메뉴 건너뛰기




Volumn 907, Issue , 2012, Pages 537-556

Fc engineering: Serum half-life modulation through FCRN binding

Author keywords

Affinity and SEC chromatography; ELISA; Radioiodination; scFv Fc; Serial blood sampling; Site specific mutagenesis; Stable transfection

Indexed keywords


EID: 84867796429     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-974-7_31     Document Type: Article
Times cited : (24)

References (31)
  • 1
    • 0015421358 scopus 로고
    • The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat
    • Jones EA, Waldmann TA (1972) The mechanism of intestinal uptake and transcellular transport of IgG in the neonatal rat. J Clin Invest 51:2916-2927
    • (1972) J Clin Invest , vol.51 , pp. 2916-2927
    • Jones, E.A.1    Waldmann, T.A.2
  • 2
    • 0024529856 scopus 로고
    • An Fc receptor structurally related to MHC class i antigens
    • Simister NE, Mostov KE (1989) An Fc receptor structurally related to MHC class I antigens. Nature 337:184-187
    • (1989) Nature , vol.337 , pp. 184-187
    • Simister, N.E.1    Mostov, K.E.2
  • 3
    • 0014022299 scopus 로고
    • The transmission of immunity from mother to young and the catabolism of immunoglobulins
    • Brambell FW (1966) The transmission of immunity from mother to young and the catabolism of immunoglobulins. Lancet 2:1087-1093
    • (1966) Lancet , vol.2 , pp. 1087-1093
    • Brambell, F.W.1
  • 4
    • 0036201914 scopus 로고    scopus 로고
    • Transcytosis and catabolism of antibody
    • Ghetie V, Ward ES (2002) Transcytosis and catabolism of antibody. Immunol Res 25:97-113
    • (2002) Immunol Res , vol.25 , pp. 97-113
    • Ghetie, V.1    Ward, E.S.2
  • 5
    • 0028089908 scopus 로고
    • Crystal structure of the complex of rat neonatal Fc receptor with Fc
    • Burmeister WP, Huber AH, Bjorkman PJ (1994) Crystal structure of the complex of rat neonatal Fc receptor with F.c. Nature 372:379-383
    • (1994) Nature , vol.372 , pp. 379-383
    • Burmeister, W.P.1    Huber, A.H.2    Bjorkman, P.J.3
  • 6
    • 0035012654 scopus 로고    scopus 로고
    • Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: Mechanism of pH-dependent binding
    • Martin WL, West AP Jr, Gan L et al (2001) Crystal structure at 2.8 A of an FcRn/heterodimeric Fc complex: mechanism of pH-dependent binding. Mol Cell 7:867-877
    • (2001) Mol Cell , vol.7 , pp. 867-877
    • Martin, W.L.1    West Jr., A.P.2    Gan, L.3
  • 7
    • 0017166982 scopus 로고
    • PH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat
    • Rodewald R (1976) pH-dependent binding of immunoglobulins to intestinal cells of the neonatal rat. J Cell Biol 71:666-669
    • (1976) J Cell Biol , vol.71 , pp. 666-669
    • Rodewald, R.1
  • 9
    • 0037415556 scopus 로고    scopus 로고
    • The major histocompatibility complexrelated Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan
    • Chaudhury C, Mehnaz S, Robinson JM et al (2003) The major histocompatibility complexrelated Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan. J Exp Med 197:315-322
    • (2003) J Exp Med , vol.197 , pp. 315-322
    • Chaudhury, C.1    Mehnaz, S.2    Robinson, J.M.3
  • 10
    • 56949084877 scopus 로고    scopus 로고
    • Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles
    • Kratz F (2008) Albumin as a drug carrier: design of prodrugs, drug conjugates and nanoparticles. J Control Release 132:171-183
    • (2008) J Control Release , vol.132 , pp. 171-183
    • Kratz, F.1
  • 11
    • 34250361507 scopus 로고    scopus 로고
    • Improved pharmacokinetics of recombinant bispeci fi c antibody molecules by fusion to human serum albumin
    • Muller D, Karle A, Meissburger B et al (2007) Improved pharmacokinetics of recombinant bispeci fi c antibody molecules by fusion to human serum albumin. J Biol Chem 282: 12650-12660
    • (2007) J Biol Chem , vol.282 , pp. 12650-12660
    • Muller, D.1    Karle, A.2    Meissburger, B.3
  • 12
    • 38849143822 scopus 로고    scopus 로고
    • Biodistribution and tumor imaging of an anti-CEA single-chain antibody-albumin fusion protein
    • Yazaki PJ, Kassa T, Cheung CW et al (2008) Biodistribution and tumor imaging of an anti-CEA single-chain antibody-albumin fusion protein. Nucl Med Biol 35:151-158
    • (2008) Nucl Med Biol , vol.35 , pp. 151-158
    • Yazaki, P.J.1    Kassa, T.2    Cheung, C.W.3
  • 13
    • 77956606620 scopus 로고    scopus 로고
    • Tuning the serum persistence of human serum albumin domain III: Diabody fusion proteins
    • Kenanova VE, Olafsen T, Salazar FB et al (2010) Tuning the serum persistence of human serum albumin domain III: diabody fusion proteins. Protein Eng Des Sel 23:789-798
    • (2010) Protein Eng des Sel , vol.23 , pp. 789-798
    • Kenanova, V.E.1    Olafsen, T.2    Salazar, F.B.3
  • 14
    • 77955418625 scopus 로고    scopus 로고
    • The production, characterisation and enhanced pharmacokinetics of scFv-albumin fusions expressed in Saccharomyces cerevisiae
    • Evans L, Hughes M, Waters J et al (2010) The production, characterisation and enhanced pharmacokinetics of scFv-albumin fusions expressed in Saccharomyces cerevisiae. Protein Expr Purif 73:113-124
    • (2010) Protein Expr Purif , vol.73 , pp. 113-124
    • Evans, L.1    Hughes, M.2    Waters, J.3
  • 15
    • 0034803881 scopus 로고    scopus 로고
    • Prolonged in vivo residence times of antibody fragments associated with albumin
    • Smith BJ, Popplewell A, Athwal D et al (2001) Prolonged in vivo residence times of antibody fragments associated with albumin. Bioconjug Chem 12:750-756
    • (2001) Bioconjug Chem , vol.12 , pp. 750-756
    • Smith, B.J.1    Popplewell, A.2    Athwal, D.3
  • 16
    • 53349171633 scopus 로고    scopus 로고
    • Improved tumor targeting of antiepidermal growth factor receptor Nanobodies through albumin binding: Taking advan tage of modular Nanobody technology
    • Tijink BM, Laeremans T, Budde M et al (2008) Improved tumor targeting of antiepidermal growth factor receptor Nanobodies through albumin binding: taking advan tage of modular Nanobody technology. Mol Cancer Ther 7:2288-2297
    • (2008) Mol Cancer Ther , vol.7 , pp. 2288-2297
    • Tijink, B.M.1    Laeremans, T.2    Budde, M.3
  • 17
    • 70350018276 scopus 로고    scopus 로고
    • Biodistribution of a bispeci fi c single-chain diabody and its half-life extended derivatives
    • Stork R, Campigna E, Robert B et al (2009) Biodistribution of a bispeci fi c single-chain diabody and its half-life extended derivatives. J Biol Chem 284:25612-25619
    • (2009) J Biol Chem , vol.284 , pp. 25612-25619
    • Stork, R.1    Campigna, E.2    Robert, B.3
  • 18
    • 36549022608 scopus 로고    scopus 로고
    • A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispeci fi c single-chain diabody with an albumin-binding domain from streptococcal protein G
    • Stork R, Muller D, Kontermann RE (2007) A novel tri-functional antibody fusion protein with improved pharmacokinetic properties generated by fusing a bispeci fi c single-chain diabody with an albumin-binding domain from streptococcal protein G. Protein Eng Des Sel 20:569-576
    • (2007) Protein Eng des Sel , vol.20 , pp. 569-576
    • Stork, R.1    Muller, D.2    Kontermann, R.E.3
  • 19
    • 77958155923 scopus 로고    scopus 로고
    • The effects of af fi nity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein
    • Hopp J, Hornig N, Zettlitz KA et al (2010) The effects of af fi nity and valency of an albumin-binding domain (ABD) on the half-life of a single-chain diabody-ABD fusion protein. Protein Eng Des Sel 23:827-834
    • (2010) Protein Eng des Sel , vol.23 , pp. 827-834
    • Hopp, J.1    Hornig, N.2    Zettlitz, K.A.3
  • 20
    • 70449706366 scopus 로고    scopus 로고
    • Receptor-Fc fusion therapeutics, traps, and MIMETIBODY technology
    • Huang C (2009) Receptor-Fc fusion therapeutics, traps, and MIMETIBODY technology. Curr Opin Biotechnol 20:692-699
    • (2009) Curr Opin Biotechnol , vol.20 , pp. 692-699
    • Huang, C.1
  • 21
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • Reichert JM (2011) Antibody-based therapeutics to watch in 2011. MAbs 3:76-99
    • (2011) MAbs , vol.3 , pp. 76-99
    • Reichert, J.M.1
  • 22
    • 33846708242 scopus 로고    scopus 로고
    • Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: Optimal pharmacokinetics for therapy
    • Kenanova V, Olafsen T, Williams LE et al (2007) Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: optimal pharmacokinetics for therapy. Cancer Res 67:718-726
    • (2007) Cancer Res , vol.67 , pp. 718-726
    • Kenanova, V.1    Olafsen, T.2    Williams, L.E.3
  • 23
    • 0028808880 scopus 로고
    • Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants
    • Raghavan M, Bonagura VR, Morrison SL et al (1995) Analysis of the pH dependence of the neonatal Fc receptor/immunoglobulin G interaction using antibody and receptor variants. Biochemistry 34:14649-14657
    • (1995) Biochemistry , vol.34 , pp. 14649-14657
    • Raghavan, M.1    Bonagura, V.R.2    Morrison, S.L.3
  • 24
    • 0032518373 scopus 로고    scopus 로고
    • Structural basis of pH-dependent antibody binding by the neonatal Fc receptor
    • Vaughn DE, Bjorkman PJ (1998) Structural basis of pH-dependent antibody binding by the neonatal Fc receptor. Structure 6:63-73
    • (1998) Structure , vol.6 , pp. 63-73
    • Vaughn, D.E.1    Bjorkman, P.J.2
  • 25
    • 0031093498 scopus 로고    scopus 로고
    • Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1
    • Medesan C, Matesoi D, Radu C et al (1997) Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1. J Immunol 158:2211-2217
    • (1997) J Immunol , vol.158 , pp. 2211-2217
    • Medesan, C.1    Matesoi, D.2    Radu, C.3
  • 26
    • 0034879134 scopus 로고    scopus 로고
    • The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans
    • Firan M, Bawdon R, Radu C et al (2001) The MHC class I-related receptor, FcRn, plays an essential role in the maternofetal transfer of gamma-globulin in humans. Int Immunol 13:993-1002
    • (2001) Int Immunol , vol.13 , pp. 993-1002
    • Firan, M.1    Bawdon, R.2    Radu, C.3
  • 27
    • 0035794194 scopus 로고    scopus 로고
    • High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R
    • Shields RL, Namenuk AK, Hong K et al (2001) High resolution mapping of the binding site on human IgG1 for Fc gamma RI, Fc gamma RII, Fc gamma RIII, and FcRn and design of IgG1 variants with improved binding to the Fc gamma R. J Biol Chem 276:6591-6604
    • (2001) J Biol Chem , vol.276 , pp. 6591-6604
    • Shields, R.L.1    Namenuk, A.K.2    Hong, K.3
  • 28
    • 19944430279 scopus 로고    scopus 로고
    • Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments
    • Kenanova V, Olafsen T, Crow DM et al (2005) Tailoring the pharmacokinetics and positron emission tomography imaging properties of anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments. Cancer Res 65: 622-631
    • (2005) Cancer Res , vol.65 , pp. 622-631
    • Kenanova, V.1    Olafsen, T.2    Crow, D.M.3
  • 29
    • 0035210960 scopus 로고    scopus 로고
    • Differences in promiscuity for antibody-FcRn interactions across species: Implications for therapeutic antibodies
    • Ober RJ, Radu CG, Ghetie V et al (2001) Differences in promiscuity for antibody-FcRn interactions across species: implications for therapeutic antibodies. Int Immunol 13: 1551-1559
    • (2001) Int Immunol , vol.13 , pp. 1551-1559
    • Ober, R.J.1    Radu, C.G.2    Ghetie, V.3
  • 30
    • 33644863034 scopus 로고    scopus 로고
    • Small animal imaging center design: The facility at the UCLA Crump Institute for Molecular Imaging
    • Stout DB, Chatziioannou AF, Lawson TP et al (2005) Small animal imaging center design: the facility at the UCLA Crump Institute for Molecular Imaging. Mol Imaging Biol 7:393-402
    • (2005) Mol Imaging Biol , vol.7 , pp. 393-402
    • Stout, D.B.1    Chatziioannou, A.F.2    Lawson, T.P.3
  • 31
    • 0028272057 scopus 로고
    • The dam and dcm strains of Escherichia coli-A review
    • Palmer BR, Marinus MG (1994) The dam and dcm strains of Escherichia coli-a review. Gene 143:1-12
    • (1994) Gene , vol.143 , pp. 1-12
    • Palmer, B.R.1    Marinus, M.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.