Small molecules reveal an alternative mechanism of Bax activation

Biochemical Journal

Volumn 473, Issue 8, 2016, Pages 1073-1083

  Brahmbhatt, Hetal ^a,b   Uehling, David ^c   Al awar, Rima ^c   Leber, Brian ^a   Andrews, David ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

Apoptosis; Bax activators; Bax oligomerization; Cysteine; Mechanism probes; Membrane permeabilization

Indexed keywords

BH3 PROTEIN; CYSTEINE; LIPOSOME; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL XL; BAX PROTEIN (53-86); MOLECULAR LIBRARY; ONCOPROTEIN; PEPTIDE FRAGMENT; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; CELL DEATH; CELL PERMEABILIZATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; MOLECULE; NONHUMAN; OLIGOMERIZATION; OUTER MEMBRANE; PRIORITY JOURNAL; ANIMAL; CELL LINE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MOLECULAR LIBRARY; MOUSE; PHARMACOLOGY;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MICE; MITOCHONDRIA; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; SMALL MOLECULE LIBRARIES;

EID: 84975104886     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BCJ20160118     Document Type: Article

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