Thermodynamic signatures of the antigen binding site of mAb 447-52D targeting the third variable region of HIV-1 gp120

Biochemistry

Volumn 52, Issue 36, 2013, Pages 6249-6257

  Killikelly, April ^a   Zhang, Hui Tang ^a   Spurrier, Brett ^a   Williams, Constance ^b   Gorny, Miroslaw K ^b   Zolla Pazner, Susan ^a,b   Kong, Xiang Peng ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY INTERACTION; ANTIGEN-BINDING SITES; BINDING AFFINITIES; HIGH RESOLUTION CRYSTAL STRUCTURE; HUMAN MONOCLONAL ANTIBODIES; HYDROGEN BOND NETWORKS; ISOTHERMAL TITRATION CALORIMETRY; SITE-SPECIFIC MUTAGENESIS;

BINDING ENERGY; COMPLEX NETWORKS; COMPLEXATION; DISEASES; EPITOPES; HYDROGEN BONDS; MONOCLONAL ANTIBODIES;

VIRUSES;

ARGININE; CATION; EPITOPE; GLYCOPROTEIN GP 120; HUMAN MONOCLONAL ANTIBODY; HUMAN MONOCLONAL ANTIBODY 447 52D; IMMUNOGLOBULIN F(AB) FRAGMENT; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANTIBODY COMBINING SITE; ANTIBODY PRODUCTION; ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; CLADISTICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENTHALPY; ENTROPY; HEAVY CHAIN; HOST CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; IC 50; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; TARGET CELL; THERMODYNAMICS; VIRUS ENTRY; VIRUS NEUTRALIZATION;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGEN-ANTIBODY REACTIONS; BINDING SITES, ANTIBODY; CRYSTALLOGRAPHY, X-RAY; EPITOPES; HIV ANTIBODIES; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; HYDROGEN BONDING; IMMUNOGLOBULIN FAB FRAGMENTS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NEUTRALIZATION TESTS; THERMODYNAMICS;

EID: 84884242637     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi400645e     Document Type: Article

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