Monoclonal antibody clearance: Impact of modulating the interaction of IgG with the neonatal Fc receptor

Journal of Biological Chemistry

Volumn 282, Issue 3, 2007, Pages 1709-1717

  Datta Mannan, Amita ^a   Witcher, Derrick R ^a   Tang, Ying ^b   Watkins, Jeffry ^b   Wroblewski, Victor J ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Signal Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING AFFINITY; HOMEOSTASIS;

ANIMALS; BINDING SITES; PHARMACOKINETICS;

ANTIBODIES;

FC RECEPTOR; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DISSOCIATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG ELIMINATION; DRUG HALF LIFE; DRUG RECEPTOR BINDING; GENE MUTATION; GENETIC VARIABILITY; IMMUNOMODULATION; IN VITRO STUDY; KINETICS; MALE; MONKEY; MOUSE; NONHUMAN; PH; PRIORITY JOURNAL; RHESUS MONKEY; SINGLE DRUG DOSE; WILD TYPE; ANIMAL; CELL LINE; CHEMISTRY; HUMAN; MACACA; METABOLISM; MUTATION; PROTEIN BINDING; SURFACE PLASMON RESONANCE;

MACACA FASCICULARIS; MACACA MULATTA; MURINAE; MUS;

ANIMALS; ANTIBODIES, MONOCLONAL; CELL LINE; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNOGLOBULIN G; KINETICS; MACACA FASCICULARIS; MACACA MULATTA; MICE; MUTATION; PROTEIN BINDING; RECEPTORS, FC; SURFACE PLASMON RESONANCE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33847330766     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M607161200     Document Type: Article

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