Structure-based design of a soluble prefusion-closed HIV-1 Env trimer with reduced CD4 affinity and improved immunogenicity

Journal of Virology

Volumn 91, Issue 10, 2017, Pages

  Chuang, Gwo Yu ^a   Geng, Hui ^a   Pancera, Marie ^a   Xu, Kai ^a   Cheng, Cheng ^a   Acharya, Priyamvada ^a   Chambers, Michael ^a   Druz, Aliaksandr ^a   Tsybovsky, Yaroslav ^b   Wanninger, Timothy G ^a   Yang, Yongping ^a   Doria Rose, Nicole A ^a   Georgiev, Ivelin S ^a   Gorman, Jason ^a   Joyce, M Gordon ^a   O'Dell, Sijy ^a   Zhou, Tongqing ^a   McDermott, Adrian B ^a   Mascola, John R ^a   Kwong, Peter D ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b FREDERICK NATIONAL LABORATORY FOR CANCER RESEARCH   (United States)

Author keywords

HIV 1; Immunogen design; Protein stabilization

Indexed keywords

CD4 ANTIGEN; MONOCLONAL ANTIBODY; PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; HUMAN IMMUNODEFICIENCY VIRUS VACCINE; NEUTRALIZING ANTIBODY; VIRUS ENVELOPE PROTEIN;

ANIMAL EXPERIMENT; ANTIGENICITY; ARTICLE; BINDING AFFINITY; BINDING SITE; BIOLOGY; CHEMICAL PHENOMENA; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; ELECTROCHEMILUMINESCENCE; ELECTRON MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNIZATION; IMMUNOGENICITY; INCUBATION TIME; NONHUMAN; PRIORITY JOURNAL; SIZE EXCLUSION CHROMATOGRAPHY; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; THERMOSTABILITY; VIRUS NEUTRALIZATION; X RAY ANALYSIS; ANIMAL; BLOOD; CHEMISTRY; GENETICS; GUINEA PIG; HUMAN; IMMUNOLOGY; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN STABILITY;

AIDS VACCINES; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIGENS, CD4; ENV GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; GUINEA PIGS; HIV ANTIBODIES; HIV ANTIGENS; HIV-1; HUMANS; PROTEIN MULTIMERIZATION; PROTEIN STABILITY;

EID: 85018322356     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02268-16     Document Type: Article

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