NAIP-NLRC4 Inflammasomes Coordinate Intestinal Epithelial Cell Expulsion with Eicosanoid and IL-18 Release via Activation of Caspase-1 and -8

Immunity

Volumn 46, Issue 4, 2017, Pages 649-659

  Rauch, Isabella ^a   Deets, Katherine A ^a   Ji, Daisy X ^a   von Moltke, Jakob ^a   Tenthorey, Jeannette L ^a   Lee, Angus Y ^a   Philip, Naomi H ^b   Ayres, Janelle S ^a   Brodsky, Igor E ^b   Gronert, Karsten ^a   Vance, Russell E ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA SCHOOL OF VETERINARY MEDICINE   (United States)

Author keywords

ASC; Caspase 1; Caspase 8; expulsion; extrusion; inflammasome; intestinal epithelial cell; Naip; Nlrc4

Indexed keywords

CASPASE 8; EFFECTOR CASPASE; GASDERMIN D; ICOSANOID; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; NEURONAL APOPTOSIS INHIBITORY PROTEIN; NLRC4 INFLAMMASOME; PROSTAGLANDIN E2; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CALCIUM BINDING PROTEIN; GSDMD PROTEIN, MOUSE; IPAF PROTEIN, MOUSE; NAIP1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOPLASM; DEHYDRATION; DIARRHEA; ENZYME ACTIVATION; IMMUNE RESPONSE; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; INTESTINE INFECTION; LYSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PYROPTOSIS; SALMONELLA; SALMONELLOSIS; SMALL INTESTINE TISSUE; ANIMAL; C57BL MOUSE; CONFOCAL MICROSCOPY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; GENETICS; INTESTINE MUCOSA; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SECRETION (PROCESS); TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CASPASE 1; CASPASE 8; EICOSANOIDS; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; INFLAMMASOMES; INTERLEUKIN-18; INTESTINAL MUCOSA; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; NEURONAL APOPTOSIS-INHIBITORY PROTEIN; SALMONELLA INFECTIONS; SALMONELLA TYPHIMURIUM;

EID: 85017405855     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2017.03.016     Document Type: Article

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