Pharmacokinetics of IgG1 monoclonal antibodies produced in humanized Pichia pastoris with specific glycoforms: A comparative study with CHO produced materials

Biologicals

Volumn 39, Issue 4, 2011, Pages 205-210

  Liu, Liming ^a   Stadheim, Andy ^b   Hamuro, Lora ^a   Pittman, Tamara ^a   Wang, Weirong ^a   Zha, Dongxing ^b   Hochman, Jerome ^a   Prueksaritanont, Thomayant ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b Merck Glycofi   (United States)

Author keywords

Afucosylation; Glycoengineering; Mannose; Monoclonal antibody; Pharmacokinetics; Pichia pastoris

Indexed keywords

FC RECEPTOR; GLYCOGEN; IMMUNOGLOBULIN G1 ANTIBODY; MANNOSE RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CHO CELL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; ENZYME ENGINEERING; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PICHIA PASTORIS; PRIORITY JOURNAL; STEADY STATE; YEAST;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PICHIA;

MAMMALIA; MUS; MUS MUSCULUS; PICHIA PASTORIS;

EID: 79961208871     PISSN: 10451056     EISSN: 10958320     Source Type: Journal    
DOI: 10.1016/j.biologicals.2011.06.002     Document Type: Article

References (25)

1. Jefferis R. Biotechnol Prog 2005, 21:11-16.
2. Sethuraman N., Stadheim T.A. Curr Opin Biotechnol 2006, 17:341-346.
3. Li H., Sethuraman N., Stadheim T.A., Zha D., Prinz B., Ballew N., et al. Nat Biotechnol 2006, 24:210-215.
4. Gerngross T.U. Nat Biotechnol 2004, 22:1409-1414.
5. Tabrizi M.A., Tseng C.M., Roskos L.K. Drug Discov Today 2006, 11:81-88.
6. Wang W., Wang E.Q., Balthasar J.P. Clin Pharmacol Ther 2008, 84:548-558.
7. Roopenian D.C., Akilesh S. Nat Rev Immunol 2007, 7:715-725.
8. Roopenian D.C., Christianson G.J., Sproule T.J., Brown A.C., Akilesh S., Jung N., et al. J Immunol 2003, 170:3528-3533.
9. Gillies S.D., Lan Y., Lo K.M., Super M., Wesolowski J. Cancer Res 1999, 59:2159-2166.
10. Matsumiya S., Yamaguchi Y., Saito J., Nagano M., Sasakawa H., Otaki S., et al. J Mol Biol 2007, 368:767-779.
11. Shields R.L., Lai J., Keck R., O'Connell L.Y., Hong K., Meng Y.G., et al. J Biol Chem 2002, 277:26733-26740.
12. Wright A., Morrison S.L. J Exp Med 1994, 180:1087-1096.
13. Rifai A., Fadden K., Morrison S.L., Chintalacharuvu K.R. J Exp Med 2000, 191:2171-2182.
14. Jones A.J., Papac D.I., Chin E.H., Keck R., Baughman S.A., Lin Y.S., et al. Glycobiology 2007, 17:529-540.
15. Millward T.A., Heitzmann M., Bill K., Langle U., Schumacher P., Forrer K. Biologicals 2008, 36:41-47.
16. Bobrowicz P., Davidson R.C., Li H., Potgieter T.I., Nett J.H., Hamilton S.R., et al. Glycobiology 2004, 14:757-766.
17. Hamilton S.R., Davidson R.C., Sethuraman N., Nett J.H., Jiang Y., Rios S., et al. Science 2006, 313:1441-1443.
18. Ober R.J., Radu C.G., Ghetie V., Ward E.S. Int Immunol 2001, 13:1551-1559.
19. Petkova S.B., Akilesh S., Sproule T.J., Christianson G.J., Al Khabbaz H., Brown A.C., et al. Int Immunol 2006, 18:1759-1769.
20. Wang W., Prueksaritanont T. Biopharm Drug Dispos 2010, 31:253-263.
21. Kanda Y., Yamada T., Mori K., Okazaki A., Inoue M., Kitajima-Miyama K., et al. Glycobiology 2007, 17:104-118.
22. Junttila T.T., Parsons K., Olsson C., Lu Y., Xin Y., Theriault J., et al. Cancer Res 2010, 70:4481-4489.
23. Dorai H., Mueller B.M., Reisfeld R.A., Gillies S.D. Hybridoma 1991, 10:211-217.
24. Tao M.H., Morrison S.L. J Immunol 1989, 143:2595-2601.
25. Zhou Q., Shankara S., Roy A., Qiu H., Estes S., McVie-Wylie A., et al. Biotechnol Bioeng 2008, 99:652-665.