Subacute calorie restriction and rapamycin discordantly alter mouse liver proteome homeostasis and reverse aging effects

Aging Cell

Volumn 14, Issue 4, 2015, Pages 547-557

  Karunadharma, Pabalu P ^a   Basisty, Nathan ^a   Dai, Dao Fu ^a   Chiao, Ying A ^a   Quarles, Ellen K ^a   Hsieh, Edward J ^a   Crispin, David ^a   Bielas, Jason H ^a,b   Ericson, Nolan G ^b   Beyer, Richard P ^a   Mackay, Vivian L ^a   Maccoss, Michael J ^a   Rabinovitch, Peter S ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

Author keywords

aging; calorie restriction; liver; mammalian target of rapamycin; protein turnover; rapamycin

Indexed keywords

DEUTERIUM; INITIATION FACTOR 2; LEUCINE; MTOR PROTEIN, MOUSE; PROTEOME; RAPAMYCIN; TARGET OF RAPAMYCIN KINASE;

AGING; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CALORIC RESTRICTION; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HALF LIFE TIME; HOMEOSTASIS; ISOTOPE LABELING; LIVER; METABOLISM; MOUSE; POLYSOME; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY;

AGING; ANIMALS; CALORIC RESTRICTION; DEUTERIUM; EUKARYOTIC INITIATION FACTOR-2; FEMALE; GENE EXPRESSION REGULATION; HALF-LIFE; HOMEOSTASIS; ISOTOPE LABELING; LEUCINE; LIVER; MICE; MICE, INBRED C57BL; POLYRIBOSOMES; PROTEIN BIOSYNTHESIS; PROTEIN STABILITY; PROTEOLYSIS; PROTEOME; SIGNAL TRANSDUCTION; SIROLIMUS; TANDEM MASS SPECTROMETRY; TOR SERINE-THREONINE KINASES;

EID: 85016512482     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/ACEL.12317     Document Type: Article

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