Practical theoretic guidance for the design of tumor-targeting agents

Methods in Enzymology

Volumn 503, Issue , 2012, Pages 255-268

  Wittrup, K Dane ^a,b   Thurber, Greg M ^a   Schmidt, Michael M ^a   Rhoden, John J ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Affinity uptake relationship; Antibody fragments; Binding site barrier; Biodistribution; compartmental model; dimensionless number; Keywords; Molecular size uptake relationship; Nanoparticle accumulation; scaling analysis; tumor antigen saturation

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR 2; IMMUNOGLOBULIN G; IRON OXIDE; NANOPARTICLE; TUMOR TARGETING AGENT; UNCLASSIFIED DRUG;

ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BINDING SITE; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXTRAVASATION; DRUG HALF LIFE; ENDOCYTOSIS; HUMAN; INTERNALIZATION; KIDNEY CLEARANCE; MOLECULAR SIZE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; TUMOR VOLUME; TUMOR XENOGRAFT;

MUS;

EID: 84855577639     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-396962-0.00010-0     Document Type: Chapter

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