A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection

Cell Chemical Biology

Volumn 24, Issue 4, 2017, Pages 493-506.e5

  Niu, Xin ^a,b   Brahmbhatt, Hetal ^a,c   Mergenthaler, Philipp ^c,d,e   Zhang, Zhi ^f   Sang, Jing ^b,c   Daude, Michael ^g   Ehlert, Fabian G R ^g   Diederich, Wibke E ^g   Wong, Eve ^a   Zhu, Weijia ^a   Pogmore, Justin ^c   Nandy, Jyoti P ^h   Satyanarayana, Maragani ^h   Jimmidi, Ravi K ⁱ   Arya, Prabhat ^h   Leber, Brian ^a   Lin, Jialing ^f   Culmsee, Carsten ^g   Yi, Jing ^b   Andrews, David W ^a,c  

^a MCMASTER UNIVERSITY   (Canada)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c UNIVERSITY OF TORONTO   (Canada)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^e BERLIN INSTITUTE OF HEALTH   (Germany)

^f UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^g PHILIPPS UNIVERSITY MARBURG   (Germany)

^h ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

ⁱ UNIVERSITY OF HYDERABAD   (India)

Author keywords

apoptosis; Bak; Bax; Bcl 2 family; excitotoxicity; mitochondrial outer membrane permeabilization; programmed cell death; small molecule inhibitors

Indexed keywords

DAN 004; MSN 125; MSN 50; OLIGOMER; PROTEIN BAK; PROTEIN BAX; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; GLUTAMIC ACID; LIPOSOME; NEUROPROTECTIVE AGENT; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EXCITOTOXICITY; HCT 116 CELL LINE; MOUSE; NEUROPROTECTION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOSYNTHESIS; CELL CULTURE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FEMALE; GENETICS; HUMAN; ISOLATION AND PURIFICATION; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE; MOLECULAR LIBRARY; NERVE CELL; PERMEABILITY; PHARMACOLOGY; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BINDING SITES; CELLS, CULTURED; FEMALE; GLUTAMIC ACID; HCT116 CELLS; HUMANS; LIPOSOMES; MALE; MICE; MITOCHONDRIAL MEMBRANES; NEURONS; NEUROPROTECTIVE AGENTS; PERMEABILITY; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 85017186875     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2017.03.011     Document Type: Article

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