Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions

Genome Biology

Volumn 18, Issue 1, 2017, Pages

  Cole, John J ^a   Robertson, Neil A ^a   Rather, Mohammed Iqbal ^a   Thomson, John P ^c   McBryan, Tony ^a   Sproul, Duncan ^c   Wang, Tina ^e   Brock, Claire ^a   Clark, William ^a   Ideker, Trey ^e   Meehan, Richard R ^c   Miller, Richard A ^b   Brown Borg, Holly M ^d   Adams, Peter D ^a,f  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF MICHIGAN   (United States)

^c WESTERN GENERAL HOSPITAL   (United Kingdom)

^d UNIVERSITY OF NORTH DAKOTA SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^f BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE; RAPAMYCIN;

AGE; AGING; AMES DWARF MOUSE; ANIMAL TISSUE; ARTICLE; CALORIC RESTRICTION; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ENHANCER REGION; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE REGULATORY NETWORK; GENOME ANALYSIS; GENOTYPE; HISTONE MODIFICATION; LIFE EXTENSION; LIFESPAN; LIVER CANCER; LIVER FUNCTION; LIVER TISSUE; MALE; MOUSE; NONHUMAN; RNA SEQUENCE; WILD TYPE MOUSE; ANIMAL; ANTIBODY SPECIFICITY; CLUSTER ANALYSIS; DWARFISM; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; LIVER; LONGEVITY; METABOLISM; PROCEDURES; REGULATORY SEQUENCE;

AGING; ANIMALS; CLUSTER ANALYSIS; CPG ISLANDS; DNA METHYLATION; DWARFISM; ENHANCER ELEMENTS, GENETIC; EPIGENESIS, GENETIC; EPIGENOMICS; FEMALE; GENE EXPRESSION REGULATION; LIVER; LONGEVITY; MALE; MICE; ORGAN SPECIFICITY; REGULATORY SEQUENCES, NUCLEIC ACID;

EID: 85016516711     PISSN: 14747596     EISSN: 1474760X     Source Type: Journal    
DOI: 10.1186/s13059-017-1185-3     Document Type: Article

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