Selective clearance of glycoforms of a complex glycoprotein pharmaceutical caused by terminal N-acetylglucosamine is similar in humans and cynomolgus monkeys

Glycobiology

Volumn 17, Issue 5, 2007, Pages 529-540

  Jones, Andrew J S ^a   Papac, Damon I ^a,c   Chin, Edward H ^a   Keck, Rodney ^a   Baughman, Sharon A ^a,d   Lin, Yvonne S ^a   Kneer, Johannes ^b   Battersby, John E ^a  

^a GENENTECH INC   (United States)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

^c Myriad Pharmacueticals Inc   (United States)

^d AMGEN INC   (United States)

Author keywords

IgG1Fc glycans; Immunoadhesin; Lenercept terminal N acetylglucosamine; Selective glycan clearance; Terminal galactose

Indexed keywords

FC RECEPTOR; GALACTOSE; GLYCAN; IMMUNOGLOBULIN G1; LENERCEPT; MANNOSE RECEPTOR; N ACETYLGLUCOSAMINE; PROTEIN P55; SIALIC ACID; TRYPSIN; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CARBOHYDRATE ANALYSIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DOSE COMPARISON; DRUG HALF LIFE; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; IMMUNOAFFINITY CHROMATOGRAPHY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MONKEY; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN DOMAIN; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; STRUCTURE ANALYSIS;

ACETYLGLUCOSAMINE; ANIMALS; GLYCOPROTEINS; GLYCOSYLATION; HALF-LIFE; HUMANS; IMMUNOGLOBULIN GAMMA-CHAINS; MACACA FASCICULARIS; POLYSACCHARIDES; RECEPTORS, TUMOR NECROSIS FACTOR; RECOMBINANT FUSION PROTEINS; SPECIES SPECIFICITY; TIME FACTORS;

MACACA FASCICULARIS;

EID: 34447296997     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwm017     Document Type: Article

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