메뉴 건너뛰기




Volumn 42, Issue 11, 2014, Pages 1881-1889

Subcutaneous absorption of biotherapeutics: Knowns and unknowns

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; CANAKINUMAB; DENOSUMAB; ETANERCEPT; GOLIMUMAB; MONOCLONAL ANTIBODY; OMALIZUMAB; RECOMBINANT PROTEIN; RILONACEPT; RITUXIMAB; ROMIPLOSTIM; TOCILIZUMAB; TRASTUZUMAB; USTEKINUMAB; BIOLOGICAL PRODUCT;

EID: 84930887027     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.114.059238     Document Type: Short Survey
Times cited : (170)

References (59)
  • 1
    • 0027475568 scopus 로고
    • Interstitial-lymphatic mechanisms in the control of extracellular fluid volume
    • Aukland K and Reed RK (1993) Interstitial-lymphatic mechanisms in the control of extracellular fluid volume. Physiol Rev 73:1-78.
    • (1993) Physiol Rev , vol.73 , pp. 1-78
    • Aukland, K.1    Reed, R.K.2
  • 2
    • 0027363278 scopus 로고
    • Effects of the anatomical region used for insulin injections on glycemia in type I diabetes subjects
    • Bantle JP, Neal L, and Frankamp LM (1993) Effects of the anatomical region used for insulin injections on glycemia in type I diabetes subjects. Diabetes Care 16:1592-1597.
    • (1993) Diabetes Care , vol.16 , pp. 1592-1597
    • Bantle, J.P.1    Neal, L.2    Frankamp, L.M.3
  • 3
    • 0018744763 scopus 로고
    • Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site
    • Berger M, Halban PA, Girardier L, Seydoux J, Offord RE, and Renold AE (1979) Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. Diabetologia 17:97-99.
    • (1979) Diabetologia , vol.17 , pp. 97-99
    • Berger, M.1    Halban, P.A.2    Girardier, L.3    Seydoux, J.4    Offord, R.E.5    Renold, A.E.6
  • 4
    • 0030040196 scopus 로고    scopus 로고
    • Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching
    • Berk DA, Swartz MA, Leu AJ, and Jain RK (1996) Transport in lymphatic capillaries. II. Microscopic velocity measurement with fluorescence photobleaching. Am J Physiol 270:H330-H337.
    • (1996) Am J Physiol , vol.270 , pp. H330-H337
    • Berk, D.A.1    Swartz, M.A.2    Leu, A.J.3    Jain, R.K.4
  • 5
    • 84985983165 scopus 로고    scopus 로고
    • Non-clinical pharmacokinetic/pharmacodynamic and early clinical studies supporting development of a novel subcutaneous formulation for the monoclonal antibody rituximab
    • Epub ahead of print
    • Bittner B, Richter WF, Hourcade-Potelleret F, Herting F, and Schmidt J (2014) Non-clinical pharmacokinetic/pharmacodynamic and early clinical studies supporting development of a novel subcutaneous formulation for the monoclonal antibody rituximab. Drug Res (Stuttg) 2014:22 Epub ahead of print.
    • (2014) Drug Res (Stuttg) , vol.2014 , pp. 22
    • Bittner, B.1    Richter, W.F.2    Hourcade-Potelleret, F.3    Herting, F.4    Schmidt, J.5
  • 6
    • 84866292134 scopus 로고    scopus 로고
    • Development of a subcutaneous formulation for trastuzumab - Nonclinical and clinical bridging approach to the approved intravenous dosing regimen
    • Bittner B, Richter WF, Hourcade-Potelleret F, McIntyre C, Herting F, Zepeda ML, and Schmidt J (2012) Development of a subcutaneous formulation for trastuzumab - nonclinical and clinical bridging approach to the approved intravenous dosing regimen. Arzneimittelforschung 62:401-409.
    • (2012) Arzneimittelforschung , vol.62 , pp. 401-409
    • Bittner, B.1    Richter, W.F.2    Hourcade-Potelleret, F.3    McIntyre, C.4    Herting, F.5    Zepeda, M.L.6    Schmidt, J.7
  • 8
    • 0034005256 scopus 로고    scopus 로고
    • Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection
    • Charman SA, Segrave AM, Edwards GA, and Porter CJ (2000) Systemic availability and lymphatic transport of human growth hormone administered by subcutaneous injection. J Pharm Sci 89:168-177.
    • (2000) J Pharm Sci , vol.89 , pp. 168-177
    • Charman, S.A.1    Segrave, A.M.2    Edwards, G.A.3    Porter, C.J.4
  • 11
    • 84863275336 scopus 로고    scopus 로고
    • Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys
    • Datta-Mannan A, Witcher DR, Lu J, and Wroblewski VJ (2012) Influence of improved FcRn binding on the subcutaneous bioavailability of monoclonal antibodies in cynomolgus monkeys. MAbs 4:267-273.
    • (2012) MAbs , vol.4 , pp. 267-273
    • Datta-Mannan, A.1    Witcher, D.R.2    Lu, J.3    Wroblewski, V.J.4
  • 12
    • 0031810433 scopus 로고    scopus 로고
    • Subcutaneous bioavailability of a PRIMATIZED IgG1 antihuman CD4 monoclonal antibody is dose dependent in transgenic mice bearing human CD4
    • Davis CB and Bugelski PJ (1998) Subcutaneous bioavailability of a PRIMATIZED IgG1 antihuman CD4 monoclonal antibody is dose dependent in transgenic mice bearing human CD4. Drug Deliv 5:95-100.
    • (1998) Drug Deliv , vol.5 , pp. 95-100
    • Davis, C.B.1    Bugelski, P.J.2
  • 14
    • 84891630467 scopus 로고    scopus 로고
    • In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice
    • Filipe V, Que I, Carpenter JF, Löwik C, and Jiskoot W (2014) In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice. Pharm Res 31:216-227.
    • (2014) Pharm Res , vol.31 , pp. 216-227
    • Filipe, V.1    Que, I.2    Carpenter, J.F.3    Löwik, C.4    Jiskoot, W.5
  • 15
    • 34547893864 scopus 로고    scopus 로고
    • Recombinant human hyaluronidase (rHuPH20): An enabling platform for subcutaneous drug and fluid administration
    • Frost GI (2007) Recombinant human hyaluronidase (rHuPH20): an enabling platform for subcutaneous drug and fluid administration. Expert Opin Drug Deliv 4:427-440.
    • (2007) Expert Opin Drug Deliv , vol.4 , pp. 427-440
    • Frost, G.I.1
  • 16
    • 3843129540 scopus 로고    scopus 로고
    • Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration
    • Hale G, Rebello P, Brettman LR, Fegan C, Kennedy B, Kimby E, Leach M, Lundin J, Mellstedt H, and Moreton P, et al. (2004) Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration. Blood 104:948-955.
    • (2004) Blood , vol.104 , pp. 948-955
    • Hale, G.1    Rebello, P.2    Brettman, L.R.3    Fegan, C.4    Kennedy, B.5    Kimby, E.6    Leach, M.7    Lundin, J.8    Mellstedt, H.9    Moreton, P.10
  • 17
    • 72949141743 scopus 로고
    • Lymphatic flow in human subjects as indicated by the disappearance of 1-131-labeled albumin from the subcutaneous tissue
    • Hollander W, Reilly P, and Burrows BA (1961) Lymphatic flow in human subjects as indicated by the disappearance of 1-131-labeled albumin from the subcutaneous tissue. J Clin Invest 40:222-233.
    • (1961) J Clin Invest , vol.40 , pp. 222-233
    • Hollander, W.1    Reilly, P.2    Burrows, B.A.3
  • 18
    • 42949168645 scopus 로고    scopus 로고
    • Subcutaneous injection technique
    • Hunter J (2008) Subcutaneous injection technique. Nurs Stand 22:41-44.
    • (2008) Nurs Stand , vol.22 , pp. 41-44
    • Hunter, J.1
  • 19
    • 0028290515 scopus 로고
    • The pharmacokinetics of recombinant human erythropoietin after subcutaneous injection at different sites
    • Jensen JD, Jensen LW, and Madsen JK (1994) The pharmacokinetics of recombinant human erythropoietin after subcutaneous injection at different sites. Eur J Clin Pharmacol 46:333-337.
    • (1994) Eur J Clin Pharmacol , vol.46 , pp. 333-337
    • Jensen, J.D.1    Jensen, L.W.2    Madsen, J.K.3
  • 21
    • 35348853262 scopus 로고    scopus 로고
    • The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model
    • Kagan L, Gershkovich P, Mendelman A, Amsili S, Ezov N, and Hoffman A (2007) The role of the lymphatic system in subcutaneous absorption of macromolecules in the rat model. Eur J Pharm Biopharm 67:759-765.
    • (2007) Eur J Pharm Biopharm , vol.67 , pp. 759-765
    • Kagan, L.1    Gershkovich, P.2    Mendelman, A.3    Amsili, S.4    Ezov, N.5    Hoffman, A.6
  • 22
    • 84871563296 scopus 로고    scopus 로고
    • Mechanisms of subcutaneous absorption of rituximab in rats
    • Kagan L and Mager DE (2013) Mechanisms of subcutaneous absorption of rituximab in rats. Drug Metab Dispos 41:248-255.
    • (2013) Drug Metab Dispos , vol.41 , pp. 248-255
    • Kagan, L.1    Mager, D.E.2
  • 23
    • 84858229014 scopus 로고    scopus 로고
    • Subcutaneous absorption of monoclonal antibodies: Role of dose, site of injection, and injection volume on rituximab pharmacokinetics in rats
    • Kagan L, Turner MR, Balu-Iyer SV, and Mager DE (2012) Subcutaneous absorption of monoclonal antibodies: role of dose, site of injection, and injection volume on rituximab pharmacokinetics in rats. Pharm Res 29:490-499.
    • (2012) Pharm Res , vol.29 , pp. 490-499
    • Kagan, L.1    Turner, M.R.2    Balu-Iyer, S.V.3    Mager, D.E.4
  • 25
    • 84897831277 scopus 로고    scopus 로고
    • Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site
    • Kinnunen HM and Mrsny RJ (2014) Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site. J Control Release 182:22-32 10.1016/j.jconrel.2014.03.011.
    • (2014) J Control Release , vol.182 , pp. 22-32
    • Kinnunen, H.M.1    Mrsny, R.J.2
  • 26
    • 0023816519 scopus 로고
    • Lymphatic transport of recombinant human tumor necrosis factor in rats
    • Kojima K, Takahashi T, and Nakanishi Y (1988) Lymphatic transport of recombinant human tumor necrosis factor in rats. J Pharmacobiodyn 11:700-706.
    • (1988) J Pharmacobiodyn , vol.11 , pp. 700-706
    • Kojima, K.1    Takahashi, T.2    Nakanishi, Y.3
  • 27
    • 0021959921 scopus 로고
    • Fate of porcine and human insulin at the subcutaneous injection site. II. In vitro degradation of insulins in the subcutaneous tissue of the rat
    • Komada F, Okumura K, and Hori R (1985) Fate of porcine and human insulin at the subcutaneous injection site. II. In vitro degradation of insulins in the subcutaneous tissue of the rat. J Pharmacobiodyn 8:33-40.
    • (1985) J Pharmacobiodyn , vol.8 , pp. 33-40
    • Komada, F.1    Okumura, K.2    Hori, R.3
  • 28
    • 84890379859 scopus 로고    scopus 로고
    • An appraisal of subcutaneous trastuzumab: A new formulation meeting clinical needs
    • Launay-Vacher V (2013) An appraisal of subcutaneous trastuzumab: a new formulation meeting clinical needs. Cancer Chemother Pharmacol 72:1361-1367.
    • (2013) Cancer Chemother Pharmacol , vol.72 , pp. 1361-1367
    • Launay-Vacher, V.1
  • 29
    • 0028282651 scopus 로고
    • Pharmacokinetics and metabolic effects of growth hormone injected subcutaneously in growth hormone deficient patients: Thigh versus abdomen
    • Laursen T, Jørgensen JO, and Christiansen JS (1994) Pharmacokinetics and metabolic effects of growth hormone injected subcutaneously in growth hormone deficient patients: thigh versus abdomen. Clin Endocrinol (Oxf) 40:373-378.
    • (1994) Clin Endocrinol (Oxf) , vol.40 , pp. 373-378
    • Laursen, T.1    Jørgensen, J.O.2    Christiansen, J.S.3
  • 30
    • 0025793820 scopus 로고
    • Demonstration of initial lymphatics in excised human skin using an extension technique and dye injection
    • Lubach D, Nissen S, and Neukam D (1991) Demonstration of initial lymphatics in excised human skin using an extension technique and dye injection. J Invest Dermatol 96:754-757.
    • (1991) J Invest Dermatol , vol.96 , pp. 754-757
    • Lubach, D.1    Nissen, S.2    Neukam, D.3
  • 32
    • 0036803408 scopus 로고    scopus 로고
    • Receptor-mediated pharmacokinetic/pharmacodynamic model of interferon-beta 1a in humans
    • Mager DE and Jusko WJ (2002) Receptor-mediated pharmacokinetic/pharmacodynamic model of interferon-beta 1a in humans. Pharm Res 19:1537-1543.
    • (2002) Pharm Res , vol.19 , pp. 1537-1543
    • Mager, D.E.1    Jusko, W.J.2
  • 35
    • 84863227700 scopus 로고    scopus 로고
    • Molecular weight is a primary determinant for lymphatic absorption of proteins following subcutaneous administration to sheep
    • McLennan DN, Porter CJ, Edwards GA, Martin SW, and Charman SA (2002) Molecular weight is a primary determinant for lymphatic absorption of proteins following subcutaneous administration to sheep. AAPS PharmSci 4:W4041.
    • (2002) AAPS PharmSci , vol.4
    • McLennan, D.N.1    Porter, C.J.2    Edwards, G.A.3    Martin, S.W.4    Charman, S.A.5
  • 36
    • 34547844245 scopus 로고    scopus 로고
    • Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy
    • Modi S, Stanton AWB, Svensson WE, Peters AM, Mortimer PS, and Levick JR (2007) Human lymphatic pumping measured in healthy and lymphoedematous arms by lymphatic congestion lymphoscintigraphy. J Physiol 583:271-285.
    • (2007) J Physiol , vol.583 , pp. 271-285
    • Modi, S.1    Stanton, A.W.B.2    Svensson, W.E.3    Peters, A.M.4    Mortimer, P.S.5    Levick, J.R.6
  • 37
    • 77955505940 scopus 로고    scopus 로고
    • Review of the mechanism of action and clinical efficacy of recombinant human hyaluronidase coadministration with current prandial insulin formulations
    • Muchmore DB and Vaughn DE (2010) Review of the mechanism of action and clinical efficacy of recombinant human hyaluronidase coadministration with current prandial insulin formulations. J Diabetes Sci Tech 4:419-428.
    • (2010) J Diabetes Sci Tech , vol.4 , pp. 419-428
    • Muchmore, D.B.1    Vaughn, D.E.2
  • 38
    • 0038297386 scopus 로고    scopus 로고
    • Interstitial exclusion of albumin in rabbit lung during development of pulmonary oedema
    • Negrini D, Tenstad O, and Wiig H (2003) Interstitial exclusion of albumin in rabbit lung during development of pulmonary oedema. J Physiol 548:907-917.
    • (2003) J Physiol , vol.548 , pp. 907-917
    • Negrini, D.1    Tenstad, O.2    Wiig, H.3
  • 39
    • 33749331350 scopus 로고    scopus 로고
    • A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles
    • Reddy ST, Berk DA, Jain RK, and Swartz MA (2006) A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles. J Appl Physiol (1985) 101:1162-1169.
    • (2006) J Appl Physiol (1985) , vol.101 , pp. 1162-1169
    • Reddy, S.T.1    Berk, D.A.2    Jain, R.K.3    Swartz, M.A.4
  • 40
    • 84862769223 scopus 로고    scopus 로고
    • Mechanistic determinants of biotherapeutics absorption following SC administration
    • Richter WF, Bhansali SG, and Morris ME (2012) Mechanistic determinants of biotherapeutics absorption following SC administration. AAPS J 14:559-570.
    • (2012) AAPS J , vol.14 , pp. 559-570
    • Richter, W.F.1    Bhansali, S.G.2    Morris, M.E.3
  • 41
    • 85051912026 scopus 로고    scopus 로고
    • Marked contribution of lymphatic route in the SC absorption of an IgG fusion protein in the rabbit
    • May 19-21, 2014, San Diego, USA
    • Richter WF, Gruyer M-S, and Birnböck H(2014). Marked contribution of lymphatic route in the SC absorption of an IgG fusion protein in the rabbit. AAPS National Biotech Conference 2014, May 19-21, 2014, San Diego, USA.
    • (2014) AAPS National Biotech Conference 2014
    • Richter, W.F.1    Gruyer, M.-S.2    Birnböck, H.3
  • 42
    • 0024392997 scopus 로고
    • Structure and function of lymphatics
    • Ryan TJ (1989) Structure and function of lymphatics. J Invest Dermatol 93(2, Suppl):18S-24S.
    • (1989) J Invest Dermatol , vol.93 , Issue.2 , pp. 18S-24S
    • Ryan, T.J.1
  • 43
    • 77953451251 scopus 로고    scopus 로고
    • First-line treatment of chronic lymphocytic leukemia: Role of alemtuzumab
    • Schweighofer CD and Wendtner CM (2010) First-line treatment of chronic lymphocytic leukemia: role of alemtuzumab. Onco Targets Ther 3:53-67.
    • (2010) Onco Targets Ther , vol.3 , pp. 53-67
    • Schweighofer, C.D.1    Wendtner, C.M.2
  • 44
    • 0034502586 scopus 로고    scopus 로고
    • Structure, function, and molecular control of the skin lymphatic system
    • Skobe M and Detmar M (2000) Structure, function, and molecular control of the skin lymphatic system. J Investig Dermatol Symp Proc 5:14-19.
    • (2000) J Investig Dermatol Symp Proc , vol.5 , pp. 14-19
    • Skobe, M.1    Detmar, M.2
  • 45
    • 0025287316 scopus 로고
    • Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration
    • Supersaxo A, Hein WR, and Steffen H (1990) Effect of molecular weight on the lymphatic absorption of water-soluble compounds following subcutaneous administration. Pharm Res 7:167-169.
    • (1990) Pharm Res , vol.7 , pp. 167-169
    • Supersaxo, A.1    Hein, W.R.2    Steffen, H.3
  • 46
    • 0016277217 scopus 로고
    • Diffusion and convection in normal and neoplastic tissues
    • Swabb EA, Wei J, and Gullino PM (1974) Diffusion and convection in normal and neoplastic tissues. Cancer Res 34:2814-2822.
    • (1974) Cancer Res , vol.34 , pp. 2814-2822
    • Swabb, E.A.1    Wei, J.2    Gullino, P.M.3
  • 47
    • 0035940071 scopus 로고    scopus 로고
    • The physiology of the lymphatic system
    • Swartz MA (2001) The physiology of the lymphatic system. Adv Drug Deliv Rev 50:3-20.
    • (2001) Adv Drug Deliv Rev , vol.50 , pp. 3-20
    • Swartz, M.A.1
  • 48
    • 0026098151 scopus 로고
    • Enhanced bioavailability of subcutaneously injected insulin by pretreatment with ointment containing protease inhibitors
    • Takeyama M, Ishida T, Kokubu N, Komada F, Iwakawa S, Okumura K, and Hori R (1991) Enhanced bioavailability of subcutaneously injected insulin by pretreatment with ointment containing protease inhibitors. Pharm Res 8:60-64.
    • (1991) Pharm Res , vol.8 , pp. 60-64
    • Takeyama, M.1    Ishida, T.2    Kokubu, N.3    Komada, F.4    Iwakawa, S.5    Okumura, K.6    Hori, R.7
  • 49
    • 0015120578 scopus 로고
    • Patterns of lymphatic drainage in the adult laboratory rat
    • Tilney NL (1971) Patterns of lymphatic drainage in the adult laboratory rat. J Anat 109:369-383.
    • (1971) J Anat , vol.109 , pp. 369-383
    • Tilney, N.L.1
  • 51
    • 54249138516 scopus 로고    scopus 로고
    • Monoclonal antibody pharmacokinetics and pharmacodynamics
    • Wang W, Wang EQ, and Balthasar JP (2008) Monoclonal antibody pharmacokinetics and pharmacodynamics. Clin Pharmacol Ther 84:548-558.
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 548-558
    • Wang, W.1    Wang, E.Q.2    Balthasar, J.P.3
  • 52
    • 74849088867 scopus 로고    scopus 로고
    • Capillary dynamics and the interstitial fluid-lymphatic system
    • Waterhouse J, Sawdon M, and Kirkman E (2010). Capillary dynamics and the interstitial fluid-lymphatic system. Anesth Intensive Care Med 11:69-74.
    • (2010) Anesth Intensive Care Med , vol.11 , pp. 69-74
    • Waterhouse, J.1    Sawdon, M.2    Kirkman, E.3
  • 53
    • 84864075113 scopus 로고    scopus 로고
    • Interstitial fluid and lymph formation and transport: Physiological regulation and roles in inflammation and cancer
    • Wiig H and Swartz MA (2012) Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. Physiol Rev 92:1005-1060.
    • (2012) Physiol Rev , vol.92 , pp. 1005-1060
    • Wiig, H.1    Swartz, M.A.2
  • 54
    • 34548077901 scopus 로고    scopus 로고
    • Interspecies comparisons of pharmacokinetics and pharmacodynamics of recombinant human erythropoietin
    • Woo S and Jusko WJ (2007) Interspecies comparisons of pharmacokinetics and pharmacodynamics of recombinant human erythropoietin. Drug Metab Dispos 35:1672-1678.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1672-1678
    • Woo, S.1    Jusko, W.J.2
  • 55
    • 85027931811 scopus 로고    scopus 로고
    • Fluorescence imaging of the lymph node uptake of proteins in mice after subcutaneous injection: Molecular weight dependence
    • Wu F, Bhansali SG, Law WC, Bergey EJ, Prasad PN, and Morris ME (2012) Fluorescence imaging of the lymph node uptake of proteins in mice after subcutaneous injection: molecular weight dependence. Pharm Res 29:1843-1853.
    • (2012) Pharm Res , vol.29 , pp. 1843-1853
    • Wu, F.1    Bhansali, S.G.2    Law, W.C.3    Bergey, E.J.4    Prasad, P.N.5    Morris, M.E.6
  • 57
    • 84877851717 scopus 로고    scopus 로고
    • The antibody drug absorption following subcutaneous or intramuscular administration and its mathematical description by coupling physiologically based absorption process with the conventional compartment pharmacokinetic model
    • Zhao L, Ji P, Li Z, Roy P, and Sahajwalla CG (2013) The antibody drug absorption following subcutaneous or intramuscular administration and its mathematical description by coupling physiologically based absorption process with the conventional compartment pharmacokinetic model. J Clin Pharmacol 53:314-325.
    • (2013) J Clin Pharmacol , vol.53 , pp. 314-325
    • Zhao, L.1    Ji, P.2    Li, Z.3    Roy, P.4    Sahajwalla, C.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.