Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response

Cell Metabolism

Volumn 19, Issue 6, 2014, Pages 952-966

  Dang, Weiwei ^a   Sutphin, George L ^b   Dorsey, Jean A ^a   Otte, Gabriel L ^a   Cao, Kajia ^a   Perry, Rocco M ^a   Wanat, Jennifer J ^a   Saviolaki, Dimitra ^c   Murakami, Christopher J ^b   Tsuchiyama, Scott ^d   Robison, Brett ^d   Gregory, Brian D ^a   Vermeulen, Michiel ^e   Shiekhattar, Ramin ^c   Johnson, F Brad ^a   Kennedy, Brian K ^c   Kaeberlein, Matt ^b   Berger, Shelley L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c WISTAR INSTITUTE   (United States)

^d BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^e UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CAMPTOTHECIN; DNA POLYMERASE; FUNGAL ENZYME; ISW 2 ENZYME; MESYLIC ACID METHYL ESTER; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAPAMYCIN; RIBOSOME DNA; TRANSCRIPTOME; UNCLASSIFIED DRUG; ATHP-2 PROTEIN, C ELEGANS; CAENORHABDITIS ELEGANS PROTEIN; ISWI PROTEIN; PEROXIDASE; PRX1 PROTEIN, S CEREVISIAE; RAD51 PROTEIN; SACCHAROMYCES CEREVISIAE PROTEIN; TRANSCRIPTION FACTOR; DOUBLE STRANDED DNA;

ARTICLE; CALORIC RESTRICTION; CELL AGING; CELL ENERGY; CHROMATIN ASSEMBLY AND DISASSEMBLY; ENZYME ACTIVE SITE; ENZYME INACTIVATION; EPISTASIS; FUNGAL STRAIN; GENE DELETION; GENE EXPRESSION; GENOTOXICITY; HOMOLOGOUS RECOMBINATION; HYDROLYSIS; LIFE EXTENSION; LIFESPAN; LONGEVITY; NONHUMAN; NUCLEOSOME; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RETROPOSON; RIBOSOME; RNA TRANSLATION; STRESS; TELOMERE SHORTENING; TRANSCRIPTION ELONGATION; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CAENORHABDITIS ELEGANS; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY; SACCHAROMYCES CEREVISIAE; CELLULAR STRESS RESPONSE; CONFORMATION; CONTROLLED STUDY; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; FUNGAL GENE; GENE INDUCTION; HUMAN; ISW2 GENE; YEAST;

ADENOSINE TRIPHOSPHATASES; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CALORIC RESTRICTION; CELL AGING; CHROMATIN ASSEMBLY AND DISASSEMBLY; DNA DAMAGE; DNA REPAIR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, FUNGAL; GENE KNOCKOUT TECHNIQUES; LONGEVITY; PEROXIDASES; RAD51 RECOMBINASE; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS;

EID: 84902280610     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2014.04.004     Document Type: Article

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