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Volumn 173, Issue , 2016, Pages 19-29

Proprotein convertase subtilisin kexin type 9 and high-density lipoprotein metabolism: Experimental animal models and clinical evidence

Author keywords

[No Author keywords available]

Indexed keywords

ALIROCUMAB; BERBERINE DERIVATIVE; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; EVOLOCUMAB; EZETIMIBE; FENOFIBRATE; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KEXIN; LIPOPROTEIN; LOW DENSITY LIPOPROTEIN RECEPTOR; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SUBTILISIN; UNCLASSIFIED DRUG; PROPROTEIN CONVERTASE 9;

EID: 84975155684     PISSN: 19315244     EISSN: 18781810     Source Type: Journal    
DOI: 10.1016/j.trsl.2015.10.004     Document Type: Review
Times cited : (52)

References (102)
  • 1
    • 33746216577 scopus 로고    scopus 로고
    • The proprotein convertases and their implication in sterol and/or lipid metabolism
    • Seidah NG, Khatib AM, Prat A. The proprotein convertases and their implication in sterol and/or lipid metabolism. Biol Chem 2006;387:871-7.
    • (2006) Biol Chem , vol.387 , pp. 871-877
    • Seidah, N.G.1    Khatib, A.M.2    Prat, A.3
  • 2
    • 84922680162 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9: From the discovery to the development of new therapies for cardiovascular diseases
    • Ferri N. Proprotein convertase subtilisin/kexin type 9: from the discovery to the development of new therapies for cardiovascular diseases. Scientifica 2012;2012:927352.
    • (2012) Scientifica , vol.2012 , pp. 927352
    • Ferri, N.1
  • 3
    • 0038394566 scopus 로고    scopus 로고
    • Precursor convertases in the secretory pathway, cytosol and extracellular milieu
    • Seidah NG, Prat A. Precursor convertases in the secretory pathway, cytosol and extracellular milieu. Essays Biochem 2002;38:79-94.
    • (2002) Essays Biochem , vol.38 , pp. 79-94
    • Seidah, N.G.1    Prat, A.2
  • 4
    • 43049141452 scopus 로고    scopus 로고
    • The activation and physiological functions of the proprotein convertases
    • Seidah NG, Mayer G, Zaid A, et al. The activation and physiological functions of the proprotein convertases. Int J Biochem Cell Biol 2008;40:1111-25.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1111-1125
    • Seidah, N.G.1    Mayer, G.2    Zaid, A.3
  • 5
    • 84897889156 scopus 로고    scopus 로고
    • PCSK9: A key modulator of cardiovascular health
    • Seidah NG, Awan Z, Chretien M, Mbikay M. PCSK9: a key modulator of cardiovascular health. Circ Res 2014;114: 1022-36.
    • (2014) Circ Res , vol.114 , pp. 1022-1036
    • Seidah, N.G.1    Awan, Z.2    Chretien, M.3    Mbikay, M.4
  • 6
    • 84908635367 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9): Lessons learned from patients with hypercholesterolemia
    • Awan Z, Baass A, Genest J. Proprotein convertase subtilisin/kexin type 9 (PCSK9): lessons learned from patients with hypercholesterolemia. Clin Chem 2014;60:1380-9.
    • (2014) Clin Chem , vol.60 , pp. 1380-1389
    • Awan, Z.1    Baass, A.2    Genest, J.3
  • 7
    • 34247899771 scopus 로고    scopus 로고
    • The proprotein convertases are potential targets in the treatment of dyslipidemia
    • Seidah NG, Prat A. The proprotein convertases are potential targets in the treatment of dyslipidemia. J Mol Med 2007;85: 685-96.
    • (2007) J Mol Med , vol.85 , pp. 685-696
    • Seidah, N.G.1    Prat, A.2
  • 8
    • 0037417807 scopus 로고    scopus 로고
    • The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation
    • Seidah NG, Benjannet S, Wickham L, et al. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci U S A 2003;100:928-33.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 928-933
    • Seidah, N.G.1    Benjannet, S.2    Wickham, L.3
  • 9
    • 10344253854 scopus 로고    scopus 로고
    • NARC-1/PCSK9 and its natural mutants: Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
    • Benjannet S, Rhainds D, Essalmani R, et al. NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem 2004;279:48865-75.
    • (2004) J Biol Chem , vol.279 , pp. 48865-48875
    • Benjannet, S.1    Rhainds, D.2    Essalmani, R.3
  • 10
    • 79953022875 scopus 로고    scopus 로고
    • In vivo evidence that furin from hepatocytes inactivates PCSK9
    • Essalmani R, Susan-Resiga D, Chamberland A, et al. In vivo evidence that furin from hepatocytes inactivates PCSK9. J Biol Chem 2011;286:4257-63.
    • (2011) J Biol Chem , vol.286 , pp. 4257-4263
    • Essalmani, R.1    Susan-Resiga, D.2    Chamberland, A.3
  • 11
    • 33750090075 scopus 로고    scopus 로고
    • The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: Functional consequences of natural mutations and posttranslational modifications
    • Benjannet S, Rhainds D, Hamelin J, Nassoury N, Seidah NG. The proprotein convertase (PC) PCSK9 is inactivated by furin and/or PC5/6A: functional consequences of natural mutations and posttranslational modifications. J Biol Chem 2006;281:30561-72.
    • (2006) J Biol Chem , vol.281 , pp. 30561-30572
    • Benjannet, S.1    Rhainds, D.2    Hamelin, J.3    Nassoury, N.4    Seidah, N.G.5
  • 12
    • 84903977790 scopus 로고    scopus 로고
    • Isolation and characterization of the circulating truncated form of PCSK9
    • Han B, Eacho PI, Knierman MD, et al. Isolation and characterization of the circulating truncated form of PCSK9. J Lipid Res 2014;55:1505-14.
    • (2014) J Lipid Res , vol.55 , pp. 1505-1514
    • Han, B.1    Eacho, P.I.2    Knierman, M.D.3
  • 13
    • 84871587036 scopus 로고    scopus 로고
    • Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels
    • Lipari MT, Li W, Moran P, et al. Furin-cleaved proprotein convertase subtilisin/kexin type 9 (PCSK9) is active and modulates low density lipoprotein receptor and serum cholesterol levels. J Biol Chem 2012;287:43482-91.
    • (2012) J Biol Chem , vol.287 , pp. 43482-43491
    • Lipari, M.T.1    Li, W.2    Moran, P.3
  • 14
    • 29944443017 scopus 로고    scopus 로고
    • Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia
    • Allard D, Amsellem S, Abifadel M, et al. Novel mutations of the PCSK9 gene cause variable phenotype of autosomal dominant hypercholesterolemia. Hum Mutat 2005;26:497.
    • (2005) Hum Mutat , vol.26 , pp. 497
    • Allard, D.1    Amsellem, S.2    Abifadel, M.3
  • 15
    • 44949241428 scopus 로고    scopus 로고
    • PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans
    • Dewpura T, Raymond A, Hamelin J, et al. PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. FEBS J 2008;275:3480-93.
    • (2008) FEBS J , vol.275 , pp. 3480-3493
    • Dewpura, T.1    Raymond, A.2    Hamelin, J.3
  • 16
    • 84890053040 scopus 로고    scopus 로고
    • PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum
    • Strom TB, Tveten K, Leren TP. PCSK9 acts as a chaperone for the LDL receptor in the endoplasmic reticulum. Biochem J 2014;457:99-105.
    • (2014) Biochem J , vol.457 , pp. 99-105
    • Strom, T.B.1    Tveten, K.2    Leren, T.P.3
  • 17
    • 70350746156 scopus 로고    scopus 로고
    • Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: Evidence for an intracellular route
    • Poirier S, Mayer G, Poupon V, et al. Dissection of the endogenous cellular pathways of PCSK9-induced low density lipoprotein receptor degradation: evidence for an intracellular route. J Biol Chem 2009;284:28856-64.
    • (2009) J Biol Chem , vol.284 , pp. 28856-28864
    • Poirier, S.1    Mayer, G.2    Poupon, V.3
  • 18
    • 84877675332 scopus 로고    scopus 로고
    • Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1)
    • Canuel M, Sun X, Asselin MC, Paramithiotis E, Prat A, Seidah NG. Proprotein convertase subtilisin/kexin type 9 (PCSK9) can mediate degradation of the low density lipoprotein receptor-related protein 1 (LRP-1). PLoS One 2013;8:e64145.
    • (2013) PLoS One , vol.8 , pp. e64145
    • Canuel, M.1    Sun, X.2    Asselin, M.C.3    Paramithiotis, E.4    Prat, A.5    Seidah, N.G.6
  • 19
    • 84908363070 scopus 로고    scopus 로고
    • Effect of alirocumab, a monoclonal proprotein convertase subtilisin/kexin 9 antibody, on lipoprotein(a) concentrations (a pooled analysis of 150 mg every two weeks dosing from phase 2 trials
    • Gaudet D, Kereiakes DJ, McKenney JM, et al. Effect of alirocumab, a monoclonal proprotein convertase subtilisin/kexin 9 antibody, on lipoprotein(a) concentrations (a pooled analysis of 150 mg every two weeks dosing from phase 2 trials). Am J Cardiol 2014;114:711-5.
    • (2014) Am J Cardiol , vol.114 , pp. 711-715
    • Gaudet, D.1    Kereiakes, D.J.2    McKenney, J.M.3
  • 20
    • 84929493809 scopus 로고    scopus 로고
    • Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor
    • Romagnuolo R, Scipione CA, Boffa MB, Marcovina SM, Seidah NG, Koschinsky ML. Lipoprotein(a) catabolism is regulated by proprotein convertase subtilisin/kexin type 9 through the low density lipoprotein receptor. J Biol Chem 2015;290:11649-62.
    • (2015) J Biol Chem , vol.290 , pp. 11649-11662
    • Romagnuolo, R.1    Scipione, C.A.2    Boffa, M.B.3    Marcovina, S.M.4    Seidah, N.G.5    Koschinsky, M.L.6
  • 21
    • 3943060193 scopus 로고    scopus 로고
    • Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia
    • Dubuc G, Chamberland A, Wassef H, et al. Statins upregulate PCSK9, the gene encoding the proprotein convertase neural apoptosis-regulated convertase-1 implicated in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 2004;24:1454-9.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1454-1459
    • Dubuc, G.1    Chamberland, A.2    Wassef, H.3
  • 22
    • 84856077137 scopus 로고    scopus 로고
    • Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: The JUPITER trial
    • Awan Z, Seidah NG, MacFadyen JG, et al. Rosuvastatin, proprotein convertase subtilisin/kexin type 9 concentrations, and LDL cholesterol response: the JUPITER trial. Clin Chem 2012;58: 183-9.
    • (2012) Clin Chem , vol.58 , pp. 183-189
    • Awan, Z.1    Seidah, N.G.2    MacFadyen, J.G.3
  • 24
    • 38949109659 scopus 로고    scopus 로고
    • Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9
    • Careskey HE, Davis RA, Alborn WE, Troutt JS, Cao G, Konrad RJ. Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9. J Lipid Res 2008; 49:394-8.
    • (2008) J Lipid Res , vol.49 , pp. 394-398
    • Careskey, H.E.1    Davis, R.A.2    Alborn, W.E.3    Troutt, J.S.4    Cao, G.5    Konrad, R.J.6
  • 25
    • 84860735288 scopus 로고    scopus 로고
    • Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: A nested case-control study
    • Huijgen R, Boekholdt SM, Arsenault BJ, et al. Plasma PCSK9 levels and clinical outcomes in the TNT (Treating to New Targets) trial: a nested case-control study. J Am Coll Cardiol 2012;59:1778-84.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 1778-1784
    • Huijgen, R.1    Boekholdt, S.M.2    Arsenault, B.J.3
  • 26
    • 84875474072 scopus 로고    scopus 로고
    • Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels
    • Berthold HK, Seidah NG, Benjannet S, Gouni-Berthold I. Evidence from a randomized trial that simvastatin, but not ezetimibe, upregulates circulating PCSK9 levels. PLoS One 2013; 8:e60095.
    • (2013) PLoS One , vol.8 , pp. e60095
    • Berthold, H.K.1    Seidah, N.G.2    Benjannet, S.3    Gouni-Berthold, I.4
  • 27
    • 17244377696 scopus 로고    scopus 로고
    • Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
    • Rashid S, Curtis DE, Garuti R, et al. Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9. Proc Natl Acad Sci U S A 2005;102:5374-9.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5374-5379
    • Rashid, S.1    Curtis, D.E.2    Garuti, R.3
  • 29
    • 73449109571 scopus 로고    scopus 로고
    • Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels
    • Davignon J, Dubuc G. Statins and ezetimibe modulate plasma proprotein convertase subtilisin kexin-9 (PCSK9) levels. Trans Am Clin Climatol Assoc 2009;120:163-73.
    • (2009) Trans Am Clin Climatol Assoc , vol.120 , pp. 163-173
    • Davignon, J.1    Dubuc, G.2
  • 30
    • 73149094934 scopus 로고    scopus 로고
    • A new method for measurement of total plasma PCSK9: Clinical applications
    • Dubuc G, Tremblay M, Pare G, et al. A new method for measurement of total plasma PCSK9: clinical applications. J Lipid Res 2010;51:140-9.
    • (2010) J Lipid Res , vol.51 , pp. 140-149
    • Dubuc, G.1    Tremblay, M.2    Pare, G.3
  • 31
    • 84930273014 scopus 로고    scopus 로고
    • Impact of ezetimibe alone or in addition to a statin on plasma PCSK9 concentrations in patients with type 2 diabetes and hypercholesterolemia: A pilot study
    • Miyoshi T, Nakamura K, Doi M, Ito H. Impact of ezetimibe alone or in addition to a statin on plasma PCSK9 concentrations in patients with type 2 diabetes and hypercholesterolemia: a pilot study. Am J Cardiovasc Drugs 2015;15:213-9.
    • (2015) Am J Cardiovasc Drugs , vol.15 , pp. 213-219
    • Miyoshi, T.1    Nakamura, K.2    Doi, M.3    Ito, H.4
  • 32
    • 79952049508 scopus 로고    scopus 로고
    • Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents
    • Konrad RJ, Troutt JS, Cao G. Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agents. Lipids Health Dis 2011;10:38.
    • (2011) Lipids Health Dis , vol.10 , pp. 38
    • Konrad, R.J.1    Troutt, J.S.2    Cao, G.3
  • 33
    • 58149476450 scopus 로고    scopus 로고
    • Relation of clinical benefit of raising high-density lipoprotein cholesterol to serum levels of low-density lipoprotein cholesterol in patients with coronary heart disease (from the Bezafibrate Infarction Prevention Trial
    • Goldenberg I, Benderly M, Sidi R, et al. Relation of clinical benefit of raising high-density lipoprotein cholesterol to serum levels of low-density lipoprotein cholesterol in patients with coronary heart disease (from the Bezafibrate Infarction Prevention Trial). Am J Cardiol 2009;103:41-5.
    • (2009) Am J Cardiol , vol.103 , pp. 41-45
    • Goldenberg, I.1    Benderly, M.2    Sidi, R.3
  • 34
    • 84880807814 scopus 로고    scopus 로고
    • Future of cholesteryl ester transfer protein (CETP) inhibitors: A pharmacological perspective
    • Mohammadpour AH, Akhlaghi F. Future of cholesteryl ester transfer protein (CETP) inhibitors: a pharmacological perspective. Clin Pharmacokinet 2013;52:615-26.
    • (2013) Clin Pharmacokinet , vol.52 , pp. 615-626
    • Mohammadpour, A.H.1    Akhlaghi, F.2
  • 35
    • 84938748425 scopus 로고    scopus 로고
    • Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidemia (TULIP): A randomised, double-blind, placebo-controlled phase 2 trial
    • Hovingh GK, Kastelein JJ, van Deventer SJ, et al. Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial. Lancet 2015;386:452-60.
    • (2015) Lancet , vol.386 , pp. 452-460
    • Hovingh, G.K.1    Kastelein, J.J.2    Van Deventer, S.J.3
  • 36
    • 84930402044 scopus 로고    scopus 로고
    • Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects
    • Millar JS, Reyes-Soffer G, Jumes P, et al. Anacetrapib lowers LDL by increasing ApoB clearance in mildly hypercholesterolemic subjects. J Clin Invest 2015;125:2510-22.
    • (2015) J Clin Invest , vol.125 , pp. 2510-2522
    • Millar, J.S.1    Reyes-Soffer, G.2    Jumes, P.3
  • 37
    • 84948799852 scopus 로고    scopus 로고
    • Anacetrapib reduces (V)LDL-cholesterol by inhibition of CETP activity and reduction of plasma PCSK9
    • Van der Tuin SJ, Kuhnast S, Berbee JF, et al. Anacetrapib reduces (V)LDL-cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res 2015;56:2085-93.
    • (2015) J Lipid Res , vol.56 , pp. 2085-2093
    • Van Der Tuin, S.J.1    Kuhnast, S.2    Berbee, J.F.3
  • 38
    • 84920513669 scopus 로고    scopus 로고
    • CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism
    • Dong B, Singh AB, Fung C, Kan K, Liu J. CETP inhibitors downregulate hepatic LDL receptor and PCSK9 expression in vitro and in vivo through a SREBP2 dependent mechanism. Atherosclerosis 2014;235:449-62.
    • (2014) Atherosclerosis , vol.235 , pp. 449-462
    • Dong, B.1    Singh, A.B.2    Fung, C.3    Kan, K.4    Liu, J.5
  • 39
    • 84937558497 scopus 로고    scopus 로고
    • New CETP inhibitor K-312 reduces PCSK9 expression: A potential effect on LDL cholesterol metabolism
    • Miyosawa K,Watanabe Y, Murakami K, et al. New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism. Am J Physiol Endocrinol Metab 2015; 309:E177-90.
    • (2015) Am J Physiol Endocrinol Metab , vol.309 , pp. E177-E190
    • Miyosawa, K.1    Watanabe, Y.2    Murakami, K.3
  • 40
    • 84919439236 scopus 로고    scopus 로고
    • Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques
    • Roddy TP, McLaren DG, Chen Y, et al. Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques. Eur J Pharmacol 2014;740:410-6.
    • (2014) Eur J Pharmacol , vol.740 , pp. 410-416
    • Roddy, T.P.1    McLaren, D.G.2    Chen, Y.3
  • 41
    • 33646547336 scopus 로고    scopus 로고
    • Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c
    • Costet P, Cariou B, Lambert G, et al. Hepatic PCSK9 expression is regulated by nutritional status via insulin and sterol regulatory element-binding protein 1c. J Biol Chem 2006;281:6211-8.
    • (2006) J Biol Chem , vol.281 , pp. 6211-6218
    • Costet, P.1    Cariou, B.2    Lambert, G.3
  • 42
    • 70450267457 scopus 로고    scopus 로고
    • PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion
    • Langhi C, Le May C, Gmyr V, et al. PCSK9 is expressed in pancreatic delta-cells and does not alter insulin secretion. Biochem Biophys Res Commun 2009;390:1288-93.
    • (2009) Biochem Biophys Res Commun , vol.390 , pp. 1288-1293
    • Langhi, C.1    Le May, C.2    Gmyr, V.3
  • 43
    • 84893982496 scopus 로고    scopus 로고
    • Nutraceutical approach to moderate cardiometabolic risk: Results of a randomized, double-blind and crossover study with Armolipid Plus
    • Ruscica M, Gomaraschi M, Mombelli G, et al. Nutraceutical approach to moderate cardiometabolic risk: results of a randomized, double-blind and crossover study with Armolipid Plus. J Clin Lipidol 2014;8:61-8.
    • (2014) J Clin Lipidol , vol.8 , pp. 61-68
    • Ruscica, M.1    Gomaraschi, M.2    Mombelli, G.3
  • 45
    • 84922831823 scopus 로고    scopus 로고
    • Inhibition of PCSK9 transcription by berberine involves down-regulation of hepatic HNF1a protein expression through the ubiquitin-proteasome degradation pathway
    • Dong B, Li H, Singh AB, Cao A, Liu J. Inhibition of PCSK9 transcription by berberine involves down-regulation of hepatic HNF1a protein expression through the ubiquitin-proteasome degradation pathway. J Biol Chem 2015;290:4047-58.
    • (2015) J Biol Chem , vol.290 , pp. 4047-4058
    • Dong, B.1    Li, H.2    Singh, A.B.3    Cao, A.4    Liu, J.5
  • 46
    • 84899899100 scopus 로고    scopus 로고
    • Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats
    • Jia YJ, Xu RX, Sun J, Tang Y, Li JJ. Enhanced circulating PCSK9 concentration by berberine through SREBP-2 pathway in high fat diet-fed rats. J Transl Med 2014;12:103.
    • (2014) J Transl Med , vol.12 , pp. 103
    • Jia, Y.J.1    Xu, R.X.2    Sun, J.3    Tang, Y.4    Li, J.J.5
  • 47
    • 0037082099 scopus 로고    scopus 로고
    • Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
    • Goldstein JL, Rawson RB, Brown MS. Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch Biochem Biophys 2002;397:139-48.
    • (2002) Arch Biochem Biophys , vol.397 , pp. 139-148
    • Goldstein, J.L.1    Rawson, R.B.2    Brown, M.S.3
  • 48
    • 27644578453 scopus 로고    scopus 로고
    • Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase
    • Jin W, Fuki IV, Seidah NG, Benjannet S, Glick JM, Rader DJ. Proprotein convertases [corrected] are responsible for proteolysis and inactivation of endothelial lipase. J Biol Chem 2005; 280:36551-9.
    • (2005) J Biol Chem , vol.280 , pp. 36551-36559
    • Jin, W.1    Fuki, I.V.2    Seidah, N.G.3    Benjannet, S.4    Glick, J.M.5    Rader, D.J.6
  • 49
    • 0037314398 scopus 로고    scopus 로고
    • Endothelial lipase is a major determinant of HDL level
    • Ishida T, Choi S, Kundu RK, et al. Endothelial lipase is a major determinant of HDL level. J Clin Invest 2003;111:347-55.
    • (2003) J Clin Invest , vol.111 , pp. 347-355
    • Ishida, T.1    Choi, S.2    Kundu, R.K.3
  • 50
    • 0032901331 scopus 로고    scopus 로고
    • A novel endothelial-derived lipase thatmodulatesHDLmetabolism
    • Jaye M, Lynch KJ, Krawiec J, et al. A novel endothelial-derived lipase thatmodulatesHDLmetabolism.NatGenet 1999;21:424-8.
    • (1999) NatGenet , vol.21 , pp. 424-428
    • Jaye, M.1    Lynch, K.J.2    Krawiec, J.3
  • 51
    • 0344406740 scopus 로고    scopus 로고
    • Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
    • Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A 2003;100:2748-53.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2748-2753
    • Ma, K.1    Cilingiroglu, M.2    Otvos, J.D.3    Ballantyne, C.M.4    Marian, A.J.5    Chan, L.6
  • 52
    • 0037354633 scopus 로고    scopus 로고
    • The lipoprotein lipase gene HindIII polymorphism is associated with lipid levels in early-onset type 2 diabetic patients
    • Ma YQ, Thomas GN, Ng MC, Critchley JA, Chan JC, Tomlinson B. The lipoprotein lipase gene HindIII polymorphism is associated with lipid levels in early-onset type 2 diabetic patients. Metabolism 2003;52:338-43.
    • (2003) Metabolism , vol.52 , pp. 338-343
    • Ma, Y.Q.1    Thomas, G.N.2    Ng, M.C.3    Critchley, J.A.4    Chan, J.C.5    Tomlinson, B.6
  • 53
    • 34547571901 scopus 로고    scopus 로고
    • Hepatic proprotein convertases modulate HDL metabolism
    • Jin W, Wang X, Millar JS, et al. Hepatic proprotein convertases modulate HDL metabolism. Cell Metab 2007;6:129-36.
    • (2007) Cell Metab , vol.6 , pp. 129-136
    • Jin, W.1    Wang, X.2    Millar, J.S.3
  • 54
    • 84884197551 scopus 로고    scopus 로고
    • Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes
    • Essalmani R, Susan-Resiga D, Chamberland A, et al. Furin is the primary in vivo convertase of angiopoietin-like 3 and endothelial lipase in hepatocytes. J Biol Chem 2013;288:26410-8.
    • (2013) J Biol Chem , vol.288 , pp. 26410-26418
    • Essalmani, R.1    Susan-Resiga, D.2    Chamberland, A.3
  • 55
    • 84964199888 scopus 로고    scopus 로고
    • Intake levels of dietary polyunsaturated fatty acids modify the association between the genetic variation in PCSK5 and HDL cholesterol
    • Jang HB, Hwang JY, Park JE, et al. Intake levels of dietary polyunsaturated fatty acids modify the association between the genetic variation in PCSK5 and HDL cholesterol. J Med Genet 2014;51:782-8.
    • (2014) J Med Genet , vol.51 , pp. 782-788
    • Jang, H.B.1    Hwang, J.Y.2    Park, J.E.3
  • 56
    • 77949429060 scopus 로고    scopus 로고
    • Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels
    • Iatan I, Dastani Z, Do R, et al. Genetic variation at the proprotein convertase subtilisin/kexin type 5 gene modulates high-density lipoprotein cholesterol levels. Circ Cardiovasc Genet 2009;2: 467-75.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 467-475
    • Iatan, I.1    Dastani, Z.2    Do, R.3
  • 57
    • 34147136507 scopus 로고    scopus 로고
    • Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice
    • Graham MJ, Lemonidis KM, Whipple CP, et al. Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice. J Lipid Res 2007; 48:763-7.
    • (2007) J Lipid Res , vol.48 , pp. 763-767
    • Graham, M.J.1    Lemonidis, K.M.2    Whipple, C.P.3
  • 58
    • 67649834056 scopus 로고    scopus 로고
    • A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
    • Chan JC, Piper DE, Cao Q, et al. A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates. Proc Natl Acad Sci U S A 2009; 106:9820-5.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 9820-9825
    • Chan, J.C.1    Piper, D.E.2    Cao, Q.3
  • 59
    • 84880901358 scopus 로고    scopus 로고
    • Decreased APOEcontaining HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9
    • Choi S, Aljakna A, Srivastava U, et al. Decreased APOEcontaining HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9. Lipids Health Dis 2013; 12:112.
    • (2013) Lipids Health Dis , vol.12 , pp. 112
    • Choi, S.1    Aljakna, A.2    Srivastava, U.3
  • 60
    • 0020013576 scopus 로고
    • Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species
    • Ha YC, Barter PJ. Differences in plasma cholesteryl ester transfer activity in sixteen vertebrate species. Comp Biochem Physiol B 1982;71:265-9.
    • (1982) Comp Biochem Physiol B , vol.71 , pp. 265-269
    • Ha, Y.C.1    Barter, P.J.2
  • 61
    • 33745026603 scopus 로고
    • The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum
    • Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest 1955;34:1345-53.
    • (1955) J Clin Invest , vol.34 , pp. 1345-1353
    • Havel, R.J.1    Eder, H.A.2    Bragdon, J.H.3
  • 63
    • 77952525684 scopus 로고    scopus 로고
    • High-density lipoprotein quantity or quality for cardiovascular prevention?
    • Calabresi L, Gomaraschi M, Franceschini G. High-density lipoprotein quantity or quality for cardiovascular prevention? Curr Pharm Des 2010;16:1494-503.
    • (2010) Curr Pharm des , vol.16 , pp. 1494-1503
    • Calabresi, L.1    Gomaraschi, M.2    Franceschini, G.3
  • 64
    • 84976897420 scopus 로고    scopus 로고
    • Relation of plasma PCSK9 levels to lipoprotein subfractions in patients with stable coronary artery disease
    • Xu RX, Li S, Zhang Y, et al. Relation of plasma PCSK9 levels to lipoprotein subfractions in patients with stable coronary artery disease. Lipids Health Dis 2014;13:188.
    • (2014) Lipids Health Dis , vol.13 , pp. 188
    • Xu, R.X.1    Li, S.2    Zhang, Y.3
  • 65
    • 2942548997 scopus 로고    scopus 로고
    • The dallas heart study: A population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health
    • Victor RG, Haley RW,Willett DL, et al. The Dallas Heart Study: a population-based probability sample for the multidisciplinary study of ethnic differences in cardiovascular health. Am J Cardiol 2004;93:1473-80.
    • (2004) Am J Cardiol , vol.93 , pp. 1473-1480
    • Victor, R.G.1    Haley, R.W.2    Willett, D.L.3
  • 67
    • 0038013035 scopus 로고    scopus 로고
    • The Quebec child and adolescent health and social survey: Design and methods of a cardiovascular risk factor survey for youth
    • Paradis G, Lambert M, O'Loughlin J, et al. The Quebec Child and Adolescent Health and Social Survey: design and methods of a cardiovascular risk factor survey for youth. Can J Cardiol 2003;19:523-31.
    • (2003) Can J Cardiol , vol.19 , pp. 523-531
    • Paradis, G.1    Lambert, M.2    O'Loughlin, J.3
  • 68
    • 69549138572 scopus 로고    scopus 로고
    • Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents
    • Baass A, Dubuc G, Tremblay M, et al. Plasma PCSK9 is associated with age, sex, and multiple metabolic markers in a population-based sample of children and adolescents. Clin Chem 2009;55:1637-45.
    • (2009) Clin Chem , vol.55 , pp. 1637-1645
    • Baass, A.1    Dubuc, G.2    Tremblay, M.3
  • 69
    • 0037603589 scopus 로고    scopus 로고
    • Mutations in PCSK9 cause autosomal dominant hypercholesterolemia
    • Abifadel M, Varret M, Rabes JP, et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nat Genet 2003;34: 154-6.
    • (2003) Nat Genet , vol.34 , pp. 154-156
    • Abifadel, M.1    Varret, M.2    Rabes, J.P.3
  • 70
    • 84885072023 scopus 로고    scopus 로고
    • The biology of PCSK9 from the endoplasmic reticulum to lysosomes: New and emerging therapeutics to control low-density lipoprotein cholesterol
    • Poirier S, Mayer G. The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol. Drug Des Devel Ther 2013;7:1135-48.
    • (2013) Drug des Devel Ther , vol.7 , pp. 1135-1148
    • Poirier, S.1    Mayer, G.2
  • 71
    • 84864770647 scopus 로고    scopus 로고
    • Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia
    • Abifadel M, Guerin M, Benjannet S, et al. Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. Atherosclerosis 2012;223:394-400.
    • (2012) Atherosclerosis , vol.223 , pp. 394-400
    • Abifadel, M.1    Guerin, M.2    Benjannet, S.3
  • 72
    • 18944392912 scopus 로고    scopus 로고
    • A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis
    • Chen SN, Ballantyne CM, Gotto AM Jr, Tan Y, Willerson JT, Marian AJ. A common PCSK9 haplotype, encompassing the E670G coding single nucleotide polymorphism, is a novel genetic marker for plasma low-density lipoprotein cholesterol levels and severity of coronary atherosclerosis. J Am Coll Cardiol 2005;45:1611-9.
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1611-1619
    • Chen, S.N.1    Ballantyne, C.M.2    Gotto, A.M.3    Tan, Y.4    Willerson, J.T.5    Marian, A.J.6
  • 73
    • 33748601835 scopus 로고    scopus 로고
    • The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women
    • Evans D, Beil FU. The E670G SNP in the PCSK9 gene is associated with polygenic hypercholesterolemia in men but not in women. BMC Med Genet 2006;7:66.
    • (2006) BMC Med Genet , vol.7 , pp. 66
    • Evans, D.1    Beil, F.U.2
  • 74
    • 73449143804 scopus 로고    scopus 로고
    • Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles
    • Norata GD, Garlaschelli K, Grigore L, et al. Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles. Atherosclerosis 2010;208:177-82.
    • (2010) Atherosclerosis , vol.208 , pp. 177-182
    • Norata, G.D.1    Garlaschelli, K.2    Grigore, L.3
  • 75
    • 59849087105 scopus 로고    scopus 로고
    • The pcsk9 gene e670g polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan
    • Hsu LA, Teng MS, Ko YL, et al. The PCSK9 gene E670G polymorphism affects low-density lipoprotein cholesterol levels but is not a risk factor for coronary artery disease in ethnic Chinese in Taiwan. Clin Chem Lab Med 2009;47:154-8.
    • (2009) Clin Chem Lab Med , vol.47 , pp. 154-158
    • Hsu, L.A.1    Teng, M.S.2    Ko, Y.L.3
  • 76
    • 40049107734 scopus 로고    scopus 로고
    • Molecular population genetics of PCSK9: A signature of recent positive selection
    • Ding K, Kullo IJ. Molecular population genetics of PCSK9: a signature of recent positive selection. Pharmacogenet Genomics 2008;18:169-79.
    • (2008) Pharmacogenet Genomics , vol.18 , pp. 169-179
    • Ding, K.1    Kullo, I.J.2
  • 77
    • 33344464808 scopus 로고    scopus 로고
    • A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol
    • Kotowski IK, Pertsemlidis A, Luke A, et al. A spectrum of PCSK9 alleles contributes to plasma levels of low-density lipoprotein cholesterol. Am J Hum Genet 2006;78:410-22.
    • (2006) Am J Hum Genet , vol.78 , pp. 410-422
    • Kotowski, I.K.1    Pertsemlidis, A.2    Luke, A.3
  • 78
    • 36849085368 scopus 로고    scopus 로고
    • The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. Men
    • Scartezini M, Hubbart C, Whittall RA, Cooper JA, Neil AH, Humphries SE. The PCSK9 gene R46L variant is associated with lower plasma lipid levels and cardiovascular risk in healthy U.K. men. Clin Sci 2007;113:435-41.
    • (2007) Clin Sci , vol.113 , pp. 435-441
    • Scartezini, M.1    Hubbart, C.2    Whittall, R.A.3    Cooper, J.A.4    Neil, A.H.5    Humphries, S.E.6
  • 79
    • 49949100564 scopus 로고    scopus 로고
    • Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population
    • Polisecki E, Peter I, Robertson M, et al. Genetic variation at the PCSK9 locus moderately lowers low-density lipoprotein cholesterol levels, but does not significantly lower vascular disease risk in an elderly population. Atherosclerosis 2008;200:95-101.
    • (2008) Atherosclerosis , vol.200 , pp. 95-101
    • Polisecki, E.1    Peter, I.2    Robertson, M.3
  • 80
    • 71849105837 scopus 로고    scopus 로고
    • Longitudinal association of pcsk9 sequence variations with low-density lipoprotein cholesterol levels: The coronary artery risk development in young adults study
    • Huang CC, Fornage M, Lloyd-Jones DM, Wei GS, Boerwinkle E, Liu K. Longitudinal association of PCSK9 sequence variations with low-density lipoprotein cholesterol levels: the Coronary Artery Risk Development in Young Adults Study. Circ Cardiovasc Genet 2009;2:354-61.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 354-361
    • Huang, C.C.1    Fornage, M.2    Lloyd-Jones, D.M.3    Wei, G.S.4    Boerwinkle, E.5    Liu, K.6
  • 81
    • 78651302317 scopus 로고    scopus 로고
    • The proprotein convertase subtilisin/kexin type 9 gene e670g polymorphism and serum lipid levels in the guangxi bai ku yao and han populations
    • Aung LH, Yin RX, Miao L, et al. The proprotein convertase subtilisin/kexin type 9 gene E670G polymorphism and serum lipid levels in the Guangxi Bai Ku Yao and Han populations. Lipids Health Dis 2011;10:5.
    • (2011) Lipids Health Dis , vol.10 , pp. 5
    • Aung, L.H.1    Yin, R.X.2    Miao, L.3
  • 82
    • 38949103409 scopus 로고    scopus 로고
    • Self-association of human PCSK9 correlates with its LDLR-degrading activity
    • Fan D, Yancey PG, Qiu S, et al. Self-association of human PCSK9 correlates with its LDLR-degrading activity. Biochemistry 2008;47:1631-9.
    • (2008) Biochemistry , vol.47 , pp. 1631-1639
    • Fan, D.1    Yancey, P.G.2    Qiu, S.3
  • 83
    • 84875460859 scopus 로고    scopus 로고
    • Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation
    • Kosenko T, Golder M, Leblond G, Weng W, Lagace TA. Low density lipoprotein binds to proprotein convertase subtilisin/kexin type-9 (PCSK9) in human plasma and inhibits PCSK9-mediated low density lipoprotein receptor degradation. J Biol Chem 2013;288:8279-88.
    • (2013) J Biol Chem , vol.288 , pp. 8279-8288
    • Kosenko, T.1    Golder, M.2    Leblond, G.3    Weng, W.4    Lagace, T.A.5
  • 84
    • 84862219022 scopus 로고    scopus 로고
    • Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy
    • McKenney JM, Koren MJ, Kereiakes DJ, Hanotin C, Ferrand AC, Stein EA. Safety and efficacy of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease, SAR236553/REGN727, in patients with primary hypercholesterolemia receiving ongoing stable atorvastatin therapy. J Am Coll Cardiol 2012;59:2344-53.
    • (2012) J Am Coll Cardiol , vol.59 , pp. 2344-2353
    • McKenney, J.M.1    Koren, M.J.2    Kereiakes, D.J.3    Hanotin, C.4    Ferrand, A.C.5    Stein, E.A.6
  • 85
    • 84858638369 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on LDL cholesterol
    • Stein EA, Mellis S, Yancopoulos GD, et al. Effect of a monoclonal antibody to PCSK9 on LDL cholesterol. N Engl J Med 2012;366:1108-18.
    • (2012) N Engl J Med , vol.366 , pp. 1108-1118
    • Stein, E.A.1    Mellis, S.2    Yancopoulos, G.D.3
  • 86
    • 84868689211 scopus 로고    scopus 로고
    • Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia
    • Roth EM, McKenney JM, Hanotin C, Asset G, Stein EA. Atorvastatin with or without an antibody to PCSK9 in primary hypercholesterolemia. N Engl J Med 2012;367:1891-900.
    • (2012) N Engl J Med , vol.367 , pp. 1891-1900
    • Roth, E.M.1    McKenney, J.M.2    Hanotin, C.3    Asset, G.4    Stein, E.A.5
  • 87
    • 84863494422 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: A phase 2 randomised controlled trial
    • Stein EA, Gipe D, Bergeron J, et al. Effect of a monoclonal antibody to PCSK9, REGN727/SAR236553, to reduce low-density lipoprotein cholesterol in patients with heterozygous familial hypercholesterolaemia on stable statin dose with or without ezetimibe therapy: a phase 2 randomised controlled trial. Lancet 2012;380:29-36.
    • (2012) Lancet , vol.380 , pp. 29-36
    • Stein, E.A.1    Gipe, D.2    Bergeron, J.3
  • 88
    • 84926191670 scopus 로고    scopus 로고
    • Efficacy and safety of alirocumab in reducing lipids and cardiovascular events
    • Robinson JG, Farnier M, Krempf M, et al. Efficacy and safety of alirocumab in reducing lipids and cardiovascular events. N Engl J Med 2015;372:1489-99.
    • (2015) N Engl J Med , vol.372 , pp. 1489-1499
    • Robinson, J.G.1    Farnier, M.2    Krempf, M.3
  • 89
    • 84871326497 scopus 로고    scopus 로고
    • Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: The GAUSS randomized trial
    • Sullivan D, Olsson AG, Scott R, et al. Effect of a monoclonal antibody to PCSK9 on low-density lipoprotein cholesterol levels in statin-intolerant patients: the GAUSS randomized trial. JAMA 2012;308:2497-506.
    • (2012) JAMA , vol.308 , pp. 2497-2506
    • Sullivan, D.1    Olsson, A.G.2    Scott, R.3
  • 90
    • 84893230270 scopus 로고    scopus 로고
    • AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III lowdensity lipoprotein cholesterol goals among high-risk patients: An analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin therapy-thrombolysis in myocardial infarction 57
    • Desai NR, Giugliano RP, Zhou J, et al. AMG 145, a monoclonal antibody against PCSK9, facilitates achievement of national cholesterol education program-adult treatment panel III lowdensity lipoprotein cholesterol goals among high-risk patients: an analysis from the LAPLACE-TIMI 57 trial (LDL-C assessment with PCSK9 monoclonal antibody inhibition combined with statin therapy-thrombolysis in myocardial infarction 57). J Am Coll Cardiol 2014;63:430-3.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 430-433
    • Desai, N.R.1    Giugliano, R.P.2    Zhou, J.3
  • 91
    • 84900303213 scopus 로고    scopus 로고
    • Effect of evolocumab or ezetimibe added to moderate-or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: The LAPLACE-2 randomized clinical trial
    • Robinson JG, Nedergaard BS, Rogers WJ, et al. Effect of evolocumab or ezetimibe added to moderate-or high-intensity statin therapy on LDL-C lowering in patients with hypercholesterolemia: the LAPLACE-2 randomized clinical trial. JAMA 2014; 311:1870-82.
    • (2014) JAMA , vol.311 , pp. 1870-1882
    • Robinson, J.G.1    Nedergaard, B.S.2    Rogers, W.J.3
  • 92
    • 84870494510 scopus 로고    scopus 로고
    • Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): A randomised, doubleblind, placebo-controlled, phase 2 study
    • Koren MJ, Scott R, Kim JB, et al. Efficacy, safety, and tolerability of a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 as monotherapy in patients with hypercholesterolaemia (MENDEL): a randomised, doubleblind, placebo-controlled, phase 2 study. Lancet 2012;380: 1995-2006.
    • (2012) Lancet , vol.380 , pp. 1995-2006
    • Koren, M.J.1    Scott, R.2    Kim, J.B.3
  • 93
    • 84869220345 scopus 로고    scopus 로고
    • Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: The Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial
    • Raal F, Scott R, Somaratne R, et al. Low-density lipoprotein cholesterol-lowering effects of AMG 145, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 serine protease in patients with heterozygous familial hypercholesterolemia: the Reduction of LDL-C with PCSK9 Inhibition in Heterozygous Familial Hypercholesterolemia Disorder (RUTHERFORD) randomized trial. Circulation 2012;126: 2408-17.
    • (2012) Circulation , vol.126 , pp. 2408-2417
    • Raal, F.1    Scott, R.2    Somaratne, R.3
  • 94
    • 84892679366 scopus 로고    scopus 로고
    • Efficacy and safety of longer-term administration of evolocumab (amg 145) in patients with hypercholesterolemia: 52-week results from the open-label study of long-term evaluation against ldl-c (osler) randomized trial
    • Koren MJ, Giugliano RP, Raal FJ, et al. Efficacy and safety of longer-term administration of evolocumab (AMG 145) in patients with hypercholesterolemia: 52-week results from the Open-Label Study of Long-Term Evaluation Against LDL-C (OSLER) randomized trial. Circulation 2014;129: 234-43.
    • (2014) Circulation , vol.129 , pp. 234-243
    • Koren, M.J.1    Giugliano, R.P.2    Raal, F.J.3
  • 95
    • 84902142901 scopus 로고    scopus 로고
    • Anti-PCSK9 monotherapy for hypercholesterolemia: The MENDEL-2 randomized, controlled phase III clinical trial of evolocumab
    • Koren MJ, Lundqvist P, Bolognese M, et al. Anti-PCSK9 monotherapy for hypercholesterolemia: The MENDEL-2 randomized, controlled phase III clinical trial of evolocumab. J Am Coll Cardiol 2014;63:2531-40.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 2531-2540
    • Koren, M.J.1    Lundqvist, P.2    Bolognese, M.3
  • 96
    • 84921483643 scopus 로고    scopus 로고
    • PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): A randomised, double-blind, placebo-controlled trial
    • Raal FJ, Stein EA, Dufour R, et al. PCSK9 inhibition with evolocumab (AMG 145) in heterozygous familial hypercholesterolaemia (RUTHERFORD-2): a randomised, double-blind, placebo-controlled trial. Lancet 2015;385:331-40.
    • (2015) Lancet , vol.385 , pp. 331-340
    • Raal, F.J.1    Stein, E.A.2    Dufour, R.3
  • 97
    • 84902157271 scopus 로고    scopus 로고
    • Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: The GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab
    • Stroes E, Colquhoun D, Sullivan D, et al. Anti-PCSK9 antibody effectively lowers cholesterol in patients with statin intolerance: The GAUSS-2 randomized, placebo-controlled phase 3 clinical trial of evolocumab. J Am Coll Cardiol 2014;63:2541-8.
    • (2014) J Am Coll Cardiol , vol.63 , pp. 2541-2548
    • Stroes, E.1    Colquhoun, D.2    Sullivan, D.3
  • 98
    • 84887164358 scopus 로고    scopus 로고
    • Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia
    • Stein EA, Honarpour N,Wasserman SM, Xu F, Scott R, Raal FJ. Effect of the proprotein convertase subtilisin/kexin 9 monoclonal antibody, AMG 145, in homozygous familial hypercholesterolemia. Circulation 2013;128:2113-20.
    • (2013) Circulation , vol.128 , pp. 2113-2120
    • Stein, E.A.1    Honarpour, N.2    Wasserman, S.M.3    Xu, F.4    Scott, R.5    Raal, F.J.6
  • 99
    • 84921459685 scopus 로고    scopus 로고
    • Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): A randomised, double-blind, placebocontrolled trial
    • Raal FJ, Honarpour N, Blom DJ, et al. Inhibition of PCSK9 with evolocumab in homozygous familial hypercholesterolaemia (TESLA Part B): a randomised, double-blind, placebocontrolled trial. Lancet 2015;385:341-50.
    • (2015) Lancet , vol.385 , pp. 341-350
    • Raal, F.J.1    Honarpour, N.2    Blom, D.J.3
  • 100
    • 84926206074 scopus 로고    scopus 로고
    • Efficacy and safety of evolocumab in reducing lipids and cardiovascular events
    • Sabatine MS, Giugliano RP, Wiviott SD, et al. Efficacy and safety of evolocumab in reducing lipids and cardiovascular events. N Engl J Med 2015;372:1500-9.
    • (2015) N Engl J Med , vol.372 , pp. 1500-1509
    • Sabatine, M.S.1    Giugliano, R.P.2    Wiviott, S.D.3
  • 101
    • 0029082222 scopus 로고
    • Pravastatin modulates cholesteryl ester transfer from HDL to apoB-containing lipoproteins and lipoprotein subspecies profile in familial hypercholesterolemia
    • Guerin M, Dolphin PJ, Talussot C, Gardette J, Berthezene F, Chapman MJ. Pravastatin modulates cholesteryl ester transfer from HDL to apoB-containing lipoproteins and lipoprotein subspecies profile in familial hypercholesterolemia. Arterioscler Thromb Vasc Biol 1995;15:1359-68.
    • (1995) Arterioscler Thromb Vasc Biol , vol.15 , pp. 1359-1368
    • Guerin, M.1    Dolphin, P.J.2    Talussot, C.3    Gardette, J.4    Berthezene, F.5    Chapman, M.J.6
  • 102
    • 0036364576 scopus 로고    scopus 로고
    • Effect of HMG-CoA reductase inhibitor on plasma cholesteryl ester transfer protein activity in primary hypercholesterolemia: Comparison among CETP/TaqIB genotype subgroups
    • Kotake H, Sekikawa A, Tokita Y, Ishigaki Y, Oikawa S. Effect of HMG-CoA reductase inhibitor on plasma cholesteryl ester transfer protein activity in primary hypercholesterolemia: comparison among CETP/TaqIB genotype subgroups. J Atheroscler Thromb 2002;9:207-12.
    • (2002) J Atheroscler Thromb , vol.9 , pp. 207-212
    • Kotake, H.1    Sekikawa, A.2    Tokita, Y.3    Ishigaki, Y.4    Oikawa, S.5


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