Approximations of the target-mediated drug disposition model and identifiability of model parameters

Journal of Pharmacokinetics and Pharmacodynamics

Volumn 35, Issue 5, 2008, Pages 573-591

  Gibiansky, Leonid ^a   Gibiansky, Ekaterina ^b   Kakkar, Tarundeep ^c   Ma, Peiming ^c  

^a QuantPharm LLC 49 Flints Grove Drive   (United States)

^b ICON Development Solutions   (United States)

^c AMGEN INC   (United States)

Author keywords

Mathematical modeling; Michaelis Menten elimination; Non linear pharmacokinetics; Target mediated drug disposition

Indexed keywords

ARTICLE; DISSOCIATION CONSTANT; DRUG ABSORPTION; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG ELIMINATION; EQUILIBRIUM CONSTANT; INTERNALIZATION; MATHEMATICAL MODEL; MICHAELIS CONSTANT; PRIORITY JOURNAL; STEADY STATE;

ALGORITHMS; ANIMALS; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; HUMANS; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS;

EID: 57749111624     PISSN: 1567567X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10928-008-9102-8     Document Type: Article

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