Bis-Michael Acceptors as Novel Probes to Study the Keap1/Nrf2/ARE Pathway

Journal of Medicinal Chemistry

Volumn 59, Issue 20, 2016, Pages 9431-9442

  Deny, Ludovic J ^a,b   Traboulsi, Hussein ^b,c   Cantin, André M ^b,c   Marsault, Éric ^a,b   Richter, Martin V ^b,c   Bélanger, Guillaume ^a,b  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITÉ DE SHERBROOKE   (Canada)

^c CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; ELECTROPHILE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LUCIFERASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFORAPHANE; TRANSCRIPTION FACTOR NRF2; ANTIOXIDANT; KEAP1 PROTEIN, HUMAN; KEAP1 PROTEIN, MOUSE;

ANIMAL CELL; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; ELECTROPHILICITY; HUMAN; HUMAN CELL; HYDROGEN BOND; LIPOPHILICITY; MOLECULAR PROBE; MOUSE; NONHUMAN; NUCLEOPHILICITY; OXIDATIVE STRESS; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAW 264.7 CELL LINE; STEREOSPECIFICITY; TRANSCRIPTION REGULATION; UBIQUITINATION; ANIMAL; CELL LINE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; HEK293 CELL LINE; METABOLISM; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANIMALS; ANTIOXIDANT RESPONSE ELEMENTS; ANTIOXIDANTS; CELL LINE; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84993967704     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.6b01132     Document Type: Article

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