DL, et al. The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. Am J Cardiol 2004;93:1473-80.
-
(2004)
Am J Cardiol
, vol.93
, pp. 1473-1480
-
-
Victor, R.G.1
Haley, R.W.2
Willett, D.L.3
-
66
-
-
67650263873
-
Genetic and metabolic determinants of plasma PCSK9 levels
-
Lakoski SG, Lagace TA, Cohen JC, Horton JD, Hobbs HH. Genetic and metabolic determinants of plasma PCSK9 levels. J Clin Endocrinol Metab 2009;94:2537-43.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 2537-2543
-
-
Lakoski, S.G.1
Lagace, T.A.2
Cohen, J.C.3
Horton, J.D.4
Hobbs, H.H.5
-
67
-
-
0038013035
-
The Quebec child and adolescent health and social survey: Design and methods of a cardiovascular risk factor survey for youth
-
Paradis G, Lambert M, O'Loughlin J, et al. The Quebec Child and Adolescent Health and Social Survey: design and methods of a cardiovascular risk factor survey for youth. Can J Cardiol 2003;19:523-31.
-
(2003)
Can J Cardiol
, vol.19
, pp. 523-531
-
-
Paradis, G.1
Lambert, M.2
O'Loughlin, J.3
-
68
-
-
69549138572
-
Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents
-
Baass A, Dubuc G, Tremblay M, et al. Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents. Clin Chem 2009;55:1637-45.
-
(2009)
Clin Chem
, vol.55
, pp. 1637-1645
-
-
Baass, A.1
Dubuc, G.2
Tremblay, M.3
-
69
-
-
0037603589
-
Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
-
Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003;34: 154-6.
-
(2003)
Nat Genet
, vol.34
, pp. 154-156
-
-
Abifadel, M.1
Varret, M.2
Rabes, J.P.3
-
70
-
-
84885072023
-
The biology of PCSK9 from the endoplasmic reticulum to lysosomes: New and emerging therapeutics to control low-density lipoprotein cholesterol
-
Poirier S, Mayer G. The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol. Drug Des Devel Ther 2013;7:1135-48.
-
(2013)
Drug des Devel Ther
, vol.7
, pp. 1135-1148
-
-
Poirier, S.1
Mayer, G.2
-
71
-
-
84864770647
-
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia
-
Abifadel M, Guerin M, Benjannet S, et al. Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. Atherosclerosis 2012;223:394-400.
-
(2012)
Atherosclerosis
, vol.223
, pp. 394-400
-
-
Abifadel, M.1
Guerin, M.2
Benjannet, S.3
-
72
-
-
18944392912
-
A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis
-
Chen SN, Ballantyne CM, Gotto AM Jr, Tan Y, Willerson JT, Marian AJ. A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol 2005;45:1611-9.
-
(2005)
J Am Coll Cardiol
, vol.45
, pp. 1611-1619
-
-
Chen, S.N.1
Ballantyne, C.M.2
Gotto, A.M.3
Tan, Y.4
Willerson, J.T.5
Marian, A.J.6
-
73
-
-
33748601835
-
The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women
-
Evans D, Beil FU. The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women. BMC Med Genet 2006;7:66.
-
(2006)
BMC Med Genet
, vol.7
, pp. 66
-
-
Evans, D.1
Beil, F.U.2
-
74
-
-
73449143804
-
Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles
-
Norata GD, Garlaschelli K, Grigore L, et al. Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles. Atherosclerosis 2010;208:177-82.
-
(2010)
Atherosclerosis
, vol.208
, pp. 177-182
-
-
Norata, G.D.1
Garlaschelli, K.2
Grigore, L.3
-
75
-
-
59849087105
-
The pcsk9 gene e670g polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan
-
Hsu LA, Teng MS, Ko YL, et al. The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan. Clin Chem Lab Med 2009;47:154-8.
-
(2009)
Clin Chem Lab Med
, vol.47
, pp. 154-158
-
-
Hsu, L.A.1
Teng, M.S.2
Ko, Y.L.3
-
76
-
-
40049107734
-
Molecular population genetics of PCSK9: A signature of recent positive selection
-
Ding K, Kullo IJ. Molecular population genetics of PCSK9: a signature of recent positive selection. Pharmacogenet Genomics 2008;18:169-79.
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 169-179
-
-
Ding, K.1
Kullo, I.J.2
-
77
-
-
33344464808
-
A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol
-
Kotowski IK, Pertsemlidis A, Luke A, et al. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet 2006;78:410-22.
-
(2006)
Am J Hum Genet
, vol.78
, pp. 410-422
-
-
Kotowski, I.K.1
Pertsemlidis, A.2
Luke, A.3
-
78
-
-
36849085368
-
The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. Men
-
Scartezini M, Hubbart C, Whittall RA, Cooper JA, Neil AH, Humphries SE. The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men. Clin Sci 2007;113:435-41.
-
(2007)
Clin Sci
, vol.113
, pp. 435-441
-
-
Scartezini, M.1
Hubbart, C.2
Whittall, R.A.3
Cooper, J.A.4
Neil, A.H.5
Humphries, S.E.6
-
79
-
-
49949100564
-
Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population
-
Polisecki E, Peter I, Robertson M, et al. Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Atherosclerosis 2008;200:95-101.
-
(2008)
Atherosclerosis
, vol.200
, pp. 95-101
-
-
Polisecki, E.1
Peter, I.2
Robertson, M.3
-
80
-
-
71849105837
-
Longitudinal association of pcsk9 sequence variations with low-density lipoprotein cholesterol levels: The coronary artery risk development in young adults study
-
Huang CC, Fornage M, Lloyd-Jones DM, Wei GS, Boerwinkle E, Liu K. Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: the Coronary Artery Risk Development in Young Adults Study. Circ Cardiovasc Genet 2009;2:354-61.
-
(2009)
Circ Cardiovasc Genet
, vol.2
, pp. 354-361
-
-
Huang, C.C.1
Fornage, M.2
Lloyd-Jones, D.M.3
Wei, G.S.4
Boerwinkle, E.5
Liu, K.6
-
81
-
-
78651302317
-
The proprotein convertase subtilisin/kexin type 9 gene e670g polymorphism and serum lipid levels in the guangxi bai ku yao and han populations
-
Aung LH, Yin RX, Miao L, et al. The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis 2011;10:5.
-
(2011)
Lipids Health Dis
, vol.10
, pp. 5
-
-
Aung, L.H.1
Yin, R.X.2
Miao, L.3
-
82
-
-
38949103409
-
Self-association of human PCSK9 correlates with its LDLR-degrading activity
-
Fan D, Yancey PG, Qiu S, et al. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry 2008;47:1631-9.
-
(2008)
Biochemistry
, vol.47
, pp. 1631-1639
-
-
Fan, D.1
Yancey, P.G.2
Qiu, S.3
-
83
-
-
84875460859
-
Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation
-
Kosenko T, Golder M, Leblond G, Weng W, Lagace TA. Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation. J Biol Chem 2013;288:8279-88.
-
(2013)
J Biol Chem
, vol.288
, pp. 8279-8288
-
-
Kosenko, T.1
Golder, M.2
Leblond, G.3
Weng, W.4
Lagace, T.A.5
-
84
-
-
84862219022
-
Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
-
McKenney JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol 2012;59:2344-53.
-
(2012)
J Am Coll Cardiol
, vol.59
, pp. 2344-2353
-
-
McKenney, J.M.1
Koren, M.J.2
Kereiakes, D.J.3
Hanotin, C.4
Ferrand, A.C.5
Stein, E.A.6
-
85
-
-
84858638369
-
Effect of a monoclonal antibody to PCSK9 on LDL cholesterol
-
Stein EA, Mellis S, Yancopoulos GD, et al. Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. N Engl J Med 2012;366:1108-18.
-
(2012)
N Engl J Med
, vol.366
, pp. 1108-1118
-
-
Stein, E.A.1
Mellis, S.2
Yancopoulos, G.D.3
-
86
-
-
84868689211
-
Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
-
Roth EM, McKenney JM, Hanotin C, Asset G, Stein EA. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med 2012;367:1891-900.
-
(2012)
N Engl J Med
, vol.367
, pp. 1891-1900
-
-
Roth, E.M.1
McKenney, J.M.2
Hanotin, C.3
Asset, G.4
Stein, E.A.5
-
87
-
-
84863494422
-
Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
-
Stein EA, Gipe D, Bergeron J, et al. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet 2012;380:29-36.
-
(2012)
Lancet
, vol.380
, pp. 29-36
-
-
Stein, E.A.1
Gipe, D.2
Bergeron, J.3
-
88
-
-
84926191670
-
Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
-
Robinson JG, Farnier M, Krempf M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 2015;372:1489-99.
-
(2015)
N Engl J Med
, vol.372
, pp. 1489-1499
-
-
Robinson, J.G.1
Farnier, M.2
Krempf, M.3
-
89
-
-
84871326497
-
Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: The GAUSS randomized trial
-
Sullivan D, Olsson AG, Scott R, et al. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA 2012;308:2497-506.
-
(2012)
JAMA
, vol.308
, pp. 2497-2506
-
-
Sullivan, D.1
Olsson, A.G.2
Scott, R.3
-
90
-
-
84893230270
-
AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III lowdensity lipoprotein cholesterol goals among high-risk patients: An analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin therapy-thrombolysis in myocardial infarction 57
-
Desai NR, Giugliano RP, Zhou J, et al. AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III lowdensity lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin therapy-thrombolysis in myocardial infarction 57). J Am Coll Cardiol 2014;63:430-3.
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 430-433
-
-
Desai, N.R.1
Giugliano, R.P.2
Zhou, J.3
-
91
-
-
84900303213
-
Effect of evolocumab or ezetimibe added to moderate-or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: The LAPLACE-2 randomized clinical trial
-
Robinson JG, Nedergaard BS, Rogers WJ, et al. Effect of evolocumab or ezetimibe added to moderate-or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA 2014; 311:1870-82.
-
(2014)
JAMA
, vol.311
, pp. 1870-1882
-
-
Robinson, J.G.1
Nedergaard, B.S.2
Rogers, W.J.3
-
92
-
-
84870494510
-
Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, doubleblind, placebo-controlled, phase 2 study
-
Koren MJ, Scott R, Kim JB, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, doubleblind, placebo-controlled, phase 2 study. Lancet 2012;380: 1995-2006.
-
(2012)
Lancet
, vol.380
, pp. 1995-2006
-
-
Koren, M.J.1
Scott, R.2
Kim, J.B.3
-
93
-
-
84869220345
-
Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial
-
Raal F, Scott R, Somaratne R, et al. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial. Circulation 2012;126: 2408-17.
-
(2012)
Circulation
, vol.126
, pp. 2408-2417
-
-
Raal, F.1
Scott, R.2
Somaratne, R.3
-
94
-
-
84892679366
-
Efficacy and safety of longer-term administration of evolocumab (amg 145) in patients with hypercholesterolemia: 52-week results from the open-label study of long-term evaluation against ldl-c (osler) randomized trial
-
Koren MJ, Giugliano RP, Raal FJ, et al. Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial. Circulation 2014;129: 234-43.
-
(2014)
Circulation
, vol.129
, pp. 234-243
-
-
Koren, M.J.1
Giugliano, R.P.2
Raal, F.J.3
-
95
-
-
84902142901
-
Anti-PCSK9 monotherapy for hypercholesterolemia: The MENDEL-2 randomized, controlled phase III clinical trial of evolocumab
-
Koren MJ, Lundqvist P, Bolognese M, et al. Anti-PCSK9 monotherapy for hypercholesterolemia: The MENDEL-2 randomized, controlled phase III clinical trial of evolocumab. J Am Coll Cardiol 2014;63:2531-40.
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 2531-2540
-
-
Koren, M.J.1
Lundqvist, P.2
Bolognese, M.3
-
96
-
-
84921483643
-
PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): A randomised, double-blind, placebo-controlled trial
-
Raal FJ, Stein EA, Dufour R, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet 2015;385:331-40.
-
(2015)
Lancet
, vol.385
, pp. 331-340
-
-
Raal, F.J.1
Stein, E.A.2
Dufour, R.3
-
97
-
-
84902157271
-
Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: The GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab
-
Stroes E, Colquhoun D, Sullivan D, et al. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: The GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J Am Coll Cardiol 2014;63:2541-8.
-
(2014)
J Am Coll Cardiol
, vol.63
, pp. 2541-2548
-
-
Stroes, E.1
Colquhoun, D.2
Sullivan, D.3
-
98
-
-
84887164358
-
Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia
-
Stein EA, Honarpour N,Wasserman SM, Xu F, Scott R, Raal FJ. Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia. Circulation 2013;128:2113-20.
-
(2013)
Circulation
, vol.128
, pp. 2113-2120
-
-
Stein, E.A.1
Honarpour, N.2
Wasserman, S.M.3
Xu, F.4
Scott, R.5
Raal, F.J.6
-
99
-
-
84921459685
-
Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): A randomised, double-blind, placebocontrolled trial
-
Raal FJ, Honarpour N, Blom DJ, et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebocontrolled trial. Lancet 2015;385:341-50.
-
(2015)
Lancet
, vol.385
, pp. 341-350
-
-
Raal, F.J.1
Honarpour, N.2
Blom, D.J.3
-
100
-
-
84926206074
-
Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
-
Sabatine MS, Giugliano RP, Wiviott SD, et al. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 2015;372:1500-9.
-
(2015)
N Engl J Med
, vol.372
, pp. 1500-1509
-
-
Sabatine, M.S.1
Giugliano, R.P.2
Wiviott, S.D.3
-
101
-
-
0029082222
-
Pravastatin modulates cholesteryl ester transfer from HDL to apoB-containing lipoproteins and lipoprotein subspecies profile in familial hypercholesterolemia
-
Guerin M, Dolphin PJ, Talussot C, Gardette J, Berthezene F, Chapman MJ. Pravastatin modulates cholesteryl ester transfer from HDL to apoB-containing lipoproteins and lipoprotein subspecies profile in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 1995;15:1359-68.
-
(1995)
Arterioscler Thromb Vasc Biol
, vol.15
, pp. 1359-1368
-
-
Guerin, M.1
Dolphin, P.J.2
Talussot, C.3
Gardette, J.4
Berthezene, F.5
Chapman, M.J.6
-
102
-
-
0036364576
-
Effect of HMG-CoA reductase inhibitor on plasma cholesteryl ester transfer protein activity in primary hypercholesterolemia: Comparison among CETP/TaqIB genotype subgroups
-
Kotake H, Sekikawa A, Tokita Y, Ishigaki Y, Oikawa S. Effect of HMG-CoA reductase inhibitor on plasma cholesteryl ester transfer protein activity in primary hypercholesterolemia: comparison among CETP/TaqIB genotype subgroups. J Atheroscler Thromb 2002;9:207-12.
-
(2002)
J Atheroscler Thromb
, vol.9
, pp. 207-212
-
-
Kotake, H.1
Sekikawa, A.2
Tokita, Y.3
Ishigaki, Y.4
Oikawa, S.5
|