Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins

Protein and Cell

Volumn 9, Issue 1, 2018, Pages 15-32

  Liu, Liming ^a  

^a MRL   (United States)

Author keywords

anti drug antibody (ADA); Fc fusion protein; FcRn; glycosylation; human PK prediction; monoclonal antibody (mAb); pharmacokinetics; target mediated drug disposition (TMDD)

Indexed keywords

ASIALOGLYCOPROTEIN RECEPTOR; DRUG ANTIBODY; ETANERCEPT; IMMUNOGLOBULIN G1; INFLIXIMAB; MONOCLONAL ANTIBODY; FC RECEPTOR; FUSION PROTEIN;

ALLOMETRY; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ANTIBODY ENGINEERING; BINDING AFFINITY; BIOACCUMULATION; CATABOLISM; CHEMICAL MODIFICATION; COMPLEMENT DEPENDENT CYTOTOXICITY; DRUG CONCENTRATION; DRUG DEVELOPMENT; DRUG DISPOSITION; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYMATIC DEGRADATION; GLYCOSYLATION; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; MACACA FASCICULARIS; MUTAGENESIS; NONHUMAN; PHARMACOKINETICS; PINOCYTOSIS; PLASMA CLEARANCE; PRIORITY JOURNAL; REVIEW; TISSUE DISTRIBUTION; VARIABLE NUMBER OF TANDEM REPEAT; ABSORPTION; ANIMAL; DOSE RESPONSE; METABOLISM;

ABSORPTION, PHYSIOLOGICAL; ANIMALS; ANTIBODIES, MONOCLONAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS; TISSUE DISTRIBUTION;

EID: 85017619523     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-017-0408-4     Document Type: Review

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