ANGPTL3 blockade with a human monoclonal antibody reduces plasma lipids in dyslipidemic mice and monkeys

Journal of Lipid Research

Volumn 56, Issue 7, 2015, Pages 1308-1317

  Gusarova, Viktoria ^a   Alexa, Corey A ^a   Wang, Yan ^b   Rafique, Ashique ^a   Kim, Jee Hae ^a   Buckler, David ^a   Mintah, Ivory J ^a   Shihanian, Lisa M ^a   Cohen, Jonathan C ^b   Hobbs, Helen H ^b   Xin, Yurong ^a   Valenzuela, David M ^a   Murphy, Andrew J ^a   Yancopoulos, George D ^a   Gromada, Jesper ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Angiopoietin like protein 3; Cholesterol; Dyslipidemia; Endothelial lipase; Hyperlipidemia; Lipoprotein lipase; Triglycerides

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 3; ENDOTHELIAL LIPASE; EVINACUMAB; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN LIPASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ANGPTL3 PROTEIN, MOUSE; LIPG PROTEIN, MOUSE; LIPID; MONOCLONAL ANTIBODY; TRIACYLGLYCEROL LIPASE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DYSLIPIDEMIA; HAPLORHINI; HEART; HYPERLIPIDEMIA; IN VITRO STUDY; LIPID BLOOD LEVEL; LIPID COMPOSITION; LIVER; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; ANIMAL; BLOOD; HUMAN; IMMUNOLOGY; MACACA FASCICULARIS; METABOLISM; RAT;

ANGIOPOIETINS; ANIMALS; ANTIBODIES, MONOCLONAL; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DYSLIPIDEMIAS; HUMANS; LIPASE; LIPIDS; LIPOPROTEIN LIPASE; MACACA FASCICULARIS; MALE; MICE; RATS; TRIGLYCERIDES;

EID: 84937132242     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M054890     Document Type: Article

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