Effects of charge on antibody tissue distribution and pharmacokinetics

Bioconjugate Chemistry

Volumn 21, Issue 12, 2010, Pages 2153-2163

  Boswell, C Andrew ^a   Tesar, Devin B ^a   Mukhyala, Kiran ^b   Theil, Frank Peter ^a   Fielder, Paul J ^a   Khawli, Leslie A ^a  

^a Department of Pharmacokinetic and Pharmacodynamic Sciences ^*  (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN-ANTIBODY REACTIONS; ANTIGENS; BLOOD; CHEMICAL MODIFICATION; CYTOLOGY; ELECTROSTATICS; PHARMACOKINETICS; TISSUE;

ANTIGEN RECOGNITION; BIOLOGICAL PROCESS; BLOOD CONCENTRATIONS; DISPOSITION KINETICS; PHARMACOKINETICS AND PHARMACODYNAMICS; PHYSICOCHEMICAL PROPERTY; POSITIVE CHARGES; POSITIVE SURFACE CHARGE; RESEARCH TOOLS; TISSUE DISTRIBUTIONS;

ANTIBODIES;

ABCIXIMAB; ADALIMUMAB; ALEMTUZUMAB; ANTIBODY; ANTIBODY CONJUGATE; BASILIXIMAB; BEVACIZUMAB; CETUXIMAB; DACLIZUMAB; IBRITUMOMAB TIUXETAN; IMMUNOGLOBULIN G; INDIUM 111; IODINE 125; OKT 3; OMALIZUMAB; ORTHOCLONE; RITUXIMAB; TOSITUMOMAB; TOSITUMOMAB I 131; TRASTUZUMAB; UNCLASSIFIED DRUG;

ANTIBODY STRUCTURE; CHEMICAL MODIFICATION; CLINICAL EVALUATION; CLINICAL RESEARCH; HUMAN; ISOELECTRIC POINT; KINETICS; MOLECULE; NONHUMAN; PLASMA CLEARANCE; REVIEW; STATIC ELECTRICITY; TISSUE DISTRIBUTION;

EID: 78650394814     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc100261d     Document Type: Review

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