Reduced elimination of IgG antibodies by engineering the variable region

Protein Engineering, Design and Selection

Volumn 23, Issue 5, 2010, Pages 385-392

  Igawa, T ^a   Tsunoda, H ^a   Tachibana, T ^a   Maeda, A ^a   Mimoto, F ^a   Moriyama, C ^a   Nanami, M ^a   Sekimori, Y ^a   Nabuchi, Y ^a   Aso, Y ^a   Hattori, K ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Anti IL6 receptor antibody; Antibody engineering; FcRn; Isoelectric point; Pharmacokinetics

Indexed keywords

ANTIBODY ENGINEERING; BINDING AFFINITIES; BIOLOGICAL ACTIVITIES; CYNOMOLGUS MONKEYS; FC REGION; FCRN; ISO-ELECTRIC POINTS; ISOELECTRIC POINT; ISOELECTRIC POINT (PI); KNOCKOUT MICE; PHARMACOKINETIC PROPERTIES; PHARMACOKINETIC STUDIES;

BINDING ENERGY; ENGINEERING; PHARMACOKINETICS; RADIOACTIVITY;

ANTIBODIES;

BETA 2 MICROGLOBULIN; FC RECEPTOR; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G1 ANTIBODY; IMMUNOGLOBULIN G4 ANTIBODY; INTERLEUKIN 6 RECEPTOR ANTIBODY; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY A1; MONOCLONAL ANTIBODY A2; MONOCLONAL ANTIBODY A3; MONOCLONAL ANTIBODY B1; MONOCLONAL ANTIBODY B2; MONOCLONAL ANTIBODY B3; MONOCLONAL ANTIBODY C1; MONOCLONAL ANTIBODY D1; MONOCLONAL ANTIBODY X1; MONOCLONAL ANTIBODY X2; MONOCLONAL ANTIBODY X3; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY ENGINEERING; ANTIGEN BINDING; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; EXPERIMENTAL MONKEY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN VARIABLE REGION; ISOELECTRIC POINT; MOUSE; NONHUMAN; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; SINGLE DRUG DOSE;

ANIMALS; ANTIBODIES, MONOCLONAL; CHO CELLS; CRICETINAE; CRICETULUS; GENETIC ENGINEERING; HALF-LIFE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN VARIABLE REGION; ISOELECTRIC POINT; MICE; PROTEIN ENGINEERING; RECEPTORS, FC;

MACACA FASCICULARIS; MUS;

EID: 77951101786     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzq009     Document Type: Article

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