메뉴 건너뛰기




Volumn 67, Issue 4, 2016, Pages 353-361

Reduction in Total Cardiovascular Events with Ezetimibe/Simvastatin Post-Acute Coronary Syndrome the IMPROVE-IT Trial

Author keywords

ezetimibe; low density lipoprotein cholesterol; simvastatin; total events

Indexed keywords

EZETIMIBE; PLACEBO; SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPOCHOLESTEROLEMIC AGENT; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

EID: 84959370789     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2015.10.077     Document Type: Article
Times cited : (175)

References (25)
  • 1
    • 71649112327 scopus 로고    scopus 로고
    • Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22) trial
    • S.A. Murphy, C.P. Cannon, S.D. Wiviott, C.H. McCabe, and E. Braunwald Reduction in recurrent cardiovascular events with intensive lipid-lowering statin therapy compared with moderate lipid-lowering statin therapy after acute coronary syndromes from the PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) trial J Am Coll Cardiol 54 2009 2358 2362
    • (2009) J Am Coll Cardiol , vol.54 , pp. 2358-2362
    • Murphy, S.A.1    Cannon, C.P.2    Wiviott, S.D.3    McCabe, C.H.4    Braunwald, E.5
  • 2
    • 71649105479 scopus 로고    scopus 로고
    • Total cardiovascular disease burden: Comparing intensive with moderate statin therapy insights from the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) trial
    • M.J. Tikkanen, M. Szarek, R. Fayyad, and et al. Total cardiovascular disease burden: comparing intensive with moderate statin therapy insights from the IDEAL (Incremental Decrease in End Points Through Aggressive Lipid Lowering) trial J Am Coll Cardiol 54 2009 2353 2357
    • (2009) J Am Coll Cardiol , vol.54 , pp. 2353-2357
    • Tikkanen, M.J.1    Szarek, M.2    Fayyad, R.3
  • 3
    • 84931411520 scopus 로고    scopus 로고
    • Ezetimibe added to statin therapy after acute coronary syndromes
    • C.P. Cannon, M.A. Blazing, R.P. Giugliano, and et al. Ezetimibe added to statin therapy after acute coronary syndromes N Engl J Med 372 2015 2387 2397
    • (2015) N Engl J Med , vol.372 , pp. 2387-2397
    • Cannon, C.P.1    Blazing, M.A.2    Giugliano, R.P.3
  • 4
    • 50949102416 scopus 로고    scopus 로고
    • Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): Comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes
    • C.P. Cannon, R.P. Giugliano, M.A. Blazing, and et al. Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes Am Heart J 156 2008 826 832
    • (2008) Am Heart J , vol.156 , pp. 826-832
    • Cannon, C.P.1    Giugliano, R.P.2    Blazing, M.A.3
  • 5
    • 84905040766 scopus 로고    scopus 로고
    • Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: Final baseline characteristics of the IMPROVE-IT study population
    • M.A. Blazing, R.P. Giugliano, C.P. Cannon, and et al. Evaluating cardiovascular event reduction with ezetimibe as an adjunct to simvastatin in 18,144 patients after acute coronary syndromes: final baseline characteristics of the IMPROVE-IT study population Am Heart J 168 2014 205 212.e1
    • (2014) Am Heart J , vol.168 , pp. 205-212e1
    • Blazing, M.A.1    Giugliano, R.P.2    Cannon, C.P.3
  • 6
    • 77951622890 scopus 로고    scopus 로고
    • An update on the IMProved reduction of outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design
    • R.M. Califf, Y. Lokhnygina, C.P. Cannon, and et al. An update on the IMProved reduction of outcomes: Vytorin Efficacy International Trial (IMPROVE-IT) design Am Heart J 159 2010 705 709
    • (2010) Am Heart J , vol.159 , pp. 705-709
    • Califf, R.M.1    Lokhnygina, Y.2    Cannon, C.P.3
  • 7
    • 79953752268 scopus 로고
    • Regression analysis of multivariate incomplete failure time data by modeling marginal distributions
    • L.J. Wei, D.Y. Lin, and L. Weissfeld Regression analysis of multivariate incomplete failure time data by modeling marginal distributions J Amer Statis Assoc 84 1989 1068 1073
    • (1989) J Amer Statis Assoc , vol.84 , pp. 1068-1073
    • Wei, L.J.1    Lin, D.Y.2    Weissfeld, L.3
  • 8
    • 70349813434 scopus 로고
    • On the regression analysis of multivariate failure time data
    • R.L. Prentice, B.J. Williams, and A.V. Peterson On the regression analysis of multivariate failure time data Biometrika 68 1981 373 379
    • (1981) Biometrika , vol.68 , pp. 373-379
    • Prentice, R.L.1    Williams, B.J.2    Peterson, A.V.3
  • 9
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: Prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • C. Baigent, A. Keech, P.M. Kearney, and et al. Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins Lancet 366 2005 1267 1278
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3
  • 10
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials
    • C. Baigent, L. Blackwell, J. Emberson, and et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials Lancet 376 2010 1670 1681
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3
  • 11
    • 11144355354 scopus 로고    scopus 로고
    • Intensive versus moderate lipid lowering with statins after acute coronary syndromes
    • C.P. Cannon, E. Braunwald, C.H. McCabe, and et al. Intensive versus moderate lipid lowering with statins after acute coronary syndromes N Engl J Med 350 2004 1495 1504
    • (2004) N Engl J Med , vol.350 , pp. 1495-1504
    • Cannon, C.P.1    Braunwald, E.2    McCabe, C.H.3
  • 12
    • 4544243333 scopus 로고    scopus 로고
    • Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: Phase Z of the A to Z trial
    • J.A. de Lemos, M.A. Blazing, S.D. Wiviott, and et al. Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial JAMA 292 2004 1307 1316
    • (2004) JAMA , vol.292 , pp. 1307-1316
    • De Lemos, J.A.1    Blazing, M.A.2    Wiviott, S.D.3
  • 13
    • 15944410609 scopus 로고    scopus 로고
    • Intensive lipid lowering with atorvastatin in patients with stable coronary disease
    • J.C. LaRosa, S.M. Grundy, D.D. Waters, and et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease N Engl J Med 352 2005 1425 1435
    • (2005) N Engl J Med , vol.352 , pp. 1425-1435
    • LaRosa, J.C.1    Grundy, S.M.2    Waters, D.D.3
  • 14
    • 27744603499 scopus 로고    scopus 로고
    • High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: The IDEAL study: A randomized controlled trial
    • T.R. Pedersen, O. Faergeman, J.J. Kastelein, and et al. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial JAMA 294 2005 2437 2445
    • (2005) JAMA , vol.294 , pp. 2437-2445
    • Pedersen, T.R.1    Faergeman, O.2    Kastelein, J.J.3
  • 15
    • 33746355566 scopus 로고    scopus 로고
    • Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy
    • C.P. Cannon, B.A. Steinberg, S.A. Murphy, and et al. Meta-analysis of cardiovascular outcomes trials comparing intensive versus moderate statin therapy J Am Coll Cardiol 48 2006 438 445
    • (2006) J Am Coll Cardiol , vol.48 , pp. 438-445
    • Cannon, C.P.1    Steinberg, B.A.2    Murphy, S.A.3
  • 16
    • 74049109446 scopus 로고    scopus 로고
    • Comparison of 80 versus 10 mg of atorvastatin on occurrence of cardiovascular events after the first event (from the Treating to New Targets [TNT] trial)
    • J.C. LaRosa, P.C. Deedwania, J. Shepherd, and et al. Comparison of 80 versus 10 mg of atorvastatin on occurrence of cardiovascular events after the first event (from the Treating to New Targets [TNT] trial) Am J Cardiol 105 2010 283 287
    • (2010) Am J Cardiol , vol.105 , pp. 283-287
    • LaRosa, J.C.1    Deedwania, P.C.2    Shepherd, J.3
  • 17
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • W.E. Boden, J.L. Probstfield, T. Anderson, and et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy N Engl J Med 365 2011 2255 2267
    • (2011) N Engl J Med , vol.365 , pp. 2255-2267
    • Boden, W.E.1    Probstfield, J.L.2    Anderson, T.3
  • 18
    • 84904252744 scopus 로고    scopus 로고
    • Effects of extended-release niacin with laropiprant in high-risk patients
    • M.J. Landray, R. Haynes, J.C. Hopewell, and et al. Effects of extended-release niacin with laropiprant in high-risk patients N Engl J Med 371 2014 203 212
    • (2014) N Engl J Med , vol.371 , pp. 203-212
    • Landray, M.J.1    Haynes, R.2    Hopewell, J.C.3
  • 19
    • 36348975228 scopus 로고    scopus 로고
    • Effects of torcetrapib in patients at high risk for coronary events
    • P.J. Barter, M. Caulfield, M. Eriksson, and et al. Effects of torcetrapib in patients at high risk for coronary events N Engl J Med 357 2007 2109 2122
    • (2007) N Engl J Med , vol.357 , pp. 2109-2122
    • Barter, P.J.1    Caulfield, M.2    Eriksson, M.3
  • 20
    • 84870045994 scopus 로고    scopus 로고
    • Effects of dalcetrapib in patients with a recent acute coronary syndrome
    • G.G. Schwartz, A.G. Olsson, M. Abt, and et al. Effects of dalcetrapib in patients with a recent acute coronary syndrome N Engl J Med 367 2012 2089 2099
    • (2012) N Engl J Med , vol.367 , pp. 2089-2099
    • Schwartz, G.G.1    Olsson, A.G.2    Abt, M.3
  • 21
    • 0037382524 scopus 로고    scopus 로고
    • Challenges and opportunities in quantifying the quality of care for acute myocardial infarction: Summary from the Acute Myocardial Infarction Working Group of the American Heart Association/American College of Cardiology First Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke
    • J.A. Spertus, M.J. Radford, N.R. Every, and et al. Challenges and opportunities in quantifying the quality of care for acute myocardial infarction: summary from the Acute Myocardial Infarction Working Group of the American Heart Association/American College of Cardiology First Scientific Forum on Quality of Care and Outcomes Research in Cardiovascular Disease and Stroke Circulation 107 2003 1681 1691
    • (2003) Circulation , vol.107 , pp. 1681-1691
    • Spertus, J.A.1    Radford, M.J.2    Every, N.R.3
  • 23
    • 84862942215 scopus 로고    scopus 로고
    • The win ratio: A new approach to the analysis of composite endpoints in clinical trials based on clinical priorities
    • S.J. Pocock, C.A. Ariti, T.J. Collier, and D. Wang The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities Eur Heart J 33 2012 176 182
    • (2012) Eur Heart J , vol.33 , pp. 176-182
    • Pocock, S.J.1    Ariti, C.A.2    Collier, T.J.3    Wang, D.4
  • 24
    • 84875616689 scopus 로고    scopus 로고
    • Evaluation of early percutaneous coronary intervention vs. Standard therapy after fibrinolysis for ST-segment elevation myocardial infarction: Contribution of weighting the composite endpoint
    • J.A. Bakal, C.M. Westerhout, W.J. Cantor, and et al. Evaluation of early percutaneous coronary intervention vs. standard therapy after fibrinolysis for ST-segment elevation myocardial infarction: contribution of weighting the composite endpoint Eur Heart J 34 2013 903 908
    • (2013) Eur Heart J , vol.34 , pp. 903-908
    • Bakal, J.A.1    Westerhout, C.M.2    Cantor, W.J.3
  • 25
    • 84928266975 scopus 로고    scopus 로고
    • Applying novel methods to assess clinical outcomes: Insights from the TRILOGY ACS trial
    • J.A. Bakal, M.T. Roe, E.M. Ohman, and et al. Applying novel methods to assess clinical outcomes: insights from the TRILOGY ACS trial Eur Heart J 36 2015 385 392a
    • (2015) Eur Heart J , vol.36 , pp. 385-392a
    • Bakal, J.A.1    Roe, M.T.2    Ohman, E.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.