Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation

Journal of Biological Chemistry

Volumn 282, Issue 4, 2007, Pages 2636-2645

  Jiang, Man ^a   Pabla, Navjotsin ^a   Murphy, Robert F ^b   Yang, Tianxin ^c   Yin, Xiao Ming ^d   Degenhardt, Kurt ^e   White, Eileen ^e   Dong, Zheng ^a,f  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

^f MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; KIDNEY; MITOCHONDRIA; NUTLINS;

CELL DEATH; CHEMOTHERAPY; GENE EXPRESSION; OLIGOMERIZATION; PROTEINS; TUMORS;

DRUG PRODUCTS;

BIM PROTEIN; CALCIUM; CISPLATIN; CYTOCHROME C; NUTLIN 3; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN MDM2; PROTEIN MDMX; PROTEIN P53; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; APOPTOSIS REGULATORY PROTEIN; BCL 2 BINDING PROTEIN, BIM; BCL-2-BINDING PROTEIN, BIM; IMIDAZOLE DERIVATIVE; MEMBRANE PROTEIN; ONCOPROTEIN; PIPERAZINE DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME RELEASE; GENE EXPRESSION; INCUBATION TIME; KIDNEY TUBULE CELL; MITOCHONDRION; MOUSE; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RAT; ANIMAL; CELL LINE; DRUG ANTAGONISM; KIDNEY PROXIMAL TUBULE; METABOLISM; NEOPLASM; PATHOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CELL LINE; CISPLATIN; CYTOCHROMES C; DRUG ANTAGONISM; IMIDAZOLES; KIDNEY TUBULES, PROXIMAL; MEMBRANE PROTEINS; MITOCHONDRIA; NEOPLASMS; PIPERAZINES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; RATS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 34047271954     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M606928200     Document Type: Article

References (44)

1. Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., Fotouhi, N., and Liu, E. A. (2004) Science 303, 844-848
2. Fischer, P. M., and Lane, D. P. (2004) Trends Pharmacol. Sci. 25, 343-346
3. Vassilev, L. T. (2004) Cell Cycle 3, 419-421
4. Cao, C., Shinohara, E. T., Subhawong, T. K., Geng, L., Woon Kim, K., Albert, J. M., Hallahan, D. E., and Lu, B. (2006) Mol. Cancer Ther. 5, 411-417
5. Coll-Mulet, L., Iglesias-Serret, D., Santidrian, A. F., Cosialls, A. M., de Frias, M., Castano, E., Campas, C., Barragan, M., de Sevilla, A. F., Domingo, A., Vassilev, L. T., Pons, G., and Gil, J. (2006) Blood 107, 4109-4114
6. Kojima, K., Konopleva, M., McQueen, T., O'Brien, S., Plunkett, W., and Andreeff, M. (2006) Blood 108, 993-1000
7. Kojima, K., Konopleva, M., Samudio, I. J., Shikami, M., Cabreira-Hansen, M., McQueen, T., Ruvolo, V., Tsao, T., Zeng, Z., Vassilev, L. T., and Andreeff, M. (2005) Blood 106, 3150-3159
8. Patton, J. T., Mayo, L. D., Singhi, A. D., Gudkov, A. V., Stark, G. R., and Jackson, M. W. (2006) Cancer Res. 66, 3169-3176
9. Ribas, J., Boix, J., and Meijer, L. (2006) Exp. Cell Res. 312, 2394-2400
10. Scoumanne, A., and Chen, X. (2006) Cancer Res. 66, 6271-6279
11. Secchiero, P., Barbarotto, E., Tiribelli, M., Zerbinati, C., di Iasio, M. G., Gonelli, A., Cavazzini, F., Campioni, D., Fanin, R., Cuneo, A., and Zauli, G. (2006) Blood 107, 4122-4129
12. Stuhmer, T., Chatterjee, M., Hildebrandt, M., Herrmann, P., Gollasch, H., Gerecke, C., Theurich, S., Cigliano, L., Manz, R. A., Daniel, P. T., Bommert, K., Vassilev, L. T., and Bargou, R. C. (2005) Blood 106, 3609-3617
13. Tovar, C., Rosinski, J., Filipovic, Z., Higgins, B., Kolinsky, K., Hilton, H., Zhao, X., Vu, B. T., Qing, W., Packman, K., Myklebost, O., Heimbrook, D. C., and Vassilev, L. T. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 1888-1893
14. Carvajal, D., Tovar, C., Yang, H., Vu, B. T., Heimbrook, D. C., and Vassilev, L. T. (2005) Cancer Res. 65, 1918-1924
15. Siddik, Z. H. (2003) Oncogene 22, 7265-7279
16. Jordan, P., and Carmo-Fonseca, M. (2000) Cell. Mol. Life Sci. 57, 1229-1235
17. Niedner, H., Christen, R., Lin, X., Kondo, A., and Howell, S. B. (2001) Mol. Pharmacol. 60, 1153-1160
18. Perez, J. M., Fuertes, M. A., Alonso, C., and Navarro-Ranninger, C. (2000) Crit. Rev. Oncol. Hematol. 35, 109-120
19. Arany, I., and Safirstein, R. L. (2003) Semin Nephrol. 23, 460-464
20. Taguchi, T., Nazneen, A., Abid, M. R., and Razzaque, M. S. (2005) Contrib. Nephrol. 148, 107-121
21. Cummings, B. S., and Schnellmann, R. G. (2002) J. Pharmacol. Exp. Ther. 302, 8-17
22. Jiang, M., Wei, Q., Wang, J., Du, C., Yu, J., Zhang, L., and Dong, Z. (2006) Oncogene 25, 4056-4066
23. Jiang, M., Yi, X., Hsu, S., Wang, C. Y., and Dong, Z. (2004) Am. J. Physiol. 287, F1140-F1147
24. Seth, R., Yang, C., Kaushal, V., Shah, S. V., and Kaushal, G. P. (2005) J. Biol. Chem. 280, 31230-31239
25. Degenhardt, K., Sundararajan, R., Lindsten, T., Thompson, C., and White, E. (2002) J. Biol. Chem. 277, 14127-14134
26. Montes de Oca Luna, R., Wagner, D. S., and Lozano, G. (1995) Nature 378, 203-206
27. Parant, J., Chavez-Reyes, A., Little, N. A., Yan, W., Reinke, V., Jochemsen, A. G., and Lozano, G. (2001) Nat. Genet. 29, 92-95
28. Dong, Z., and Wang, J. (2004) J. Biol. Chem. 279, 9215-9221
29. Dong, Z., Saikumar, P., Patel, Y., Weinberg, J. M., and Venkatachalam, M. A. (2000) Biochem. J. 347, 669-677
30. Kim, T. H., Zhao, Y., Barber, M. J., Kuharsky, D. K., and Yin, X. M. (2000) J. Biol. Chem. 275, 39474-39481
31. Yi, X., Yin, X. M., and Dong, Z. (2003) J. Biol. Chem. 278, 16992-16999
32. Adams, J. M., and Cory, S. (1998) Science 281, 1322-1326
33. Bernardi, P., Petronilli, V., Di Lisa, F., and Forte, M. (2001) Trends Biochem. Sci. 26, 112-117
34. Danial, N. N., and Korsmeyer, S. J. (2004) Cell 116, 205-219
35. Green, D. R., and Kroemer, G. (2004) Science 305, 626-629
36. Wang, X. (2001) Genes Dev. 15, 2922-2933
37. Tsujimoto, Y. (2003) J. Cell. Physiol. 195, 158-167
38. Hu, B., Gilkes, D. M., Farooqi, B., Sebti, S. M., and Chen, J. (2006) J. Biol. Chem. 281, 33030-33035
39. Wade, M., Wong, E. T., Tang, M., Stommel, J. M., and Wahl, G. M. (2006) J. Biol. Chem. 281, 33036-33044
40. Park, M. S., De Leon, M., and Devarajan, P. (2002) J. Am. Soc. Nephrol. 13, 858-865
41. Kuwana, T., Bouchier-Hayes, L., Chipuk, J. E., Bonzon, C., Sullivan, B. A., Green, D. R., and Newmeyer, D. D. (2005) Mol. Cell 17, 525-535
42. Thompson, T., Tovar, C., Yang, H., Carvajal, D., Vu, B. T., Xu, Q., Wahl, G. M., Heimbrook, D. C., and Vassilev, L. T. (2004) J. Biol. Chem. 279, 53015-53022
43. Megyesi, J., Safirstein, R. L., and Price, P. M. (1998) J. Clin. Invest. 101, 777-782
44. Wei, M. C., Zong, W. X., Cheng, E. H., Lindsten, T., Panoutsakopoulou, V., Ross, A. J., Roth, K. A., MacGregor, G. R., Thompson, C. B., and Korsmeyer, S. J. (2001) Science 292, 727-730