Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death

European Journal of Medicinal Chemistry

Volumn 134, Issue , 2017, Pages 72-85

  Tu, Zhi Shan ^a   Wang, Qi ^a   Sun, Dan Dan ^a   Dai, Fang ^a   Zhou, Bo ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Catechol; Curcumin; Cytoprotective activity; Michael acceptor; Nrf2

Indexed keywords

1,7 BIS(3,4 DIHYDROXYPHENYL) 4,4 DIMETHYLHEPTA 1,6 DIENE 3,5 DIONE; 1,7 BIS(3,4 DIHYDROXYPHENYL) 4,4 DIMETHYLHEPTANE 3,5 DIONE; CATECHOL; COPPER ION; CURCUMIN; CYTOPROTECTIVE AGENT; IRON CHELATING AGENT; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEIN KINASE B; QUINONE DERIVATIVE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TERT BUTYL HYDROPEROXIDE; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; ANTIOXIDANT; CATECHOL DERIVATIVE; NFE2L2 PROTEIN, HUMAN;

ARTICLE; CELL DEATH; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG MECHANISM; DRUG OXIDATION; DRUG SCREENING; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROPHILICITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; PROTEIN STABILITY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; AGONISTS; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; HEP-G2 CELL LINE; METABOLISM; OXIDATIVE STRESS; SYNTHESIS;

ANTIOXIDANTS; CATECHOLS; CELL DEATH; CURCUMIN; CYTOPROTECTION; HEP G2 CELLS; HUMANS; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 85017189531     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2017.04.008     Document Type: Article

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