BH3-in-groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

EMBO Journal

Volumn 35, Issue 2, 2016, Pages 208-236

  Zhang, Zhi ^a   Subramaniam, Sabareesh ^b   Kale, Justin ^c   Liao, Chenyi ^d   Huang, Bo ^e   Brahmbhatt, Hetal ^c   Condon, Samson G F ^b   Lapolla, Suzanne M ^a   Hays, Franklin A ^a,f   Ding, Jingzhen ^a   He, Feng ^a   Zhang, Xuejun C ^e   Li, Jianing ^d   Senes, Alessandro ^b   Andrews, David W ^c   Lin, Jialing ^a,f  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c Sunnybrook Health Sciences Centre   (Canada)

^d UNIVERSITY OF VERMONT   (United States)

^e INSTITUTE OF BIOPHYSICS   (China)

^f UNIVERSITY OF OKLAHOMA   (United States)

Author keywords

Apoptosis Bcl 2 proteins; membrane permeabilization; mitochondrial membranes; oligomerization

Indexed keywords

BH3 PROTEIN; CYTOCHROME C; DIMER; PROTEIN BAX; PROTEIN BAK; PROTEIN BINDING;

ALPHA CHAIN; ALPHA HELIX; APOPTOSIS; ARTICLE; BOUND FRACTION; CHEMICAL LABELING; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; DELETION MUTANT; DIMERIZATION; ENERGY TRANSFER; MITOCHONDRION; MOLECULAR DYNAMICS; MOLECULAR WEIGHT; OLIGOMERIZATION; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN CROSS LINKING; ANIMAL; CELL LINE; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MITOCHONDRIAL MEMBRANE; PHYSIOLOGY;

ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CELL LINE; DIMERIZATION; IMMUNOPRECIPITATION; MITOCHONDRIAL MEMBRANES; PROTEIN BINDING;

EID: 84955390719     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.15252/embj.201591552     Document Type: Article

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